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Conserved domains on  [gi|1370453318|ref|XP_024303189|]
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methyltransferase-like protein 25B isoform X9 [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 133-222 1.09e-17

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam13679:

Pssm-ID: 473071 [Multi-domain]  Cd Length: 138  Bit Score: 77.61  E-value: 1.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453318 133 KKQHEIRRLGELVKKLSDF----TGCTQVVDVGSGQGHLSRFMA-LGLGLMVKSIEGDQRLVERAQRLDQElLQALEKEE 207
Cdd:pfam13679   1 KKLHQVEHLAEFIAPLLKElldeNGPITIVDHGAGKGYLGFILYyLKYGVRVYGIDTRAELVEKANALAQK-LGFNKRMS 79

                          90
                  ....*....|....*
gi 1370453318 208 KRNPQVVQTSPRHSP 222
Cdd:pfam13679  80 FLEGTIAGSTPVELP 94
 
Name Accession Description Interval E-value
Methyltransf_32 pfam13679
Methyltransferase domain; This family appears to be a methyltransferase domain.
 133-222 1.09e-17

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 379330 [Multi-domain]  Cd Length: 138  Bit Score: 77.61  E-value: 1.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453318 133 KKQHEIRRLGELVKKLSDF----TGCTQVVDVGSGQGHLSRFMA-LGLGLMVKSIEGDQRLVERAQRLDQElLQALEKEE 207
Cdd:pfam13679   1 KKLHQVEHLAEFIAPLLKElldeNGPITIVDHGAGKGYLGFILYyLKYGVRVYGIDTRAELVEKANALAQK-LGFNKRMS 79

                          90
                  ....*....|....*
gi 1370453318 208 KRNPQVVQTSPRHSP 222
Cdd:pfam13679  80 FLEGTIAGSTPVELP 94
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 139-199 3.37e-03

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 36.92  E-value: 3.37e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370453318 139 RRLGELVKKLSDFTGctQVVDVGSGQGHLSRFMAlGLGLMVKSIEGDQRLVERAQRLDQEL 199
Cdd:COG2227    12 RRLAALLARLLPAGG--RVLDVGCGTGRLALALA-RRGADVTGVDISPEALEIARERAAEL 69
 
Name Accession Description Interval E-value
Methyltransf_32 pfam13679
Methyltransferase domain; This family appears to be a methyltransferase domain.
 133-222 1.09e-17

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 379330 [Multi-domain]  Cd Length: 138  Bit Score: 77.61  E-value: 1.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453318 133 KKQHEIRRLGELVKKLSDF----TGCTQVVDVGSGQGHLSRFMA-LGLGLMVKSIEGDQRLVERAQRLDQElLQALEKEE 207
Cdd:pfam13679   1 KKLHQVEHLAEFIAPLLKElldeNGPITIVDHGAGKGYLGFILYyLKYGVRVYGIDTRAELVEKANALAQK-LGFNKRMS 79

                          90
                  ....*....|....*
gi 1370453318 208 KRNPQVVQTSPRHSP 222
Cdd:pfam13679  80 FLEGTIAGSTPVELP 94
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 139-199 3.37e-03

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 36.92  E-value: 3.37e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370453318 139 RRLGELVKKLSDFTGctQVVDVGSGQGHLSRFMAlGLGLMVKSIEGDQRLVERAQRLDQEL 199
Cdd:COG2227    12 RRLAALLARLLPAGG--RVLDVGCGTGRLALALA-RRGADVTGVDISPEALEIARERAAEL 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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