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Conserved domains on  [gi|1370510068|ref|XP_024302514|]
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zinc finger protein 680 isoform X3 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
44-181 3.61e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 3.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068  44 KPYKCEECGKAFNQSSTLIKHK--KIHIEE--KPFKCEE--CGKAFSLFSILSKHKIIHTGDKPYKCDECH-------KA 110
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNssskfspLL 367

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370510068 111 FNWFATLTNHKRIHTGEKPFKCE--ECGKDFNQFSNLTKHKKIHTGEKP--YKCEECGKAFNQFANLTRHKKIHT 181
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
156-318 7.94e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 7.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068 156 KPYKCEECGKAFNQFANLTRHK--KIHTGE--KSYKCEE--CGKAFIQSSNLTEHMRIHTGEKPYKCEEC------GKAF 223
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068 224 NGCSSLTRHKRIHTRENTYKC---EECGKGFTLFSTLTNHKVIHTGEKS--YKCDECGNVFNWPATLANHKRIHAREKPY 298
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170       180
                  ....*....|....*....|
gi 1370510068 299 KCEECGKaFNRSSHLTRHKK 318
Cdd:COG5048   448 LCSILKS-FRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
44-181 3.61e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 3.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068  44 KPYKCEECGKAFNQSSTLIKHK--KIHIEE--KPFKCEE--CGKAFSLFSILSKHKIIHTGDKPYKCDECH-------KA 110
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNssskfspLL 367

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370510068 111 FNWFATLTNHKRIHTGEKPFKCE--ECGKDFNQFSNLTKHKKIHTGEKP--YKCEECGKAFNQFANLTRHKKIHT 181
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
156-318 7.94e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 7.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068 156 KPYKCEECGKAFNQFANLTRHK--KIHTGE--KSYKCEE--CGKAFIQSSNLTEHMRIHTGEKPYKCEEC------GKAF 223
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068 224 NGCSSLTRHKRIHTRENTYKC---EECGKGFTLFSTLTNHKVIHTGEKS--YKCDECGNVFNWPATLANHKRIHAREKPY 298
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170       180
                  ....*....|....*....|
gi 1370510068 299 KCEECGKaFNRSSHLTRHKK 318
Cdd:COG5048   448 LCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
200-224 1.04e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.04e-04
                          10        20
                  ....*....|....*....|....*
gi 1370510068 200 NLTEHMRIHTGEKPYKCEECGKAFN 224
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
144-169 2.41e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.41e-04
                          10        20
                  ....*....|....*....|....*.
gi 1370510068 144 NLTKHKKIHTGEKPYKCEECGKAFNQ 169
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
44-181 3.61e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 3.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068  44 KPYKCEECGKAFNQSSTLIKHK--KIHIEE--KPFKCEE--CGKAFSLFSILSKHKIIHTGDKPYKCDECH-------KA 110
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNssskfspLL 367

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370510068 111 FNWFATLTNHKRIHTGEKPFKCE--ECGKDFNQFSNLTKHKKIHTGEKP--YKCEECGKAFNQFANLTRHKKIHT 181
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
156-318 7.94e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 7.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068 156 KPYKCEECGKAFNQFANLTRHK--KIHTGE--KSYKCEE--CGKAFIQSSNLTEHMRIHTGEKPYKCEEC------GKAF 223
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068 224 NGCSSLTRHKRIHTRENTYKC---EECGKGFTLFSTLTNHKVIHTGEKS--YKCDECGNVFNWPATLANHKRIHAREKPY 298
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170       180
                  ....*....|....*....|
gi 1370510068 299 KCEECGKaFNRSSHLTRHKK 318
Cdd:COG5048   448 LCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
44-327 1.15e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068  44 KPYKCEECGKAFNQSSTLIKHKKIHIEEKPFKC--EECGKAFSLFSILSKHKIIHTGDKPYKC-DECHKAFNWFATLTNH 120
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068 121 KRIHTGEKPFKCEECGKDFNQFSNLTK--HKKIHTGEKPYK---------------------CEECGKAFNQFANLTRHK 177
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068 178 KIHTGEKSYKCEECGKAFIQSSNLTEHMRIHTgEKPYKCEECGKAFNGCSSLTRHKRIHTRENTYKCEECGKGFTLFSTL 257
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068 258 TNHKVIHTGE-------KSYKCDECGNVFNWPATLANHKR--IHARE--KPYKCEE--CGKAFNRSSHLTRHKKIHTGEK 324
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350


                  ...
gi 1370510068 325 LYK 327
Cdd:COG5048   351 PAK 353
zf-H2C2_2 pfam13465
Zinc-finger double domain;
200-224 1.04e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.04e-04
                          10        20
                  ....*....|....*....|....*
gi 1370510068 200 NLTEHMRIHTGEKPYKCEECGKAFN 224
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
144-169 2.41e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.41e-04
                          10        20
                  ....*....|....*....|....*.
gi 1370510068 144 NLTKHKKIHTGEKPYKCEECGKAFNQ 169
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
172-197 6.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 6.00e-04
                          10        20
                  ....*....|....*....|....*.
gi 1370510068 172 NLTRHKKIHTGEKSYKCEECGKAFIQ 197
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
99-172 6.30e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 6.30e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370510068  99 DKPYKCDECHKAFNWFATLTNHKRIHTGEKPFKCEECGKDFNQF--SNLTKHKKIHTGEKPYKCEECGKAFNQFAN 172
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLSNSKAS 106
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
56-334 1.01e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068  56 NQSSTLIKHKKIHIEE----KPFKCEECGKAFSLFSILSKHKIIHTGDKPYKC--DECHKAFNWFATLTNHKRIHTGEKP 129
Cdd:COG5048    12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068 130 FKCEECGKDFNQFSNLTK-HKKIHTGEKPYKCEECGKA---FNQFANLTRHKKIHTGEKSYKCEECGKAFIQSSNLTEHM 205
Cdd:COG5048    92 DLNSKSLPLSNSKASSSSlSSSSSNSNDNNLLSSHSLPpssRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPL 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068 206 RIHtgekpykcEECGKAFNGCSSLTRHKRIHTRENTYKCEECGKgFTLFSTLTNHKVIHTGEKSYKCDECGNVF------ 279
Cdd:COG5048   172 PAN--------SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSpkslls 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068 280 -----NWPATLANHKRIHARE------------------------KPYKCEECGKAFNRSSHLTRHK--KIHTGEKLyKP 328
Cdd:COG5048   243 qspssLSSSDSSSSASESPRSslptassqssspnesdsssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGESL-KP 321


                  ....*.
gi 1370510068 329 EKCDNN 334
Cdd:COG5048   322 FSCPYS 327
zf-H2C2_2 pfam13465
Zinc-finger double domain;
117-141 1.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|....*
gi 1370510068 117 LTNHKRIHTGEKPFKCEECGKDFNQ 141
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 41-111 1.76e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 1.76e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370510068  41 MGEKPYKCE--ECGKAFNQSSTLIKHKKiHIEEKPFKCEECGKafslfsilSKHKIIHTGDKPYKCDECHKAF 111
Cdd:COG5189   345 KDGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRY 408
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1-150 3.02e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 3.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068   1 MLSHLTQHIR--IHTRENSYKCEE----CGKVLNWFSELIKHKGIHMGEKPYKC--EECGKAFNQSST-----LIKHKKI 67
Cdd:COG5048   301 RSSPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKD 380

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068  68 HIEEKPFKCE--ECGKAFSLFSILSKHKIIHTGDKP--YKCDECHKAFNWFATLTNHKRIHTGEKPFKCEECGKdFNQFS 143
Cdd:COG5048   381 LKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDL 459


                  ....*..
gi 1370510068 144 NLTKHKK 150
Cdd:COG5048   460 DLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
2-321 3.76e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 3.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068   2 LSHLTQHIRIHTRENSYKCEECGKVlNWFS---ELIKHKGIHMGEKPYKCE---------------------------EC 51
Cdd:COG5048    46 LEHLTRHIRSHTGEKPSQCSYSGCD-KSFSrplELSRHLRTHHNNPSDLNSkslplsnskasssslsssssnsndnnlLS 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068  52 GKAFNQSSTLIKHKKIHIEEKPFKCEECGKAFSLFSILSKHKIIHTGDKPYKCDECHKA----------FNWFATLTNHK 121
Cdd:COG5048   125 SHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNlsllissnvsTSIPSSSENSP 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068 122 RIHTGEKPFKCEECGKDfNQFSNLTKHKKIHTGEKPYKCE---------------ECGKAFNQFANLTRHKKIHTGE--- 183
Cdd:COG5048   205 LSSSYSIPSSSSDQNLE-NSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLPTASSQSSSPNESDSsse 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370510068 184 ----KSYKCEECGKAFIQSSNLTEHMR--IHTGE--KPYKCEE--CGKAFNGCSSLTRHKRIHT--RENTYKCEECGKGF 251
Cdd:COG5048   284 kgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTsiSPAKEKLLNSSSKF 363

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370510068 252 TLFST-----LTNHKVIHTGEKSYKCD--ECGNVFNWPATLANHKRIHAREKP--YKCEECGKAFNRSSHLTRHKKIHT 321
Cdd:COG5048   364 SPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
89-112 4.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.07e-03
                          10        20
                  ....*....|....*....|....
gi 1370510068  89 LSKHKIIHTGDKPYKCDECHKAFN 112
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 186-208 5.34e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 5.34e-03
                          10        20
                  ....*....|....*....|...
gi 1370510068 186 YKCEECGKAFIQSSNLTEHMRIH 208
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
32-57 5.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 5.57e-03
                          10        20
                  ....*....|....*....|....*.
gi 1370510068  32 ELIKHKGIHMGEKPYKCEECGKAFNQ 57
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 298-320 7.91e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.43  E-value: 7.91e-03
                          10        20
                  ....*....|....*....|...
gi 1370510068 298 YKCEECGKAFNRSSHLTRHKKIH 320
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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