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Conserved domains on  [gi|1370514175|ref|XP_024303249|]
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ankyrin repeat domain-containing protein 18A isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
 390-680 4.45e-111

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


:

Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 348.13  E-value: 4.45e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  390 NFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELE 469
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  470 KEKHNKERLEAEVESLHSSLATAINEYNEIVERK-DLELVLWRADD--VSRHEKMGSNISQLTDKNELLTEQVHKARVKF 546
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKrDLELAFQRERDewLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  547 NTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDA 626
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370514175  627 RKEGDNKE-IVINIHRDC--------LENGKED-LLEERNKELMKEYNYLKEKLLQCEKEKAER 680
Cdd:pfam14915  241 QNKADAKEkTVIDIQDQFqdivkklqAESEKQVlLLEERNKELINECNHLKERLYQYEKEKAER 304
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-268 9.48e-40

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 149.33  E-value: 9.48e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   29 DIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKA 108
Cdd:COG0666     48 ALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLA 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  109 VHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLK 188
Cdd:COG0666    128 AYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLE 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  189 NQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDN 268
Cdd:COG0666    208 AGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 926-1032 1.53e-33

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


:

Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 124.78  E-value: 1.53e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  926 LKKKELTLKDVECKFSKMKTAYEEV-TTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLP 1004
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDSnKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90       100
                   ....*....|....*....|....*....
gi 1370514175 1005 TRPEPELPCVENLN-SIELNRKYIPKTAI 1032
Cdd:pfam12001   81 TRPVLESPCVGNLNnSLVLNRNFIPRENL 109
SMC_N super family cl47134
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 523-970 1.18e-07

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


The actual alignment was detected with superfamily member TIGR02169:

Pssm-ID: 481474 [Multi-domain]  Cd Length: 1164  Bit Score: 56.23  E-value: 1.18e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  523 SNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQmhpngeaKESQSIGKQ 602
Cdd:TIGR02169  667 LFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQ-------EEEKLKERL 739

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  603 NSLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLkekllqcEKEKAEREV 682
Cdd:TIGR02169  740 EELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKL-------EEEVSRIEA 812

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  683 IVREFQEELVDHLKTFSISESplegtshchinlnetwtSKKKLFQVEIQPEEKHEEFRKLFELISLlnytadQIRKKNRE 762
Cdd:TIGR02169  813 RLREIEQKLNRLTLEKEYLEK-----------------EIQELQEQRIDLKEQIKSIEKEIENLNG------KKEELEEE 869

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  763 LEEeatgykkclemtinmLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEkeavssecVNLAKDNEVLHQELL 842
Cdd:TIGR02169  870 LEE---------------LEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQ--------IEKKRKRLSELKAKL 926

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  843 SmrNVQEKCEKLEKDKKMLEEEVLNLkthmekdmVELGKLQEYKSELDERavqeIEKLEEIHLQKQAEYEKQLEQLNkdn 922
Cdd:TIGR02169  927 E--ALEEELSEIEDPKGEDEEIPEEE--------LSLEDVQAELQRVEEE----IRALEPVNMLAIQEYEEVLKRLD--- 989

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 1370514175  923 taSLKKKELTLKdveckfsKMKTAYEEVTTELEEFK-EAFAGAVKANNS 970
Cdd:TIGR02169  990 --ELKEKRAKLE-------EERKAILERIEEYEKKKrEVFMEAFEAINE 1029
 
Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
 390-680 4.45e-111

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 348.13  E-value: 4.45e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  390 NFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELE 469
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  470 KEKHNKERLEAEVESLHSSLATAINEYNEIVERK-DLELVLWRADD--VSRHEKMGSNISQLTDKNELLTEQVHKARVKF 546
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKrDLELAFQRERDewLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  547 NTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDA 626
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370514175  627 RKEGDNKE-IVINIHRDC--------LENGKED-LLEERNKELMKEYNYLKEKLLQCEKEKAER 680
Cdd:pfam14915  241 QNKADAKEkTVIDIQDQFqdivkklqAESEKQVlLLEERNKELINECNHLKERLYQYEKEKAER 304
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-268 9.48e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 149.33  E-value: 9.48e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   29 DIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKA 108
Cdd:COG0666     48 ALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLA 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  109 VHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLK 188
Cdd:COG0666    128 AYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLE 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  189 NQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDN 268
Cdd:COG0666    208 AGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 926-1032 1.53e-33

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 124.78  E-value: 1.53e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  926 LKKKELTLKDVECKFSKMKTAYEEV-TTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLP 1004
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDSnKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90       100
                   ....*....|....*....|....*....
gi 1370514175 1005 TRPEPELPCVENLN-SIELNRKYIPKTAI 1032
Cdd:pfam12001   81 TRPVLESPCVGNLNnSLVLNRNFIPRENL 109
Ank_2 pfam12796
Ankyrin repeats (3 copies);
138-230 4.33e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.38  E-value: 4.33e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  138 LHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNqANIHAVDNfKRTALILAVQHNLSSIVT 217
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1370514175  218 LLLQQNIRISSQD 230
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 60-275 6.79e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 78.47  E-value: 6.79e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   60 DLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALH 139
Cdd:PHA02874   116 DVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLH 195

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  140 YAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQhMVEFLLkNQANIHAVDNFKRTALILAVQHNLS-SIVTL 218
Cdd:PHA02874   196 NAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRS-AIELLI-NNASINDQDIDGSTPLHHAINPPCDiDIIDI 273

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  219 LLQQNIRISSQDMFGQTAEDYAL-----CSDLRSI--------------RQQILEHK----NKMLKNHLRNDNQEAAAMK 275
Cdd:PHA02874   274 LLYHKADISIKDNKGENPIDTAFkyinkDPVIKDIianavlikeadklkDSDFLEHIeikdNKEFSDFIKECNEEIEDMK 353
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
416-961 4.44e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 60.85  E-value: 4.44e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  416 KKYIQEIKSITEINANFEKSVRLNEKMITKTvarySQQLNDLKAENARLNSELEKEKHNKERLEAEVESLhsslaTAINE 495
Cdd:PRK03918   175 KRRIERLEKFIKRTENIEELIKEKEKELEEV----LREINEISSELPELREELEKLEKEVKELEELKEEI-----EELEK 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  496 YNEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARvKFNTLKGKLRETRDALREKTLALGSVQLDLR 575
Cdd:PRK03918   246 ELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAE-EYIKLSEFYEEYLDELREIEKRLSRLEEEIN 324

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  576 QAQHRIKEMKQMHPNGE---AKESQSIGKQNSLEERIRQ-QELENLLLERQLEDARKEGDNKEIVINihrdclengKEDL 651
Cdd:PRK03918   325 GIEERIKELEEKEERLEelkKKLKELEKRLEELEERHELyEEAKAKKEELERLKKRLTGLTPEKLEK---------ELEE 395

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  652 LEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQE----------ELVDHLKTFSISESPLEgTSHCHINLNETWTS 721
Cdd:PRK03918   396 LEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKakgkcpvcgrELTEEHRKELLEEYTAE-LKRIEKELKEIEEK 474

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  722 KKKLFQVEIQPEEKHEEFRKLFELISLlnytADQIRkknrELEEEATGYkkclemtinmlnafanedfschgdlNTDQLK 801
Cdd:PRK03918   475 ERKLRKELRELEKVLKKESELIKLKEL----AEQLK----ELEEKLKKY-------------------------NLEELE 521

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  802 MDI-LFKKLKQKFNDLVAEKEAVSSECvnlakdnevlhqellsmrnvqEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELG 880
Cdd:PRK03918   522 KKAeEYEKLKEKLIKLKGEIKSLKKEL---------------------EKLEELKKKLAELEKKLDELEEELAELLKELE 580

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  881 KLQEYKSELDERAVQEIEKLEEIHLQ-KQAEYEKQLEQlnkdntASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKE 959
Cdd:PRK03918   581 ELGFESVEELEERLKELEPFYNEYLElKDAEKELEREE------KELKKLEEELDKAFEELAETEKRLEELRKELEELEK 654


                   ..
gi 1370514175  960 AF 961
Cdd:PRK03918   655 KY 656
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 523-970 1.18e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 56.23  E-value: 1.18e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  523 SNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQmhpngeaKESQSIGKQ 602
Cdd:TIGR02169  667 LFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQ-------EEEKLKERL 739

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  603 NSLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLkekllqcEKEKAEREV 682
Cdd:TIGR02169  740 EELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKL-------EEEVSRIEA 812

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  683 IVREFQEELVDHLKTFSISESplegtshchinlnetwtSKKKLFQVEIQPEEKHEEFRKLFELISLlnytadQIRKKNRE 762
Cdd:TIGR02169  813 RLREIEQKLNRLTLEKEYLEK-----------------EIQELQEQRIDLKEQIKSIEKEIENLNG------KKEELEEE 869

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  763 LEEeatgykkclemtinmLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEkeavssecVNLAKDNEVLHQELL 842
Cdd:TIGR02169  870 LEE---------------LEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQ--------IEKKRKRLSELKAKL 926

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  843 SmrNVQEKCEKLEKDKKMLEEEVLNLkthmekdmVELGKLQEYKSELDERavqeIEKLEEIHLQKQAEYEKQLEQLNkdn 922
Cdd:TIGR02169  927 E--ALEEELSEIEDPKGEDEEIPEEE--------LSLEDVQAELQRVEEE----IRALEPVNMLAIQEYEEVLKRLD--- 989

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 1370514175  923 taSLKKKELTLKdveckfsKMKTAYEEVTTELEEFK-EAFAGAVKANNS 970
Cdd:TIGR02169  990 --ELKEKRAKLE-------EERKAILERIEEYEKKKrEVFMEAFEAINE 1029
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 49-259 2.09e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 55.02  E-value: 2.09e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   49 EVERCLTRRFRDldardrkdrTVLHLACAHGRVQVVTLLLhrRCQ-IDICDR--LNRTPLMKAV-HSQEEAcAIVLLECG 124
Cdd:cd22192      7 ELHLLQQKRISE---------SPLLLAAKENDVQAIKKLL--KCPsCDLFQRgaLGETALHVAAlYDNLEA-AVVLMEAA 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  125 A----NPNIEDIY-GNTALHYAVYNKGTSLAERLLSHHA--------------NIEALNKEGNTPLLFAINSRRQHMVEF 185
Cdd:cd22192     75 PelvnEPMTSDLYqGETALHIAVVNQNLNLVRELIARGAdvvspratgtffrpGPKNLIYYGEHPLSFAACVGNEEIVRL 154

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370514175  186 LLKNQANIHAVDNFKRTALilavqHnlssivTLLLQQNIRISSQdMFgqtaeDYALCSDlRSIRQQILEH-KNKM 259
Cdd:cd22192    155 LIEHGADIRAQDSLGNTVL-----H------ILVLQPNKTFACQ-MY-----DLILSYD-KEDDLQPLDLvPNNQ 211
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 393-691 2.22e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.45  E-value: 2.22e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  393 LKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKsVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEK 472
Cdd:TIGR02168  696 LEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLAR-LEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAE 774

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  473 HNKERLEAEVESLHSSLATAINEyneiverkdlelvlwraddvsrhekMGSNISQLTDknellteqvhkarvkfntLKGK 552
Cdd:TIGR02168  775 EELAEAEAEIEELEAQIEQLKEE-------------------------LKALREALDE------------------LRAE 811

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  553 LRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQqelenllLERQLEDARKEGDN 632
Cdd:TIGR02168  812 LTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEE-------LESELEALLNERAS 884

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370514175  633 KEIVINIHRDCLENGKEDL--LEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEEL 691
Cdd:TIGR02168  885 LEEALALLRSELEELSEELreLESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERL 945
PTZ00121 PTZ00121
MAEBL; Provisional
 338-966 1.07e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.22  E-value: 1.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  338 KPANLKKRKERAKAEHNLKVASEEKQ--ERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKE 415
Cdd:PTZ00121  1291 KADEAKKAEEKKKADEAKKKAEEAKKadEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAE 1370

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  416 KKYIQEIKSITEINANFEKSVRLNEkmITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINE 495
Cdd:PTZ00121  1371 KKKEEAKKKADAAKKKAEEKKKADE--AKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADE 1448

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  496 YNEIVERKDlelvlwRADDVSRHEKMGSNISQLTDKNELlTEQVHKARVKFNTLKGKLRETRDALREKTLALgsvqlDLR 575
Cdd:PTZ00121  1449 AKKKAEEAK------KAEEAKKKAEEAKKADEAKKKAEE-AKKADEAKKKAEEAKKKADEAKKAAEAKKKAD-----EAK 1516

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  576 QAQHRIK--EMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINiHRDCLENGKEDLLE 653
Cdd:PTZ00121  1517 KAEEAKKadEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALR-KAEEAKKAEEARIE 1595

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  654 ERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEelvdhlktfsisesplegtshchinlnetwtsKKKLFQVEIQPE 733
Cdd:PTZ00121  1596 EVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEE--------------------------------KKKVEQLKKKEA 1643

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  734 E---KHEEFRKLFELISLlnyTADQIRKKNRELEEEATGYKKclemtinmlnafANEDfschgdlntDQLKMDILFKKlk 810
Cdd:PTZ00121  1644 EekkKAEELKKAEEENKI---KAAEEAKKAEEDKKKAEEAKK------------AEED---------EKKAAEALKKE-- 1697

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  811 qkfndlvaEKEAVSSECVNLAKDNEVLHQELLSmRNVQEKCEKLEKDKKMLEEEvlnlkthmEKDMVELGKLQEYKSELD 890
Cdd:PTZ00121  1698 --------AEEAKKAEELKKKEAEEKKKAEELK-KAEEENKIKAEEAKKEAEED--------KKKAEEAKKDEEEKKKIA 1760

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514175  891 ERAVQEIEKLEEIHLQKQAEYEkqlEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVK 966
Cdd:PTZ00121  1761 HLKKEEEKKAEEIRKEKEAVIE---EELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIK 1833
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 340-994 1.53e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 52.67  E-value: 1.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  340 ANLKKRKERA----------KAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLK---KDIAMLKEELYA 406
Cdd:pfam02463  165 SRLKRKKKEAlkklieetenLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLdylKLNEERIDLLQE 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  407 IKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLH 486
Cdd:pfam02463  245 LLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKK 324

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  487 SSLATAINEYNEIVERKDLELVLWRADdvsrhEKMGSNISQLTDKNELLTEQVHKARVKFnTLKGKLRETRDALREKTLA 566
Cdd:pfam02463  325 KAEKELKKEKEEIEELEKELKELEIKR-----EAEEEEEEELEKLQEKLEQLEEELLAKK-KLESERLSSAAKLKEEELE 398

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  567 LGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEivinihrdclEN 646
Cdd:pfam02463  399 LKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELE----------LK 468

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  647 GKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVRE---FQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKK 723
Cdd:pfam02463  469 KSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGlkvLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTA 548

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  724 KLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEdFSCHGDLNTDQLKMD 803
Cdd:pfam02463  549 VIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKAT-LEADEDDKRAKVVEG 627

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  804 ILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHqeLLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQ 883
Cdd:pfam02463  628 ILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKS--EVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKE 705

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  884 EYKSELDERAVQEIEKLEEIHLQ--------KQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELE 955
Cdd:pfam02463  706 QREKEELKKLKLEAEELLADRVQeaqdkineELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEK 785

                          650       660       670
                   ....*....|....*....|....*....|....*....
gi 1370514175  956 EFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQ 994
Cdd:pfam02463  786 LKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLI 824
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 406-629 7.48e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.76  E-value: 7.48e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  406 AIKNDSLRKEKKYIQeiKSITEINANFEKsVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESL 485
Cdd:COG4942     19 ADAAAEAEAELEQLQ--QEIAELEKELAA-LKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAEL 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  486 HSSLATAINEYNEIV------ERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDA 559
Cdd:COG4942     96 RAELEAQKEELAELLralyrlGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAE 175

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370514175  560 LREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIgkqnsLEERIRQQELENLL--LERQLEDARKE 629
Cdd:COG4942    176 LEALLAELEEERAALEALKAERQKLLARLEKELAELAAEL-----AELQQEAEELEALIarLEAEAAAAAER 242
COG5022 COG5022
Myosin heavy chain [General function prediction only];
342-953 1.64e-04

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 45.84  E-value: 1.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  342 LKKRKE-RAKAEHNLKVASEEKQERLQRSENKQPQD----------SQSYGKKKDAmygnFMLKKDIAMLK--------- 401
Cdd:COG5022    806 LGSRKEyRSYLACIIKLQKTIKREKKLRETEEVEFSlkaevliqkfGRSLKAKKRF----SLLKKETIYLQsaqrvelae 881

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  402 ----EELYAIKNDSLRKEKKYiQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNdlkaeNARLNSELEKEKHNKER 477
Cdd:COG5022    882 rqlqELKIDVKSISSLKLVNL-ELESEIIELKKSLSSDLIENLEFKTELIARLKKLLN-----NIDLEEGPSIEYVKLPE 955

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  478 LEaEVESLHSSLATAINEYNEIVerkdlelvlwraddvsrhEKMGSNISQLTDKNELLtEQVHKARVKFNTLKGKLRETR 557
Cdd:COG5022    956 LN-KLHEVESKLKETSEEYEDLL------------------KKSTILVREGNKANSEL-KNFKKELAELSKQYGALQEST 1015

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  558 DALREKTLALGSVQLDLRQAQHRIKEMKQMhpngeaKESQSIGKQNSLEERIRQQELENLLLERQLEDA-RKEGDNKEIV 636
Cdd:COG5022   1016 KQLKELPVEVAELQSASKIISSESTELSIL------KPLQKLKGLLLLENNQLQARYKALKLRRENSLLdDKQLYQLEST 1089

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  637 INihrdcLENG-KEDLLEERNKELMKEYNYL--------KEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEG 707
Cdd:COG5022   1090 EN-----LLKTiNVKDLEVTNRNLVKPANVLqfivaqmiKLNLLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEAN 1164

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  708 TSHCHINLNETWTSKKKLFQVEIQPEEKH------EEFRKLFELISLLNYTADQIRKKNRELEEEA---TGYKKCLEMTI 778
Cdd:COG5022   1165 LEALPSPPPFAALSEKRLYQSALYDEKSKlsssevNDLKNELIALFSKIFSGWPRGDKLKKLISEGwvpTEYSTSLKGFN 1244

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  779 NMLNAFAnedfschgdlNTDQLKMDILFKKLKQKFNDLVA---EKEAVSSECVNLAKDNEVLHQELLSMR---------- 845
Cdd:COG5022   1245 NLNKKFD----------TPASMSNEKLLSLLNSIDNLLSSyklEEEVLPATINSLLQYINVGLFNALRTKasslrwksat 1314

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  846 NVQEKCEklEKDKKMLEEEVLNLKTHMEKDM--VELGKLQEYK-SELDER--AVQ-----EIEKLeeIHLQKQAEYEKQL 915
Cdd:COG5022   1315 EVNYNSE--ELDDWCREFEISDVDEELEELIqaVKVLQLLKDDlNKLDELldACYslnpaEIQNL--KSRYDPADKENNL 1390

                          650       660       670
                   ....*....|....*....|....*....|....*....
gi 1370514175  916 E-QLNKDNTASLKKKELTLKDveCKFSKMKTAYEEVTTE 953
Cdd:COG5022   1391 PkEILKKIEALLIKQELQLSL--EGKDETEVHLSEIFSE 1427
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 93-235 4.09e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.22  E-value: 4.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   93 QIDICDRLNRTPLMKAVHSQEEACAIVLLEcgaNPNIEDIYGNTALHYAVYN-----------KGTSLAERLLSHHANIE 161
Cdd:TIGR00870   44 NINCPDRLGRSALFVAAIENENLELTELLL---NLSCRGAVGDTLLHAISLEyvdaveaillhLLAAFRKSGPLELANDQ 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  162 ALNKE--GNTPLLFAINSRRQHMVEFLLKNQANIHA------------VDNFK--RTALILAVQHNLSSIVTLLLQQNIR 225
Cdd:TIGR00870  121 YTSEFtpGITALHLAAHRQNYEIVKLLLERGASVPAracgdffvksqgVDSFYhgESPLNAAACLGSPSIVALLSEDPAD 200

                          170
                   ....*....|
gi 1370514175  226 ISSQDMFGQT 235
Cdd:TIGR00870  201 ILTADSLGNT 210
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 133-162 9.01e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 9.01e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1370514175   133 YGNTALHYAVYNKGTSLAERLLSHHANIEA 162
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
 390-680 4.45e-111

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 348.13  E-value: 4.45e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  390 NFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELE 469
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  470 KEKHNKERLEAEVESLHSSLATAINEYNEIVERK-DLELVLWRADD--VSRHEKMGSNISQLTDKNELLTEQVHKARVKF 546
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKrDLELAFQRERDewLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  547 NTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDA 626
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370514175  627 RKEGDNKE-IVINIHRDC--------LENGKED-LLEERNKELMKEYNYLKEKLLQCEKEKAER 680
Cdd:pfam14915  241 QNKADAKEkTVIDIQDQFqdivkklqAESEKQVlLLEERNKELINECNHLKERLYQYEKEKAER 304
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-268 9.48e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 149.33  E-value: 9.48e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   29 DIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKA 108
Cdd:COG0666     48 ALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLA 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  109 VHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLK 188
Cdd:COG0666    128 AYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLE 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  189 NQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDN 268
Cdd:COG0666    208 AGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-277 4.42e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 138.55  E-value: 4.42e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   29 DIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKA 108
Cdd:COG0666     15 LLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAA 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  109 VHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLK 188
Cdd:COG0666     95 ARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  189 NQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDN 268
Cdd:COG0666    175 AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLT 254


                   ....*....
gi 1370514175  269 QEAAAMKNE 277
Cdd:COG0666    255 ALLLAAAAG 263
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-236 4.59e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 135.85  E-value: 4.59e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   38 IHRAAIKGDAAEVERCLTRRFrDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACA 117
Cdd:COG0666     91 LHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIV 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  118 IVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVD 197
Cdd:COG0666    170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKD 249

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1370514175  198 NFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTA 236
Cdd:COG0666    250 KDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 926-1032 1.53e-33

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 124.78  E-value: 1.53e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  926 LKKKELTLKDVECKFSKMKTAYEEV-TTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLP 1004
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDSnKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90       100
                   ....*....|....*....|....*....
gi 1370514175 1005 TRPEPELPCVENLN-SIELNRKYIPKTAI 1032
Cdd:pfam12001   81 TRPVLESPCVGNLNnSLVLNRNFIPRENL 109
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-204 6.97e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 108.89  E-value: 6.97e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   38 IHRAAIKGDAAEVERCLTRRFrDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACA 117
Cdd:COG0666    124 LHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  118 IVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVD 197
Cdd:COG0666    203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282


                   ....*..
gi 1370514175  198 NFKRTAL 204
Cdd:COG0666    283 LDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
54-276 8.39e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 103.11  E-value: 8.39e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   54 LTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIY 133
Cdd:COG0666      7 LLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  134 GNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLS 213
Cdd:COG0666     87 GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNL 166

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370514175  214 SIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHK-NKMLKNHLRNDNQEAAAMKN 276
Cdd:COG0666    167 EIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGaDVNAKDNDGKTALDLAAENG 230
Ank_2 pfam12796
Ankyrin repeats (3 copies);
138-230 4.33e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.38  E-value: 4.33e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  138 LHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNqANIHAVDNfKRTALILAVQHNLSSIVT 217
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1370514175  218 LLLQQNIRISSQD 230
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
72-164 2.43e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.46  E-value: 2.43e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   72 LHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECgANPNIEDiYGNTALHYAVYNKGTSLAE 151
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1370514175  152 RLLSHHANIEALN 164
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 60-275 6.79e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 78.47  E-value: 6.79e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   60 DLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALH 139
Cdd:PHA02874   116 DVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLH 195

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  140 YAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQhMVEFLLkNQANIHAVDNFKRTALILAVQHNLS-SIVTL 218
Cdd:PHA02874   196 NAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRS-AIELLI-NNASINDQDIDGSTPLHHAINPPCDiDIIDI 273

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  219 LLQQNIRISSQDMFGQTAEDYAL-----CSDLRSI--------------RQQILEHK----NKMLKNHLRNDNQEAAAMK 275
Cdd:PHA02874   274 LLYHKADISIKDNKGENPIDTAFkyinkDPVIKDIianavlikeadklkDSDFLEHIeikdNKEFSDFIKECNEEIEDMK 353
Ank_2 pfam12796
Ankyrin repeats (3 copies);
105-197 2.83e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.37  E-value: 2.83e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  105 LMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLShHANIEALNkEGNTPLLFAINSRRQHMVE 184
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1370514175  185 FLLKNQANIHAVD 197
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 74-236 4.17e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 73.14  E-value: 4.17e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   74 LACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIV---LLECGANPNIEDIYGNTALHYAVYNKGT-SL 149
Cdd:PHA03095    20 LNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERCGFTPLHLYLYNATTlDV 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  150 AERLLSHHANIEALNKEGNTPLL-----FAINSRrqhMVEFLLKNQANIHAVDNFKRTAL-ILAVQHNLS-SIVTLLLQQ 222
Cdd:PHA03095   100 IKLLIKAGADVNAKDKVGRTPLHvylsgFNINPK---VIRLLLRKGADVNALDLYGMTPLaVLLKSRNANvELLRLLIDA 176

                          170
                   ....*....|....
gi 1370514175  223 NIRISSQDMFGQTA 236
Cdd:PHA03095   177 GADVYAVDDRFRSL 190
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 28-208 4.42e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 72.99  E-value: 4.42e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   28 YDIRDWELRKIHRAAIKgdAAEVERCLTRRFRDLDARDR-KDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLM 106
Cdd:PHA02878   129 QTIDLVYIDKKSKDDII--EAEITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLH 206

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  107 KAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAV-YNKGTSLAERLLSHHANIEALNK-EGNTPLLFAINSRRQhmVE 184
Cdd:PHA02878   207 HAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVgYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSIKSERK--LK 284

                          170       180
                   ....*....|....*....|....
gi 1370514175  185 FLLKNQANIHAVDNFKRTALILAV 208
Cdd:PHA02878   285 LLLEYGADINSLNSYKLTPLSSAV 308
Ank_2 pfam12796
Ankyrin repeats (3 copies);
38-131 1.54e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 64.37  E-value: 1.54e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   38 IHRAAIKGDAAEVERcLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLhRRCQIDICDRlNRTPLMKAVHSQEEACA 117
Cdd:pfam12796    1 LHLAAKNGNLELVKL-LLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKDN-GRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 1370514175  118 IVLLECGANPNIED 131
Cdd:pfam12796   78 KLLLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 119-229 8.36e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 68.75  E-value: 8.36e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  119 VLLECGANPNIEDIY-GNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVD 197
Cdd:PHA02878   152 LLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARD 231

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1370514175  198 NFKRTALILAVQHNLS-SIVTLLLQQNIRISSQ 229
Cdd:PHA02878   232 KCGNTPLHISVGYCKDyDILKLLLEHGVDVNAK 264
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 26-192 1.09e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 68.09  E-value: 1.09e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   26 PGYDIRDWElRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPL 105
Cdd:PHA02875    61 PDVKYPDIE-SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPL 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  106 MKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLL-FAINSRRQHMVE 184
Cdd:PHA02875   140 HLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALcYAIENNKIDIVR 219


                   ....*...
gi 1370514175  185 FLLKNQAN 192
Cdd:PHA02875   220 LFIKRGAD 227
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 30-223 1.74e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 68.55  E-value: 1.74e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   30 IRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHG-RVQVVTLLLHRRCQIDICDRLNRTPLMKA 108
Cdd:PHA02876   269 IDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQA 348

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  109 -VHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHM-VEFL 186
Cdd:PHA02876   349 sTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPYMsVKTL 428

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1370514175  187 LKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQN 223
Cdd:PHA02876   429 IDRGANVNSKNKDLSTPLHYACKKNCKLDVIEMLLDN 465
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 42-199 8.11e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 65.46  E-value: 8.11e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   42 AIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAH--GRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIV 119
Cdd:PHA03100    80 YNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKIL 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  120 ------------------LLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQH 181
Cdd:PHA03100   160 kllidkgvdinaknrvnyLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKE 239

                          170
                   ....*....|....*...
gi 1370514175  182 MVEFLLKNQANIHAVDNF 199
Cdd:PHA03100   240 IFKLLLNNGPSIKTIIET 257
PHA03095 PHA03095
ankyrin-like protein; Provisional
 45-255 8.85e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 65.82  E-value: 8.85e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   45 GDAAEVERCLTRRFRDLDARDRKDRTVLHLacahgrvqvvtLLLHRrcqidicdrlNRTPLMKavhsqeeacaiVLLECG 124
Cdd:PHA03095    60 EKVKDIVRLLLEAGADVNAPERCGFTPLHL-----------YLYNA----------TTLDVIK-----------LLIKAG 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  125 ANPNIEDIYGNTALHyaVYNKG----TSLAERLLSHHANIEALNKEGNTPLLFAINSRRQ--HMVEFLLKNQANIHAVDN 198
Cdd:PHA03095   108 ADVNAKDKVGRTPLH--VYLSGfninPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNAnvELLRLLIDAGADVYAVDD 185

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370514175  199 FKRTAL--ILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYA--LCSDLRSIRQQILEH 255
Cdd:PHA03095   186 RFRSLLhhHLQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMatGSSCKRSLVLPLLIA 246
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 60-265 1.45e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 64.69  E-value: 1.45e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   60 DLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAV---HSQEEACAIV--LLECGANPNIEDIYG 134
Cdd:PHA03100    27 LNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSnikYNLTDVKEIVklLLEYGANVNAPDNNG 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  135 NTALHYAVYNKGTS--LAERLLSHHANIEALNKEGNTPLLFAI--NSRRQHMVEFLLKNQANIHAVDNFKR--------- 201
Cdd:PHA03100   107 ITPLLYAISKKSNSysIVEYLLDNGANVNIKNSDGENLLHLYLesNKIDLKILKLLIDKGVDINAKNRVNYllsygvpin 186

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370514175  202 -------TALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKN--KMLKNHLR 265
Cdd:PHA03100   187 ikdvygfTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPsiKTIIETLL 259
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 69-222 7.41e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 62.32  E-value: 7.41e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   69 RTVLHLACAHGRVQVVTLLLHRRCQI-DICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGT 147
Cdd:PHA02875    69 ESELHDAVEEGDVKAVEELLDLGKFAdDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514175  148 SLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVD-NFKRTALILAVQHNLSSIVTLLLQQ 222
Cdd:PHA02875   149 KGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGkNGCVAALCYAIENNKIDIVRLFIKR 224
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 34-240 8.95e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 62.77  E-value: 8.95e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   34 ELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDIC--DRL----------- 100
Cdd:PHA02876   144 EYMKLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIalDDLsvlecavdskn 223

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  101 ----------------NRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTS-LAERLLSHHANIEAL 163
Cdd:PHA02876   224 idtikaiidnrsninkNDLSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAK 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  164 NKEGNTPL-LFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILA--VQHNLSSIVTlLLQQNIRISSQDMFGQTAEDYA 240
Cdd:PHA02876   304 NIKGETPLyLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQAstLDRNKDIVIT-LLELGANVNARDYCDKTPIHYA 382
PHA03095 PHA03095
ankyrin-like protein; Provisional
 60-211 2.26e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 61.19  E-value: 2.26e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   60 DLDARDRKDRTVLHlACAHG---RVQVVTLLLhrRCQIDICDR--LNRTPLMKAVHSQEEACAIV--LLECGANPNIEDI 132
Cdd:PHA03095   109 DVNAKDKVGRTPLH-VYLSGfniNPKVIRLLL--RKGADVNALdlYGMTPLAVLLKSRNANVELLrlLIDAGADVYAVDD 185

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  133 YGNTALHY-AVYNKG-TSLAERLLSHHANIEALNKEGNTPL-LFAINS--RRQHMVEFLLKNqANIHAVDNFKRTALILA 207
Cdd:PHA03095   186 RFRSLLHHhLQSFKPrARIVRELIRAGCDPAATDMLGNTPLhSMATGSscKRSLVLPLLIAG-ISINARNRYGQTPLHYA 264


                   ....
gi 1370514175  208 VQHN 211
Cdd:PHA03095   265 AVFN 268
PHA03095 PHA03095
ankyrin-like protein; Provisional
 60-198 2.96e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 60.81  E-value: 2.96e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   60 DLDARDRKDRTVLHLAC--AHGRVQVVTLLLHRRCQIDICDRLNRTPL-MKAVHSQEEACAIV-LLECGANPNIEDIYGN 135
Cdd:PHA03095   179 DVYAVDDRFRSLLHHHLqsFKPRARIVRELIRAGCDPAATDMLGNTPLhSMATGSSCKRSLVLpLLIAGISINARNRYGQ 258

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370514175  136 TALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDN 198
Cdd:PHA03095   259 TPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVAA 321
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 68-241 3.14e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 60.75  E-value: 3.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   68 DRTVLHLACAHGrvQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGT 147
Cdd:PHA02874    93 DTSILPIPCIEK--DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFF 170

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  148 SLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVtlLLQQNIRIS 227
Cdd:PHA02874   171 DIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIE--LLINNASIN 248

                          170
                   ....*....|....
gi 1370514175  228 SQDMFGQTAEDYAL 241
Cdd:PHA02874   249 DQDIDGSTPLHHAI 262
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
416-961 4.44e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 60.85  E-value: 4.44e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  416 KKYIQEIKSITEINANFEKSVRLNEKMITKTvarySQQLNDLKAENARLNSELEKEKHNKERLEAEVESLhsslaTAINE 495
Cdd:PRK03918   175 KRRIERLEKFIKRTENIEELIKEKEKELEEV----LREINEISSELPELREELEKLEKEVKELEELKEEI-----EELEK 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  496 YNEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARvKFNTLKGKLRETRDALREKTLALGSVQLDLR 575
Cdd:PRK03918   246 ELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAE-EYIKLSEFYEEYLDELREIEKRLSRLEEEIN 324

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  576 QAQHRIKEMKQMHPNGE---AKESQSIGKQNSLEERIRQ-QELENLLLERQLEDARKEGDNKEIVINihrdclengKEDL 651
Cdd:PRK03918   325 GIEERIKELEEKEERLEelkKKLKELEKRLEELEERHELyEEAKAKKEELERLKKRLTGLTPEKLEK---------ELEE 395

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  652 LEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQE----------ELVDHLKTFSISESPLEgTSHCHINLNETWTS 721
Cdd:PRK03918   396 LEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKakgkcpvcgrELTEEHRKELLEEYTAE-LKRIEKELKEIEEK 474

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  722 KKKLFQVEIQPEEKHEEFRKLFELISLlnytADQIRkknrELEEEATGYkkclemtinmlnafanedfschgdlNTDQLK 801
Cdd:PRK03918   475 ERKLRKELRELEKVLKKESELIKLKEL----AEQLK----ELEEKLKKY-------------------------NLEELE 521

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  802 MDI-LFKKLKQKFNDLVAEKEAVSSECvnlakdnevlhqellsmrnvqEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELG 880
Cdd:PRK03918   522 KKAeEYEKLKEKLIKLKGEIKSLKKEL---------------------EKLEELKKKLAELEKKLDELEEELAELLKELE 580

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  881 KLQEYKSELDERAVQEIEKLEEIHLQ-KQAEYEKQLEQlnkdntASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKE 959
Cdd:PRK03918   581 ELGFESVEELEERLKELEPFYNEYLElKDAEKELEREE------KELKKLEEELDKAFEELAETEKRLEELRKELEELEK 654


                   ..
gi 1370514175  960 AF 961
Cdd:PRK03918   655 KY 656
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 80-230 9.46e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 58.91  E-value: 9.46e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   80 RVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHY-----AVYNKGTSLAERLL 154
Cdd:PHA03100    14 KVKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYlsnikYNLTDVKEIVKLLL 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  155 SHHANIEALNKEGNTPLLFAINSRRQH--MVEFLLKNQANIHAVDNFKRTALILAVQHNL--SSIVTLLLQQNIRISSQD 230
Cdd:PHA03100    94 EYGANVNAPDNNGITPLLYAISKKSNSysIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDINAKN 173
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 87-220 8.38e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 56.41  E-value: 8.38e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   87 LLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAeRLLSHHANIEALNKE 166
Cdd:PLN03192   544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIF-RILYHFASISDPHAA 622

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1370514175  167 GNTpLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLL 220
Cdd:PLN03192   623 GDL-LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 523-970 1.18e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 56.23  E-value: 1.18e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  523 SNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQmhpngeaKESQSIGKQ 602
Cdd:TIGR02169  667 LFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQ-------EEEKLKERL 739

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  603 NSLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLkekllqcEKEKAEREV 682
Cdd:TIGR02169  740 EELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKL-------EEEVSRIEA 812

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  683 IVREFQEELVDHLKTFSISESplegtshchinlnetwtSKKKLFQVEIQPEEKHEEFRKLFELISLlnytadQIRKKNRE 762
Cdd:TIGR02169  813 RLREIEQKLNRLTLEKEYLEK-----------------EIQELQEQRIDLKEQIKSIEKEIENLNG------KKEELEEE 869

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  763 LEEeatgykkclemtinmLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEkeavssecVNLAKDNEVLHQELL 842
Cdd:TIGR02169  870 LEE---------------LEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQ--------IEKKRKRLSELKAKL 926

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  843 SmrNVQEKCEKLEKDKKMLEEEVLNLkthmekdmVELGKLQEYKSELDERavqeIEKLEEIHLQKQAEYEKQLEQLNkdn 922
Cdd:TIGR02169  927 E--ALEEELSEIEDPKGEDEEIPEEE--------LSLEDVQAELQRVEEE----IRALEPVNMLAIQEYEEVLKRLD--- 989

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 1370514175  923 taSLKKKELTLKdveckfsKMKTAYEEVTTELEEFK-EAFAGAVKANNS 970
Cdd:TIGR02169  990 --ELKEKRAKLE-------EERKAILERIEEYEKKKrEVFMEAFEAINE 1029
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 41-209 1.60e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 55.64  E-value: 1.60e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   41 AAIKGDAAEVERcLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVL 120
Cdd:PLN03192   532 VASTGNAALLEE-LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRIL 610

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  121 LECGA--NPNIediyGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAV-- 196
Cdd:PLN03192   611 YHFASisDPHA----AGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAnt 686

                          170
                   ....*....|....
gi 1370514175  197 -DNFKRTALILAVQ 209
Cdd:PLN03192   687 dDDFSPTELRELLQ 700
Ank_5 pfam13857
Ankyrin repeats (many copies);
120-174 1.71e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 48.88  E-value: 1.71e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514175  120 LLECG-ANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFA 174
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 49-259 2.09e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 55.02  E-value: 2.09e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   49 EVERCLTRRFRDldardrkdrTVLHLACAHGRVQVVTLLLhrRCQ-IDICDR--LNRTPLMKAV-HSQEEAcAIVLLECG 124
Cdd:cd22192      7 ELHLLQQKRISE---------SPLLLAAKENDVQAIKKLL--KCPsCDLFQRgaLGETALHVAAlYDNLEA-AVVLMEAA 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  125 A----NPNIEDIY-GNTALHYAVYNKGTSLAERLLSHHA--------------NIEALNKEGNTPLLFAINSRRQHMVEF 185
Cdd:cd22192     75 PelvnEPMTSDLYqGETALHIAVVNQNLNLVRELIARGAdvvspratgtffrpGPKNLIYYGEHPLSFAACVGNEEIVRL 154

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370514175  186 LLKNQANIHAVDNFKRTALilavqHnlssivTLLLQQNIRISSQdMFgqtaeDYALCSDlRSIRQQILEH-KNKM 259
Cdd:cd22192    155 LIEHGADIRAQDSLGNTVL-----H------ILVLQPNKTFACQ-MY-----DLILSYD-KEDDLQPLDLvPNNQ 211
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 393-691 2.22e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.45  E-value: 2.22e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  393 LKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKsVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEK 472
Cdd:TIGR02168  696 LEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLAR-LEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAE 774

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  473 HNKERLEAEVESLHSSLATAINEyneiverkdlelvlwraddvsrhekMGSNISQLTDknellteqvhkarvkfntLKGK 552
Cdd:TIGR02168  775 EELAEAEAEIEELEAQIEQLKEE-------------------------LKALREALDE------------------LRAE 811

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  553 LRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQqelenllLERQLEDARKEGDN 632
Cdd:TIGR02168  812 LTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEE-------LESELEALLNERAS 884

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370514175  633 KEIVINIHRDCLENGKEDL--LEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEEL 691
Cdd:TIGR02168  885 LEEALALLRSELEELSEELreLESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERL 945
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 340-997 2.63e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.06  E-value: 2.63e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  340 ANLKKRKERAKAE-HNLKVASEEKQERLQRSENKQPQDSQSYGKkkdamygnfmLKKDIAMLKEELYAIKNDsLRKEKKY 418
Cdd:TIGR02168  298 SRLEQQKQILRERlANLERQLEELEAQLEELESKLDELAEELAE----------LEEKLEELKEELESLEAE-LEELEAE 366

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  419 IQEIKSIteINANFEKSVRLNEKmitktVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAineyne 498
Cdd:TIGR02168  367 LEELESR--LEELEEQLETLRSK-----VAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEA------ 433

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  499 ivERKDLElvlwraddvsrhekmgsniSQLTDKNELLTEQVHkarvKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQ 578
Cdd:TIGR02168  434 --ELKELQ-------------------AELEELEEELEELQE----ELERLEEALEELREELEEAEQALDAAERELAQLQ 488

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  579 HRIKEMKQMHpngEAKESQSIGKQNSLEERIRQQELENLLLErQLEDARKEGDNKEIVinihrdcLENGKEDLLEERNKE 658
Cdd:TIGR02168  489 ARLDSLERLQ---ENLEGFSEGVKALLKNQSGLSGILGVLSE-LISVDEGYEAAIEAA-------LGGRLQAVVVENLNA 557

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  659 LMKEYNYLKEKLL--------------QCEKEKAEREVIVREFQEELVDHLKT---FSISESPLEGTSHCHINLNETWTS 721
Cdd:TIGR02168  558 AKKAIAFLKQNELgrvtflpldsikgtEIQGNDREILKNIEGFLGVAKDLVKFdpkLRKALSYLLGGVLVVDDLDNALEL 637

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  722 KKKL-------------------------------FQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGY 770
Cdd:TIGR02168  638 AKKLrpgyrivtldgdlvrpggvitggsaktnssiLERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQL 717

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  771 KKCLEmtinmlnafanedfschgDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRnvqEK 850
Cdd:TIGR02168  718 RKELE------------------ELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAE---EE 776

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  851 CEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEiHLQKQAEYEKQLEQLNKdntaSLKKKE 930
Cdd:TIGR02168  777 LAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLES-LERRIAATERRLEDLEE----QIEELS 851

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370514175  931 LTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMK 997
Cdd:TIGR02168  852 EDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELE 918
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 119-197 2.88e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.90  E-value: 2.88e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370514175  119 VLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVD 197
Cdd:PTZ00322   100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELG 178
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 400-960 3.42e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 54.64  E-value: 3.42e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  400 LKEELYAIKNDSLRKEKK-------YIQEIKSITEINANFEKsVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEK 472
Cdd:TIGR04523   38 LEKKLKTIKNELKNKEKElknldknLNKDEEKINNSNNKIKI-LEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDK 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  473 HNKERLEAEVESL---------------------HSSLATAINEYNEIVERK-DLELVLWRADD---------------V 515
Cdd:TIGR04523  117 EQKNKLEVELNKLekqkkenkknidkflteikkkEKELEKLNNKYNDLKKQKeELENELNLLEKeklniqknidkiknkL 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  516 SRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKE 595
Cdd:TIGR04523  197 LKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKEL 276

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  596 SQSIGKQNSLEERIRQQELENLLL-------------------ERQLEDARKEGDNKEIVINIHRDCLENGKEDL--LEE 654
Cdd:TIGR04523  277 EQNNKKIKELEKQLNQLKSEISDLnnqkeqdwnkelkselknqEKKLEEIQNQISQNNKIISQLNEQISQLKKELtnSES 356

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  655 RNKELMKEynyLKEKLLQCEKEKAErevivrefQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKlfQVEIQPEE 734
Cdd:TIGR04523  357 ENSEKQRE---LEEKQNEIEKLKKE--------NQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIK--KLQQEKEL 423

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  735 KHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEdfschgdLNTDQLKMDILFKKLKQKFN 814
Cdd:TIGR04523  424 LEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRS-------INKIKQNLEQKQKELKSKEK 496

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  815 DLvaekEAVSSECVNLAKDNEVLHQELLSMRnvqEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELgKLQEYKSELDERAv 894
Cdd:TIGR04523  497 EL----KKLNEEKKELEEKVKDLTKKISSLK---EKIEKLESEKKEKESKISDLEDELNKDDFEL-KKENLEKEIDEKN- 567

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370514175  895 QEIEKLEEIH---LQKQAEYE---KQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEA 960
Cdd:TIGR04523  568 KEIEELKQTQkslKKKQEEKQeliDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSK 639
Ank_4 pfam13637
Ankyrin repeats (many copies);
134-187 4.09e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.65  E-value: 4.09e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1370514175  134 GNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLL 187
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
393-900 4.45e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 54.30  E-value: 4.45e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  393 LKKDIAMLKEELYAIKnDSLRKEKKYIQE----IKSITEINANFEKSVRLNEKM---------ITKTVARYSQQLNDLKA 459
Cdd:PRK03918   250 LEGSKRKLEEKIRELE-ERIEELKKEIEEleekVKELKELKEKAEEYIKLSEFYeeyldelreIEKRLSRLEEEINGIEE 328

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  460 ENARLNSELEKEKHNKERLEaEVESLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQV 539
Cdd:PRK03918   329 RIKELEEKEERLEELKKKLK-ELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEI 407

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  540 HKARVKFNTLKGKLRETRDA--------------------------LREKTLALGSVQLDLRQAQHRIKEMKQMHPN--G 591
Cdd:PRK03918   408 SKITARIGELKKEIKELKKAieelkkakgkcpvcgrelteehrkelLEEYTAELKRIEKELKEIEEKERKLRKELREleK 487

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  592 EAKESQSIGKQNSLEERIR--QQELENLLLERQLEDARKEGDNKEIVINIHRDcLENGKEDLleERNKELMKEYNYLKEK 669
Cdd:PRK03918   488 VLKKESELIKLKELAEQLKelEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGE-IKSLKKEL--EKLEELKKKLAELEKK 564

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  670 LLQCEKEKAEREVIVREFQEELVDHLktfsisESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLL 749
Cdd:PRK03918   565 LDELEEELAELLKELEELGFESVEEL------EERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAET 638

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  750 NYTADQIRKKNRELEEEatgykkclemtinmlnaFANEDFSchgdlntdqlKMDILFKKLKQKFNDLVAEKEAVSSECVN 829
Cdd:PRK03918   639 EKRLEELRKELEELEKK-----------------YSEEEYE----------ELREEYLELSRELAGLRAELEELEKRREE 691

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370514175  830 LAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVlnlkthmekdmvelGKLQEYKSELDERAVQEIEKL 900
Cdd:PRK03918   692 IKKTLEKLKEELEEREKAKKELEKLEKALERVEELR--------------EKVKKYKALLKERALSKVGEI 748
PTZ00121 PTZ00121
MAEBL; Provisional
 338-966 1.07e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.22  E-value: 1.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  338 KPANLKKRKERAKAEHNLKVASEEKQ--ERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKE 415
Cdd:PTZ00121  1291 KADEAKKAEEKKKADEAKKKAEEAKKadEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAE 1370

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  416 KKYIQEIKSITEINANFEKSVRLNEkmITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINE 495
Cdd:PTZ00121  1371 KKKEEAKKKADAAKKKAEEKKKADE--AKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADE 1448

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  496 YNEIVERKDlelvlwRADDVSRHEKMGSNISQLTDKNELlTEQVHKARVKFNTLKGKLRETRDALREKTLALgsvqlDLR 575
Cdd:PTZ00121  1449 AKKKAEEAK------KAEEAKKKAEEAKKADEAKKKAEE-AKKADEAKKKAEEAKKKADEAKKAAEAKKKAD-----EAK 1516

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  576 QAQHRIK--EMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINiHRDCLENGKEDLLE 653
Cdd:PTZ00121  1517 KAEEAKKadEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALR-KAEEAKKAEEARIE 1595

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  654 ERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEelvdhlktfsisesplegtshchinlnetwtsKKKLFQVEIQPE 733
Cdd:PTZ00121  1596 EVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEE--------------------------------KKKVEQLKKKEA 1643

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  734 E---KHEEFRKLFELISLlnyTADQIRKKNRELEEEATGYKKclemtinmlnafANEDfschgdlntDQLKMDILFKKlk 810
Cdd:PTZ00121  1644 EekkKAEELKKAEEENKI---KAAEEAKKAEEDKKKAEEAKK------------AEED---------EKKAAEALKKE-- 1697

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  811 qkfndlvaEKEAVSSECVNLAKDNEVLHQELLSmRNVQEKCEKLEKDKKMLEEEvlnlkthmEKDMVELGKLQEYKSELD 890
Cdd:PTZ00121  1698 --------AEEAKKAEELKKKEAEEKKKAEELK-KAEEENKIKAEEAKKEAEED--------KKKAEEAKKDEEEKKKIA 1760

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514175  891 ERAVQEIEKLEEIHLQKQAEYEkqlEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVK 966
Cdd:PTZ00121  1761 HLKKEEEKKAEEIRKEKEAVIE---EELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIK 1833
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 340-994 1.53e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 52.67  E-value: 1.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  340 ANLKKRKERA----------KAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLK---KDIAMLKEELYA 406
Cdd:pfam02463  165 SRLKRKKKEAlkklieetenLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLdylKLNEERIDLLQE 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  407 IKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLH 486
Cdd:pfam02463  245 LLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKK 324

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  487 SSLATAINEYNEIVERKDLELVLWRADdvsrhEKMGSNISQLTDKNELLTEQVHKARVKFnTLKGKLRETRDALREKTLA 566
Cdd:pfam02463  325 KAEKELKKEKEEIEELEKELKELEIKR-----EAEEEEEEELEKLQEKLEQLEEELLAKK-KLESERLSSAAKLKEEELE 398

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  567 LGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEivinihrdclEN 646
Cdd:pfam02463  399 LKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELE----------LK 468

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  647 GKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVRE---FQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKK 723
Cdd:pfam02463  469 KSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGlkvLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTA 548

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  724 KLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEdFSCHGDLNTDQLKMD 803
Cdd:pfam02463  549 VIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKAT-LEADEDDKRAKVVEG 627

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  804 ILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHqeLLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQ 883
Cdd:pfam02463  628 ILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKS--EVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKE 705

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  884 EYKSELDERAVQEIEKLEEIHLQ--------KQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELE 955
Cdd:pfam02463  706 QREKEELKKLKLEAEELLADRVQeaqdkineELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEK 785

                          650       660       670
                   ....*....|....*....|....*....|....*....
gi 1370514175  956 EFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQ 994
Cdd:pfam02463  786 LKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLI 824
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 42-123 2.10e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 51.82  E-value: 2.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   42 AIKGDAAEVeRCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLL 121
Cdd:PTZ00322    90 AASGDAVGA-RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168


                   ..
gi 1370514175  122 EC 123
Cdd:PTZ00322   169 RH 170
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
117-255 4.74e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 49.57  E-value: 4.74e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  117 AIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAV 196
Cdd:COG0666      4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370514175  197 DNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEH 255
Cdd:COG0666     84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA 142
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 42-255 6.74e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.88  E-value: 6.74e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   42 AIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLL 121
Cdd:PHA02878    44 AVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTLVAIKDAFNNRNVEIFKIILTN 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  122 ECGANPNIEDIYGNTALHYAVYNkgTSLAERLLSHHANIEALNKE-GNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFK 200
Cdd:PHA02878   124 RYKNIQTIDLVYIDKKSKDDIIE--AEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTN 201

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514175  201 RTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLR-SIRQQILEH 255
Cdd:PHA02878   202 NSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYCKDyDILKLLLEH 257
Ank_4 pfam13637
Ankyrin repeats (many copies);
167-220 6.76e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.19  E-value: 6.76e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1370514175  167 GNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLL 220
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 406-629 7.48e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.76  E-value: 7.48e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  406 AIKNDSLRKEKKYIQeiKSITEINANFEKsVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESL 485
Cdd:COG4942     19 ADAAAEAEAELEQLQ--QEIAELEKELAA-LKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAEL 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  486 HSSLATAINEYNEIV------ERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDA 559
Cdd:COG4942     96 RAELEAQKEELAELLralyrlGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAE 175

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370514175  560 LREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIgkqnsLEERIRQQELENLL--LERQLEDARKE 629
Cdd:COG4942    176 LEALLAELEEERAALEALKAERQKLLARLEKELAELAAEL-----AELQQEAEELEALIarLEAEAAAAAER 242
Ank_4 pfam13637
Ankyrin repeats (many copies);
69-121 7.99e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.19  E-value: 7.99e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1370514175   69 RTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLL 121
Cdd:pfam13637    2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
392-920 1.10e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 49.68  E-value: 1.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  392 MLKKDIAMLKEELYA---IKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKmitktVARYSQQLNDLKAENARLNSEL 468
Cdd:PRK03918   173 EIKRRIERLEKFIKRtenIEELIKEKEKELEEVLREINEISSELPELREELEK-----LEKEVKELEELKEEIEELEKEL 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  469 EKEKHNKERLEAEVESLHSSLATAINEYNEIVER-KDLELVLWRADDVSR-------HEKMGSNISQLTDKNELLTEQVH 540
Cdd:PRK03918   248 ESLEGSKRKLEEKIRELEERIEELKKEIEELEEKvKELKELKEKAEEYIKlsefyeeYLDELREIEKRLSRLEEEINGIE 327

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  541 KARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLE 620
Cdd:PRK03918   328 ERIKELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEI 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  621 RQLEDARKEGDNKEIVINIHRDCLENGK-------EDLLEERNKELMKEYnylKEKLLQCEKEKAEREVIVREFQEELVD 693
Cdd:PRK03918   408 SKITARIGELKKEIKELKKAIEELKKAKgkcpvcgRELTEEHRKELLEEY---TAELKRIEKELKEIEEKERKLRKELRE 484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  694 HLKTFSISE--SPLEGTSHCHINLNEtwtsKKKLFQVEiQPEEKHEEFRKLFEL-------ISLLNYTADQIRKKNRELE 764
Cdd:PRK03918   485 LEKVLKKESelIKLKELAEQLKELEE----KLKKYNLE-ELEKKAEEYEKLKEKliklkgeIKSLKKELEKLEELKKKLA 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  765 EEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKK---LKQKFNDLVAEKEAVSSECVNLAKDNEVLHQEL 841
Cdd:PRK03918   560 ELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYNEyleLKDAEKELEREEKELKKLEEELDKAFEELAETE 639

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  842 LSMRNVQEKCEKLEKdkKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDER---AVQEIEKLEEiHLQKQAEYEKQLEQL 918
Cdd:PRK03918   640 KRLEELRKELEELEK--KYSEEEYEELREEYLELSRELAGLRAELEELEKRreeIKKTLEKLKE-ELEEREKAKKELEKL 716


                   ..
gi 1370514175  919 NK 920
Cdd:PRK03918   717 EK 718
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 342-964 1.30e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 49.67  E-value: 1.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  342 LKKRKERAKAE-HNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYgnfMLKKDIAMLKEELYAIKNDSLRKEKKyiq 420
Cdd:TIGR02168  230 LVLRLEELREElEELQEELKEAEEELEELTAELQELEEKLEELRLEVS---ELEEEIEELQKELYALANEISRLEQQ--- 303

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  421 eiksITEINANFEKSVRlNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHS---SLATAINEYN 497
Cdd:TIGR02168  304 ----KQILRERLANLER-QLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAeleELESRLEELE 378

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  498 EIVE---RKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKA-----RVKFNTLKGKLRETRDALREKTLALGS 569
Cdd:TIGR02168  379 EQLEtlrSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELlkkleEAELKELQAELEELEEELEELQEELER 458

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  570 VQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINI------HRDC 643
Cdd:TIGR02168  459 LEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELisvdegYEAA 538

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  644 LEN----GKEDLLEERNKELMKEYNYLKEKLL--------------QCEKEKAEREVIVREFQEELVDHLKT---FSISE 702
Cdd:TIGR02168  539 IEAalggRLQAVVVENLNAAKKAIAFLKQNELgrvtflpldsikgtEIQGNDREILKNIEGFLGVAKDLVKFdpkLRKAL 618

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  703 SPLEGTSHCHINLNETWTSKKKL-------------------------------FQVEIQPEEKHEEFRKLFELISLLNY 751
Cdd:TIGR02168  619 SYLLGGVLVVDDLDNALELAKKLrpgyrivtldgdlvrpggvitggsaktnssiLERRREIEELEEKIEELEEKIAELEK 698

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  752 TADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLA 831
Cdd:TIGR02168  699 ALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELA 778

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  832 KDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTH----------MEKDMVELGKLQEYKSELDERAVQEIEKLE 901
Cdd:TIGR02168  779 EAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEaanlrerlesLERRIAATERRLEDLEEQIEELSEDIESLA 858

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514175  902 EIHLQKQAEYEKQLEQLNK---------DNTASLK----KKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGA 964
Cdd:TIGR02168  859 AEIEELEELIEELESELEAllnerasleEALALLRseleELSEELRELESKRSELRRELEELREKLAQLELRLEGL 934
Ank_4 pfam13637
Ankyrin repeats (many copies);
34-88 1.31e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.42  E-value: 1.31e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1370514175   34 ELRKIHRAAIKGDAAEVERCLTRRFrDLDARDRKDRTVLHLACAHGRVQVVTLLL 88
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGA-DINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
153-207 1.36e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.49  E-value: 1.36e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514175  153 LLSH-HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILA 207
Cdd:pfam13857    1 LLEHgPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 393-975 1.71e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 49.28  E-value: 1.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  393 LKKDIAMLKEELYAIKNDSLRKE--------KKYIQEIKSIT-EINANFEKSVRLNEKMitktvARYSQQLNDLKAENAR 463
Cdd:TIGR02168  218 LKAELRELELALLVLRLEELREEleelqeelKEAEEELEELTaELQELEEKLEELRLEV-----SELEEEIEELQKELYA 292

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  464 LNSELEKEKHNKERLEAEVESLHSSLAtAINEYNEIVERKDLELvlwrADDVSRHEKmgsNISQLTDKNELLTEQVHKAR 543
Cdd:TIGR02168  293 LANEISRLEQQKQILRERLANLERQLE-ELEAQLEELESKLDEL----AEELAELEE---KLEELKEELESLEAELEELE 364

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  544 VKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMkqmhpngEAKESQSIGKQNSLEERIRQQELENLLLERQL 623
Cdd:TIGR02168  365 AELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERL-------EARLERLEDRRERLQQEIEELLKKLEEAELKE 437

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  624 EDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQE------ELVDHLKT 697
Cdd:TIGR02168  438 LQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGfsegvkALLKNQSG 517

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  698 FS---------IS---------ESPLEGtshchiNLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKK 759
Cdd:TIGR02168  518 LSgilgvlselISvdegyeaaiEAALGG------RLQAVVVENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDR 591

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  760 NRELEEE-ATGYKKCLEMTINMLNAFANEDFSchGDLNTDQLKMDI-LFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVL 837
Cdd:TIGR02168  592 EILKNIEgFLGVAKDLVKFDPKLRKALSYLLG--GVLVVDDLDNALeLAKKLRPGYRIVTLDGDLVRPGGVITGGSAKTN 669

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  838 HqellSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELD------ERAVQEIEKLEEIHLQKQAEY 911
Cdd:TIGR02168  670 S----SILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRkeleelSRQISALRKDLARLEAEVEQL 745

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370514175  912 EKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAyEEVTTELEEFKEAFAGAVKANNSMSKKL 975
Cdd:TIGR02168  746 EERIAQLSKELTELEAEIEELEERLEEAEEELAEA-EAEIEELEAQIEQLKEELKALREALDEL 808
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 495-696 6.06e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 47.24  E-value: 6.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  495 EYNEIVERKDLELVLWRADDVSRhekmgsNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDL 574
Cdd:COG1196    217 ELKEELKELEAELLLLKLRELEA------ELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEE 290

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  575 RQAQHRIKEMkqmhpngEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEgdnkeivinihrdclengkEDLLEE 654
Cdd:COG1196    291 YELLAELARL-------EQDIARLEERRRELEERLEELEEELAELEEELEELEEE-------------------LEELEE 344

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1370514175  655 RNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELVDHLK 696
Cdd:COG1196    345 ELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAE 386
Ank_5 pfam13857
Ankyrin repeats (many copies);
54-105 6.11e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.56  E-value: 6.11e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1370514175   54 LTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPL 105
Cdd:pfam13857    2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 393-975 6.38e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 47.32  E-value: 6.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  393 LKKDIAMLKEELYAIKNDSLRKE------KKYIQEIKSITeinanfeksvrlnekmitktvarysQQLNDLKAENARLNS 466
Cdd:TIGR04523  178 LEKEKLNIQKNIDKIKNKLLKLElllsnlKKKIQKNKSLE-------------------------SQISELKKQNNQLKD 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  467 ELEKEKHNKERLEAEVESLHSSLATAINEYNEIV---ERKDLELvlwraddvsrhEKMGSNISQLTD-----KNELLTEQ 538
Cdd:TIGR04523  233 NIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKkqlSEKQKEL-----------EQNNKKIKELEKqlnqlKSEISDLN 301

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  539 VHKARVKFNTLKGKLRETRDALREktlalgsVQLDLRQAQHRIKEMKQmhpngeakesqsigKQNSLEERIRQQELENLL 618
Cdd:TIGR04523  302 NQKEQDWNKELKSELKNQEKKLEE-------IQNQISQNNKIISQLNE--------------QISQLKKELTNSESENSE 360

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  619 LERQLEDARKEGDNkeivinihrdcLENGKEDLLEErNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELVDHLKTF 698
Cdd:TIGR04523  361 KQRELEEKQNEIEK-----------LKKENQSYKQE-IKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEI 428

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  699 SISESPLEGTSHCHINLNETWTSKKKLFqveiqpeEKHEEFRKLFEliSLLNYTADQIRKKNRELEEEatgyKKCLEMTI 778
Cdd:TIGR04523  429 ERLKETIIKNNSEIKDLTNQDSVKELII-------KNLDNTRESLE--TQLKVLSRSINKIKQNLEQK----QKELKSKE 495

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  779 NMLNAFANEDFSCHGdlNTDQLKMDIlfKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDK 858
Cdd:TIGR04523  496 KELKKLNEEKKELEE--KVKDLTKKI--SSLKEKIEKLESEKKEKESKISDLEDELNKDDFELKKENLEKEIDEKNKEIE 571

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  859 KMLEEEVLNLKTHMEKDMvelgKLQEYKSElderaVQEIEKLEEIHLQKQAEYEKQLEQLNKDNtaslKKKELTLKDVEC 938
Cdd:TIGR04523  572 ELKQTQKSLKKKQEEKQE----LIDQKEKE-----KKDLIKEIEEKEKKISSLEKELEKAKKEN----EKLSSIIKNIKS 638

                          570       580       590
                   ....*....|....*....|....*....|....*..
gi 1370514175  939 KFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKL 975
Cdd:TIGR04523  639 KKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKI 675
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 60-175 6.64e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.98  E-value: 6.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   60 DLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAI-VLLECGANPNIEDIYGNTAL 138
Cdd:PHA02876   367 NVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPYMSVkTLIDRGANVNSKNKDLSTPL 446

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1370514175  139 HYAVYNK-GTSLAERLLSHHANIEALNKEGNTPLLFAI 175
Cdd:PHA02876   447 HYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIAL 484
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 343-895 7.99e-05

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 47.04  E-value: 7.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  343 KKRKERAKAEHNLKVASEEKQERLQRSENKQPQDS----QSYGKKKDAMYGNFM--LKKDIAMLKEELYAIKndslRKEK 416
Cdd:pfam15921  266 QDRIEQLISEHEVEITGLTEKASSARSQANSIQSQleiiQEQARNQNSMYMRQLsdLESTVSQLRSELREAK----RMYE 341

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  417 KYIQEI-KSITEINANFEKSvRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERL----------------- 478
Cdd:pfam15921  342 DKIEELeKQLVLANSELTEA-RTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLwdrdtgnsitidhlrre 420

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  479 ----EAEVESLHSSLATAINEYNEIVERKdLELVLWRADDVsrhEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLR 554
Cdd:pfam15921  421 lddrNMEVQRLEALLKAMKSECQGQMERQ-MAAIQGKNESL---EKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSER 496

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  555 ETRD---ALREKTLALGS-----------VQLDLRQAQHRIKE---MKQMHPNGEAKESQSIGKQNSLEerIRQQELENL 617
Cdd:pfam15921  497 TVSDltaSLQEKERAIEAtnaeitklrsrVDLKLQELQHLKNEgdhLRNVQTECEALKLQMAEKDKVIE--ILRQQIENM 574

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  618 LlerQL--EDARKEGdnkeiVINIHRDCLEngKEdlLEERNKELmKEYNYLKEKllqceKEKAEREVIVREFQEELvDHL 695
Cdd:pfam15921  575 T---QLvgQHGRTAG-----AMQVEKAQLE--KE--INDRRLEL-QEFKILKDK-----KDAKIRELEARVSDLEL-EKV 635

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  696 KTFSISESPLEGTSHCHIN----LNETWTSKKKLFQVEIQPEEKHEEFR-KLFELISLLNYTADQIRKKNRELEEEATGY 770
Cdd:pfam15921  636 KLVNAGSERLRAVKDIKQErdqlLNEVKTSRNELNSLSEDYEVLKRNFRnKSEEMETTTNKLKMQLKSAQSELEQTRNTL 715

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  771 KK-------CLEMTINMLNAFANEdfscHGDLNTDQLKMDILFKKLKQKFND---LVAEKEAVSSECVNLAKDNEVLHQE 840
Cdd:pfam15921  716 KSmegsdghAMKVAMGMQKQITAK----RGQIDALQSKIQFLEEAMTNANKEkhfLKEEKNKLSQELSTVATEKNKMAGE 791

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1370514175  841 LlsmrnvqekcEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQ 895
Cdd:pfam15921  792 L----------EVLRSQERRLKEKVANMEVALDKASLQFAECQDIIQRQEQESVR 836
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 333-735 8.16e-05

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 47.14  E-value: 8.16e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  333 ETAAMKPANLKkrkeRAKAEHNLKVAS--EEKQERLQRSENKQPQDSQSYGKKKDAMYGN-FMLKKDIAMLKEELYAIKN 409
Cdd:pfam12128  254 ESAELRLSHLH----FGYKSDETLIASrqEERQETSAELNQLLRTLDDQWKEKRDELNGElSAADAAVAKDRSELEALED 329

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  410 DSLRKEKKYIQEIKSITEINANFEKSVRLNEKMI-----------TKTVARYSQQLNDLKAENARLNSELEKEKHNKERL 478
Cdd:pfam12128  330 QHGAFLDADIETAAADQEQLPSWQSELENLEERLkaltgkhqdvtAKYNRRRSKIKEQNNRDIAGIKDKLAKIREARDRQ 409

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  479 EAEVES--------LHSSLATAINEYNEIVERKDL----------------ELVLWRADDVSRHEKMGSNISQLTDKNEL 534
Cdd:pfam12128  410 LAVAEDdlqaleseLREQLEAGKLEFNEEEYRLKSrlgelklrlnqatatpELLLQLENFDERIERAREEQEAANAEVER 489

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  535 LTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKqmhpNGEAKE-SQSIGKQNSLEERIRQQe 613
Cdd:pfam12128  490 LQSELRQARKRRDQASEALRQASRRLEERQSALDELELQLFPQAGTLLHFL----RKEAPDwEQSIGKVISPELLHRTD- 564

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  614 lenllLERQLEDARKEGDNKEIVINIHRDCLENGK----EDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQE 689
Cdd:pfam12128  565 -----LDPEVWDGSVGGELNLYGVKLDLKRIDVPEwaasEEELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASR 639

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|
gi 1370514175  690 ELVDHLKTFSISESPLEGTSHCHINL----NETWTSKKKLFQVEIQPEEK 735
Cdd:pfam12128  640 EETFARTALKNARLDLRRLFDEKQSEkdkkNKALAERKDSANERLNSLEA 689
Ank_4 pfam13637
Ankyrin repeats (many copies);
101-154 8.36e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.11  E-value: 8.36e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1370514175  101 NRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLL 154
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 133-165 9.10e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.74  E-value: 9.10e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1370514175  133 YGNTALHYAVYNKG-TSLAERLLSHHANIEALNK 165
Cdd:pfam00023    1 DGNTPLHLAAGRRGnLEIVKLLLSKGADVNARDK 34
PTZ00121 PTZ00121
MAEBL; Provisional
 335-981 1.57e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 1.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  335 AAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQpqdsqsygKKKDAMYGNFMLKKDIAMLKEElyaikndslrk 414
Cdd:PTZ00121  1180 AARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEAR--------KAEDAKKAEAVKKAEEAKKDAE----------- 1240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  415 EKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDL-KAENARLNSELEKEKHNKERLEAEVESLHSSLATAI 493
Cdd:PTZ00121  1241 EAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELkKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEA 1320

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  494 NEYNEIVERKDLELV-----LWRADDVSR--HEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDA--LREKT 564
Cdd:PTZ00121  1321 KKKAEEAKKKADAAKkkaeeAKKAAEAAKaeAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKAdeAKKKA 1400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  565 LALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCL 644
Cdd:PTZ00121  1401 EEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAE 1480

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  645 ENGKEDLLEERNKELMKEYNYLKEKllqcEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKK 724
Cdd:PTZ00121  1481 EAKKADEAKKKAEEAKKKADEAKKA----AEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEE 1556

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  725 LFQVEiqPEEKHEEFRKLFELISLLNYTADQIRK-KNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMD 803
Cdd:PTZ00121  1557 LKKAE--EKKKAEEAKKAEEDKNMALRKAEEAKKaEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKK 1634

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  804 ILFKKLKQ-----KFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVE 878
Cdd:PTZ00121  1635 VEQLKKKEaeekkKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEE 1714

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  879 LGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKElTLKDVECKFSKMKTAYEEVTTELEEFK 958
Cdd:PTZ00121  1715 KKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEE-EKKAEEIRKEKEAVIEEELDEEDEKRR 1793

                          650       660
                   ....*....|....*....|...
gi 1370514175  959 EAFAGAVKANNSMSKKLMKSDKK 981
Cdd:PTZ00121  1794 MEVDKKIKDIFDNFANIIEGGKE 1816
COG5022 COG5022
Myosin heavy chain [General function prediction only];
342-953 1.64e-04

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 45.84  E-value: 1.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  342 LKKRKE-RAKAEHNLKVASEEKQERLQRSENKQPQD----------SQSYGKKKDAmygnFMLKKDIAMLK--------- 401
Cdd:COG5022    806 LGSRKEyRSYLACIIKLQKTIKREKKLRETEEVEFSlkaevliqkfGRSLKAKKRF----SLLKKETIYLQsaqrvelae 881

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  402 ----EELYAIKNDSLRKEKKYiQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNdlkaeNARLNSELEKEKHNKER 477
Cdd:COG5022    882 rqlqELKIDVKSISSLKLVNL-ELESEIIELKKSLSSDLIENLEFKTELIARLKKLLN-----NIDLEEGPSIEYVKLPE 955

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  478 LEaEVESLHSSLATAINEYNEIVerkdlelvlwraddvsrhEKMGSNISQLTDKNELLtEQVHKARVKFNTLKGKLRETR 557
Cdd:COG5022    956 LN-KLHEVESKLKETSEEYEDLL------------------KKSTILVREGNKANSEL-KNFKKELAELSKQYGALQEST 1015

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  558 DALREKTLALGSVQLDLRQAQHRIKEMKQMhpngeaKESQSIGKQNSLEERIRQQELENLLLERQLEDA-RKEGDNKEIV 636
Cdd:COG5022   1016 KQLKELPVEVAELQSASKIISSESTELSIL------KPLQKLKGLLLLENNQLQARYKALKLRRENSLLdDKQLYQLEST 1089

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  637 INihrdcLENG-KEDLLEERNKELMKEYNYL--------KEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEG 707
Cdd:COG5022   1090 EN-----LLKTiNVKDLEVTNRNLVKPANVLqfivaqmiKLNLLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEAN 1164

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  708 TSHCHINLNETWTSKKKLFQVEIQPEEKH------EEFRKLFELISLLNYTADQIRKKNRELEEEA---TGYKKCLEMTI 778
Cdd:COG5022   1165 LEALPSPPPFAALSEKRLYQSALYDEKSKlsssevNDLKNELIALFSKIFSGWPRGDKLKKLISEGwvpTEYSTSLKGFN 1244

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  779 NMLNAFAnedfschgdlNTDQLKMDILFKKLKQKFNDLVA---EKEAVSSECVNLAKDNEVLHQELLSMR---------- 845
Cdd:COG5022   1245 NLNKKFD----------TPASMSNEKLLSLLNSIDNLLSSyklEEEVLPATINSLLQYINVGLFNALRTKasslrwksat 1314

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  846 NVQEKCEklEKDKKMLEEEVLNLKTHMEKDM--VELGKLQEYK-SELDER--AVQ-----EIEKLeeIHLQKQAEYEKQL 915
Cdd:COG5022   1315 EVNYNSE--ELDDWCREFEISDVDEELEELIqaVKVLQLLKDDlNKLDELldACYslnpaEIQNL--KSRYDPADKENNL 1390

                          650       660       670
                   ....*....|....*....|....*....|....*....
gi 1370514175  916 E-QLNKDNTASLKKKELTLKDveCKFSKMKTAYEEVTTE 953
Cdd:COG5022   1391 PkEILKKIEALLIKQELQLSL--EGKDETEVHLSEIFSE 1427
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 653-995 1.65e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.83  E-value: 1.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  653 EERNKELMKEYNYLKEKLlQCEKEKAEReviVREFQEELVDhlktfsisespLEGTSHCHiNLNETWTSKKklfQVEIQP 732
Cdd:TIGR02169  186 IERLDLIIDEKRQQLERL-RREREKAER---YQALLKEKRE-----------YEGYELLK-EKEALERQKE---AIERQL 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  733 EEKHEEFRKLFELISLLNytaDQIRKKNRELEEEAtgyKKCLEMTINMLNAFANEDFSCHGDLntDQLKMDILFKKLKQK 812
Cdd:TIGR02169  247 ASLEEELEKLTEEISELE---KRLEEIEQLLEELN---KKIKDLGEEEQLRVKEKIGELEAEI--ASLERSIAEKERELE 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  813 fnDLVAEkeavssecvnLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELG----KLQEYKSE 888
Cdd:TIGR02169  319 --DAEER----------LAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEevdkEFAETRDE 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  889 LDERaVQEIEKLEEIHLQKQAEYEKQLEQLNKdNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVKAN 968
Cdd:TIGR02169  387 LKDY-REKLEKLKREINELKRELDRLQEELQR-LSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADL 464

                          330       340
                   ....*....|....*....|....*..
gi 1370514175  969 NSMSKKLMKSDKKIAVISTKLfTEKQR 995
Cdd:TIGR02169  465 SKYEQELYDLKEEYDRVEKEL-SKLQR 490
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 64-191 1.74e-04

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 43.33  E-value: 1.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   64 RDRKDRTVLHLACAHGrvQVVTLLLHRRCQID----ICDRLNR--TPLMKAVHSQEEACAI----VLLECGANPNIED-I 132
Cdd:PHA02736    13 PDIEGENILHYLCRNG--GVTDLLAFKNAISDenryLVLEYNRhgKQCVHIVSNPDKADPQeklkLLMEWGADINGKErV 90

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  133 YGNTALHYAVYNKGTSLAERLLSH-HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQA 191
Cdd:PHA02736    91 FGNTPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTPYYVACERHDAKMMNILRAKGA 150
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 345-586 2.30e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 45.20  E-value: 2.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  345 RKERAKAEHNLKVASEEKQERLQR-SENKQPQDSQ-SYGKKKDamygNFMLKKDIAMLKEELYAIKndsLRKEKKYIQEI 422
Cdd:pfam10174  474 KKENKDLKEKVSALQPELTEKESSlIDLKEHASSLaSSGLKKD----SKLKSLEIAVEQKKEECSK---LENQLKKAHNA 546

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  423 KSITEINANFEKSVRLNEKmitkTVARYSQQLNDLKAENARLNS---ELEKEKHNKERLEAEVESLHS------SLATAI 493
Cdd:pfam10174  547 EEAVRTNPEINDRIRLLEQ----EVARYKEESGKAQAEVERLLGilrEVENEKNDKDKKIAELESLTLrqmkeqNKKVAN 622

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  494 NEYNEIVERKDLELVLWRAddvsRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLD 573
Cdd:pfam10174  623 IKHGQQEMKKKGAQLLEEA----RRREDNLADNSQQLQLEELMGALEKTRQELDATKARLSSTQQSLAEKDGHLTNLRAE 698

                          250
                   ....*....|...
gi 1370514175  574 LRQAQHRIKEMKQ 586
Cdd:pfam10174  699 RRKQLEEILEMKQ 711
Ank_5 pfam13857
Ankyrin repeats (many copies);
86-141 2.92e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.64  E-value: 2.92e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514175   86 LLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYA 141
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 393-690 3.30e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.06  E-value: 3.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  393 LKKDIAMLKEELYAIKN--DSLRKEKKYI-QEIKSITEINANFEKSVRLNEK---MITKTVARYSQQLNDLKAENARLNS 466
Cdd:TIGR02169  672 EPAELQRLRERLEGLKRelSSLQSELRRIeNRLDELSQELSDASRKIGEIEKeieQLEQEEEKLKERLEELEEDLSSLEQ 751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  467 ELEKEKHNKERLEAEVESLHSSLATAINEYNEIvERKDLElvlwraddvsrhekmgSNISQLTDKNELLTEQVHKarvkf 546
Cdd:TIGR02169  752 EIENVKSELKELEARIEELEEDLHKLEEALNDL-EARLSH----------------SRIPEIQAELSKLEEEVSR----- 809

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  547 ntLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDA 626
Cdd:TIGR02169  810 --IEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDL 887

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370514175  627 RKEGDNKEivinIHRDCLENGKEDLLEERNKeLMKEYNYLKEKLLQCEKEKAEREVIVREFQEE 690
Cdd:TIGR02169  888 KKERDELE----AQLRELERKIEELEAQIEK-KRKRLSELKAKLEALEEELSEIEDPKGEDEEI 946
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 103-241 7.53e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.44  E-value: 7.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  103 TPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANI-EALNKEGNTPLLFAINSRRQH 181
Cdd:PHA02875    37 SPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFAdDVFYKDGMTPLHLATILKKLD 116

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  182 MVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYAL 241
Cdd:PHA02875   117 IMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAM 176
YkyA pfam10368
Putative cell-wall binding lipoprotein; YkyA is a family of proteins containing a lipoprotein ...
 846-960 1.10e-03

Putative cell-wall binding lipoprotein; YkyA is a family of proteins containing a lipoprotein signal and a hydrolase domain. It is similar to cell wall binding proteins and might also be recognisable by a host immune defence system. It is thus likely to belong to pathways important for pathogenicity.


Pssm-ID: 431235 [Multi-domain]  Cd Length: 185  Bit Score: 41.42  E-value: 1.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  846 NVQEKCEKLEKDKKMLE---EEVLNLKTHMEKdmVELGKLQEYKSELderaVQEIEKLEEIHLQKQAEYEKQLEqLNKDN 922
Cdd:pfam10368   62 NVEEREELLEKEKESIEeakEEFKKIKEIIEE--IEDEELKKEAEEL----IDAMEERYEAYDELYDAYKKALE-LDKEL 134

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1370514175  923 TASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEA 960
Cdd:pfam10368  135 YEMLKDEDLTLEELQEQIEKINESYEEVKEANEQFNEY 172
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
531-965 1.30e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.83  E-value: 1.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  531 KNELLTEQVHKARVKFNTLKGK---LRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQ--NSL 605
Cdd:COG4717     65 KPELNLKELKELEEELKEAEEKeeeYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEALEAelAEL 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  606 EERIRQ--QELENLL-LERQLEDARKEGDNKEIVINIHRDCLENGKEDLLE---ERNKELMKEYNYLKEKLLQCEKEKAE 679
Cdd:COG4717    145 PERLEEleERLEELReLEEELEELEAELAELQEELEELLEQLSLATEEELQdlaEELEELQQRLAELEEELEEAQEELEE 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  680 REVIVREFQEELVDH--------LKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLLNY 751
Cdd:COG4717    225 LEEELEQLENELEAAaleerlkeARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEA 304

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  752 TADQIRKKNRELEEEA-TGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKfnDLVAEKEAVssecvnL 830
Cdd:COG4717    305 EELQALPALEELEEEElEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLE--ELEQEIAAL------L 376

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  831 AKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMvELGKLQEYKSELD--ERAVQEIEKLEEIHLQKQ 908
Cdd:COG4717    377 AEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELL-EALDEEELEEELEelEEELEELEEELEELREEL 455

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370514175  909 AEYEKQLEQLNKDNTASLKKKEL-----TLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAV 965
Cdd:COG4717    456 AELEAELEQLEEDGELAELLQELeelkaELRELAEEWAALKLALELLEEAREEYREERLPPV 517
PRK11281 PRK11281
mechanosensitive channel MscK;
838-964 1.43e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 42.98  E-value: 1.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  838 HQELLSMRNVQEKCEKLeKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDErAVQEIEKLEeihlQKQAEYEKQLEQ 917
Cdd:PRK11281    32 NGDLPTEADVQAQLDAL-NKQKLLEAEDKLVQQDLEQTLALLDKIDRQKEETEQ-LKQQLAQAP----AKLRQAQAELEA 105

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1370514175  918 LNKDNTASLKK--KELTLKDVECKFskmktayEEVTTELEEFKEAFAGA 964
Cdd:PRK11281   106 LKDDNDEETREtlSTLSLRQLESRL-------AQTLDQLQNAQNDLAEY 147
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 393-662 1.43e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.00  E-value: 1.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  393 LKKDIAMLKEELYAIKNDSLRKEKKYIQ-EIKSITEINANFEKSVRLNEKMITK---TVARYSQQLNDLKAENARLNSEL 468
Cdd:COG1196    218 LKEELKELEAELLLLKLRELEAELEELEaELEELEAELEELEAELAELEAELEElrlELEELELELEEAQAEEYELLAEL 297

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  469 EKEKH--------------NKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEkmgsnisQLTDKNEL 534
Cdd:COG1196    298 ARLEQdiarleerrreleeRLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAE-------AEEALLEA 370

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  535 LTEQVHKARVKFNTLKGKLRETRDALREKTlALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQEL 614
Cdd:COG1196    371 EAELAEAEEELEELAEELLEALRAAAELAA-QLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAE 449

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 1370514175  615 ENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKE 662
Cdd:COG1196    450 EEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLL 497
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 523-694 1.74e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.45  E-value: 1.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  523 SNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGE-AKESQSIGK 601
Cdd:COG1579     17 SELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRnNKEYEALQK 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  602 Q-NSLEERIRQQELENLLLERQLEDARKEGDNKEIVINihrdclenGKEDLLEERNKELMKEYNYLKEKLlqcEKEKAER 680
Cdd:COG1579     97 EiESLKRRISDLEDEILELMERIEELEEELAELEAELA--------ELEAELEEKKAELDEELAELEAEL---EELEAER 165

                          170
                   ....*....|....
gi 1370514175  681 EVIVREFQEELVDH 694
Cdd:COG1579    166 EELAAKIPPELLAL 179
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 166-198 1.77e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.88  E-value: 1.77e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1370514175  166 EGNTPLLFAINSRRQH-MVEFLLKNQANIHAVDN 198
Cdd:pfam00023    1 DGNTPLHLAAGRRGNLeIVKLLLSKGADVNARDK 34
PTZ00121 PTZ00121
MAEBL; Provisional
 336-983 2.01e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 2.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  336 AMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQpqdsqsygKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKE 415
Cdd:PTZ00121  1103 AKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDAR--------KAEEARKAEDAKRVEIARKAEDARKAEEARKAED 1174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  416 KKYIQEIKSITEINANFEksVRLNEKMITKTVARYSQqlNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINE 495
Cdd:PTZ00121  1175 AKKAEAARKAEEVRKAEE--LRKAEDARKAEAARKAE--EERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERN 1250

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  496 YNEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELL-TEQVHKA--RVKFNTLKGKLRETRDALREKTLAlGSVQL 572
Cdd:PTZ00121  1251 NEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKkADEAKKAeeKKKADEAKKKAEEAKKADEAKKKA-EEAKK 1329

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  573 DLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLL 652
Cdd:PTZ00121  1330 KADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADE 1409

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  653 EERNKELMKEYNYLKEKLLqcEKEKAErEVIVREFQEELVDHLKTFSISESPLEgtshchiNLNETWTSKKKLFQVEIQP 732
Cdd:PTZ00121  1410 LKKAAAAKKKADEAKKKAE--EKKKAD-EAKKKAEEAKKADEAKKKAEEAKKAE-------EAKKKAEEAKKADEAKKKA 1479

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  733 EE--KHEEFRKlfelisllnyTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKK-- 808
Cdd:PTZ00121  1480 EEakKADEAKK----------KAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKad 1549

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  809 -LKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKceKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKS 887
Cdd:PTZ00121  1550 eLKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEA--RIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKK 1627

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  888 ELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKEltlkdveckfSKMKTAYEEVTTELEEFKEAfAGAVKA 967
Cdd:PTZ00121  1628 AEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKA----------EEDKKKAEEAKKAEEDEKKA-AEALKK 1696

                          650
                   ....*....|....*.
gi 1370514175  968 NNSMSKKLMKSDKKIA 983
Cdd:PTZ00121  1697 EAEEAKKAEELKKKEA 1712
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 344-504 2.91e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.98  E-value: 2.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  344 KRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKkkdamygnfmLKKDIAMLKEELyaikndslRKEKKYIQEIK 423
Cdd:TIGR02169  848 QIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGD----------LKKERDELEAQL--------RELERKIEELE 909

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  424 SiteinANFEKSVRLNEKMITKTVArySQQLNDLKAENARLNSE------LEKEKHNKERLEAEVESLHSSLATAINEYN 497
Cdd:TIGR02169  910 A-----QIEKKRKRLSELKAKLEAL--EEELSEIEDPKGEDEEIpeeelsLEDVQAELQRVEEEIRALEPVNMLAIQEYE 982


                   ....*..
gi 1370514175  498 EIVERKD 504
Cdd:TIGR02169  983 EVLKRLD 989
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 60-149 3.01e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.19  E-value: 3.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   60 DLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGanPNIEDIYGntalh 139
Cdd:PHA03100   184 PINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNG--PSIKTIIE----- 256

                           90
                   ....*....|
gi 1370514175  140 YAVYNKGTSL 149
Cdd:PHA03100   257 TLLYFKDKDL 266
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 93-235 4.09e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.22  E-value: 4.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175   93 QIDICDRLNRTPLMKAVHSQEEACAIVLLEcgaNPNIEDIYGNTALHYAVYN-----------KGTSLAERLLSHHANIE 161
Cdd:TIGR00870   44 NINCPDRLGRSALFVAAIENENLELTELLL---NLSCRGAVGDTLLHAISLEyvdaveaillhLLAAFRKSGPLELANDQ 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  162 ALNKE--GNTPLLFAINSRRQHMVEFLLKNQANIHA------------VDNFK--RTALILAVQHNLSSIVTLLLQQNIR 225
Cdd:TIGR00870  121 YTSEFtpGITALHLAAHRQNYEIVKLLLERGASVPAracgdffvksqgVDSFYhgESPLNAAACLGSPSIVALLSEDPAD 200

                          170
                   ....*....|
gi 1370514175  226 ISSQDMFGQT 235
Cdd:TIGR00870  201 ILTADSLGNT 210
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 443-613 4.12e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.97  E-value: 4.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  443 ITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNE-----------------IVERKDL 505
Cdd:COG3883     35 AQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGEraralyrsggsvsyldvLLGSESF 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  506 ELVLWRADdvsrhekmgsNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQldlRQAQHRIKEMK 585
Cdd:COG3883    115 SDFLDRLS----------ALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAK---AELEAQQAEQE 181

                          170       180
                   ....*....|....*....|....*...
gi 1370514175  586 QMHPNGEAKESQSIGKQNSLEERIRQQE 613
Cdd:COG3883    182 ALLAQLSAEEAAAEAQLAELEAELAAAE 209
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 382-774 4.68e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 41.19  E-value: 4.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  382 KKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSiteinaNFEKsvrlNEKMItKTVARYSQQLNDLKAEN 461
Cdd:TIGR00606  723 KRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKN------DIEE----QETLL-GTIMPEEESAKVCLTDV 791

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  462 ARLNSELEKEKHNKERLEAEVESLHSS-LATAINEYNEIVERKDLELvlwraddvsrhEKMGSNISQLTDKNELLTEQVH 540
Cdd:TIGR00606  792 TIMERFQMELKDVERKIAQQAAKLQGSdLDRTVQQVNQEKQEKQHEL-----------DTVVSKIELNRKLIQDQQEQIQ 860

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  541 KARVKFNTLKG-KLRETRDALREKTLALGSVQLdLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLL 619
Cdd:TIGR00606  861 HLKSKTNELKSeKLQIGTNLQRRQQFEEQLVEL-STEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKA 939

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  620 ERQLEDARKEGDNkeivINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEElvdhLKTFS 699
Cdd:TIGR00606  940 QDKVNDIKEKVKN----IHGYMKDIENKIQDGKDDYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRQD----IDTQK 1011

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  700 ISESPLEGTSHCHINLNETWTSKKKLFQV-----EIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCL 774
Cdd:TIGR00606 1012 IQERWLQDNLTLRKRENELKEVEEELKQHlkemgQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKEL 1091
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 167-235 5.58e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 40.94  E-value: 5.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  167 GNTPLLFAINSRRQHMVEFLLKNQANIHAVDN---FKRTA-----------LILAVQHNLSSIVTLLLQ---QNIRISSQ 229
Cdd:cd22196     94 GQTALHIAIERRNMHLVELLVQNGADVHARASgefFKKKKggpgfyfgelpLSLAACTNQLDIVKFLLEnphSPADISAR 173


                   ....*.
gi 1370514175  230 DMFGQT 235
Cdd:cd22196    174 DSMGNT 179
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 166-235 6.25e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 40.55  E-value: 6.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  166 EGNTPLLFAINSRRQHMVEFLLKNQANIHAVDN--------------FKRTALILAVQHNLSSIVTLLLQ---QNIRISS 228
Cdd:cd22193     75 EGQTALHIAIERRQGDIVALLVENGADVHAHAKgrffqpkyqgegfyFGELPLSLAACTNQPDIVQYLLEnehQPADIEA 154


                   ....*..
gi 1370514175  229 QDMFGQT 235
Cdd:cd22193    155 QDSRGNT 161
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 134-204 6.45e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 40.56  E-value: 6.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  134 GNTALHYAVYNKGTSLAERLLSHHANIEA--------LNKEGN------TPLLFAINSRRQHMVEFLLKNQ---ANIHAV 196
Cdd:cd22196     94 GQTALHIAIERRNMHLVELLVQNGADVHArasgeffkKKKGGPgfyfgeLPLSLAACTNQLDIVKFLLENPhspADISAR 173


                   ....*...
gi 1370514175  197 DNFKRTAL 204
Cdd:cd22196    174 DSMGNTVL 181
PRK12704 PRK12704
phosphodiesterase; Provisional
 856-956 6.47e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 40.53  E-value: 6.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  856 KDKKMLE--EEVLNLKTHMEKdmvelgklqeyksELDERAvQEIEKLEEIHLQKQAEYEKQLEQLNK-DNTASLKKKELT 932
Cdd:PRK12704    55 KKEALLEakEEIHKLRNEFEK-------------ELRERR-NELQKLEKRLLQKEENLDRKLELLEKrEEELEKKEKELE 120

                           90       100
                   ....*....|....*....|....*.
gi 1370514175  933 --LKDVECKFSKMKTAYEEVTTELEE 956
Cdd:PRK12704   121 qkQQELEKKEEELEELIEEQLQELER 146
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 69-99 7.60e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.34  E-value: 7.60e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1370514175   69 RTVLHLACAH-GRVQVVTLLLHRRCQIDICDR 99
Cdd:pfam00023    3 NTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 412-1017 7.94e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 40.48  E-value: 7.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  412 LRKEKKYIQEIKSITE-INANFEKSVRLNEKMITKTVA--RYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSS 488
Cdd:pfam05483  115 IEAQRKAIQELQFENEkVSLKLEEEIQENKDLIKENNAtrHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEK 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  489 LATAINEYNEIVERKDLELVLWRADDVSR----HEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDA---LR 561
Cdd:pfam05483  195 MILAFEELRVQAENARLEMHFKLKEDHEKiqhlEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKanqLE 274

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  562 EKT-LALGSVQLDLRQAQHRIKEMKQMhpngEAKESQSIGKQNSLEE--RIRQQELENLLLER--QLEDARKEGDNKEIV 636
Cdd:pfam05483  275 EKTkLQDENLKELIEKKDHLTKELEDI----KMSLQRSMSTQKALEEdlQIATKTICQLTEEKeaQMEELNKAKAAHSFV 350

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  637 INiHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREvivrefqeelvDHLKTFSISESPLEgtshchiNLN 716
Cdd:pfam05483  351 VT-EFEATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELE-----------EMTKFKNNKEVELE-------ELK 411

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  717 ETWTSKKKLFQVEIQPEEKHEEFR-KLFELISLLnytadQIRKKN-RELEEEATGYKKCLEmtinmlnafanedfscHGD 794
Cdd:pfam05483  412 KILAEDEKLLDEKKQFEKIAEELKgKEQELIFLL-----QAREKEiHDLEIQLTAIKTSEE----------------HYL 470

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  795 LNTDQLKMDILFKKLKQKfndlvaekeAVSSECVNLAKDNEVLHQELLSMrnvqekceKLEKDKKmlEEEVLNLKTHMEK 874
Cdd:pfam05483  471 KEVEDLKTELEKEKLKNI---------ELTAHCDKLLLENKELTQEASDM--------TLELKKH--QEDIINCKKQEER 531

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  875 DMVELGKLQEYKSELDEravqEIEKLEEIHLQKQAEYEKQL---EQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVT 951
Cdd:pfam05483  532 MLKQIENLEEKEMNLRD----ELESVREEFIQKGDEVKCKLdksEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKN 607

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514175  952 TELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENL 1017
Cdd:pfam05483  608 KNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKISEEKL 673
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 486-689 8.87e-03

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 40.01  E-value: 8.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  486 HSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTL 565
Cdd:pfam05667  258 SAALAGTEATSGASRSAQDLAELLSSFSGSSTTDTGLTKGSRFTHTEKLQFTNEAPAATSSPPTKVETEEELQQQREEEL 337

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  566 AlgSVQLDLRQAQHRIKEMKqmhpnGEAKESQSIGKQnsLEERIRQQELENLLLERQLEDARK------EGDN-----KE 634
Cdd:pfam05667  338 E--ELQEQLEDLESSIQELE-----KEIKKLESSIKQ--VEEELEELKEQNEELEKQYKVKKKtldllpDAEEniaklQA 408

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1370514175  635 IVINIHRDCLENGKEdlLEERNKELMKEYNYLKEkllQCEKEKAEREVIVREFQE 689
Cdd:pfam05667  409 LVDASAQRLVELAGQ--WEKHRVPLIEEYRALKE---AKSNKEDESQRKLEEIKE 458
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 133-162 9.01e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 9.01e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1370514175   133 YGNTALHYAVYNKGTSLAERLLSHHANIEA 162
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 411-917 9.10e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 40.09  E-value: 9.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  411 SLRKEKKYIQEIKSITEINANFEKSVrlnEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLA 490
Cdd:pfam05483  167 SAEKTKKYEYEREETRQVYMDLNNNI---EKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVS 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  491 TAINEYNEIVER-KDLELVLWRADDvsrhekmgsNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGS 569
Cdd:pfam05483  244 LLLIQITEKENKmKDLTFLLEESRD---------KANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKA 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  570 VQLDLRQAQHRIKEMK-----QMHPNGEAKESQSI------GKQNSLEERIR--QQELEN-------LLLERQ-----LE 624
Cdd:pfam05483  315 LEEDLQIATKTICQLTeekeaQMEELNKAKAAHSFvvtefeATTCSLEELLRteQQRLEKnedqlkiITMELQkksseLE 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  625 DARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEK----LLQC-EKEKAEREVIV------REFQEELVD 693
Cdd:pfam05483  395 EMTKFKNNKEVELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQelifLLQArEKEIHDLEIQLtaiktsEEHYLKEVE 474

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  694 HLKTFSISES--PLEGTSHCHINLNETwtskKKLFQveiQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYK 771
Cdd:pfam05483  475 DLKTELEKEKlkNIELTAHCDKLLLEN----KELTQ---EASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLR 547

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  772 KCLEMTINMLNAFANEdFSCHGD--------LNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQ---- 839
Cdd:pfam05483  548 DELESVREEFIQKGDE-VKCKLDkseenarsIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKkgsa 626

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  840 ELLSMRNVQEKCEKLE---------------------KDKKMLEEEVLNlktHMEKDMVELGKLQEYKSELDERAVQEIE 898
Cdd:pfam05483  627 ENKQLNAYEIKVNKLElelasakqkfeeiidnyqkeiEDKKISEEKLLE---EVEKAKAIADEAVKLQKEIDKRCQHKIA 703

                          570
                   ....*....|....*....
gi 1370514175  899 KLEEIHLQKQAEYEKQLEQ 917
Cdd:pfam05483  704 EMVALMEKHKHQYDKIIEE 722
PTZ00121 PTZ00121
MAEBL; Provisional
 328-657 9.91e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 9.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  328 MRPCPETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNfmLKKDIAMLKEELYAI 407
Cdd:PTZ00121  1598 MKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENK--IKAAEEAKKAEEDKK 1675

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  408 KNDSLRKE-----------KKYIQEIKSITEINANFEKSVRLNEKMitktvaRYSQQLNDLKAENARLNSELEKEKHNKE 476
Cdd:PTZ00121  1676 KAEEAKKAeedekkaaealKKEAEEAKKAEELKKKEAEEKKKAEEL------KKAEEENKIKAEEAKKEAEEDKKKAEEA 1749

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  477 RLEAEVESLHSSLATAINEYNEIVeRKDLELVL---WRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKgkl 553
Cdd:PTZ00121  1750 KKDEEEKKKIAHLKKEEEKKAEEI-RKEKEAVIeeeLDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSK--- 1825

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514175  554 rETRD-ALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQ-------QELENLLLERQLED 625
Cdd:PTZ00121  1826 -EMEDsAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEieeadeiEKIDKDDIEREIPN 1904

                          330       340       350
                   ....*....|....*....|....*....|..
gi 1370514175  626 ARKEGDNKEIvINIHRDCLENGKEDLLEERNK 657
Cdd:PTZ00121  1905 NNMAGKNNDI-IDDKLDKDEYIKRDAEETREE 1935
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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