RNA-binding protein with multiple splicing isoform X15 [Homo sapiens]
Protein Classification
RNA-binding protein( domain architecture ID 106745)
RNA-binding protein containing an RNA recognition motif (RRM)
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| RRM_SF super family | cl17169 | RNA recognition motif (RRM) superfamily; RRM, also known as RBD (RNA binding domain) or RNP ... |
21-38 | 5.66e-05 | ||
RNA recognition motif (RRM) superfamily; RRM, also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs). The actual alignment was detected with superfamily member cd12684: Pssm-ID: 473069 [Multi-domain] Cd Length: 83 Bit Score: 39.51 E-value: 5.66e-05
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| Name | Accession | Description | Interval | E-value | ||
| RRM_cpo | cd12684 | RNA recognition motif (RRM) found in Drosophila couch potato (cpo) coding RNA-binding protein ... |
21-38 | 5.66e-05 | ||
RNA recognition motif (RRM) found in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins; This subfamily corresponds to the RRM of Cpo, an RNA-binding protein encoded by Drosophila couch potato (cpo) gene. Cpo contains a well conserved RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain). It may control the processing of RNA molecules required for the proper functioning of the peripheral nervous system (PNS). Pssm-ID: 410085 [Multi-domain] Cd Length: 83 Bit Score: 39.51 E-value: 5.66e-05
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| Name | Accession | Description | Interval | E-value | ||
| RRM_cpo | cd12684 | RNA recognition motif (RRM) found in Drosophila couch potato (cpo) coding RNA-binding protein ... |
21-38 | 5.66e-05 | ||
RNA recognition motif (RRM) found in Drosophila couch potato (cpo) coding RNA-binding protein and similar proteins; This subfamily corresponds to the RRM of Cpo, an RNA-binding protein encoded by Drosophila couch potato (cpo) gene. Cpo contains a well conserved RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain). It may control the processing of RNA molecules required for the proper functioning of the peripheral nervous system (PNS). Pssm-ID: 410085 [Multi-domain] Cd Length: 83 Bit Score: 39.51 E-value: 5.66e-05
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| RRM_RBPMS | cd12682 | RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing ... |
14-36 | 1.06e-03 | ||
RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing (RBP-MS); This subfamily corresponds to the RRM of RBP-MS, also termed heart and RRM expressed sequence (hermes), an RNA-binding proteins found in various vertebrate species. It contains an RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain). RBP-MS physically interacts with Smad2, Smad3 and Smad4 and plays a role in regulation of Smad-mediated transcriptional activity. In addition, RBP-MS may be involved in regulation of mRNA translation and localization during Xenopus laevis development. Pssm-ID: 410083 [Multi-domain] Cd Length: 76 Bit Score: 36.18 E-value: 1.06e-03
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