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Conserved domains on  [gi|1207111504|ref|XP_021335691|]
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supervillin isoform X6 [Danio rerio]

Protein Classification

supervillin family protein( domain architecture ID 10181714)

supervillin family protein, a villin/gelsolin superfamily member, directly binds and cross-links F-actin; also regulates myosin II contractility subjacent to plasma membranes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
gelsolin_S4_like cd11293
Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; ...
 1375-1486 6.77e-44

Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


:

Pssm-ID: 200449  Cd Length: 101  Bit Score: 154.74  E-value: 6.77e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504 1375 FEISTLSVDVWHILEFDYSRLPKQSIGQFHEGDTYVVKWKYMISravgkrlhseriigpGKEKCCYFFWQGRNSTVNEKG 1454
Cdd:cd11293      2 YDDGSGKVEVWRIENDEKVPVPKEEYGQFYGGDCYIVLYTYQGG---------------GKEEHILYFWQGRHSSQDERA 66

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1207111504 1455 TSALMTVELDEE---RGAQVQVQQGKEPPCFLQCF 1486
Cdd:cd11293     67 AAALLTVELDEElkgRAVQVRVVQGKEPPHFLALF 101
gelsolin_S2_like cd11289
Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; ...
 1071-1167 5.48e-33

Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


:

Pssm-ID: 200445  Cd Length: 92  Bit Score: 123.50  E-value: 5.48e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504 1071 KLMLIQVKGRRHVQTRLVEPRASSLNSGDCFLLITPHHCFIWIGEFANVIEKAKAAELATFVQTKHDLGCRASYVQTIEE 1150
Cdd:cd11289      1 KPRLLHVKGRRNVRAREVELSWSSLNSGDVFILDLGSTIYQWNGSKSNRFEKAKAMQLAQGIRDERRLGRAKVIVLDEGD 80

                           90
                   ....*....|....*..
gi 1207111504 1151 GANTHThaakdFWKILG 1167
Cdd:cd11289     81 TNESPE-----FWKVLG 92
gelsolin_S5_like cd11288
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; ...
 1508-1611 4.04e-24

Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


:

Pssm-ID: 200444  Cd Length: 92  Bit Score: 98.07  E-value: 4.04e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504 1508 WRLYCVRGEKPIEGHLLEAVCHCSSLRSRTSMILLNiPKaSLYLWHGCKAQVHTRDVGRTTANKIKEqcpleaglhsssK 1587
Cdd:cd11288      3 TRLFQVRGNGSGNTRAVEVDADASSLNSNDVFVLKT-PS-SVYLWVGKGSSEDERELAKDVASFLKP------------K 68

                           90       100
                   ....*....|....*....|....
gi 1207111504 1588 VSIQECDEGAEPQGFWEALGKRDR 1611
Cdd:cd11288     69 ASLQEVAEGSEPDEFWEALGGKSE 92
gelsolin_like cd11280
Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin ...
 1192-1292 2.96e-16

Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


:

Pssm-ID: 200436  Cd Length: 88  Bit Score: 75.48  E-value: 2.96e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504 1192 NCIYRLMEDKlvphDDYWGRVPRCS-MLNPKEVLVFDFGSEVYVWHGKEVTLAQRKVAFQLAKHLWNGtfdytncdinpl 1270
Cdd:cd11280      2 PRLYRVRGSK----AIEIEEVPLASsSLDSDDVFVLDTGSEIYIWQGRASSQAELAAAALLAKELDEE------------ 65

                           90       100
                   ....*....|....*....|...
gi 1207111504 1271 DPGECNALIPRKGQG-RPDWAVF 1292
Cdd:cd11280     66 RKGKPEIVRIRQGQEpREFWSLF 88
ADF_gelsolin super family cl15697
Actin depolymerization factor/cofilin- and gelsolin-like domains; Actin depolymerization ...
 1628-1749 3.01e-13

Actin depolymerization factor/cofilin- and gelsolin-like domains; Actin depolymerization factor/cofilin-like domains are present in a family of essential eukaryotic actin regulatory proteins; these proteins enhance the turnover rate of actin and interact with actin monomers as well as actin filaments.


The actual alignment was detected with superfamily member cd11291:

Pssm-ID: 472830 [Multi-domain]  Cd Length: 99  Bit Score: 67.32  E-value: 3.01e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504 1628 PRLFQLSSASGeFAAVEFVYPsrepnlvnsmpFLQEDLytATQpALFLVDNHHEVYLWQGwwpqdSESTgsarirwDSDR 1707
Cdd:cd11291      2 PRLFRCSNESG-FFKVEEISD-----------FSQDDL--DTD-DIMLLDTGDEVFVWVG-----SESS-------DEEK 54

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1207111504 1708 KCAMETVLQYSK----EKNEKKTPKsYLIHAGLEPLTFTNMFPSWE 1749
Cdd:cd11291     55 KEALTSAKKYIEtdplGRSKPRTPI-YLVKQGNEPPTFTGYFHAWD 99
VHP pfam02209
Villin headpiece domain;
1805-1847 3.67e-12

Villin headpiece domain;


:

Pssm-ID: 460493  Cd Length: 36  Bit Score: 62.01  E-value: 3.67e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1207111504 1805 YLSDEDFEgvgasgkKALEMTRSEYEALPGWKQVNVKKAKGLF 1847
Cdd:pfam02209    1 YLSDEDFE-------EVFGMSREEFYKLPKWKQNNLKKKAGLF 36
 
Name Accession Description Interval E-value
gelsolin_S4_like cd11293
Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; ...
 1375-1486 6.77e-44

Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200449  Cd Length: 101  Bit Score: 154.74  E-value: 6.77e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504 1375 FEISTLSVDVWHILEFDYSRLPKQSIGQFHEGDTYVVKWKYMISravgkrlhseriigpGKEKCCYFFWQGRNSTVNEKG 1454
Cdd:cd11293      2 YDDGSGKVEVWRIENDEKVPVPKEEYGQFYGGDCYIVLYTYQGG---------------GKEEHILYFWQGRHSSQDERA 66

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1207111504 1455 TSALMTVELDEE---RGAQVQVQQGKEPPCFLQCF 1486
Cdd:cd11293     67 AAALLTVELDEElkgRAVQVRVVQGKEPPHFLALF 101
gelsolin_S2_like cd11289
Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; ...
 1071-1167 5.48e-33

Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200445  Cd Length: 92  Bit Score: 123.50  E-value: 5.48e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504 1071 KLMLIQVKGRRHVQTRLVEPRASSLNSGDCFLLITPHHCFIWIGEFANVIEKAKAAELATFVQTKHDLGCRASYVQTIEE 1150
Cdd:cd11289      1 KPRLLHVKGRRNVRAREVELSWSSLNSGDVFILDLGSTIYQWNGSKSNRFEKAKAMQLAQGIRDERRLGRAKVIVLDEGD 80

                           90
                   ....*....|....*..
gi 1207111504 1151 GANTHThaakdFWKILG 1167
Cdd:cd11289     81 TNESPE-----FWKVLG 92
gelsolin_S5_like cd11288
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; ...
 1508-1611 4.04e-24

Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200444  Cd Length: 92  Bit Score: 98.07  E-value: 4.04e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504 1508 WRLYCVRGEKPIEGHLLEAVCHCSSLRSRTSMILLNiPKaSLYLWHGCKAQVHTRDVGRTTANKIKEqcpleaglhsssK 1587
Cdd:cd11288      3 TRLFQVRGNGSGNTRAVEVDADASSLNSNDVFVLKT-PS-SVYLWVGKGSSEDERELAKDVASFLKP------------K 68

                           90       100
                   ....*....|....*....|....
gi 1207111504 1588 VSIQECDEGAEPQGFWEALGKRDR 1611
Cdd:cd11288     69 ASLQEVAEGSEPDEFWEALGGKSE 92
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1074-1168 2.62e-21

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 90.04  E-value: 2.62e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504  1074 LIQVKGRRHVQTRLVEPRASSLNSGDCFLLITPHHCFIWIGEFANVIEKAKAAELAtfVQTKHDLGCRASYVQTIEEGAN 1153
Cdd:smart00262    2 LVRVKGKRNVRVPEVPFSQGSLNSGDCYILDTGSEIYVWVGKKSSQDEKKKAAELA--VELDDTLGPGPVQVRVVDEGKE 79

                            90
                    ....*....|....*
gi 1207111504  1154 THThaakdFWKILGG 1168
Cdd:smart00262   80 PPE-----FWSLFGG 89
gelsolin_like cd11280
Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin ...
 1192-1292 2.96e-16

Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200436  Cd Length: 88  Bit Score: 75.48  E-value: 2.96e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504 1192 NCIYRLMEDKlvphDDYWGRVPRCS-MLNPKEVLVFDFGSEVYVWHGKEVTLAQRKVAFQLAKHLWNGtfdytncdinpl 1270
Cdd:cd11280      2 PRLYRVRGSK----AIEIEEVPLASsSLDSDDVFVLDTGSEIYIWQGRASSQAELAAAALLAKELDEE------------ 65

                           90       100
                   ....*....|....*....|...
gi 1207111504 1271 DPGECNALIPRKGQG-RPDWAVF 1292
Cdd:cd11280     66 RKGKPEIVRIRQGQEpREFWSLF 88
gelsolin_S6_like cd11291
Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins; ...
 1628-1749 3.01e-13

Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200447 [Multi-domain]  Cd Length: 99  Bit Score: 67.32  E-value: 3.01e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504 1628 PRLFQLSSASGeFAAVEFVYPsrepnlvnsmpFLQEDLytATQpALFLVDNHHEVYLWQGwwpqdSESTgsarirwDSDR 1707
Cdd:cd11291      2 PRLFRCSNESG-FFKVEEISD-----------FSQDDL--DTD-DIMLLDTGDEVFVWVG-----SESS-------DEEK 54

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1207111504 1708 KCAMETVLQYSK----EKNEKKTPKsYLIHAGLEPLTFTNMFPSWE 1749
Cdd:cd11291     55 KEALTSAKKYIEtdplGRSKPRTPI-YLVKQGNEPPTFTGYFHAWD 99
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1384-1489 1.20e-12

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 65.39  E-value: 1.20e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504  1384 VWHILEFDYSRLP--KQSIGQFHEGDTYVVKWKYMIsravgkrlhseriigpgkekccyFFWQGRNSTVNEKGTSALMTV 1461
Cdd:smart00262    2 LVRVKGKRNVRVPevPFSQGSLNSGDCYILDTGSEI-----------------------YVWVGKKSSQDEKKKAAELAV 58

                            90       100       110
                    ....*....|....*....|....*....|..
gi 1207111504  1462 ELDEERG---AQVQ-VQQGKEPPCFLQCFNGG 1489
Cdd:smart00262   59 ELDDTLGpgpVQVRvVDEGKEPPEFWSLFGGW 90
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1511-1607 3.39e-12

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 63.85  E-value: 3.39e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504  1511 YCVRGEKPIEGHLLEAVCHCSSLRSRTSMILLNipKASLYLWHGCKAQVHTRDVGRTTANKIKEQCPleaglhsSSKVSI 1590
Cdd:smart00262    1 FLVRVKGKRNVRVPEVPFSQGSLNSGDCYILDT--GSEIYVWVGKKSSQDEKKKAAELAVELDDTLG-------PGPVQV 71

                            90
                    ....*....|....*..
gi 1207111504  1591 QECDEGAEPQGFWEALG 1607
Cdd:smart00262   72 RVVDEGKEPPEFWSLFG 88
VHP pfam02209
Villin headpiece domain;
1805-1847 3.67e-12

Villin headpiece domain;


Pssm-ID: 460493  Cd Length: 36  Bit Score: 62.01  E-value: 3.67e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1207111504 1805 YLSDEDFEgvgasgkKALEMTRSEYEALPGWKQVNVKKAKGLF 1847
Cdd:pfam02209    1 YLSDEDFE-------EVFGMSREEFYKLPKWKQNNLKKKAGLF 36
VHP smart00153
Villin headpiece domain;
1805-1847 1.92e-10

Villin headpiece domain;


Pssm-ID: 128458  Cd Length: 36  Bit Score: 57.33  E-value: 1.92e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1207111504  1805 YLSDEDFEgvgasgkKALEMTRSEYEALPGWKQVNVKKAKGLF 1847
Cdd:smart00153    1 YLSDEDFE-------EVFGMTREEFYKLPLWKQNQLKKKKGLF 36
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1659-1748 1.12e-07

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 51.14  E-value: 1.12e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504  1659 PFLQEDLYTAtqpALFLVDNHHEVYLWQGwwpqdSESTgsarirwDSDRKCAMETVLQYSKEKNEKKTPkSYLIHAGLEP 1738
Cdd:smart00262   17 PFSQGSLNSG---DCYILDTGSEIYVWVG-----KKSS-------QDEKKKAAELAVELDDTLGPGPVQ-VRVVDEGKEP 80

                            90
                    ....*....|
gi 1207111504  1739 LTFTNMFPSW 1748
Cdd:smart00262   81 PEFWSLFGGW 90
Gelsolin pfam00626
Gelsolin repeat;
1092-1129 1.88e-06

Gelsolin repeat;


Pssm-ID: 395501 [Multi-domain]  Cd Length: 76  Bit Score: 47.30  E-value: 1.88e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1207111504 1092 ASSLNSGDCFLLITPHHCFIWIGEFANVIEKAKAAELA 1129
Cdd:pfam00626   12 QESLNSGDCYLLDNGFTIFLWVGKGSSLLEKLFAALLA 49
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1216-1311 1.91e-06

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 47.67  E-value: 1.91e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504  1216 SMLNPKEVLVFDFGSEVYVWHGKEVTLAQRKVAFQLAKHLWNGtfdytncdinpldpgecnaLIPRKGQGRpdwavfgRL 1295
Cdd:smart00262   21 GSLNSGDCYILDTGSEIYVWVGKKSSQDEKKKAAELAVELDDT-------------------LGPGPVQVR-------VV 74

                            90
                    ....*....|....*.
gi 1207111504  1296 TQHNETTLFKEKFLDW 1311
Cdd:smart00262   75 DEGKEPPEFWSLFGGW 90
Gelsolin pfam00626
Gelsolin repeat;
1441-1483 3.53e-03

Gelsolin repeat;


Pssm-ID: 395501 [Multi-domain]  Cd Length: 76  Bit Score: 38.06  E-value: 3.53e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1207111504 1441 FFWQGRNSTVNEKGTSALMTVELD-EERGA---QVQVQQGKEPPCFL 1483
Cdd:pfam00626   30 FLWVGKGSSLLEKLFAALLAAQLDdDERFPlpeVIRVPQGKEPARFL 76
 
Name Accession Description Interval E-value
gelsolin_S4_like cd11293
Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; ...
 1375-1486 6.77e-44

Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200449  Cd Length: 101  Bit Score: 154.74  E-value: 6.77e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504 1375 FEISTLSVDVWHILEFDYSRLPKQSIGQFHEGDTYVVKWKYMISravgkrlhseriigpGKEKCCYFFWQGRNSTVNEKG 1454
Cdd:cd11293      2 YDDGSGKVEVWRIENDEKVPVPKEEYGQFYGGDCYIVLYTYQGG---------------GKEEHILYFWQGRHSSQDERA 66

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1207111504 1455 TSALMTVELDEE---RGAQVQVQQGKEPPCFLQCF 1486
Cdd:cd11293     67 AAALLTVELDEElkgRAVQVRVVQGKEPPHFLALF 101
gelsolin_S2_like cd11289
Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; ...
 1071-1167 5.48e-33

Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200445  Cd Length: 92  Bit Score: 123.50  E-value: 5.48e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504 1071 KLMLIQVKGRRHVQTRLVEPRASSLNSGDCFLLITPHHCFIWIGEFANVIEKAKAAELATFVQTKHDLGCRASYVQTIEE 1150
Cdd:cd11289      1 KPRLLHVKGRRNVRAREVELSWSSLNSGDVFILDLGSTIYQWNGSKSNRFEKAKAMQLAQGIRDERRLGRAKVIVLDEGD 80

                           90
                   ....*....|....*..
gi 1207111504 1151 GANTHThaakdFWKILG 1167
Cdd:cd11289     81 TNESPE-----FWKVLG 92
gelsolin_S5_like cd11288
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; ...
 1508-1611 4.04e-24

Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200444  Cd Length: 92  Bit Score: 98.07  E-value: 4.04e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504 1508 WRLYCVRGEKPIEGHLLEAVCHCSSLRSRTSMILLNiPKaSLYLWHGCKAQVHTRDVGRTTANKIKEqcpleaglhsssK 1587
Cdd:cd11288      3 TRLFQVRGNGSGNTRAVEVDADASSLNSNDVFVLKT-PS-SVYLWVGKGSSEDERELAKDVASFLKP------------K 68

                           90       100
                   ....*....|....*....|....
gi 1207111504 1588 VSIQECDEGAEPQGFWEALGKRDR 1611
Cdd:cd11288     69 ASLQEVAEGSEPDEFWEALGGKSE 92
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1074-1168 2.62e-21

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 90.04  E-value: 2.62e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504  1074 LIQVKGRRHVQTRLVEPRASSLNSGDCFLLITPHHCFIWIGEFANVIEKAKAAELAtfVQTKHDLGCRASYVQTIEEGAN 1153
Cdd:smart00262    2 LVRVKGKRNVRVPEVPFSQGSLNSGDCYILDTGSEIYVWVGKKSSQDEKKKAAELA--VELDDTLGPGPVQVRVVDEGKE 79

                            90
                    ....*....|....*
gi 1207111504  1154 THThaakdFWKILGG 1168
Cdd:smart00262   80 PPE-----FWSLFGG 89
gelsolin_S5_like cd11288
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; ...
 1073-1171 8.53e-18

Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200444  Cd Length: 92  Bit Score: 79.97  E-value: 8.53e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504 1073 MLIQVKGRRHVQTRLVE--PRASSLNSGDCFLLITPHHCFIWIGEFANVIEKAKAAELATFvqtkhdLGCRASYvQTIEE 1150
Cdd:cd11288      4 RLFQVRGNGSGNTRAVEvdADASSLNSNDVFVLKTPSSVYLWVGKGSSEDERELAKDVASF------LKPKASL-QEVAE 76

                           90       100
                   ....*....|....*....|.
gi 1207111504 1151 GANThthaaKDFWKILGGQTS 1171
Cdd:cd11288     77 GSEP-----DEFWEALGGKSE 92
gelsolin_like cd11280
Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin ...
 1192-1292 2.96e-16

Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200436  Cd Length: 88  Bit Score: 75.48  E-value: 2.96e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504 1192 NCIYRLMEDKlvphDDYWGRVPRCS-MLNPKEVLVFDFGSEVYVWHGKEVTLAQRKVAFQLAKHLWNGtfdytncdinpl 1270
Cdd:cd11280      2 PRLYRVRGSK----AIEIEEVPLASsSLDSDDVFVLDTGSEIYIWQGRASSQAELAAAALLAKELDEE------------ 65

                           90       100
                   ....*....|....*....|...
gi 1207111504 1271 DPGECNALIPRKGQG-RPDWAVF 1292
Cdd:cd11280     66 RKGKPEIVRIRQGQEpREFWSLF 88
gelsolin_S1_like cd11290
Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins; ...
 1382-1495 8.45e-14

Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin_like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200446  Cd Length: 113  Bit Score: 69.17  E-value: 8.45e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504 1382 VDVWHILEFDYSRLPKQSIGQFHEGDTYVVkwkymisravgkrLHSERIiGPGKEKCCYFFWQGRNSTVNEKGTSALMTV 1461
Cdd:cd11290     10 LQIWRIENFELVPVPESFYGKFYEGDSYIV-------------LKTTLD-PSGSLSYDIHYWLGKEASQDEAGAAAIKAV 75

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1207111504 1462 ELDEERGAQ-VQVQ--QGKEPPCFLQCFNGGMIVHAG 1495
Cdd:cd11290     76 ELDDYLGGRpVQHRevQGHESEEFLSYFKKGIIYIEG 112
gelsolin_S6_like cd11291
Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins; ...
 1628-1749 3.01e-13

Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200447 [Multi-domain]  Cd Length: 99  Bit Score: 67.32  E-value: 3.01e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504 1628 PRLFQLSSASGeFAAVEFVYPsrepnlvnsmpFLQEDLytATQpALFLVDNHHEVYLWQGwwpqdSESTgsarirwDSDR 1707
Cdd:cd11291      2 PRLFRCSNESG-FFKVEEISD-----------FSQDDL--DTD-DIMLLDTGDEVFVWVG-----SESS-------DEEK 54

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1207111504 1708 KCAMETVLQYSK----EKNEKKTPKsYLIHAGLEPLTFTNMFPSWE 1749
Cdd:cd11291     55 KEALTSAKKYIEtdplGRSKPRTPI-YLVKQGNEPPTFTGYFHAWD 99
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1384-1489 1.20e-12

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 65.39  E-value: 1.20e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504  1384 VWHILEFDYSRLP--KQSIGQFHEGDTYVVKWKYMIsravgkrlhseriigpgkekccyFFWQGRNSTVNEKGTSALMTV 1461
Cdd:smart00262    2 LVRVKGKRNVRVPevPFSQGSLNSGDCYILDTGSEI-----------------------YVWVGKKSSQDEKKKAAELAV 58

                            90       100       110
                    ....*....|....*....|....*....|..
gi 1207111504  1462 ELDEERG---AQVQ-VQQGKEPPCFLQCFNGG 1489
Cdd:smart00262   59 ELDDTLGpgpVQVRvVDEGKEPPEFWSLFGGW 90
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1511-1607 3.39e-12

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 63.85  E-value: 3.39e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504  1511 YCVRGEKPIEGHLLEAVCHCSSLRSRTSMILLNipKASLYLWHGCKAQVHTRDVGRTTANKIKEQCPleaglhsSSKVSI 1590
Cdd:smart00262    1 FLVRVKGKRNVRVPEVPFSQGSLNSGDCYILDT--GSEIYVWVGKKSSQDEKKKAAELAVELDDTLG-------PGPVQV 71

                            90
                    ....*....|....*..
gi 1207111504  1591 QECDEGAEPQGFWEALG 1607
Cdd:smart00262   72 RVVDEGKEPPEFWSLFG 88
VHP pfam02209
Villin headpiece domain;
1805-1847 3.67e-12

Villin headpiece domain;


Pssm-ID: 460493  Cd Length: 36  Bit Score: 62.01  E-value: 3.67e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1207111504 1805 YLSDEDFEgvgasgkKALEMTRSEYEALPGWKQVNVKKAKGLF 1847
Cdd:pfam02209    1 YLSDEDFE-------EVFGMSREEFYKLPKWKQNNLKKKAGLF 36
VHP smart00153
Villin headpiece domain;
1805-1847 1.92e-10

Villin headpiece domain;


Pssm-ID: 128458  Cd Length: 36  Bit Score: 57.33  E-value: 1.92e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1207111504  1805 YLSDEDFEgvgasgkKALEMTRSEYEALPGWKQVNVKKAKGLF 1847
Cdd:smart00153    1 YLSDEDFE-------EVFGMTREEFYKLPLWKQNQLKKKKGLF 36
gelsolin_S3_like cd11292
Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; ...
 1216-1308 3.55e-09

Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200448  Cd Length: 98  Bit Score: 55.72  E-value: 3.55e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504 1216 SMLNPKEVLVFDFGSEVYVWHGKEVTLAQRKVAFQLAkhlwngtfdytncdinpldpgecNALIPRKgqGRPDWAVFGRL 1295
Cdd:cd11292     29 EMLDSEDCYILDCGSEIFVWVGKGASLDERKAALKNA-----------------------EEFLRKK--KRPPYTQVTRV 83

                           90
                   ....*....|...
gi 1207111504 1296 TQHNETTLFKEKF 1308
Cdd:cd11292     84 TEGGESALFKSKF 96
gelsolin_like cd11280
Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin ...
 1628-1745 5.05e-09

Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200436  Cd Length: 88  Bit Score: 55.07  E-value: 5.05e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504 1628 PRLFQLSSASgefaAVEFVYPSREPNLVNSMPFLQEDLYTatqpalflvdnhhEVYLWQGWwpqdsestGSARIRWDSDR 1707
Cdd:cd11280      2 PRLYRVRGSK----AIEIEEVPLASSSLDSDDVFVLDTGS-------------EIYIWQGR--------ASSQAELAAAA 56

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1207111504 1708 KCAMETvlqyskEKNEKKTPKSYLIHAGLEPLTFTNMF 1745
Cdd:cd11280     57 LLAKEL------DEERKGKPEIVRIRQGQEPREFWSLF 88
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1659-1748 1.12e-07

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 51.14  E-value: 1.12e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504  1659 PFLQEDLYTAtqpALFLVDNHHEVYLWQGwwpqdSESTgsarirwDSDRKCAMETVLQYSKEKNEKKTPkSYLIHAGLEP 1738
Cdd:smart00262   17 PFSQGSLNSG---DCYILDTGSEIYVWVG-----KKSS-------QDEKKKAAELAVELDDTLGPGPVQ-VRVVDEGKEP 80

                            90
                    ....*....|
gi 1207111504  1739 LTFTNMFPSW 1748
Cdd:smart00262   81 PEFWSLFGGW 90
gelsolin_S3_like cd11292
Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; ...
 1093-1164 4.92e-07

Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200448  Cd Length: 98  Bit Score: 49.56  E-value: 4.92e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207111504 1093 SSLNSGDCFLLITPHHCFIWIGEFANVIEKAKAAELAT-FVQTKHdlgcRASY--VQTIEEGAntHTHAAKDFWK 1164
Cdd:cd11292     29 EMLDSEDCYILDCGSEIFVWVGKGASLDERKAALKNAEeFLRKKK----RPPYtqVTRVTEGG--ESALFKSKFA 97
Gelsolin pfam00626
Gelsolin repeat;
1092-1129 1.88e-06

Gelsolin repeat;


Pssm-ID: 395501 [Multi-domain]  Cd Length: 76  Bit Score: 47.30  E-value: 1.88e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1207111504 1092 ASSLNSGDCFLLITPHHCFIWIGEFANVIEKAKAAELA 1129
Cdd:pfam00626   12 QESLNSGDCYLLDNGFTIFLWVGKGSSLLEKLFAALLA 49
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1216-1311 1.91e-06

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 47.67  E-value: 1.91e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111504  1216 SMLNPKEVLVFDFGSEVYVWHGKEVTLAQRKVAFQLAKHLWNGtfdytncdinpldpgecnaLIPRKGQGRpdwavfgRL 1295
Cdd:smart00262   21 GSLNSGDCYILDTGSEIYVWVGKKSSQDEKKKAAELAVELDDT-------------------LGPGPVQVR-------VV 74

                            90
                    ....*....|....*.
gi 1207111504  1296 TQHNETTLFKEKFLDW 1311
Cdd:smart00262   75 DEGKEPPEFWSLFGGW 90
gelsolin_like cd11280
Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin ...
 1088-1166 2.05e-06

Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200436  Cd Length: 88  Bit Score: 47.36  E-value: 2.05e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207111504 1088 VEPRASSLNSGDCFLLITPHHCFIWIGEFANVIEKAKAAELAtfVQTKHDLGCRASYVQtIEEGanthtHAAKDFWKIL 1166
Cdd:cd11280     18 VPLASSSLDSDDVFVLDTGSEIYIWQGRASSQAELAAAALLA--KELDEERKGKPEIVR-IRQG-----QEPREFWSLF 88
gelsolin_S5_like cd11288
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; ...
 1213-1259 2.70e-05

Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200444  Cd Length: 92  Bit Score: 44.53  E-value: 2.70e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1207111504 1213 PRCSMLNPKEVLVFDFGSEVYVWHGKEVTLAQRKVAFQLAKHLWNGT 1259
Cdd:cd11288     23 ADASSLNSNDVFVLKTPSSVYLWVGKGSSEDERELAKDVASFLKPKA 69
gelsolin_like cd11280
Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin ...
 1441-1486 6.14e-05

Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200436  Cd Length: 88  Bit Score: 43.51  E-value: 6.14e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1207111504 1441 FFWQGRNSTVNEKGTSALMTVELDEERG---AQVQVQQGKEPPCFLQCF 1486
Cdd:cd11280     40 YIWQGRASSQAELAAAALLAKELDEERKgkpEIVRIRQGQEPREFWSLF 88
Gelsolin pfam00626
Gelsolin repeat;
1441-1483 3.53e-03

Gelsolin repeat;


Pssm-ID: 395501 [Multi-domain]  Cd Length: 76  Bit Score: 38.06  E-value: 3.53e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1207111504 1441 FFWQGRNSTVNEKGTSALMTVELD-EERGA---QVQVQQGKEPPCFL 1483
Cdd:pfam00626   30 FLWVGKGSSLLEKLFAALLAAQLDdDERFPlpeVIRVPQGKEPARFL 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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