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Conserved domains on  [gi|1370511073|ref|XP_024302723|]
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STARD3 N-terminal-like protein isoform X1 [Homo sapiens]

Protein Classification

MENTAL domain-containing protein( domain architecture ID 10564576)

MENTAL domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MENTAL pfam10457
Cholesterol-capturing domain; Human meta-static lymph node (MLN) 64 is a late endosomal ...
 49-212 1.96e-87

Cholesterol-capturing domain; Human meta-static lymph node (MLN) 64 is a late endosomal membrane protein, and carries this MENTAL (MLN64N-terminal) domain at its N-terminus. The domain is composed of four trans-membrane helices with three short intervening loops. The function of the domain is to capture cholesterol and pass it to the associated START domain pfam01852 for transfer to a cytosolic acceptor protein or membrane. In mammals, the MENTAL domain is involved in the localization of MLN64 and MENTHO in late endosomes, and also in homo-and of hetero-interactions of these two proteins.


:

Pssm-ID: 463097  Cd Length: 177  Bit Score: 256.45  E-value: 1.96e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370511073  49 SDVRRTFCLFVTFDLLFVTLLWIIELNVNG-GIENTLEKEVMQYDYYSSYFDIFLLAVFRFKVLILAYAVCRLRHWWAIA 127
Cdd:pfam10457   1 SDVRRFFCLFVTFDLLFTSLLWLICLVINGeNIKKAFEKEVLHYNIKTSLFDIVLLAAFRFLVLLLFYALLRLNHWWIIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370511073 128 LTTAVTSAFLLAKVILSKLF--SQGAFGYVLPIISFILAWIETWFLDFKVLPQEAEEENRLL-IVQDASERAALIPGG-- 202
Cdd:pfam10457  81 ITTAVSCAFLIVKVFLYDWLssSQPVFGVLLIITSFVLAWIEAWFLDFKVLPQEAEAERRYLaAITSADERAPLLQPGpe 160

                         170
                  ....*....|....*
gi 1370511073 203 -----LSDGQFYSPP 212
Cdd:pfam10457 161 grsnnQSDGNFYSPP 175
 
Name Accession Description Interval E-value
MENTAL pfam10457
Cholesterol-capturing domain; Human meta-static lymph node (MLN) 64 is a late endosomal ...
 49-212 1.96e-87

Cholesterol-capturing domain; Human meta-static lymph node (MLN) 64 is a late endosomal membrane protein, and carries this MENTAL (MLN64N-terminal) domain at its N-terminus. The domain is composed of four trans-membrane helices with three short intervening loops. The function of the domain is to capture cholesterol and pass it to the associated START domain pfam01852 for transfer to a cytosolic acceptor protein or membrane. In mammals, the MENTAL domain is involved in the localization of MLN64 and MENTHO in late endosomes, and also in homo-and of hetero-interactions of these two proteins.


Pssm-ID: 463097  Cd Length: 177  Bit Score: 256.45  E-value: 1.96e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370511073  49 SDVRRTFCLFVTFDLLFVTLLWIIELNVNG-GIENTLEKEVMQYDYYSSYFDIFLLAVFRFKVLILAYAVCRLRHWWAIA 127
Cdd:pfam10457   1 SDVRRFFCLFVTFDLLFTSLLWLICLVINGeNIKKAFEKEVLHYNIKTSLFDIVLLAAFRFLVLLLFYALLRLNHWWIIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370511073 128 LTTAVTSAFLLAKVILSKLF--SQGAFGYVLPIISFILAWIETWFLDFKVLPQEAEEENRLL-IVQDASERAALIPGG-- 202
Cdd:pfam10457  81 ITTAVSCAFLIVKVFLYDWLssSQPVFGVLLIITSFVLAWIEAWFLDFKVLPQEAEAERRYLaAITSADERAPLLQPGpe 160

                         170
                  ....*....|....*
gi 1370511073 203 -----LSDGQFYSPP 212
Cdd:pfam10457 161 grsnnQSDGNFYSPP 175
 
Name Accession Description Interval E-value
MENTAL pfam10457
Cholesterol-capturing domain; Human meta-static lymph node (MLN) 64 is a late endosomal ...
 49-212 1.96e-87

Cholesterol-capturing domain; Human meta-static lymph node (MLN) 64 is a late endosomal membrane protein, and carries this MENTAL (MLN64N-terminal) domain at its N-terminus. The domain is composed of four trans-membrane helices with three short intervening loops. The function of the domain is to capture cholesterol and pass it to the associated START domain pfam01852 for transfer to a cytosolic acceptor protein or membrane. In mammals, the MENTAL domain is involved in the localization of MLN64 and MENTHO in late endosomes, and also in homo-and of hetero-interactions of these two proteins.


Pssm-ID: 463097  Cd Length: 177  Bit Score: 256.45  E-value: 1.96e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370511073  49 SDVRRTFCLFVTFDLLFVTLLWIIELNVNG-GIENTLEKEVMQYDYYSSYFDIFLLAVFRFKVLILAYAVCRLRHWWAIA 127
Cdd:pfam10457   1 SDVRRFFCLFVTFDLLFTSLLWLICLVINGeNIKKAFEKEVLHYNIKTSLFDIVLLAAFRFLVLLLFYALLRLNHWWIIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370511073 128 LTTAVTSAFLLAKVILSKLF--SQGAFGYVLPIISFILAWIETWFLDFKVLPQEAEEENRLL-IVQDASERAALIPGG-- 202
Cdd:pfam10457  81 ITTAVSCAFLIVKVFLYDWLssSQPVFGVLLIITSFVLAWIEAWFLDFKVLPQEAEAERRYLaAITSADERAPLLQPGpe 160

                         170
                  ....*....|....*
gi 1370511073 203 -----LSDGQFYSPP 212
Cdd:pfam10457 161 grsnnQSDGNFYSPP 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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