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Conserved domains on  [gi|1370452835|ref|XP_024302240|]
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kelch-like protein 20 isoform X6 [Homo sapiens]

Protein Classification

kelch repeat domain-containing protein( domain architecture ID 1000219)

kelch repeat domain-containing protein such as human kelch-like protein 1 that may play a role in organizing the actin cytoskeleton of the brain cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
155-411 8.55e-60

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 195.76  E-value: 8.55e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 155 EWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSdVAPTSTCRTS-VGVAVLGGFLYAVGG-- 231
Cdd:COG3055     2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSE-LAPLPGPPRHhAAAVAQDGKLYVFGGft 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 232 --QDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRK 309
Cdd:COG3055    81 gaNPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 310 HLGCAV-YQDMIYAVGGRDDTTElssaerynprTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGttYLKTIEVFDPD 388
Cdd:COG3055   161 HLAAAVlPDGKILVIGGRNGSGF----------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPA 228

                         250       260
                  ....*....|....*....|...
gi 1370452835 389 ANTWRLYGGMNYRRLGGGVGVIK 411
Cdd:COG3055   229 TNTWTALGELPTPRHGHAAVLTD 251
BACK super family cl28903
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 10-74 1.26e-41

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


The actual alignment was detected with superfamily member cd18459:

Pssm-ID: 475122 [Multi-domain]  Cd Length: 100  Bit Score: 142.57  E-value: 1.26e-41
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLS 74
Cdd:cd18459    36 EVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNIQERRPHLPQVLQHVRLPLLS 100
Kelch smart00612
Kelch domain;
130-176 2.14e-14

Kelch domain;


:

Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 66.81  E-value: 2.14e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1370452835  130 VLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDD 176
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
155-411 8.55e-60

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 195.76  E-value: 8.55e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 155 EWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSdVAPTSTCRTS-VGVAVLGGFLYAVGG-- 231
Cdd:COG3055     2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSE-LAPLPGPPRHhAAAVAQDGKLYVFGGft 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 232 --QDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRK 309
Cdd:COG3055    81 gaNPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 310 HLGCAV-YQDMIYAVGGRDDTTElssaerynprTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGttYLKTIEVFDPD 388
Cdd:COG3055   161 HLAAAVlPDGKILVIGGRNGSGF----------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPA 228

                         250       260
                  ....*....|....*....|...
gi 1370452835 389 ANTWRLYGGMNYRRLGGGVGVIK 411
Cdd:COG3055   229 TNTWTALGELPTPRHGHAAVLTD 251
PHA03098 PHA03098
kelch-like protein; Provisional
 15-397 2.61e-57

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 196.53  E-value: 2.61e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835  15 EEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFL-----VGTVGSDPLIK 89
Cdd:PHA03098  144 PDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIkklkrWKLRIKKKKIV 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835  90 SDEECRDLVDEAKNYLllpQERPLMQGPRTRPrkpircgeVLFAVGGWcsGDAISSVERYDPqTNEWRMVASMSKRRCgV 169
Cdd:PHA03098  224 FNKRCIKIIYSKKYNL---NKILPRSSTFGSI--------IYIHITMS--IFTYNYITNYSP-LSEINTIIDIHYVYC-F 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 170 GVSVLDDLLYAVGGHDGSSY-LNSVERYDPKTNQWSsDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKE 248
Cdd:PHA03098  289 GSVVLNNVIYFIGGMNKNNLsVNSVVSYDTKTKSWN-KVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGE 367

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 249 NKWTRVASMSTRRLGVAVAVLGGFLYAVGG-SDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGR- 326
Cdd:PHA03098  368 SKWREEPPLIFPRYNPCVVNVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIs 447

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370452835 327 --DDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGG 397
Cdd:PHA03098  448 yiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCK 520
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 10-74 1.26e-41

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 142.57  E-value: 1.26e-41
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLS 74
Cdd:cd18459    36 EVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNIQERRPHLPQVLQHVRLPLLS 100
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 10-82 1.50e-32

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 118.42  E-value: 1.50e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTV 82
Cdd:pfam07707  30 EVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKHLPELLSAVRLPLLSPQYLLNLV 102
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 10-79 8.90e-29

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 108.20  E-value: 8.90e-29
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835   10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLV 79
Cdd:smart00875  30 EVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREHLPELLEHVRLPLLSPDYLL 99
Kelch smart00612
Kelch domain;
226-271 6.08e-15

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 68.35  E-value: 6.08e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1370452835  226 LYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGG 271
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
130-176 2.14e-14

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 66.81  E-value: 2.14e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1370452835  130 VLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDD 176
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 165-204 2.36e-13

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 63.79  E-value: 2.36e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1370452835 165 RRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWS 204
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWS 40
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 127-163 4.42e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 51.84  E-value: 4.42e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1370452835 127 CGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMS 163
Cdd:pfam01344  10 VGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
155-411 8.55e-60

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 195.76  E-value: 8.55e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 155 EWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSdVAPTSTCRTS-VGVAVLGGFLYAVGG-- 231
Cdd:COG3055     2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSE-LAPLPGPPRHhAAAVAQDGKLYVFGGft 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 232 --QDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRK 309
Cdd:COG3055    81 gaNPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 310 HLGCAV-YQDMIYAVGGRDDTTElssaerynprTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGttYLKTIEVFDPD 388
Cdd:COG3055   161 HLAAAVlPDGKILVIGGRNGSGF----------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPA 228

                         250       260
                  ....*....|....*....|...
gi 1370452835 389 ANTWRLYGGMNYRRLGGGVGVIK 411
Cdd:COG3055   229 TNTWTALGELPTPRHGHAAVLTD 251
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
128-386 1.76e-57

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 189.98  E-value: 1.76e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 128 GEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMS-KRRCGVGVSVLDDLLYAVGG----HDGSSYLNSVERYDPKTNQ 202
Cdd:COG3055    22 DGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGGftgaNPSSTPLNDVYVYDPATNT 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 203 WSsDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVL-GGFLYAVGGSDG 281
Cdd:COG3055   102 WT-KLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGKILVIGGRNG 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 282 TSPLNTverynpqenrWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTteLSSAERYNPRTNQWSPVVAMTSRRSGVGLA 361
Cdd:COG3055   181 SGFSNT----------WTTLAPLPTARAGHAAAVLGGKILVFGGESGF--SDEVEAYDPATNTWTALGELPTPRHGHAAV 248

                         250       260
                  ....*....|....*....|....*....
gi 1370452835 362 VVNGQLMAVGGFD----GTTYLKTIEVFD 386
Cdd:COG3055   249 LTDGKVYVIGGETkpgvRTPLVTSAEVYD 277
PHA03098 PHA03098
kelch-like protein; Provisional
 15-397 2.61e-57

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 196.53  E-value: 2.61e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835  15 EEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFL-----VGTVGSDPLIK 89
Cdd:PHA03098  144 PDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIkklkrWKLRIKKKKIV 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835  90 SDEECRDLVDEAKNYLllpQERPLMQGPRTRPrkpircgeVLFAVGGWcsGDAISSVERYDPqTNEWRMVASMSKRRCgV 169
Cdd:PHA03098  224 FNKRCIKIIYSKKYNL---NKILPRSSTFGSI--------IYIHITMS--IFTYNYITNYSP-LSEINTIIDIHYVYC-F 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 170 GVSVLDDLLYAVGGHDGSSY-LNSVERYDPKTNQWSsDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKE 248
Cdd:PHA03098  289 GSVVLNNVIYFIGGMNKNNLsVNSVVSYDTKTKSWN-KVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGE 367

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 249 NKWTRVASMSTRRLGVAVAVLGGFLYAVGG-SDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGR- 326
Cdd:PHA03098  368 SKWREEPPLIFPRYNPCVVNVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIs 447

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370452835 327 --DDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGG 397
Cdd:PHA03098  448 yiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCK 520
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 10-74 1.26e-41

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 142.57  E-value: 1.26e-41
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLS 74
Cdd:cd18459    36 EVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNIQERRPHLPQVLQHVRLPLLS 100
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 2-111 3.69e-39

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 137.14  E-value: 3.69e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835   2 VHGRKANAQVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGT 81
Cdd:cd18452    27 VFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKEEREDYLPELLQYVRLPLLSPRYITDV 106

                          90       100       110
                  ....*....|....*....|....*....|
gi 1370452835  82 VGSDPLIKSDEECRDLVDEAKNYLLLPQER 111
Cdd:cd18452   107 VDAEPLIRCSLECRDLVDEAKKFHLRPELR 136
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 9-89 1.03e-37

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 132.74  E-value: 1.03e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835   9 AQVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLI 88
Cdd:cd18445    34 SEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPENRKEHLAELLEHVRLPLLSPEYLVQRVEEEELI 113


                  .
gi 1370452835  89 K 89
Cdd:cd18445   114 K 114
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 10-82 1.50e-32

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 118.42  E-value: 1.50e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTV 82
Cdd:pfam07707  30 EVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKHLPELLSAVRLPLLSPQYLLNLV 102
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 9-78 3.61e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 109.70  E-value: 3.61e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835   9 AQVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFL 78
Cdd:cd18457    34 IEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRENREEYLPELLSKVRLPLLRPQFL 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 10-79 8.90e-29

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 108.20  E-value: 8.90e-29
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835   10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLV 79
Cdd:smart00875  30 EVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREHLPELLEHVRLPLLSPDYLL 99
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 10-104 4.40e-27

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 104.76  E-value: 4.40e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIK 89
Cdd:cd18513    35 EVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKEARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIK 114

                          90
                  ....*....|....*
gi 1370452835  90 SDEECRDLVDEAKNY 104
Cdd:cd18513   115 NNNTCKDFLIEAMKY 129
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 10-82 2.92e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 101.78  E-value: 2.92e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTV 82
Cdd:cd18446    35 QVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKESERLPLLPRVLENVRLPLLDPWYFVETV 107
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 10-78 1.14e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 97.40  E-value: 1.14e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFL 78
Cdd:cd18444    36 EVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLPERKKHLAKLLALIRLPLLTPQFL 104
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 9-104 1.40e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 92.40  E-value: 1.40e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835   9 AQVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLI 88
Cdd:cd18512    34 SDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKEVRQEHMAHLMEHVRLPLLSREYLVQRVEEETLV 113

                          90
                  ....*....|....*.
gi 1370452835  89 KSDEECRDLVDEAKNY 104
Cdd:cd18512   114 KNSSACKDYLIEAMKY 129
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 10-78 4.00e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 87.81  E-value: 4.00e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFL 78
Cdd:cd18511    36 EVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDVEQRRKDLSKLLAYIRLPLLAPQFL 104
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 10-78 2.84e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 82.76  E-value: 2.84e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFL 78
Cdd:cd18509    36 EVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCSDLSMLLAYIRLPLLPPQLL 104
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 10-78 3.34e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 82.27  E-value: 3.34e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFL 78
Cdd:cd18510    36 EVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDLQNRQKDLGMLLSYIRLPLLPPQLL 104
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 9-65 4.23e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 81.57  E-value: 4.23e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370452835   9 AQVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVL 65
Cdd:cd18458    35 SEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDEENRRQYLEALL 91
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 10-77 1.98e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 80.04  E-value: 1.98e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKF 77
Cdd:cd18456    35 EVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVDGRRQHVPRLMKCVRLPLLSRDF 102
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 9-73 6.55e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 78.35  E-value: 6.55e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370452835   9 AQVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLL 73
Cdd:cd18514    34 ETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLEKRKDYLPELLRNVRLALL 98
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 10-74 6.87e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 75.75  E-value: 6.87e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLS 74
Cdd:cd18467    35 DVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQERQKYLAQLLHCVRLPLLS 99
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 10-71 9.42e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 75.04  E-value: 9.42e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLP 71
Cdd:cd18448    36 EVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDPQHRKRHLDDLLSQVRLP 97
Kelch smart00612
Kelch domain;
226-271 6.08e-15

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 68.35  E-value: 6.08e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1370452835  226 LYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGG 271
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 10-78 1.06e-14

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 69.43  E-value: 1.06e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFL 78
Cdd:cd18466    35 EVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKRKKHVVEVLEPVRFPLLPPQRL 103
Kelch smart00612
Kelch domain;
130-176 2.14e-14

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 66.81  E-value: 2.14e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1370452835  130 VLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDD 176
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
177-224 2.38e-14

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 66.81  E-value: 2.38e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1370452835  177 LLYAVGGHDGSSYLNSVERYDPKTNQWSSdVAPTSTCRTSVGVAVLGG 224
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTP-LPSMPTPRSGHGVAVING 47
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 10-69 2.66e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 68.11  E-value: 2.66e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVR 69
Cdd:cd18455    34 DVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEERKVHLKDLMSSCW 93
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 10-73 3.65e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 67.94  E-value: 3.65e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLL 73
Cdd:cd18477    35 LVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKENRQKALPTVFESIRFRLL 98
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 9-73 3.82e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 67.91  E-value: 3.82e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370452835   9 AQVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLL 73
Cdd:cd18464    33 TTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRRHEVLPELLRSVRLALL 97
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 9-78 6.04e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 67.44  E-value: 6.04e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835   9 AQVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFL 78
Cdd:cd18468    33 PDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKNRKQHIAELLAVVRLPFIHPSYL 102
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 11-73 7.03e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 67.09  E-value: 7.03e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370452835  11 VMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLL 73
Cdd:cd18516    36 IARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERTKALPVLLESIRFRLM 98
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 165-204 2.36e-13

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 63.79  E-value: 2.36e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1370452835 165 RRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWS 204
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWS 40
Kelch smart00612
Kelch domain;
320-365 4.42e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 63.35  E-value: 4.42e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1370452835  320 IYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNG 365
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 9-75 4.81e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 64.75  E-value: 4.81e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370452835   9 AQVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSP 75
Cdd:cd18485    34 TEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRKSRVQHLVELLKQVRLELVSP 100
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 10-52 5.70e-13

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 63.97  E-value: 5.70e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKY 52
Cdd:cd18508    34 EVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKH 76
Kelch smart00612
Kelch domain;
273-318 1.53e-12

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 61.81  E-value: 1.53e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1370452835  273 LYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQD 318
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 260-305 1.77e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 61.47  E-value: 1.77e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1370452835 260 RRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMG 305
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 214-258 1.98e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 61.47  E-value: 1.98e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1370452835 214 RTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMS 258
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 9-57 2.21e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 62.34  E-value: 2.21e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1370452835   9 AQVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQER 57
Cdd:cd18480    34 SLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLEAR 82
PHA02790 PHA02790
Kelch-like protein; Provisional
 28-397 3.11e-12

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 68.15  E-value: 3.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835  28 IISSDELNVRSEEQVFNAVMAWVkysiQERRPQLPQVL----QHVRLPLLSPKFLVGT---VGSDPLIKSDEECRdlvde 100
Cdd:PHA02790  171 ILESDELNVPDEDYVVDFVIKWY----MKRRNRLGNLLllikNVIRSNYLSPRGINNVkwiLDCTKIFHCDKQPR----- 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 101 aKNYlllpqERPLMQGPRTRPR--------KPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRcgvgvs 172
Cdd:PHA02790  242 -KSY-----KYPFIEYPMNMDQiidifhmcTSTHVGEVVYLIGGWMNNEIHNNAIAVNYISNNWIPIPPMNSPR------ 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 173 vlddlLYAVGGhdgssylnsverydPKTNQwssdvaptstcrtsvgvavlggfLYAVGGQDGVSClniVERYDPKENKWT 252
Cdd:PHA02790  310 -----LYASGV--------------PANNK-----------------------LYVVGGLPNPTS---VERWFHGDAAWV 344

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 253 RVASMSTRRLGVAVAVLGGFLYAVGGSDGTSplNTVERYNPQENRWHtIAPMGTRRKHLGCA-VYQDMIYAVGgrddtte 331
Cdd:PHA02790  345 NMPSLLKPRCNPAVASINNVIYVIGGHSETD--TTTEYLLPNHDQWQ-FGPSTYYPHYKSCAlVFGRRLFLVG------- 414

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370452835 332 lSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGG 397
Cdd:PHA02790  415 -RNAEFYCESSNTWTLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSWNIWDG 479
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 10-73 6.42e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 61.71  E-value: 6.42e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLL 73
Cdd:cd18517    35 QISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKENRVKSLGEIFDCIRFRLM 98
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 11-52 8.48e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 60.70  E-value: 8.48e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1370452835  11 VMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKY 52
Cdd:cd18450    37 AKDSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDH 78
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 10-75 8.52e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 61.30  E-value: 8.52e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELnVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSP 75
Cdd:cd18476    35 DVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPKARKGYIHDLFKKVRLQYVHP 99
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 11-73 1.91e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 60.37  E-value: 1.91e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370452835  11 VMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLL 73
Cdd:cd18515    35 ICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKRHCYLSELLQTVRLALL 97
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 11-74 2.46e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 60.15  E-value: 2.46e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370452835  11 VMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLS 74
Cdd:cd18469    38 VSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHDPQARAAHLPELLSLVHLSLLT 101
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 11-70 2.51e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 59.68  E-value: 2.51e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835  11 VMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRL 70
Cdd:cd18479    36 VYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRI 95
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 5-71 2.63e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 59.87  E-value: 2.63e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370452835   5 RKANAQVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQH-VRLP 71
Cdd:cd18483    30 RKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQSKREMHLPEIFAKcIRMP 97
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 354-399 6.83e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 56.85  E-value: 6.83e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1370452835 354 RRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMN 399
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
PLN02193 PLN02193
nitrile-specifier protein
 214-392 6.98e-11

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 63.82  E-value: 6.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 214 RTSVGVAVLGGFLYAVGGQdgvsclniverYDPKE--NKWTRVASMSTRR---------------LGVAVAVLGGFLYAV 276
Cdd:PLN02193  166 RCSHGIAQVGNKIYSFGGE-----------FTPNQpiDKHLYVFDLETRTwsispatgdvphlscLGVRMVSIGSTLYVF 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 277 GGSDGTSPLNTVERYNPQENRWHTIAPMG---TRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQW----SPVV 349
Cdd:PLN02193  235 GGRDASRQYNGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWfhcsTPGD 314

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1370452835 350 AMTSrRSGVGLAVVNGQLMAVGGFDGTTyLKTIEVFDPDANTW 392
Cdd:PLN02193  315 SFSI-RGGAGLEVVQGKVWVVYGFNGCE-VDDVHYYDPVQDKW 355
Kelch smart00612
Kelch domain;
366-410 8.82e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 56.80  E-value: 8.82e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1370452835  366 QLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVI 410
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
PLN02153 PLN02153
epithiospecifier protein
 166-372 9.34e-11

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 62.70  E-value: 9.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 166 RCGVGVSVLDDLLYAVGGH-------DGSSYLnsverYDPKTNQWS----SDVAPTSTCRTSVGVAVlGGFLYAVGGQDG 234
Cdd:PLN02153   23 RCSHGIAVVGDKLYSFGGElkpnehiDKDLYV-----FDFNTHTWSiapaNGDVPRISCLGVRMVAV-GTKLYIFGGRDE 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 235 VSCLNIVERYDPKENKWTRVASMSTR-----RLGVAVAVLGGFLYAVGG-SDG---TSP--LNTVERYNPQENRWHTIAP 303
Cdd:PLN02153   97 KREFSDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGvSKGglmKTPerFRTIEAYNIADGKWVQLPD 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 304 MG---TRRKHLGCAVYQDMIYAV---------GGRDDtTELSSAERYNPRTNQWSPVV---AMTSRRSGVGLAVVNGQLM 368
Cdd:PLN02153  177 PGenfEKRGGAGFAVVQGKIWVVygfatsilpGGKSD-YESNAVQFFDPASGKWTEVEttgAKPSARSVFAHAVVGKYII 255


                  ....
gi 1370452835 369 AVGG 372
Cdd:PLN02153  256 IFGG 259
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 307-352 9.91e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 56.47  E-value: 9.91e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1370452835 307 RRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMT 352
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 10-72 3.55e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 56.60  E-value: 3.55e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPL 72
Cdd:cd18447    36 EVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPYMVDILAKVRFPL 98
PHA02713 PHA02713
hypothetical protein; Provisional
 149-356 4.56e-10

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 61.56  E-value: 4.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 149 YDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHD-GSSYLNSVERYDPKtNQWSSDVAPTSTCRTSVGVAVLGGFLY 227
Cdd:PHA02713  277 YNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNfNNPSLNKVYKINIE-NKIHVELPPMIKNRCRFSLAVIDDTIY 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 228 AVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGS------------------DGTSPLNTVE 289
Cdd:PHA02713  356 AIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRtehidytsvhhmnsidmeEDTHSSNKVI 435

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370452835 290 RYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGG-RDDTTELSSAERYNPRT-NQWSPVVAMTSRRS 356
Cdd:PHA02713  436 RYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVVCDiKDEKNVKTCIFRYNTNTyNGWELITTTESRLS 504
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 9-52 7.31e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 55.09  E-value: 7.31e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1370452835   9 AQVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKY 52
Cdd:cd18463    35 VEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 9-73 9.18e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 55.57  E-value: 9.18e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370452835   9 AQVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLL 73
Cdd:cd18460    34 VELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPKHRQHFWPELLQHVRLPFV 98
PHA03098 PHA03098
kelch-like protein; Provisional
 128-211 1.62e-09

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 59.78  E-value: 1.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 128 GEVLFAVGGWCSGDAI---SSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWS 204
Cdd:PHA03098  437 DGKIYVIGGISYIDNIkvyNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516


                  ....*..
gi 1370452835 205 SDVAPTS 211
Cdd:PHA03098  517 LFCKFPK 523
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 8-74 3.51e-09

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 53.77  E-value: 3.51e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370452835   8 NAQ-VMESEEFMLLPANQLIDIISSDELNVrSEEQVFNAVMAWVKYSiQERRPQLPQVLQHVRLPLLS 74
Cdd:cd14822    32 NAQeVLSSEGFLTLSKSALKELLSRDSFCA-PEVDIFNAVRRWCEHN-PDSKEDAKEILEAVRLPLMS 97
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 127-163 4.42e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 51.84  E-value: 4.42e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1370452835 127 CGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMS 163
Cdd:pfam01344  10 VGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
PRK14131 PRK14131
N-acetylneuraminate epimerase;
247-372 5.35e-09

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 57.72  E-value: 5.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 247 KENKWTRVASM-STRRLGVAVAVLGGFLYAVGGS----DGTSP--LNTVERYNPQENRWH---TIAPMGTrRKHLGCAVY 316
Cdd:PRK14131   60 PSKGWTKIAAFpGGPREQAVAAFIDGKLYVFGGIgktnSEGSPqvFDDVYKYDPKTNSWQkldTRSPVGL-AGHVAVSLH 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 317 QDMIYAVGGRD---------DTTEL---SSAER----------------------YNPRTNQWSPVVAMT-SRRSGVGLA 361
Cdd:PRK14131  139 NGKAYITGGVNknifdgyfeDLAAAgkdKTPKDkindayfdkkpedyffnkevlsYDPSTNQWKNAGESPfLGTAGSAVV 218

                         170
                  ....*....|.
gi 1370452835 362 VVNGQLMAVGG 372
Cdd:PRK14131  219 IKGNKLWLING 229
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 10-73 9.15e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 49.91  E-value: 9.15e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSiQERRPQLPQVLQHVRLPLL 73
Cdd:cd18465    35 QIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHD-PSRRASASHVLCHIRFPLM 97
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 5-50 1.02e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 49.04  E-value: 1.02e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1370452835   5 RKANAQVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWV 50
Cdd:cd18474    30 LRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWV 75
PLN02193 PLN02193
nitrile-specifier protein
 149-325 1.30e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 53.42  E-value: 1.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 149 YDPQTNEWRM---VASMSKRRC-GVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWS--SDVAPTSTCRTSVGVAVL 222
Cdd:PLN02193  198 FDLETRTWSIspaTGDVPHLSClGVRMVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKllTPVEEGPTPRSFHSMAAD 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 223 GGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMS---TRRLGVAVAVLGGFLYAVGGSDGTSpLNTVERYNPQENRWH 299
Cdd:PLN02193  278 EENVYVFGGVSATARLKTLDSYNIVDKKWFHCSTPGdsfSIRGGAGLEVVQGKVWVVYGFNGCE-VDDVHYYDPVQDKWT 356

                         170       180
                  ....*....|....*....|....*....
gi 1370452835 300 TIAPMGTR---RKHLGCAVYQDMIYAVGG 325
Cdd:PLN02193  357 QVETFGVRpseRSVFASAAVGKHIVIFGG 385
Kelch_6 pfam13964
Kelch motif;
261-308 2.42e-07

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 46.94  E-value: 2.42e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1370452835 261 RLGVAVAVLGGFLYAVGG-SDGTSPLNTVERYNPQENRWHTIAPMGTRR 308
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
PHA02713 PHA02713
hypothetical protein; Provisional
 244-384 8.99e-07

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 51.16  E-value: 8.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 244 YDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSP-LNTVERYNPqENRWHT-IAPMGTRRKHLGCAVYQDMIY 321
Cdd:PHA02713  277 YNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNFNNPsLNKVYKINI-ENKIHVeLPPMIKNRCRFSLAVIDDTIY 355

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370452835 322 AVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGfdGTTYLKTIEV 384
Cdd:PHA02713  356 AIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGG--RTEHIDYTSV 416
Kelch_6 pfam13964
Kelch motif;
213-261 3.01e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 43.86  E-value: 3.01e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1370452835 213 CRTSVGVAVLGGFLYAVGGQ-DGVSCLNIVERYDPKENKWTRVASMSTRR 261
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 5-57 3.75e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 44.95  E-value: 3.75e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370452835   5 RKANAQVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQER 57
Cdd:cd18451    30 RRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAEER 82
PRK14131 PRK14131
N-acetylneuraminate epimerase;
267-390 6.37e-06

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 48.09  E-value: 6.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 267 AVLGGFLYaVG-GSDGTS--PLNTveryNPQENRWHTIAPM-GTRRKHLGCAVYQDMIYAVGGRDDTTE------LSSAE 336
Cdd:PRK14131   35 AIDNNTVY-VGlGSAGTSwyKLDL----NAPSKGWTKIAAFpGGPREQAVAAFIDGKLYVFGGIGKTNSegspqvFDDVY 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370452835 337 RYNPRTNQWSPVvaMTsrRSGVGLAVV------NGQLMAVGG-----FDGttYLKTIEVFDPDAN 390
Cdd:PRK14131  110 KYDPKTNSWQKL--DT--RSPVGLAGHvavslhNGKAYITGGvnkniFDG--YFEDLAAAGKDKT 168
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 14-52 1.20e-05

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 43.11  E-value: 1.20e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1370452835  14 SEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKY 52
Cdd:cd18503    39 TREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77
PLN02153 PLN02153
epithiospecifier protein
 214-392 1.56e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 46.52  E-value: 1.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 214 RTSVGVAVLGGFLYAVGGQ--DGVSCLNIVERYDPKENKWT------RVASMSTrrLGVAVAVLGGFLYAVGGSDGTSPL 285
Cdd:PLN02153   23 RCSHGIAVVGDKLYSFGGElkPNEHIDKDLYVFDFNTHTWSiapangDVPRISC--LGVRMVAVGTKLYIFGGRDEKREF 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 286 NTVERYNPQENRWHTIAPMGTR-----RKHLGCAVYQDMIYAVGG------RDDTTELSSAERYNPRTNQWSPVV---AM 351
Cdd:PLN02153  101 SDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGvskgglMKTPERFRTIEAYNIADGKWVQLPdpgEN 180

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1370452835 352 TSRRSGVGLAVVNGQLMAVGGFdGTTYL---------KTIEVFDPDANTW 392
Cdd:PLN02153  181 FEKRGGAGFAVVQGKIWVVYGF-ATSILpggksdyesNAVQFFDPASGKW 229
Kelch_6 pfam13964
Kelch motif;
308-355 2.19e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.55  E-value: 2.19e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1370452835 308 RKHLGCAVYQDMIYAVGGRDDTTELSSA-ERYNPRTNQWSPVVAMTSRR 355
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNASPALNKlEVYNPLTKSWEELPPLPTPR 50
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 9-50 3.01e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 41.99  E-value: 3.01e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1370452835   9 AQVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWV 50
Cdd:cd18472    34 AEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
Kelch_6 pfam13964
Kelch motif;
355-402 6.72e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.01  E-value: 6.72e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1370452835 355 RSGVGLAVVNGQLMAVGGF-DGTTYLKTIEVFDPDANTWRLYGGMNYRR 402
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50
PRK14131 PRK14131
N-acetylneuraminate epimerase;
220-279 8.85e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 44.24  E-value: 8.85e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370452835 220 AVLGGFLYAVGG-----QDG-VSCLNIVERYDPKENKWTRVASMSTRRL--GVAVAVLGGFLYAVGGS 279
Cdd:PRK14131   81 AFIDGKLYVFGGigktnSEGsPQVFDDVYKYDPKTNSWQKLDTRSPVGLagHVAVSLHNGKAYITGGV 148
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 14-69 1.11e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 40.95  E-value: 1.11e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370452835  14 SEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVR 69
Cdd:cd18482    40 EEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANLKERAASAAEVLKCVR 95
Kelch_4 pfam13418
Galactose oxidase, central domain;
165-204 1.51e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 39.13  E-value: 1.51e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1370452835 165 RRCGVGVSVLDDLLYAVGGHDGS-SYLNSVERYDPKTNQWS 204
Cdd:pfam13418   2 RAYHTSTSIPDDTIYLFGGEGEDgTLLSDLWVFDLSTNEWT 42
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 165-204 2.23e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 38.47  E-value: 2.23e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1370452835 165 RRCGVGVSVLDDLLYAVGGHD--GSSYLNSVERYDPKTNQWS 204
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDglGDLSSSDVLVYDPETNVWT 42
Kelch_4 pfam13418
Galactose oxidase, central domain;
260-306 2.83e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 38.36  E-value: 2.83e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1370452835 260 RRLGVAVAVLGGFLYAVGGSDG-TSPLNTVERYNPQENRWHTIAPMGT 306
Cdd:pfam13418   2 RAYHTSTSIPDDTIYLFGGEGEdGTLLSDLWVFDLSTNEWTRLGSLPS 49
BACK_BTBD7 cd18489
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); ...
 10-61 2.88e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains and a BACK domain.


Pssm-ID: 350564  Cd Length: 98  Bit Score: 39.60  E-value: 2.88e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVrSEEQVFNAVMAWVKYS----IQERRPQL 61
Cdd:cd18489    36 QIAQSPVLFELTKEYLIEALQSDFLQA-SELDILKAVLKWGEHQlikrMEEREPNL 90
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 10-50 2.91e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 39.10  E-value: 2.91e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1370452835  10 QVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWV 50
Cdd:cd18493    34 KVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
Kelch_6 pfam13964
Kelch motif;
166-214 2.94e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.47  E-value: 2.94e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1370452835 166 RCGVGVSVLDDLLYAVGG-HDGSSYLNSVERYDPKTNQWSSdVAPTSTCR 214
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEE-LPPLPTPR 50
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 9-72 3.03e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 39.72  E-value: 3.03e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370452835   9 AQVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPL 72
Cdd:cd18462    34 EEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVEKRIECAYDLLSSIKLDL 97
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 15-73 3.16e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 39.89  E-value: 3.16e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370452835  15 EEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIqeRRPQLPQVLQHVRLPLL 73
Cdd:cd18471    42 EEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHNC--RYQYMDELLQYVRFGLM 98
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 9-56 3.38e-04

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 39.53  E-value: 3.38e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1370452835   9 AQVMESEEFMLLPANQlIDII--SSDELNVRSEEQVFNAVMAWVKYSIQE 56
Cdd:cd18502    34 EEVAESKEFLKLPRLQ-IEVIleSNQELESINERKLCQLVLEWVQRSIEE 82
Kelch_3 pfam13415
Galactose oxidase, central domain;
223-269 3.72e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 38.04  E-value: 3.72e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1370452835 223 GGFLYAVGG--QDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVL 269
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
PRK14131 PRK14131
N-acetylneuraminate epimerase;
152-278 4.84e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 41.92  E-value: 4.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 152 QTNEWRMVASM-SKRRCGVGVSVLDDLLYAVGG-----HDGS-SYLNSVERYDPKTNQWSSdvAPTSTCRT---SVGVAV 221
Cdd:PRK14131   60 PSKGWTKIAAFpGGPREQAVAAFIDGKLYVFGGigktnSEGSpQVFDDVYKYDPKTNSWQK--LDTRSPVGlagHVAVSL 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 222 LGGFLYAVGG----------QDGVSC------------------------LNIVERYDPKENKWtRVASMST--RRLGVA 265
Cdd:PRK14131  138 HNGKAYITGGvnknifdgyfEDLAAAgkdktpkdkindayfdkkpedyffNKEVLSYDPSTNQW-KNAGESPflGTAGSA 216

                         170
                  ....*....|...
gi 1370452835 266 VAVLGGFLYAVGG 278
Cdd:PRK14131  217 VVIKGNKLWLING 229
PLN02153 PLN02153
epithiospecifier protein
 128-278 5.84e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 41.90  E-value: 5.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 128 GEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMS-----KRRCGVGVSVLDDLLYAVGGHDGSSYLNSVER------Y 196
Cdd:PLN02153   85 GTKLYIFGGRDEKREFSDFYSYDTVKNEWTFLTKLDeeggpEARTFHSMASDENHVYVFGGVSKGGLMKTPERfrtieaY 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 197 DPKTNQWSS--DVAPTSTCRTSVGVAVLGGFLYAV---------GGQDGVSClNIVERYDPKENKWTRVASMSTR---RL 262
Cdd:PLN02153  165 NIADGKWVQlpDPGENFEKRGGAGFAVVQGKIWVVygfatsilpGGKSDYES-NAVQFFDPASGKWTEVETTGAKpsaRS 243

                         170
                  ....*....|....*.
gi 1370452835 263 GVAVAVLGGFLYAVGG 278
Cdd:PLN02153  244 VFAHAVVGKYIIIFGG 259
Kelch_4 pfam13418
Galactose oxidase, central domain;
307-348 6.23e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.59  E-value: 6.23e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1370452835 307 RRKHLGCAVYQDMIYAVGGR-DDTTELSSAERYNPRTNQWSPV 348
Cdd:pfam13418   2 RAYHTSTSIPDDTIYLFGGEgEDGTLLSDLWVFDLSTNEWTRL 44
Kelch_3 pfam13415
Galactose oxidase, central domain;
128-174 7.19e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 37.27  E-value: 7.19e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1370452835 128 GEVLFAVGGWC--SGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVL 174
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 260-304 1.01e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 36.93  E-value: 1.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1370452835 260 RRLGVAVAVLGGFLYAVGGSDGTSPL--NTVERYNPQENRWHTIAPM 304
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLssSDVLVYDPETNVWTEVPRL 47
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
137-296 1.11e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.45  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 137 WCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVgghdgSSYLNSVERYDPKTNQwssDVAPTSTCRTS 216
Cdd:COG3391    83 YVANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVA-----DSGNGRVSVIDTATGK---VVATIPVGAGP 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370452835 217 VGVAV--LGGFLYAV-GGQDGVSClnIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTS--PLNTVERY 291
Cdd:COG3391   155 HGIAVdpDGKRLYVAnSGSNTVSV--IVSVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYVANRGSNTSngGSNTVSVI 232


                  ....*
gi 1370452835 292 NPQEN 296
Cdd:COG3391   233 DLATL 237
Kelch_3 pfam13415
Galactose oxidase, central domain;
270-308 1.69e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 36.11  E-value: 1.69e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1370452835 270 GGFLYAVGGSD--GTSPLNTVERYNPQENRWHTIAPMGTRR 308
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIGDLPPPR 41
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 11-71 1.97e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 37.40  E-value: 1.97e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370452835  11 VMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSiQERRPQLPQVLQHVRLP 71
Cdd:cd18449    36 LLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHE-DDRMQFAAKLMENIRFP 95
BACK_KBTBD4 cd18481
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 9-57 2.84e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also termed BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates.


Pssm-ID: 350556  Cd Length: 88  Bit Score: 36.79  E-value: 2.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1370452835   9 AQVMESEEFMLLPANQLIDIISSdelNVRSEEQVFNAVMAWVKYSIQER 57
Cdd:cd18481    34 SQLHQTEEFLNLPLRLLTDIIKD---GVPCSQNPTAAIEAWINHNKEER 79
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 14-73 9.15e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 35.51  E-value: 9.15e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370452835  14 SEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQL-----PQVLQHVRLPLL 73
Cdd:cd18461    39 TETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLYHYTPEQVEKDQVslqepPKLLEAVRFPLM 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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