|
Name |
Accession |
Description |
Interval |
E-value |
| CCDC144C |
pfam14915 |
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ... |
327-617 |
3.92e-113 |
|
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.
Pssm-ID: 464371 [Multi-domain] Cd Length: 304 Bit Score: 354.29 E-value: 3.92e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 327 NFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELE 406
Cdd:pfam14915 1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 407 KEKHNKERLEAEVESLHSSLATAINEYNEIVERK-DLELVLWRADD--VSRHEKMGSNISQLTDKNELLTEQVHKARVKF 483
Cdd:pfam14915 81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKrDLELAFQRERDewLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 484 NTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDA 563
Cdd:pfam14915 161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370514181 564 RKEGDNKE-IVINIHRDC--------LENGKED-LLEERNKELMKEYNYLKEKLLQCEKEKAER 617
Cdd:pfam14915 241 QNKADAKEkTVIDIQDQFqdivkklqAESEKQVlLLEERNKELINECNHLKERLYQYEKEKAER 304
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
29-268 |
8.63e-41 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 152.42 E-value: 8.63e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 29 DIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKA 108
Cdd:COG0666 48 ALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLA 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 109 VHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLK 188
Cdd:COG0666 128 AYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLE 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 189 NQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDN 268
Cdd:COG0666 208 AGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
29-301 |
1.66e-37 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 142.79 E-value: 1.66e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 29 DIRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKA 108
Cdd:COG0666 15 LLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 109 VHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLK 188
Cdd:COG0666 95 ARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 189 NQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDN 268
Cdd:COG0666 175 AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLT 254
|
250 260 270
....*....|....*....|....*....|...
gi 1370514181 269 QETAAMKPANLKKRKERAKAEHNLKVASEEKQE 301
Cdd:COG0666 255 ALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
38-236 |
5.49e-36 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 138.55 E-value: 5.49e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 38 IHRAAIKGDAAEVERCLTRRFrDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACA 117
Cdd:COG0666 91 LHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIV 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 118 IVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVD 197
Cdd:COG0666 170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKD 249
|
170 180 190
....*....|....*....|....*....|....*....
gi 1370514181 198 NFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTA 236
Cdd:COG0666 250 KDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
|
|
| DUF3496 |
pfam12001 |
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ... |
863-969 |
3.57e-34 |
|
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.
Pssm-ID: 463425 [Multi-domain] Cd Length: 109 Bit Score: 126.70 E-value: 3.57e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 863 LKKKELTLKDVECKFSKMKTAYEEV-TTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLP 941
Cdd:pfam12001 1 RSQMELRIKDLESELSKMKTSQEDSnKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80
|
90 100
....*....|....*....|....*....
gi 1370514181 942 TRPEPELPCVENLN-SIELNRKYIPKTAI 969
Cdd:pfam12001 81 TRPVLESPCVGNLNnSLVLNRNFIPRENL 109
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
38-204 |
1.23e-26 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 111.20 E-value: 1.23e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 38 IHRAAIKGDAAEVERCLTRRFrDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACA 117
Cdd:COG0666 124 LHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 118 IVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVD 197
Cdd:COG0666 203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282
|
....*..
gi 1370514181 198 NFKRTAL 204
Cdd:COG0666 283 LDLLTLL 289
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
54-274 |
2.19e-25 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 107.73 E-value: 2.19e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 54 LTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIY 133
Cdd:COG0666 7 LLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 134 GNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLS 213
Cdd:COG0666 87 GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNL 166
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370514181 214 SIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNkmlKNHLRNDNQETAAM 274
Cdd:COG0666 167 EIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA---DVNAKDNDGKTALD 224
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
138-230 |
2.58e-16 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 75.15 E-value: 2.58e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 138 LHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNqANIHAVDNfKRTALILAVQHNLSSIVT 217
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 1370514181 218 LLLQQNIRISSQD 230
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
72-164 |
1.50e-15 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 72.84 E-value: 1.50e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 72 LHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECgANPNIEDiYGNTALHYAVYNKGTSLAE 151
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 1370514181 152 RLLSHHANIEALN 164
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
60-275 |
2.29e-15 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 80.01 E-value: 2.29e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 60 DLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALH 139
Cdd:PHA02874 116 DVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLH 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 140 YAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQhMVEfLLKNQANIHAVDNFKRTALILAVQHNLS-SIVTL 218
Cdd:PHA02874 196 NAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRS-AIE-LLINNASINDQDIDGSTPLHHAINPPCDiDIIDI 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 219 LLQQNIRISSQDMFGQTAEDYAL-----CSDLRSI--------------RQQILEHK----NKMLKNHLRNDNQETAAMK 275
Cdd:PHA02874 274 LLYHKADISIKDNKGENPIDTAFkyinkDPVIKDIianavlikeadklkDSDFLEHIeikdNKEFSDFIKECNEEIEDMK 353
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
105-197 |
1.75e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 70.14 E-value: 1.75e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 105 LMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLShHANIEALNkEGNTPLLFAINSRRQHMVE 184
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 1370514181 185 FLLKNQANIHAVD 197
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
74-236 |
2.26e-13 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 73.91 E-value: 2.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 74 LACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACA-IV--LLECGANPNIEDIYGNTALHYAVYNKGT-SL 149
Cdd:PHA03095 20 LNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKdIVrlLLEAGADVNAPERCGFTPLHLYLYNATTlDV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 150 AERLLSHHANIEALNKEGNTPLL-----FAINSRrqhMVEFLLKNQANIHAVDNFKRTAL-ILAVQHNLS-SIVTLLLQQ 222
Cdd:PHA03095 100 IKLLIKAGADVNAKDKVGRTPLHvylsgFNINPK---VIRLLLRKGADVNALDLYGMTPLaVLLKSRNANvELLRLLIDA 176
|
170
....*....|....
gi 1370514181 223 NIRISSQDMFGQTA 236
Cdd:PHA03095 177 GADVYAVDDRFRSL 190
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
28-208 |
2.39e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 73.76 E-value: 2.39e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 28 YDIRDWELRKIHRAAIKgdAAEVERCLTRRFRDLDARDR-KDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLM 106
Cdd:PHA02878 129 QTIDLVYIDKKSKDDII--EAEITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLH 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 107 KAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAV-YNKGTSLAERLLSHHANIEALNK-EGNTPLLFAINSRRQhmVE 184
Cdd:PHA02878 207 HAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVgYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSIKSERK--LK 284
|
170 180
....*....|....*....|....
gi 1370514181 185 FLLKNQANIHAVDNFKRTALILAV 208
Cdd:PHA02878 285 LLLEYGADINSLNSYKLTPLSSAV 308
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
38-131 |
9.23e-13 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 65.14 E-value: 9.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 38 IHRAAIKGDAAEVERcLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLhRRCQIDICDRlNRTPLMKAVHSQEEACA 117
Cdd:pfam12796 1 LHLAAKNGNLELVKL-LLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKDN-GRTALHYAARSGHLEIV 77
|
90
....*....|....
gi 1370514181 118 IVLLECGANPNIED 131
Cdd:pfam12796 78 KLLLEKGADINVKD 91
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
119-229 |
4.94e-12 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 69.91 E-value: 4.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 119 VLLECGANPNIEDIY-GNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVD 197
Cdd:PHA02878 152 LLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARD 231
|
90 100 110
....*....|....*....|....*....|...
gi 1370514181 198 NFKRTALILAVQHNLS-SIVTLLLQQNIRISSQ 229
Cdd:PHA02878 232 KCGNTPLHISVGYCKDyDILKLLLEHGVDVNAK 264
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
26-192 |
6.72e-12 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 68.86 E-value: 6.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 26 PGYDIRDWElRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPL 105
Cdd:PHA02875 61 PDVKYPDIE-SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 106 MKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLL-FAINSRRQHMVE 184
Cdd:PHA02875 140 HLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALcYAIENNKIDIVR 219
|
....*...
gi 1370514181 185 FLLKNQAN 192
Cdd:PHA02875 220 LFIKRGAD 227
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
30-223 |
1.32e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 68.94 E-value: 1.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 30 IRDWELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHG-RVQVVTLLLHRRCQIDICDRLNRTPLMKA 108
Cdd:PHA02876 269 IDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQA 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 109 -VHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHM-VEFL 186
Cdd:PHA02876 349 sTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPYMsVKTL 428
|
170 180 190
....*....|....*....|....*....|....*..
gi 1370514181 187 LKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQN 223
Cdd:PHA02876 429 IDRGANVNSKNKDLSTPLHYACKKNCKLDVIEMLLDN 465
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
60-351 |
2.62e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 67.00 E-value: 2.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 60 DLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAV---HSQEEACAIV--LLECGANPNIEDIYG 134
Cdd:PHA03100 27 LNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSnikYNLTDVKEIVklLLEYGANVNAPDNNG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 135 NTALHYAVYNKGTS--LAERLLSHHANIEALNKEGNTPLLFAI--NSRRQHMVEFLLKNQANIHAVDNFKR--------- 201
Cdd:PHA03100 107 ITPLLYAISKKSNSysIVEYLLDNGANVNIKNSDGENLLHLYLesNKIDLKILKLLIDKGVDINAKNRVNYllsygvpin 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 202 -------TALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYAlcsdlrsIRQQILEHKNKMLKNHlrndnqetaam 274
Cdd:PHA03100 187 ikdvygfTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIA-------ILNNNKEIFKLLLNNG----------- 248
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370514181 275 kpANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRK 351
Cdd:PHA03100 249 --PSIKTIIETLLYFKDKDLNTITKIKMLKKSIMYMFLLDPGFYKNRKLIENSKSLKDVINECEKEIERMKEIKLNK 323
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
42-199 |
2.84e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 67.00 E-value: 2.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 42 AIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAH--GRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIV 119
Cdd:PHA03100 80 YNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKIL 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 120 ------------------LLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQH 181
Cdd:PHA03100 160 kllidkgvdinaknrvnyLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKE 239
|
170
....*....|....*...
gi 1370514181 182 MVEFLLKNQANIHAVDNF 199
Cdd:PHA03100 240 IFKLLLNNGPSIKTIIET 257
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
45-255 |
4.47e-11 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 66.59 E-value: 4.47e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 45 GDAAEVERCLTRRFRDLDARDRKDRTVLHLacahgrvqvvtLLLHRrcqidicdrlNRTPLMKavhsqeeacaiVLLECG 124
Cdd:PHA03095 60 EKVKDIVRLLLEAGADVNAPERCGFTPLHL-----------YLYNA----------TTLDVIK-----------LLIKAG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 125 ANPNIEDIYGNTALHyaVYNKG----TSLAERLLSHHANIEALNKEGNTPLLFAINSRRQ--HMVEFLLKNQANIHAVDN 198
Cdd:PHA03095 108 ADVNAKDKVGRTPLH--VYLSGfninPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNAnvELLRLLIDAGADVYAVDD 185
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370514181 199 FKRTAL--ILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYA--LCSDLRSIRQQILEH 255
Cdd:PHA03095 186 RFRSLLhhHLQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMatGSSCKRSLVLPLLIA 246
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
353-898 |
2.15e-10 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 65.09 E-value: 2.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 353 KKYIQEIKSITEINANFEKSVRLNEKMITKTvarySQQLNDLKAENARLNSELEKEKHNKERLEAEVESLhsslaTAINE 432
Cdd:PRK03918 175 KRRIERLEKFIKRTENIEELIKEKEKELEEV----LREINEISSELPELREELEKLEKEVKELEELKEEI-----EELEK 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 433 YNEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARvKFNTLKGKLRETRDALREKTLALGSVQLDLR 512
Cdd:PRK03918 246 ELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAE-EYIKLSEFYEEYLDELREIEKRLSRLEEEIN 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 513 QAQHRIKEMKQMHPNGE---AKESQSIGKQNSLEERIRQ-QELENLLLERQLEDARKEGDNKEIVINihrdclengKEDL 588
Cdd:PRK03918 325 GIEERIKELEEKEERLEelkKKLKELEKRLEELEERHELyEEAKAKKEELERLKKRLTGLTPEKLEK---------ELEE 395
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 589 LEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQE----------ELVDHLKTFSISESPLEgTSHCHINLNETWTS 658
Cdd:PRK03918 396 LEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKakgkcpvcgrELTEEHRKELLEEYTAE-LKRIEKELKEIEEK 474
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 659 KKKLFQVEIQPEEKHEEFRKLFELISLlnytADQIRkknrELEEEATGYkkclemtinmlnafanedfschgdlNTDQLK 738
Cdd:PRK03918 475 ERKLRKELRELEKVLKKESELIKLKEL----AEQLK----ELEEKLKKY-------------------------NLEELE 521
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 739 MDI-LFKKLKQKFNDLVAEKEAVSSECvnlakdnevlhqellsmrnvqEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELG 817
Cdd:PRK03918 522 KKAeEYEKLKEKLIKLKGEIKSLKKEL---------------------EKLEELKKKLAELEKKLDELEEELAELLKELE 580
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 818 KLQEYKSELDERAVQEIEKLEEIHLQ-KQAEYEKQLEQlnkdntASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKE 896
Cdd:PRK03918 581 ELGFESVEELEERLKELEPFYNEYLElKDAEKELEREE------KELKKLEEELDKAFEELAETEKRLEELRKELEELEK 654
|
..
gi 1370514181 897 AF 898
Cdd:PRK03918 655 KY 656
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
69-343 |
4.55e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 63.09 E-value: 4.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 69 RTVLHLACAHGRVQVVTLLLHRRCQI-DICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGT 147
Cdd:PHA02875 69 ESELHDAVEEGDVKAVEELLDLGKFAdDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 148 SLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVD-NFKRTALILAVQHNLSSIVTLLLQQNirI 226
Cdd:PHA02875 149 KGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGkNGCVAALCYAIENNKIDIVRLFIKRG--A 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 227 SSQDMFGQTAEDYAlcsdlrsirqqILEhknkMLKNHLRNDNQETAAMKPANL-----KKRKERAKAEHNlKVASEEKQE 301
Cdd:PHA02875 227 DCNIMFMIEGEECT-----------ILD----MICNMCTNLESEAIDALIADIairihKKTIRRDEGFKN-NMSTIEDKE 290
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1370514181 302 RLQRSENKQPQD-----SQSYGKKkdAMYGNFMLKKDIAMLKEELYA 343
Cdd:PHA02875 291 EFKDVFEKCIIElrrikSEKIGKK--NILDLCILEKNSHNLDENILA 335
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
34-240 |
5.82e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 63.54 E-value: 5.82e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 34 ELRKIHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDIC--DRL----------- 100
Cdd:PHA02876 144 EYMKLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIalDDLsvlecavdskn 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 101 ----------------NRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTS-LAERLLSHHANIEAL 163
Cdd:PHA02876 224 idtikaiidnrsninkNDLSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAK 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 164 NKEGNTPL-LFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILA--VQHNLSSIVTlLLQQNIRISSQDMFGQTAEDYA 240
Cdd:PHA02876 304 NIKGETPLyLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQAstLDRNKDIVIT-LLELGANVNARDYCDKTPIHYA 382
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
60-211 |
1.18e-09 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 61.96 E-value: 1.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 60 DLDARDRKDRTVLHlACAHG---RVQVVTLLLhrRCQIDICDR--LNRTPLMKAVHSQEEACAIV--LLECGANPNIEDI 132
Cdd:PHA03095 109 DVNAKDKVGRTPLH-VYLSGfniNPKVIRLLL--RKGADVNALdlYGMTPLAVLLKSRNANVELLrlLIDAGADVYAVDD 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 133 YGNTALHY-AVYNKG-TSLAERLLSHHANIEALNKEGNTPL-LFAINS--RRQHMVEFLLKNqANIHAVDNFKRTALILA 207
Cdd:PHA03095 186 RFRSLLHHhLQSFKPrARIVRELIRAGCDPAATDMLGNTPLhSMATGSscKRSLVLPLLIAG-ISINARNRYGQTPLHYA 264
|
....
gi 1370514181 208 VQHN 211
Cdd:PHA03095 265 AVFN 268
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
60-198 |
1.87e-09 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 61.58 E-value: 1.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 60 DLDARDRKDRTVLHLAC--AHGRVQVVTLLLHRRCQIDICDRLNRTPL-MKAVHSQEEACAIV-LLECGANPNIEDIYGN 135
Cdd:PHA03095 179 DVYAVDDRFRSLLHHHLqsFKPRARIVRELIRAGCDPAATDMLGNTPLhSMATGSSCKRSLVLpLLIAGISINARNRYGQ 258
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370514181 136 TALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDN 198
Cdd:PHA03095 259 TPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVAA 321
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
68-241 |
1.90e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 61.52 E-value: 1.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 68 DRTVLHLACAHGrvQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGT 147
Cdd:PHA02874 93 DTSILPIPCIEK--DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFF 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 148 SLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVtlLLQQNIRIS 227
Cdd:PHA02874 171 DIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIE--LLINNASIN 248
|
170
....*....|....
gi 1370514181 228 SQDMFGQTAEDYAL 241
Cdd:PHA02874 249 DQDIDGSTPLHHAI 262
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
80-230 |
4.00e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 60.06 E-value: 4.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 80 RVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHY-----AVYNKGTSLAERLL 154
Cdd:PHA03100 14 KVKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYlsnikYNLTDVKEIVKLLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 155 SHHANIEALNKEGNTPLLFAINSRRQH--MVEFLLKNQANIHAVDNFKRTALILAVQHNL--SSIVTLLLQQNIRISSQD 230
Cdd:PHA03100 94 EYGANVNAPDNNGITPLLYAISKKSNSysIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDINAKN 173
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
337-897 |
6.54e-09 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 60.03 E-value: 6.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 337 LKEELYAIKNDSLRKEKK-------YIQEIKSITEINANFEKsVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEK 409
Cdd:TIGR04523 38 LEKKLKTIKNELKNKEKElknldknLNKDEEKINNSNNKIKI-LEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDK 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 410 HNKERLEAEVESL---------------------HSSLATAINEYNEIVERK-DLELVLWRADD---------------V 452
Cdd:TIGR04523 117 EQKNKLEVELNKLekqkkenkknidkflteikkkEKELEKLNNKYNDLKKQKeELENELNLLEKeklniqknidkiknkL 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 453 SRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKE 532
Cdd:TIGR04523 197 LKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKEL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 533 SQSIGKQNSLEERIRQQELENLLL-------------------ERQLEDARKEGDNKEIVINIHRDCLENGKEDL--LEE 591
Cdd:TIGR04523 277 EQNNKKIKELEKQLNQLKSEISDLnnqkeqdwnkelkselknqEKKLEEIQNQISQNNKIISQLNEQISQLKKELtnSES 356
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 592 RNKELMKEynyLKEKLLQCEKEKAErevivrefQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKlfQVEIQPEE 671
Cdd:TIGR04523 357 ENSEKQRE---LEEKQNEIEKLKKE--------NQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIK--KLQQEKEL 423
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 672 KHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEdfschgdLNTDQLKMDILFKKLKQKFN 751
Cdd:TIGR04523 424 LEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRS-------INKIKQNLEQKQKELKSKEK 496
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 752 DLvaekEAVSSECVNLAKDNEVLHQELLSMRnvqEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELgKLQEYKSELDERAv 831
Cdd:TIGR04523 497 EL----KKLNEEKKELEEKVKDLTKKISSLK---EKIEKLESEKKEKESKISDLEDELNKDDFEL-KKENLEKEIDEKN- 567
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370514181 832 QEIEKLEEIH---LQKQAEYE---KQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEA 897
Cdd:TIGR04523 568 KEIEELKQTQkslKKKQEEKQeliDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSK 639
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
460-907 |
1.97e-08 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 58.93 E-value: 1.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 460 SNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQmhpngeaKESQSIGKQ 539
Cdd:TIGR02169 667 LFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQ-------EEEKLKERL 739
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 540 NSLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEkllqcekEKAEREV 619
Cdd:TIGR02169 740 EELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEE-------EVSRIEA 812
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 620 IVREFQEELVDHLKTFSISESplegtshchinlnetwtSKKKLFQVEIQPEEKHEEFRKLFELISLlnytadQIRKKNRE 699
Cdd:TIGR02169 813 RLREIEQKLNRLTLEKEYLEK-----------------EIQELQEQRIDLKEQIKSIEKEIENLNG------KKEELEEE 869
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 700 LEEeatgykkclemtinmLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEkeavssecVNLAKDNEVLHQELL 779
Cdd:TIGR02169 870 LEE---------------LEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQ--------IEKKRKRLSELKAKL 926
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 780 SmrNVQEKCEKLEKDKKMLEEEVLNLkthmekdmVELGKLQEYKSELDERavqeIEKLEEIHLQKQAEYEKQLEQLNkdn 859
Cdd:TIGR02169 927 E--ALEEELSEIEDPKGEDEEIPEEE--------LSLEDVQAELQRVEEE----IRALEPVNMLAIQEYEEVLKRLD--- 989
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1370514181 860 taSLKKKELTLKdveckfsKMKTAYEEVTTELEEFK-EAFAGAVKANNS 907
Cdd:TIGR02169 990 --ELKEKRAKLE-------EERKAILERIEEYEKKKrEVFMEAFEAINE 1029
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
330-837 |
2.97e-08 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 58.15 E-value: 2.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 330 LKKDIAMLKEELYAIKnDSLRKEKKYIQE----IKSITEINANFEKSVRLNEKM---------ITKTVARYSQQLNDLKA 396
Cdd:PRK03918 250 LEGSKRKLEEKIRELE-ERIEELKKEIEEleekVKELKELKEKAEEYIKLSEFYeeyldelreIEKRLSRLEEEINGIEE 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 397 ENARLNSELEKEKHNKERLEaEVESLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQV 476
Cdd:PRK03918 329 RIKELEEKEERLEELKKKLK-ELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEI 407
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 477 HKARVKFNTLKGKLRETRDA--------------------------LREKTLALGSVQLDLRQAQHRIKEMKQMHPN--G 528
Cdd:PRK03918 408 SKITARIGELKKEIKELKKAieelkkakgkcpvcgrelteehrkelLEEYTAELKRIEKELKEIEEKERKLRKELREleK 487
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 529 EAKESQSIGKQNSLEERIR--QQELENLLLERQLEDARKEGDNKEIVINIHRDcLENGKEDLleERNKELMKEYNYLKEK 606
Cdd:PRK03918 488 VLKKESELIKLKELAEQLKelEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGE-IKSLKKEL--EKLEELKKKLAELEKK 564
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 607 LLQCEKEKAEREVIVREFQEELVDHLktfsisESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLL 686
Cdd:PRK03918 565 LDELEEELAELLKELEELGFESVEEL------EERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAET 638
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 687 NYTADQIRKKNRELEEEatgykkclemtinmlnaFANEDFSchgdlntdqlKMDILFKKLKQKFNDLVAEKEAVSSECVN 766
Cdd:PRK03918 639 EKRLEELRKELEELEKK-----------------YSEEEYE----------ELREEYLELSRELAGLRAELEELEKRREE 691
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370514181 767 LAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVlnlkthmekdmvelGKLQEYKSELDERAVQEIEKL 837
Cdd:PRK03918 692 IKKTLEKLKEELEEREKAKKELEKLEKALERVEELR--------------EKVKKYKALLKERALSKVGEI 748
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
277-934 |
3.10e-08 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 58.14 E-value: 3.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 277 ANLKKRKERAKAE-HNLKVASEEKQERLQRSENKQPQDSQSYGkkkdamygnfMLKKDIAMLKEELYAIKNDsLRKEKKY 355
Cdd:TIGR02168 298 SRLEQQKQILRERlANLERQLEELEAQLEELESKLDELAEELA----------ELEEKLEELKEELESLEAE-LEELEAE 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 356 IQEIKSIteINANFEKSVRLNEKmitktVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAineyne 435
Cdd:TIGR02168 367 LEELESR--LEELEEQLETLRSK-----VAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEA------ 433
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 436 ivERKDLElvlwraddvsrhekmgsniSQLTDKNELLTEQVHkarvKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQ 515
Cdd:TIGR02168 434 --ELKELQ-------------------AELEELEEELEELQE----ELERLEEALEELREELEEAEQALDAAERELAQLQ 488
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 516 HRIKEMKQMHpngEAKESQSIGKQNSLEERIRQQELENLLLErQLEDARKEGDNKEIVinihrdcLENGKEDLLEERNKE 595
Cdd:TIGR02168 489 ARLDSLERLQ---ENLEGFSEGVKALLKNQSGLSGILGVLSE-LISVDEGYEAAIEAA-------LGGRLQAVVVENLNA 557
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 596 LMKEYNYLKEKLL--------------QCEKEKAEREVIVREFQEELVDHLKT---FSISESPLEGTSHCHINLNETWTS 658
Cdd:TIGR02168 558 AKKAIAFLKQNELgrvtflpldsikgtEIQGNDREILKNIEGFLGVAKDLVKFdpkLRKALSYLLGGVLVVDDLDNALEL 637
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 659 KKKL-------------------------------FQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGY 707
Cdd:TIGR02168 638 AKKLrpgyrivtldgdlvrpggvitggsaktnssiLERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQL 717
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 708 KKCLEmtinmlnafanedfschgDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRnvqEK 787
Cdd:TIGR02168 718 RKELE------------------ELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAE---EE 776
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 788 CEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEiHLQKQAEYEKQLEQLNKdntaSLKKKE 867
Cdd:TIGR02168 777 LAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLES-LERRIAATERRLEDLEE----QIEELS 851
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370514181 868 LTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMK 934
Cdd:TIGR02168 852 EDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELE 918
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
330-628 |
7.61e-08 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 56.99 E-value: 7.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 330 LKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKsVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEK 409
Cdd:TIGR02168 696 LEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLAR-LEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAE 774
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 410 HNKERLEAEVESLHSSLATAINEyneiverkdlelvlwraddvsrhekMGSNISQLTDknellteqvhkarvkfntLKGK 489
Cdd:TIGR02168 775 EELAEAEAEIEELEAQIEQLKEE-------------------------LKALREALDE------------------LRAE 811
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 490 LRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQqelenllLERQLEDARKEGDN 569
Cdd:TIGR02168 812 LTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEE-------LESELEALLNERAS 884
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370514181 570 KEIVINIHRDCLENGKEDL--LEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEEL 628
Cdd:TIGR02168 885 LEEALALLRSELEELSEELreLESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERL 945
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
87-220 |
7.87e-08 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 56.80 E-value: 7.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 87 LLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAeRLLSHHANIEALNKE 166
Cdd:PLN03192 544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIF-RILYHFASISDPHAA 622
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1370514181 167 GNTpLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLL 220
Cdd:PLN03192 623 GDL-LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
277-931 |
7.93e-08 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 56.90 E-value: 7.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 277 ANLKKRKERA----------KAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFMLK---KDIAMLKEELYA 343
Cdd:pfam02463 165 SRLKRKKKEAlkklieetenLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLdylKLNEERIDLLQE 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 344 IKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLH 423
Cdd:pfam02463 245 LLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKK 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 424 SSLATAINEYNEIVERKDLELVLWRADdvsrhEKMGSNISQLTDKNELLTEQVHKARVKFnTLKGKLRETRDALREKTLA 503
Cdd:pfam02463 325 KAEKELKKEKEEIEELEKELKELEIKR-----EAEEEEEEELEKLQEKLEQLEEELLAKK-KLESERLSSAAKLKEEELE 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 504 LGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEivinihrdclEN 583
Cdd:pfam02463 399 LKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELE----------LK 468
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 584 GKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVRE---FQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKK 660
Cdd:pfam02463 469 KSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGlkvLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTA 548
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 661 KLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEdFSCHGDLNTDQLKMD 740
Cdd:pfam02463 549 VIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKAT-LEADEDDKRAKVVEG 627
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 741 ILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHqeLLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQ 820
Cdd:pfam02463 628 ILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKS--EVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKE 705
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 821 EYKSELDERAVQEIEKLEEIHLQ--------KQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELE 892
Cdd:pfam02463 706 QREKEELKKLKLEAEELLADRVQeaqdkineELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEK 785
|
650 660 670
....*....|....*....|....*....|....*....
gi 1370514181 893 EFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQ 931
Cdd:pfam02463 786 LKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLI 824
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
120-174 |
1.28e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 49.27 E-value: 1.28e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514181 120 LLECG-ANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFA 174
Cdd:pfam13857 1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
275-903 |
1.30e-07 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 56.30 E-value: 1.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 275 KPANLKKRKERAKAEHNLKVASEEKQ--ERLQRSENKQPQDSQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKE 352
Cdd:PTZ00121 1291 KADEAKKAEEKKKADEAKKKAEEAKKadEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAE 1370
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 353 KKYIQEIKSITEINANFEKSVRLNEkmITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINE 432
Cdd:PTZ00121 1371 KKKEEAKKKADAAKKKAEEKKKADE--AKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADE 1448
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 433 YNEIVERKDlelvlwRADDVSRHEKMGSNISQLTDKNELlTEQVHKARVKFNTLKGKLRETRDALREKTLALgsvqlDLR 512
Cdd:PTZ00121 1449 AKKKAEEAK------KAEEAKKKAEEAKKADEAKKKAEE-AKKADEAKKKAEEAKKKADEAKKAAEAKKKAD-----EAK 1516
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 513 QAQHRIK--EMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINiHRDCLENGKEDLLE 590
Cdd:PTZ00121 1517 KAEEAKKadEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALR-KAEEAKKAEEARIE 1595
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 591 ERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEelvdhlktfsisesplegtshchinlnetwtsKKKLFQVEIQPE 670
Cdd:PTZ00121 1596 EVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEE--------------------------------KKKVEQLKKKEA 1643
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 671 E---KHEEFRKLFELISLlnyTADQIRKKNRELEEEATGYKKclemtinmlnafANEDfschgdlntDQLKMDILFKKlk 747
Cdd:PTZ00121 1644 EekkKAEELKKAEEENKI---KAAEEAKKAEEDKKKAEEAKK------------AEED---------EKKAAEALKKE-- 1697
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 748 qkfndlvaEKEAVSSECVNLAKDNEVLHQELLSmRNVQEKCEKLEKDKKMLEEEvlnlkthmEKDMVELGKLQEYKSELD 827
Cdd:PTZ00121 1698 --------AEEAKKAEELKKKEAEEKKKAEELK-KAEEENKIKAEEAKKEAEED--------KKKAEEAKKDEEEKKKIA 1760
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514181 828 ERAVQEIEKLEEIHLQKQAEYEkqlEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVK 903
Cdd:PTZ00121 1761 HLKKEEEKKAEEIRKEKEAVIE---EELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIK 1833
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
41-209 |
1.46e-07 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 56.03 E-value: 1.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 41 AAIKGDAAEVERcLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVL 120
Cdd:PLN03192 532 VASTGNAALLEE-LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRIL 610
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 121 LECGA--NPNIediyGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAV-- 196
Cdd:PLN03192 611 YHFASisDPHA----AGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAnt 686
|
170
....*....|....
gi 1370514181 197 -DNFKRTALILAVQ 209
Cdd:PLN03192 687 dDDFSPTELRELLQ 700
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
49-259 |
2.21e-07 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 55.02 E-value: 2.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 49 EVERCLTRRFRDldardrkdrTVLHLACAHGRVQVVTLLLhrRCQ-IDICDR--LNRTPLMKAV-HSQEEAcAIVLLECG 124
Cdd:cd22192 7 ELHLLQQKRISE---------SPLLLAAKENDVQAIKKLL--KCPsCDLFQRgaLGETALHVAAlYDNLEA-AVVLMEAA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 125 A----NPNIEDIY-GNTALHYAVYNKGTSLAERLLSHHA--------------NIEALNKEGNTPLLFAINSRRQHMVEF 185
Cdd:cd22192 75 PelvnEPMTSDLYqGETALHIAVVNQNLNLVRELIARGAdvvspratgtffrpGPKNLIYYGEHPLSFAACVGNEEIVRL 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370514181 186 LLKNQANIHAVDNFKRTALilavqHnlssivTLLLQQNIRISSQdMFgqtaeDYALCSDlRSIRQQILEH-KNKM 259
Cdd:cd22192 155 LIEHGADIRAQDSLGNTVL-----H------ILVLQPNKTFACQ-MY-----DLILSYD-KEDDLQPLDLvPNNQ 211
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
119-197 |
2.91e-07 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 54.90 E-value: 2.91e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370514181 119 VLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVD 197
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELG 178
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
134-187 |
4.07e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 47.65 E-value: 4.07e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1370514181 134 GNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLL 187
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
215-934 |
4.35e-07 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 54.59 E-value: 4.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 215 IVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQ-QILEHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKaehnlk 293
Cdd:pfam02463 189 IIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEyLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEK------ 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 294 vaSEEKQERLQRSENKQPQdSQSYGKKKDAMYGNFMLKKDIAMLKEELyaiKNDSLRKEKKYIQEIKSITEINANFEKSV 373
Cdd:pfam02463 263 --EEEKLAQVLKENKEEEK-EKKLQEEELKLLAKEEEELKSELLKLER---RKVDDEEKLKESEKEKKKAEKELKKEKEE 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 374 RLNEKMITKTVARYSQQlndLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVERKDLELVlwRADDVS 453
Cdd:pfam02463 337 IEELEKELKELEIKREA---EEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEK--EAQLLL 411
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 454 RHEKMgsNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKemkqmhpngEAKES 533
Cdd:pfam02463 412 ELARQ--LEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLK---------ETQLV 480
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 534 QSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDClENGKEDLLEERNKELMKEYNYLKEKLLQCEKE 613
Cdd:pfam02463 481 KLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISA-HGRLGDLGVAVENYKVAISTAVIVEVSATADE 559
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 614 KAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPE---------EKHEEFRKLFELIS 684
Cdd:pfam02463 560 VEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADeddkrakvvEGILKDTELTKLKE 639
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 685 LLNYTADQIRKKNRELEEEA--TGYKKCLEMTINMLNAFANEDFSCHGDLNT-----DQLKMDILFKKLKQKFNDLVAEK 757
Cdd:pfam02463 640 SAKAKESGLRKGVSLEEGLAekSEVKASLSELTKELLEIQELQEKAESELAKeeilrRQLEIKKKEQREKEELKKLKLEA 719
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 758 EAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLE-KDKKMLEEEVLNLKTHMEKDMVE-----LGKLQEYKSELDERAV 831
Cdd:pfam02463 720 EELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKsRLKKEEKEEEKSELSLKEKELAEerektEKLKVEEEKEEKLKAQ 799
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 832 QEIEKLEEIHLQKQAEyekQLEQLNKDNTASLKKKELTLKDVEcKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKK 911
Cdd:pfam02463 800 EEELRALEEELKEEAE---LLEEEQLLIEQEEKIKEEELEELA-LELKEEQKLEKLAEEELERLEEEITKEELLQELLLK 875
|
730 740
....*....|....*....|...
gi 1370514181 912 LMKSDKKIAVISTKLFTEKQRMK 934
Cdd:pfam02463 876 EEELEEQKLKDELESKEEKEKEE 898
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
247-912 |
5.59e-07 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 53.87 E-value: 5.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 247 SIRQQILEHKNKM--LKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDam 324
Cdd:TIGR04523 86 DLNDKLKKNKDKInkLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYND-- 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 325 ygnfmLKKDIAMLKEELYAIKNDSLRKEKKyiqeIKSITEINANFEKSVRLNEKMITKTvARYSQQLNDLKAENARLNSE 404
Cdd:TIGR04523 164 -----LKKQKEELENELNLLEKEKLNIQKN----IDKIKNKLLKLELLLSNLKKKIQKN-KSLESQISELKKQNNQLKDN 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 405 LEKEKHNKERLEAEVESLHSSLATAINEYNEIV---ERKDLELvlwraddvsrhEKMGSNISQLTD-----KNELLTEQV 476
Cdd:TIGR04523 234 IEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKkqlSEKQKEL-----------EQNNKKIKELEKqlnqlKSEISDLNN 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 477 HKARVKFNTLKGKLRETRDALREktlalgsVQLDLRQAQHRIKEMKQmhpngeakesqsigKQNSLEERIRQQELENLLL 556
Cdd:TIGR04523 303 QKEQDWNKELKSELKNQEKKLEE-------IQNQISQNNKIISQLNE--------------QISQLKKELTNSESENSEK 361
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 557 ERQLEDARKEGDNkeivinihrdcLENGKEDLLEErNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELVDHLKTFS 636
Cdd:TIGR04523 362 QRELEEKQNEIEK-----------LKKENQSYKQE-IKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIE 429
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 637 ISESPLEGTSHCHINLNETWTSKKKLFqveiqpeEKHEEFRKLFEliSLLNYTADQIRKKNRELEEEatgyKKCLEMTIN 716
Cdd:TIGR04523 430 RLKETIIKNNSEIKDLTNQDSVKELII-------KNLDNTRESLE--TQLKVLSRSINKIKQNLEQK----QKELKSKEK 496
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 717 MLNAFANEDFSCHGdlNTDQLKMDIlfKKLKQKFNDLVAEKEAVSSECVNLA----KDNEVLHQELL--SMRNVQEKCEK 790
Cdd:TIGR04523 497 ELKKLNEEKKELEE--KVKDLTKKI--SSLKEKIEKLESEKKEKESKISDLEdelnKDDFELKKENLekEIDEKNKEIEE 572
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 791 LEKDKKMLEeevlnlKTHMEKDMvelgKLQEYKSElderaVQEIEKLEEIHLQKQAEYEKQLEQLNKDNtaslKKKELTL 870
Cdd:TIGR04523 573 LKQTQKSLK------KKQEEKQE----LIDQKEKE-----KKDLIKEIEEKEKKISSLEKELEKAKKEN----EKLSSII 633
|
650 660 670 680
....*....|....*....|....*....|....*....|..
gi 1370514181 871 KDVECKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKL 912
Cdd:TIGR04523 634 KNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKI 675
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
117-274 |
9.79e-07 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 51.88 E-value: 9.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 117 AIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAV 196
Cdd:COG0666 4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370514181 197 DNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKnkmLKNHLRNDNQETAAM 274
Cdd:COG0666 84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAG---ADVNAQDNDGNTPLH 158
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
329-857 |
9.92e-07 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 53.14 E-value: 9.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 329 MLKKDIAMLKEELYA---IKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKmitktVARYSQQLNDLKAENARLNSEL 405
Cdd:PRK03918 173 EIKRRIERLEKFIKRtenIEELIKEKEKELEEVLREINEISSELPELREELEK-----LEKEVKELEELKEEIEELEKEL 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 406 EKEKHNKERLEAEVESLHSSLATAINEYNEIVER-KDLELVLWRADdvsRHEKMGSNISQLTDKNELLTEQVHKARVKFN 484
Cdd:PRK03918 248 ESLEGSKRKLEEKIRELEERIEELKKEIEELEEKvKELKELKEKAE---EYIKLSEFYEEYLDELREIEKRLSRLEEEIN 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 485 TLKGKLREtrdaLREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEaKESQSIGKQNSLEERIRQQELENLLLE-RQLEDA 563
Cdd:PRK03918 325 GIEERIKE----LEEKEERLEELKKKLKELEKRLEELEERHELYE-EAKAKKEELERLKKRLTGLTPEKLEKElEELEKA 399
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 564 RKEGDNKEIVINIHRDCLENGKED---------------------LLEERNKELMKEYnylKEKLLQCEKEKAEREVIVR 622
Cdd:PRK03918 400 KEEIEEEISKITARIGELKKEIKElkkaieelkkakgkcpvcgreLTEEHRKELLEEY---TAELKRIEKELKEIEEKER 476
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 623 EFQEELVDHLKTFSISE--SPLEGTSHCHINLNEtwtsKKKLFQVEiQPEEKHEEFRKLFEL-------ISLLNYTADQI 693
Cdd:PRK03918 477 KLRKELRELEKVLKKESelIKLKELAEQLKELEE----KLKKYNLE-ELEKKAEEYEKLKEKliklkgeIKSLKKELEKL 551
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 694 RKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKK---LKQKFNDLVAEKEAVSSECVNLAKD 770
Cdd:PRK03918 552 EELKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYNEyleLKDAEKELEREEKELKKLEEELDKA 631
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 771 NEVLHQELLSMRNVQEKCEKLEKdkKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDER---AVQEIEKLEEiHLQKQAE 847
Cdd:PRK03918 632 FEELAETEKRLEELRKELEELEK--KYSEEEYEELREEYLELSRELAGLRAELEELEKRreeIKKTLEKLKE-ELEEREK 708
|
570
....*....|
gi 1370514181 848 YEKQLEQLNK 857
Cdd:PRK03918 709 AKKELEKLEK 718
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
42-123 |
2.14e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 51.82 E-value: 2.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 42 AIKGDAAEVeRCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLL 121
Cdd:PTZ00322 90 AASGDAVGA-RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
|
..
gi 1370514181 122 EC 123
Cdd:PTZ00322 169 RH 170
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
279-901 |
2.17e-06 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 52.37 E-value: 2.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 279 LKKRKERAKAE-HNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYgnfMLKKDIAMLKEELYAIKNDSLRKEKKyiq 357
Cdd:TIGR02168 230 LVLRLEELREElEELQEELKEAEEELEELTAELQELEEKLEELRLEVS---ELEEEIEELQKELYALANEISRLEQQ--- 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 358 eiksITEINANFEKSVRlNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHS---SLATAINEYN 434
Cdd:TIGR02168 304 ----KQILRERLANLER-QLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAeleELESRLEELE 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 435 EIVE---RKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKA-----RVKFNTLKGKLRETRDALREKTLALGS 506
Cdd:TIGR02168 379 EQLEtlrSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELlkkleEAELKELQAELEELEEELEELQEELER 458
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 507 VQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINI------HRDC 580
Cdd:TIGR02168 459 LEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELisvdegYEAA 538
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 581 LEN----GKEDLLEERNKELMKEYNYLKEKLL--------------QCEKEKAEREVIVREFQEELVDHLKT---FSISE 639
Cdd:TIGR02168 539 IEAalggRLQAVVVENLNAAKKAIAFLKQNELgrvtflpldsikgtEIQGNDREILKNIEGFLGVAKDLVKFdpkLRKAL 618
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 640 SPLEGTSHCHINLNETWTSKKKL-------------------------------FQVEIQPEEKHEEFRKLFELISLLNY 688
Cdd:TIGR02168 619 SYLLGGVLVVDDLDNALELAKKLrpgyrivtldgdlvrpggvitggsaktnssiLERRREIEELEEKIEELEEKIAELEK 698
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 689 TADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLA 768
Cdd:TIGR02168 699 ALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELA 778
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 769 KDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTH----------MEKDMVELGKLQEYKSELDERAVQEIEKLE 838
Cdd:TIGR02168 779 EAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEaanlrerlesLERRIAATERRLEDLEEQIEELSEDIESLA 858
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514181 839 EIHLQKQAEYEKQLEQLNK---------DNTASLK----KKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGA 901
Cdd:TIGR02168 859 AEIEELEELIEELESELEAllnerasleEALALLRseleELSEELRELESKRSELRRELEELREKLAQLELRLEGL 934
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
330-912 |
2.66e-06 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 51.98 E-value: 2.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 330 LKKDIAMLKEELYAIKNDSLRKE--------KKYIQEIKSIT-EINANFEKSVRLNEKMitktvARYSQQLNDLKAENAR 400
Cdd:TIGR02168 218 LKAELRELELALLVLRLEELREEleelqeelKEAEEELEELTaELQELEEKLEELRLEV-----SELEEEIEELQKELYA 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 401 LNSELEKEKHNKERLEAEVESLHSSLAtAINEYNEIVERKDLELvlwrADDVSRHEKmgsNISQLTDKNELLTEQVHKAR 480
Cdd:TIGR02168 293 LANEISRLEQQKQILRERLANLERQLE-ELEAQLEELESKLDEL----AEELAELEE---KLEELKEELESLEAELEELE 364
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 481 VKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMkqmhpngEAKESQSIGKQNSLEERIRQQELENLLLERQL 560
Cdd:TIGR02168 365 AELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERL-------EARLERLEDRRERLQQEIEELLKKLEEAELKE 437
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 561 EDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQE------ELVDHLKT 634
Cdd:TIGR02168 438 LQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGfsegvkALLKNQSG 517
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 635 FS---------IS---------ESPLEGtshchiNLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLLNYTADQIRKK 696
Cdd:TIGR02168 518 LSgilgvlselISvdegyeaaiEAALGG------RLQAVVVENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDR 591
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 697 NRELEEE-ATGYKKCLEMTINMLNAFANEDFSchGDLNTDQLKMDI-LFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVL 774
Cdd:TIGR02168 592 EILKNIEgFLGVAKDLVKFDPKLRKALSYLLG--GVLVVDDLDNALeLAKKLRPGYRIVTLDGDLVRPGGVITGGSAKTN 669
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 775 HqellSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELD------ERAVQEIEKLEEIHLQKQAEY 848
Cdd:TIGR02168 670 S----SILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRkeleelSRQISALRKDLARLEAEVEQL 745
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370514181 849 EKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAyEEVTTELEEFKEAFAGAVKANNSMSKKL 912
Cdd:TIGR02168 746 EERIAQLSKELTELEAEIEELEERLEEAEEELAEA-EAEIEELEAQIEQLKEELKALREALDEL 808
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
42-255 |
4.54e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 50.65 E-value: 4.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 42 AIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLL 121
Cdd:PHA02878 44 AVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTLVAIKDAFNNRNVEIFKIILTN 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 122 ECGANPNIEDIYGNTALHYAVYNkgTSLAERLLSHHANIEALNKE-GNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFK 200
Cdd:PHA02878 124 RYKNIQTIDLVYIDKKSKDDIIE--AEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTN 201
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514181 201 RTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLR-SIRQQILEH 255
Cdd:PHA02878 202 NSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYCKDyDILKLLLEH 257
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
264-841 |
5.29e-06 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 50.89 E-value: 5.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 264 LRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDS----QSYGKKKDAMYGNFM--LKKDIAML 337
Cdd:pfam15921 250 LKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQleiiQEQARNQNSMYMRQLsdLESTVSQL 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 338 KEELYAIKndslRKEKKYIQEI-KSITEINANFEKSvRLNEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERL- 415
Cdd:pfam15921 330 RSELREAK----RMYEDKIEELeKQLVLANSELTEA-RTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLw 404
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 416 --------------------EAEVESLHSSLATAINEYNEIVERKdLELVLWRADDVsrhEKMGSNISQLTDKNELLTEQ 475
Cdd:pfam15921 405 drdtgnsitidhlrrelddrNMEVQRLEALLKAMKSECQGQMERQ-MAAIQGKNESL---EKVSSLTAQLESTKEMLRKV 480
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 476 VHKARVKFNTLKGKLRETRD---ALREKTLALGS-----------VQLDLRQAQHRIKE---MKQMHPNGEAKESQSIGK 538
Cdd:pfam15921 481 VEELTAKKMTLESSERTVSDltaSLQEKERAIEAtnaeitklrsrVDLKLQELQHLKNEgdhLRNVQTECEALKLQMAEK 560
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 539 QNSLEerIRQQELENLLlerQL--EDARKEGdnkeiVINIHRDCLEngKEdlLEERNKELmKEYNYLKEKllqceKEKAE 616
Cdd:pfam15921 561 DKVIE--ILRQQIENMT---QLvgQHGRTAG-----AMQVEKAQLE--KE--INDRRLEL-QEFKILKDK-----KDAKI 620
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 617 REVIVREFQEELvDHLKTFSISESPLEGTSHCHIN----LNETWTSKKKLFQVEIQPEEKHEEFR-KLFELISLLNYTAD 691
Cdd:pfam15921 621 RELEARVSDLEL-EKVKLVNAGSERLRAVKDIKQErdqlLNEVKTSRNELNSLSEDYEVLKRNFRnKSEEMETTTNKLKM 699
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 692 QIRKKNRELEEEATGYKK-------CLEMTINMLNAFANEdfscHGDLNTDQLKMDILFKKLKQKFND---LVAEKEAVS 761
Cdd:pfam15921 700 QLKSAQSELEQTRNTLKSmegsdghAMKVAMGMQKQITAK----RGQIDALQSKIQFLEEAMTNANKEkhfLKEEKNKLS 775
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 762 SECVNLAKDNEVLHQELlsmrnvqekcEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQeyksELDERAVQEIEKLEEIH 841
Cdd:pfam15921 776 QELSTVATEKNKMAGEL----------EVLRSQERRLKEKVANMEVALDKASLQFAECQ----DIIQRQEQESVRLKLQH 841
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
167-220 |
6.74e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 44.57 E-value: 6.74e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1370514181 167 GNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLL 220
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
69-121 |
7.73e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 44.19 E-value: 7.73e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1370514181 69 RTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLL 121
Cdd:pfam13637 2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
153-207 |
1.02e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 43.87 E-value: 1.02e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514181 153 LLSH-HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILA 207
Cdd:pfam13857 1 LLEHgPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
221-904 |
1.19e-05 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 49.84 E-value: 1.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 221 QQNIRISSQDMFGQTAEDYALcsdlrsirQQILEHKNKMLKNHLRNDNQETAAMKPANLKkrkeRAKAEHNLKVAS--EE 298
Cdd:pfam12128 213 PPKSRLNRQQVEHWIRDIQAI--------AGIMKIRPEFTKLQQEFNTLESAELRLSHLH----FGYKSDETLIASrqEE 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 299 KQERLQRSENKQPQDSQSYGKKKDAMYGN-FMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNE 377
Cdd:pfam12128 281 RQETSAELNQLLRTLDDQWKEKRDELNGElSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLE 360
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 378 KMI-----------TKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVES--------LHSSLATAINEYNEIVE 438
Cdd:pfam12128 361 ERLkaltgkhqdvtAKYNRRRSKIKEQNNRDIAGIKDKLAKIREARDRQLAVAEDdlqaleseLREQLEAGKLEFNEEEY 440
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 439 RKDL----------------ELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTL 502
Cdd:pfam12128 441 RLKSrlgelklrlnqatatpELLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQS 520
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 503 ALGSVQLDLRQAQHRIKEMKqmhpNGEAKE-SQSIGKQNSLEERIRQQelenllLERQLEDARKEGDNKEIVINIHRDCL 581
Cdd:pfam12128 521 ALDELELQLFPQAGTLLHFL----RKEAPDwEQSIGKVISPELLHRTD------LDPEVWDGSVGGELNLYGVKLDLKRI 590
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 582 ENGK----EDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINL----N 653
Cdd:pfam12128 591 DVPEwaasEEELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEkdkkN 670
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 654 ETWTSKKKLFQVEIQPEEKheefrKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTInmlnafanedfschgDLN 733
Cdd:pfam12128 671 KALAERKDSANERLNSLEA-----QLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVEGAL---------------DAQ 730
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 734 TDQLKMDILFKKLKQKfNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDkkmlEEEVLNLKTHM-EKD 812
Cdd:pfam12128 731 LALLKAAIAARRSGAK-AELKALETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVR----RQEVLRYFDWYqETW 805
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 813 MVELGKLQEYKSELDeravQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKEL---TLKDVECKFSKMKTAYEEVTT 889
Cdd:pfam12128 806 LQRRPRLATQLSNIE----RAISELQQQLARLIADTKLRRAKLEMERKASEKQQVRlseNLRGLRCEMSKLATLKEDANS 881
|
730 740
....*....|....*....|....*..
gi 1370514181 890 E------------LEEFKEAFAGAVKA 904
Cdd:pfam12128 882 EqaqgsigerlaqLEDLKLKRDYLSES 908
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
34-88 |
1.23e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 43.80 E-value: 1.23e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1370514181 34 ELRKIHRAAIKGDAAEVERCLTRRFrDLDARDRKDRTVLHLACAHGRVQVVTLLL 88
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGA-DINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| COG5022 |
COG5022 |
Myosin heavy chain [General function prediction only]; |
279-890 |
2.91e-05 |
|
Myosin heavy chain [General function prediction only];
Pssm-ID: 227355 [Multi-domain] Cd Length: 1463 Bit Score: 48.54 E-value: 2.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 279 LKKRKE-RAKAEHNLKVASEEKQERLQRSENKQPQD----------SQSYGKKKDAmygnFMLKKDIAMLK--------- 338
Cdd:COG5022 806 LGSRKEyRSYLACIIKLQKTIKREKKLRETEEVEFSlkaevliqkfGRSLKAKKRF----SLLKKETIYLQsaqrvelae 881
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 339 ----EELYAIKNDSLRKEKKYiQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNdlkaeNARLNSELEKEKHNKER 414
Cdd:COG5022 882 rqlqELKIDVKSISSLKLVNL-ELESEIIELKKSLSSDLIENLEFKTELIARLKKLLN-----NIDLEEGPSIEYVKLPE 955
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 415 LEaEVESLHSSLATAINEYNEIVerkdlelvlwraddvsrhEKMGSNISQLTDKNELLtEQVHKARVKFNTLKGKLRETR 494
Cdd:COG5022 956 LN-KLHEVESKLKETSEEYEDLL------------------KKSTILVREGNKANSEL-KNFKKELAELSKQYGALQEST 1015
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 495 DALREKTLALGSVQLDLRQAQHRIKEMKQMhpngeaKESQSIGKQNSLEERIRQQELENLLLERQLEDA-RKEGDNKEIV 573
Cdd:COG5022 1016 KQLKELPVEVAELQSASKIISSESTELSIL------KPLQKLKGLLLLENNQLQARYKALKLRRENSLLdDKQLYQLEST 1089
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 574 INihrdcLENG-KEDLLEERNKELMKEYNYL--------KEKLLQCEKEKAEREVIVREFQEELVDHLKTFSISESPLEG 644
Cdd:COG5022 1090 EN-----LLKTiNVKDLEVTNRNLVKPANVLqfivaqmiKLNLLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEAN 1164
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 645 TSHCHINLNETWTSKKKLFQVEIQPEEKH------EEFRKLFELISLLNYTADQIRKKNRELEEEA---TGYKKCLEMTI 715
Cdd:COG5022 1165 LEALPSPPPFAALSEKRLYQSALYDEKSKlsssevNDLKNELIALFSKIFSGWPRGDKLKKLISEGwvpTEYSTSLKGFN 1244
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 716 NMLNAFAnedfschgdlNTDQLKMDILFKKLKQKFNDLVA---EKEAVSSECVNLAKDNEVLHQELLSMR---------- 782
Cdd:COG5022 1245 NLNKKFD----------TPASMSNEKLLSLLNSIDNLLSSyklEEEVLPATINSLLQYINVGLFNALRTKasslrwksat 1314
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 783 NVQEKCEklEKDKKMLEEEVLNLKTHMEKDM--VELGKLQEYK-SELDER--AVQ-----EIEKLeeIHLQKQAEYEKQL 852
Cdd:COG5022 1315 EVNYNSE--ELDDWCREFEISDVDEELEELIqaVKVLQLLKDDlNKLDELldACYslnpaEIQNL--KSRYDPADKENNL 1390
|
650 660 670
....*....|....*....|....*....|....*....
gi 1370514181 853 E-QLNKDNTASLKKKELTLKDveCKFSKMKTAYEEVTTE 890
Cdd:COG5022 1391 PkEILKKIEALLIKQELQLSL--EGKDETEVHLSEIFSE 1427
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
397-633 |
3.21e-05 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 48.39 E-value: 3.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 397 EN-ARLN---SELEKekhNKERLEAEVEslhsslaTAiNEYNEIVER-KDLELVLWRADDVSRHEKmgsnISQLTDKNEL 471
Cdd:COG1196 186 ENlERLEdilGELER---QLEPLERQAE-------KA-ERYRELKEElKELEAELLLLKLRELEAE----LEELEAELEE 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 472 LTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMkqmhpngEAKESQSIGKQNSLEERIRQQEL 551
Cdd:COG1196 251 LEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARL-------EQDIARLEERRRELEERLEELEE 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 552 ENLLLERQLEDARKEgdnkeivinihrdclengkEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELVDH 631
Cdd:COG1196 324 ELAELEEELEELEEE-------------------LEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEEL 384
|
..
gi 1370514181 632 LK 633
Cdd:COG1196 385 AE 386
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
590-932 |
3.70e-05 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 48.14 E-value: 3.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 590 EERNKELMKEYNYLKEKLlQCEKEKAEReviVREFQEELVDhlktfsisespLEGTSHCHiNLNETWTSKKklfQVEIQP 669
Cdd:TIGR02169 186 IERLDLIIDEKRQQLERL-RREREKAER---YQALLKEKRE-----------YEGYELLK-EKEALERQKE---AIERQL 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 670 EEKHEEFRKLFELISLLNytaDQIRKKNRELEEEAtgyKKCLEMTINMLNAFANEDFSCHGDLntDQLKMDILFKKLKQK 749
Cdd:TIGR02169 247 ASLEEELEKLTEEISELE---KRLEEIEQLLEELN---KKIKDLGEEEQLRVKEKIGELEAEI--ASLERSIAEKERELE 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 750 fnDLVAEkeavssecvnLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELG----KLQEYKSE 825
Cdd:TIGR02169 319 --DAEER----------LAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEevdkEFAETRDE 386
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 826 LDERaVQEIEKLEEIHLQKQAEYEKQLEQLNKdNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAVKAN 905
Cdd:TIGR02169 387 LKDY-REKLEKLKREINELKRELDRLQEELQR-LSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADL 464
|
330 340
....*....|....*....|....*..
gi 1370514181 906 NSMSKKLMKSDKKIAVISTKLfTEKQR 932
Cdd:TIGR02169 465 SKYEQELYDLKEEYDRVEKEL-SKLQR 490
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
38-205 |
3.90e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 47.65 E-value: 3.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 38 IHrAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAV-HSQEeac 116
Cdd:PHA02874 161 IH-IAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIiHNRS--- 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 117 AIVLLECGANPNIEDIYGNTALHYAV-YNKGTSLAERLLSHHANIEALNKEGNTPLLFAINS-RRQHMVEFLLKNQANIH 194
Cdd:PHA02874 237 AIELLINNASINDQDIDGSTPLHHAInPPCDIDIIDILLYHKADISIKDNKGENPIDTAFKYiNKDPVIKDIIANAVLIK 316
|
170
....*....|.
gi 1370514181 195 AVDNFKRTALI 205
Cdd:PHA02874 317 EADKLKDSDFL 327
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
272-918 |
4.06e-05 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 48.21 E-value: 4.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 272 AAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQpqdsqsygKKKDAMYGNFMLKKDIAMLKEElyaikndslrk 351
Cdd:PTZ00121 1180 AARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEAR--------KAEDAKKAEAVKKAEEAKKDAE----------- 1240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 352 EKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQLNDL-KAENARLNSELEKEKHNKERLEAEVESLHSSLATAI 430
Cdd:PTZ00121 1241 EAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELkKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEA 1320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 431 NEYNEIVERKDLELV-----LWRADDVSR--HEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDA--LREKT 501
Cdd:PTZ00121 1321 KKKAEEAKKKADAAKkkaeeAKKAAEAAKaeAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKAdeAKKKA 1400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 502 LALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCL 581
Cdd:PTZ00121 1401 EEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAE 1480
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 582 ENGKEDLLEERNKELMKEYNYLKEKllqcEKEKAEREVIVREFQEELVDHLKTFSISESPLEGTSHCHINLNETWTSKKK 661
Cdd:PTZ00121 1481 EAKKADEAKKKAEEAKKKADEAKKA----AEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEE 1556
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 662 LFQVEiqPEEKHEEFRKLFELISLLNYTADQIRK-KNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMD 740
Cdd:PTZ00121 1557 LKKAE--EKKKAEEAKKAEEDKNMALRKAEEAKKaEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKK 1634
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 741 ILFKKLKQ-----KFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVE 815
Cdd:PTZ00121 1635 VEQLKKKEaeekkKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEE 1714
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 816 LGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKElTLKDVECKFSKMKTAYEEVTTELEEFK 895
Cdd:PTZ00121 1715 KKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEE-EKKAEEIRKEKEAVIEEELDEEDEKRR 1793
|
650 660
....*....|....*....|...
gi 1370514181 896 EAFAGAVKANNSMSKKLMKSDKK 918
Cdd:PTZ00121 1794 MEVDKKIKDIFDNFANIIEGGKE 1816
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
54-105 |
4.91e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 41.95 E-value: 4.91e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1370514181 54 LTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPL 105
Cdd:pfam13857 2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
60-175 |
5.33e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 47.37 E-value: 5.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 60 DLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDICDRLNRTPLMKAVHSQEEACAI-VLLECGANPNIEDIYGNTAL 138
Cdd:PHA02876 367 NVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPYMSVkTLIDRGANVNSKNKDLSTPL 446
|
90 100 110
....*....|....*....|....*....|....*...
gi 1370514181 139 HYAVYNK-GTSLAERLLSHHANIEALNKEGNTPLLFAI 175
Cdd:PHA02876 447 HYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIAL 484
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
133-165 |
7.97e-05 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 40.74 E-value: 7.97e-05
10 20 30
....*....|....*....|....*....|....
gi 1370514181 133 YGNTALHYAVYNKG-TSLAERLLSHHANIEALNK 165
Cdd:pfam00023 1 DGNTPLHLAAGRRGnLEIVKLLLSKGADVNARDK 34
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
101-154 |
8.25e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 41.49 E-value: 8.25e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1370514181 101 NRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLL 154
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Cast |
pfam10174 |
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ... |
282-523 |
9.21e-05 |
|
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.
Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 46.74 E-value: 9.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 282 RKERAKAEHNLKVASEEKQERLQR-SENKQPQDSQ-SYGKKKDamygNFMLKKDIAMLKEELYAIKndsLRKEKKYIQEI 359
Cdd:pfam10174 474 KKENKDLKEKVSALQPELTEKESSlIDLKEHASSLaSSGLKKD----SKLKSLEIAVEQKKEECSK---LENQLKKAHNA 546
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 360 KSITEINANFEKSVRLNEKmitkTVARYSQQLNDLKAENARLNS---ELEKEKHNKERLEAEVESLHS------SLATAI 430
Cdd:pfam10174 547 EEAVRTNPEINDRIRLLEQ----EVARYKEESGKAQAEVERLLGilrEVENEKNDKDKKIAELESLTLrqmkeqNKKVAN 622
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 431 NEYNEIVERKDLELVLWRAddvsRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLD 510
Cdd:pfam10174 623 IKHGQQEMKKKGAQLLEEA----RRREDNLADNSQQLQLEELMGALEKTRQELDATKARLSSTQQSLAEKDGHLTNLRAE 698
|
250
....*....|...
gi 1370514181 511 LRQAQHRIKEMKQ 523
Cdd:pfam10174 699 RRKQLEEILEMKQ 711
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
330-627 |
1.06e-04 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 46.60 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 330 LKKDIAMLKEELYAIKN--DSLRKEKKYI-QEIKSITEINANFEKSVRLNEK---MITKTVARYSQQLNDLKAENARLNS 403
Cdd:TIGR02169 672 EPAELQRLRERLEGLKRelSSLQSELRRIeNRLDELSQELSDASRKIGEIEKeieQLEQEEEKLKERLEELEEDLSSLEQ 751
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 404 ELEKEKHNKERLEAEVESLHSslatAINEYNEIVErkDLElvlwraDDVSRHEkmgsnISQLTDKNELLTEQVHKarvkf 483
Cdd:TIGR02169 752 EIENVKSELKELEARIEELEE----DLHKLEEALN--DLE------ARLSHSR-----IPEIQAELSKLEEEVSR----- 809
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 484 ntLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDA 563
Cdd:TIGR02169 810 --IEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDL 887
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370514181 564 RKEGDNKEivinIHRDCLENGKEDLLEERNKeLMKEYNYLKEKLLQCEKEKAEREVIVREFQEE 627
Cdd:TIGR02169 888 KKERDELE----AQLRELERKIEELEAQIEK-KRKRLSELKAKLEALEEELSEIEDPKGEDEEI 946
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
265-920 |
1.13e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 46.67 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 265 RNDNQETAAMKPAnlKKRKERAKAEHNLKVASEEK-QERLQRSEN----KQPQDSQSYGKKKDAMYGNFMLKKDIAMLKE 339
Cdd:PTZ00121 1084 KEDNRADEATEEA--FGKAEEAKKTETGKAEEARKaEEAKKKAEDarkaEEARKAEDARKAEEARKAEDAKRVEIARKAE 1161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 340 ELYAIKNDSLRKEKKYIQEIKSITEINANFEksVRLNEKMITKTVARYSQqlNDLKAENARLNSELEKEKHNKERLEAEV 419
Cdd:PTZ00121 1162 DARKAEEARKAEDAKKAEAARKAEEVRKAEE--LRKAEDARKAEAARKAE--EERKAEEARKAEDAKKAEAVKKAEEAKK 1237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 420 ESLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELL-TEQVHKA--RVKFNTLKGKLRETRDA 496
Cdd:PTZ00121 1238 DAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKkADEAKKAeeKKKADEAKKKAEEAKKA 1317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 497 LREKTLAlGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDNKEIVINI 576
Cdd:PTZ00121 1318 DEAKKKA-EEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEA 1396
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 577 HRDCLENGKEDLLEERNKELMKEYNYLKEKLLqcEKEKAErEVIVREFQEELVDHLKTFSISESPLEgtshchiNLNETW 656
Cdd:PTZ00121 1397 KKKAEEDKKKADELKKAAAAKKKADEAKKKAE--EKKKAD-EAKKKAEEAKKADEAKKKAEEAKKAE-------EAKKKA 1466
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 657 TSKKKLFQVEIQPEE--KHEEFRKlfelisllnyTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANEDFSCHGDLNT 734
Cdd:PTZ00121 1467 EEAKKADEAKKKAEEakKADEAKK----------KAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKA 1536
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 735 DQLKMDILFKK---LKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKceKLEKDKKMLEEEVLNLKTHMEK 811
Cdd:PTZ00121 1537 DEAKKAEEKKKadeLKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEA--RIEEVMKLYEEEKKMKAEEAKK 1614
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 812 DMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKEltlkdveckfSKMKTAYEEVTTEL 891
Cdd:PTZ00121 1615 AEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKA----------EEDKKKAEEAKKAE 1684
|
650 660
....*....|....*....|....*....
gi 1370514181 892 EEFKEAfAGAVKANNSMSKKLMKSDKKIA 920
Cdd:PTZ00121 1685 EDEKKA-AEALKKEAEEAKKAEELKKKEA 1712
|
|
| PHA02736 |
PHA02736 |
Viral ankyrin protein; Provisional |
64-191 |
1.60e-04 |
|
Viral ankyrin protein; Provisional
Pssm-ID: 165103 [Multi-domain] Cd Length: 154 Bit Score: 43.33 E-value: 1.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 64 RDRKDRTVLHLACAHGrvQVVTLLLHRRCQID----ICDRLNR--TPLMKAVHSQEEACAI----VLLECGANPNIED-I 132
Cdd:PHA02736 13 PDIEGENILHYLCRNG--GVTDLLAFKNAISDenryLVLEYNRhgKQCVHIVSNPDKADPQeklkLLMEWGADINGKErV 90
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 133 YGNTALHYAVYNKGTSLAERLLSH-HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQA 191
Cdd:PHA02736 91 FGNTPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTPYYVACERHDAKMMNILRAKGA 150
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
86-141 |
2.39e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 40.02 E-value: 2.39e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514181 86 LLLHRRCQIDICDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYA 141
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
468-902 |
4.03e-04 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 44.37 E-value: 4.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 468 KNELLTEQVHKARVKFNTLKGK---LRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQ--NSL 542
Cdd:COG4717 65 KPELNLKELKELEEELKEAEEKeeeYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEALEAelAEL 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 543 EERIRQ--QELENLL-LERQLEDARKEGDNKEIVINIHRDCLENGKEDLLE---ERNKELMKEYNYLKEKLLQCEKEKAE 616
Cdd:COG4717 145 PERLEEleERLEELReLEEELEELEAELAELQEELEELLEQLSLATEEELQdlaEELEELQQRLAELEEELEEAQEELEE 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 617 REVIVREFQEELVDH--------LKTFSISESPLEGTSHCHINLNETWTSKKKLFQVEIQPEEKHEEFRKLFELISLLNY 688
Cdd:COG4717 225 LEEELEQLENELEAAaleerlkeARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEA 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 689 TADQIRKKNRELEEEA-TGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKfnDLVAEKEAVssecvnL 767
Cdd:COG4717 305 EELQALPALEELEEEElEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLE--ELEQEIAAL------L 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 768 AKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMvELGKLQEYKSELD--ERAVQEIEKLEEIHLQKQ 845
Cdd:COG4717 377 AEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELL-EALDEEELEEELEelEEELEELEEELEELREEL 455
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370514181 846 AEYEKQLEQLNKDNTASLKKKEL-----TLKDVECKFSKMKTAYEEVTTELEEFKEAFAGAV 902
Cdd:COG4717 456 AELEAELEQLEEDGELAELLQELeelkaELRELAEEWAALKLALELLEEAREEYREERLPPV 517
|
|
| YkyA |
pfam10368 |
Putative cell-wall binding lipoprotein; YkyA is a family of proteins containing a lipoprotein ... |
783-897 |
4.03e-04 |
|
Putative cell-wall binding lipoprotein; YkyA is a family of proteins containing a lipoprotein signal and a hydrolase domain. It is similar to cell wall binding proteins and might also be recognisable by a host immune defence system. It is thus likely to belong to pathways important for pathogenicity.
Pssm-ID: 431235 [Multi-domain] Cd Length: 185 Bit Score: 42.58 E-value: 4.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 783 NVQEKCEKLEKDKKMLE---EEVLNLKTHMEKdmVELGKLQEYKSELderaVQEIEKLEEIHLQKQAEYEKQLEqLNKDN 859
Cdd:pfam10368 62 NVEEREELLEKEKESIEeakEEFKKIKEIIEE--IEDEELKKEAEEL----IDAMEERYEAYDELYDAYKKALE-LDKEL 134
|
90 100 110
....*....|....*....|....*....|....*...
gi 1370514181 860 TASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEA 897
Cdd:pfam10368 135 YEMLKDEDLTLEELQEQIEKINESYEEVKEANEQFNEY 172
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
244-445 |
4.07e-04 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 44.72 E-value: 4.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 244 DLRSIRQQILeHKNKMLKNHLRNDNQETAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDA 323
Cdd:pfam15921 650 DIKQERDQLL-NEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKV 728
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 324 MYGnfmLKKDIAMLKEELyaiknDSLRKEKKYIQEIKSiteiNANFEKSVRLNEKmitktvARYSQQLNDLKAENARLNS 403
Cdd:pfam15921 729 AMG---MQKQITAKRGQI-----DALQSKIQFLEEAMT----NANKEKHFLKEEK------NKLSQELSTVATEKNKMAG 790
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1370514181 404 ELEKEKHNKERLEAEVESLHSSLATAINEYNE---IVERKDLELV 445
Cdd:pfam15921 791 ELEVLRSQERRLKEKVANMEVALDKASLQFAEcqdIIQRQEQESV 835
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
349-954 |
5.15e-04 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 44.33 E-value: 5.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 349 LRKEKKYIQEIKSITE-INANFEKSVRLNEKMITKTVA--RYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSS 425
Cdd:pfam05483 115 IEAQRKAIQELQFENEkVSLKLEEEIQENKDLIKENNAtrHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEK 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 426 LATAINEYNEIVERKDLELVLWRADDVSR----HEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDA---LR 498
Cdd:pfam05483 195 MILAFEELRVQAENARLEMHFKLKEDHEKiqhlEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKanqLE 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 499 EKT-LALGSVQLDLRQAQHRIKEMKQMhpngEAKESQSIGKQNSLEE--RIRQQELENLLLER--QLEDARKEGDNKEIV 573
Cdd:pfam05483 275 EKTkLQDENLKELIEKKDHLTKELEDI----KMSLQRSMSTQKALEEdlQIATKTICQLTEEKeaQMEELNKAKAAHSFV 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 574 INiHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREvivrefqeelvDHLKTFSISESPLEgtshchiNLN 653
Cdd:pfam05483 351 VT-EFEATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELE-----------EMTKFKNNKEVELE-------ELK 411
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 654 ETWTSKKKLFQVEIQPEEKHEEFR-KLFELISLLnytadQIRKKN-RELEEEATGYKKCLEmtinmlnafanedfscHGD 731
Cdd:pfam05483 412 KILAEDEKLLDEKKQFEKIAEELKgKEQELIFLL-----QAREKEiHDLEIQLTAIKTSEE----------------HYL 470
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 732 LNTDQLKMDILFKKLKQKfndlvaekeAVSSECVNLAKDNEVLHQELLSMrnvqekceKLEKDKKmlEEEVLNLKTHMEK 811
Cdd:pfam05483 471 KEVEDLKTELEKEKLKNI---------ELTAHCDKLLLENKELTQEASDM--------TLELKKH--QEDIINCKKQEER 531
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 812 DMVELGKLQEYKSELDEravqEIEKLEEIHLQKQAEYEKQL---EQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVT 888
Cdd:pfam05483 532 MLKQIENLEEKEMNLRD----ELESVREEFIQKGDEVKCKLdksEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKN 607
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514181 889 TELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENL 954
Cdd:pfam05483 608 KNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKISEEKL 673
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
348-896 |
5.71e-04 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 44.33 E-value: 5.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 348 SLRKEKKYIQEIKSITEINANFEKSVrlnEKMITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLA 427
Cdd:pfam05483 167 SAEKTKKYEYEREETRQVYMDLNNNI---EKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVS 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 428 TAINEYNEIVER-KDLELVLWRADDvsrhekmgsNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGS 506
Cdd:pfam05483 244 LLLIQITEKENKmKDLTFLLEESRD---------KANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKA 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 507 VQLDLRQAQHRIKEMK-----QMHPNGEAKESQSI------GKQNSLEERIR--QQELEN-------LLLERQ-----LE 561
Cdd:pfam05483 315 LEEDLQIATKTICQLTeekeaQMEELNKAKAAHSFvvtefeATTCSLEELLRteQQRLEKnedqlkiITMELQkksseLE 394
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 562 DARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEK----LLQC-EKEKAEREVIV------REFQEELVD 630
Cdd:pfam05483 395 EMTKFKNNKEVELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQelifLLQArEKEIHDLEIQLtaiktsEEHYLKEVE 474
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 631 HLKTFSISES--PLEGTSHCHINLNETwtskKKLFQveiQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYK 708
Cdd:pfam05483 475 DLKTELEKEKlkNIELTAHCDKLLLEN----KELTQ---EASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLR 547
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 709 KCLEMTINMLNAFANEdFSCHGD--------LNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQ---- 776
Cdd:pfam05483 548 DELESVREEFIQKGDE-VKCKLDkseenarsIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKkgsa 626
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 777 ELLSMRNVQEKCEKLE---------------------KDKKMLEEEVLNlktHMEKDMVELGKLQEYKSELDERAVQEIE 835
Cdd:pfam05483 627 ENKQLNAYEIKVNKLElelasakqkfeeiidnyqkeiEDKKISEEKLLE---EVEKAKAIADEAVKLQKEIDKRCQHKIA 703
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514181 836 KLEEIHLQKQAEYEKQLEQlnKDNTASLKK----KELTLK-DVECKFSKMKTAYEEVTTELEEFKE 896
Cdd:pfam05483 704 EMVALMEKHKHQYDKIIEE--RDSELGLYKnkeqEQSSAKaALEIELSNIKAELLSLKKQLEIEKE 767
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
460-631 |
6.66e-04 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 42.60 E-value: 6.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 460 SNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGE-AKESQSIGK 538
Cdd:COG1579 17 SELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRnNKEYEALQK 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 539 Q-NSLEERIRQQELENLLLERQLEDARKEGDNKEIVINihrdclenGKEDLLEERNKELMKEYNYLKEKLlqcEKEKAER 617
Cdd:COG1579 97 EiESLKRRISDLEDEILELMERIEELEEELAELEAELA--------ELEAELEEKKAELDEELAELEAEL---EELEAER 165
|
170
....*....|....
gi 1370514181 618 EVIVREFQEELVDH 631
Cdd:COG1579 166 EELAAKIPPELLAL 179
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
330-599 |
7.33e-04 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 43.77 E-value: 7.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 330 LKKDIAMLKEELYAIKNDSLRKEKKYIQ-EIKSITEINANFEKSVRLNEKMITK---TVARYSQQLNDLKAENARLNSEL 405
Cdd:COG1196 218 LKEELKELEAELLLLKLRELEAELEELEaELEELEAELEELEAELAELEAELEElrlELEELELELEEAQAEEYELLAEL 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 406 EKEKH--------------NKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRADDVSRHEkmgsnisQLTDKNEL 471
Cdd:COG1196 298 ARLEQdiarleerrreleeRLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAE-------AEEALLEA 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 472 LTEQVHKARVKFNTLKGKLRETRDALREKTlALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQEL 551
Cdd:COG1196 371 EAELAEAEEELEELAEELLEALRAAAELAA-QLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAE 449
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1370514181 552 ENLLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKE 599
Cdd:COG1196 450 EEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLL 497
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
246-441 |
1.05e-03 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 43.52 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 246 RSIRQQILEHKnkmlKNHLRNDNQETAAmkpanlkKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKkkdamy 325
Cdd:TIGR02169 824 LTLEKEYLEKE----IQELQEQRIDLKE-------QIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGD------ 886
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 326 gnfmLKKDIAMLKEELyaikndslRKEKKYIQEIKSiteinANFEKSVRLNEKMITKTVArySQQLNDLKAENARLNSE- 404
Cdd:TIGR02169 887 ----LKKERDELEAQL--------RELERKIEELEA-----QIEKKRKRLSELKAKLEAL--EEELSEIEDPKGEDEEIp 947
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1370514181 405 -----LEKEKHNKERLEAEVESLHSSLATAINEYNEIVERKD 441
Cdd:TIGR02169 948 eeelsLEDVQAELQRVEEEIRALEPVNMLAIQEYEEVLKRLD 989
|
|
| PRK11281 |
PRK11281 |
mechanosensitive channel MscK; |
775-901 |
1.34e-03 |
|
mechanosensitive channel MscK;
Pssm-ID: 236892 [Multi-domain] Cd Length: 1113 Bit Score: 42.98 E-value: 1.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 775 HQELLSMRNVQEKCEKLeKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDErAVQEIEKLEeihlQKQAEYEKQLEQ 854
Cdd:PRK11281 32 NGDLPTEADVQAQLDAL-NKQKLLEAEDKLVQQDLEQTLALLDKIDRQKEETEQ-LKQQLAQAP----AKLRQAQAELEA 105
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1370514181 855 LNKDNTASLKK--KELTLKDVECKFskmktayEEVTTELEEFKEAFAGA 901
Cdd:PRK11281 106 LKDDNDEETREtlSTLSLRQLESRL-------AQTLDQLQNAQNDLAEY 147
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
319-711 |
1.46e-03 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 43.11 E-value: 1.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 319 KKKDAMYGNFMLKKDIAMLKEELYAIKNDSLRKEKKYIQEIKSiteinaNFEKsvrlNEKMItKTVARYSQQLNDLKAEN 398
Cdd:TIGR00606 723 KRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKN------DIEE----QETLL-GTIMPEEESAKVCLTDV 791
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 399 ARLNSELEKEKHNKERLEAEVESLHSS-LATAINEYNEIVERKDLELvlwraddvsrhEKMGSNISQLTDKNELLTEQVH 477
Cdd:TIGR00606 792 TIMERFQMELKDVERKIAQQAAKLQGSdLDRTVQQVNQEKQEKQHEL-----------DTVVSKIELNRKLIQDQQEQIQ 860
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 478 KARVKFNTLKG-KLRETRDALREKTLALGSVQLdLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLL 556
Cdd:TIGR00606 861 HLKSKTNELKSeKLQIGTNLQRRQQFEEQLVEL-STEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKA 939
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 557 ERQLEDARKEGDNkeivINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEElvdhLKTFS 636
Cdd:TIGR00606 940 QDKVNDIKEKVKN----IHGYMKDIENKIQDGKDDYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRQD----IDTQK 1011
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 637 ISESPLEGTSHCHINLNETWTSKKKLFQV-----EIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCL 711
Cdd:TIGR00606 1012 IQERWLQDNLTLRKRENELKEVEEELKQHlkemgQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKEL 1091
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
166-198 |
1.61e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 37.27 E-value: 1.61e-03
10 20 30
....*....|....*....|....*....|....
gi 1370514181 166 EGNTPLLFAINSRRQH-MVEFLLKNQANIHAVDN 198
Cdd:pfam00023 1 DGNTPLHLAAGRRGNLeIVKLLLSKGADVNARDK 34
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
249-594 |
2.08e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 42.44 E-value: 2.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 249 RQQILEHKNKMLKNHLRNDNQETAAMKPANLKKRKE-RAKAEHnLKVASEEKQ--ERLQRSENKQPQDSQSYGKKKDAMy 325
Cdd:PTZ00121 1582 KAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEaKIKAEE-LKKAEEEKKkvEQLKKKEAEEKKKAEELKKAEEEN- 1659
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 326 gnfMLKKDIAMLKEELYAIKNDSLRKE-----------KKYIQEIKSITEINANFEKSVRLNEKMitktvaRYSQQLNDL 394
Cdd:PTZ00121 1660 ---KIKAAEEAKKAEEDKKKAEEAKKAeedekkaaealKKEAEEAKKAEELKKKEAEEKKKAEEL------KKAEEENKI 1730
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 395 KAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVeRKDLELVL---WRADDVSRHEKMGSNISQLTDKNEL 471
Cdd:PTZ00121 1731 KAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEI-RKEKEAVIeeeLDEEDEKRRMEVDKKIKDIFDNFAN 1809
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 472 LTEQVHKARVKFNTLKgklrETRD-ALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQ-- 548
Cdd:PTZ00121 1810 IIEGGKEGNLVINDSK----EMEDsAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEie 1885
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1370514181 549 -----QELENLLLERQLEDARKEGDNKEIvINIHRDCLENGKEDLLEERNK 594
Cdd:PTZ00121 1886 eadeiEKIDKDDIEREIPNNNMAGKNNDI-IDDKLDKDEYIKRDAEETREE 1935
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
249-896 |
2.30e-03 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 42.34 E-value: 2.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 249 RQQILEHKNKMLKNHLRNDNQETAAMKPAnLKKRKERAKAEHNLKVASE---------------EKQERLQRSENKQPQD 313
Cdd:TIGR00606 445 KKEILEKKQEELKFVIKELQQLEGSSDRI-LELDQELRKAERELSKAEKnsltetlkkevkslqNEKADLDRKLRKLDQE 523
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 314 SQSYGKKKDAMYGNFMLKKDIAMLKEELYAIKNdslrkekkyiQEIKSITEINANFEksvrlNEKMITKTVARYSQQLND 393
Cdd:TIGR00606 524 MEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKS----------RHSDELTSLLGYFP-----NKKQLEDWLHSKSKEINQ 588
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 394 LKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEIVERKDLELVLWRaddvsrhekmgsnisqltdknelLT 473
Cdd:TIGR00606 589 TRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVCGSQDEESDLER-----------------------LK 645
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 474 EQVHKARVKFNTLKGKLRETRDALREKTLALGSVQLDLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELEN 553
Cdd:TIGR00606 646 EEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRR 725
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 554 LLLERQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKelMKEYNYLKEKLLQCEK--EKAEREV-IVREFQEELVD 630
Cdd:TIGR00606 726 DEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKND--IEEQETLLGTIMPEEEsaKVCLTDVtIMERFQMELKD 803
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 631 HLKTFSISESPLEGtshchINLNETWTskkklfQVEIQPEEKHEEFRKLFELISLLnytadqirkknreleeeatgyKKC 710
Cdd:TIGR00606 804 VERKIAQQAAKLQG-----SDLDRTVQ------QVNQEKQEKQHELDTVVSKIELN---------------------RKL 851
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 711 LEmtinmlnafanedfschgdlntDQLKMdilFKKLKQKFNDLVAEKEAVSSecvNLAKDNEVLHQELLSMRNVQEkCEK 790
Cdd:TIGR00606 852 IQ----------------------DQQEQ---IQHLKSKTNELKSEKLQIGT---NLQRRQQFEEQLVELSTEVQS-LIR 902
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 791 LEKDKKmleEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEiHLQKQAEYEKQLEQLNKDNtaslkkKELTL 870
Cdd:TIGR00606 903 EIKDAK---EQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKE-KVKNIHGYMKDIENKIQDG------KDDYL 972
|
650 660
....*....|....*....|....*.
gi 1370514181 871 KDVECKFSKMKTAYEEVTTELEEFKE 896
Cdd:TIGR00606 973 KQKETELNTVNAQLEECEKHQEKINE 998
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
380-550 |
2.96e-03 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 41.35 E-value: 2.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 380 ITKTVARYSQQLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNE-----------------IVERKDL 442
Cdd:COG3883 35 AQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGEraralyrsggsvsyldvLLGSESF 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 443 ELVLWRADdvsrhekmgsNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQldlRQAQHRIKEMK 522
Cdd:COG3883 115 SDFLDRLS----------ALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAK---AELEAQQAEQE 181
|
170 180
....*....|....*....|....*...
gi 1370514181 523 QMHPNGEAKESQSIGKQNSLEERIRQQE 550
Cdd:COG3883 182 ALLAQLSAEEAAAEAQLAELEAELAAAE 209
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
793-893 |
3.94e-03 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 41.30 E-value: 3.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 793 KDKKMLE--EEVLNLKTHMEKdmvelgklqeyksELDERAvQEIEKLEEIHLQKQAEYEKQLEQLNK-DNTASLKKKELT 869
Cdd:PRK12704 55 KKEALLEakEEIHKLRNEFEK-------------ELRERR-NELQKLEKRLLQKEENLDRKLELLEKrEEELEKKEKELE 120
|
90 100
....*....|....*....|....*.
gi 1370514181 870 --LKDVECKFSKMKTAYEEVTTELEE 893
Cdd:PRK12704 121 qkQQELEKKEEELEELIEEQLQELER 146
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
93-235 |
3.99e-03 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 41.22 E-value: 3.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 93 QIDICDRLNRTPLMKAVHSQEEACAIVLLEcgaNPNIEDIYGNTALHYAVYN-----------KGTSLAERLLSHHANIE 161
Cdd:TIGR00870 44 NINCPDRLGRSALFVAAIENENLELTELLL---NLSCRGAVGDTLLHAISLEyvdaveaillhLLAAFRKSGPLELANDQ 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 162 ALNKE--GNTPLLFAINSRRQHMVEFLLKNQANIHA------------VDNFK--RTALILAVQHNLSSIVTLLLQQNIR 225
Cdd:TIGR00870 121 YTSEFtpGITALHLAAHRQNYEIVKLLLERGASVPAracgdffvksqgVDSFYhgESPLNAAACLGSPSIVALLSEDPAD 200
|
170
....*....|
gi 1370514181 226 ISSQDMFGQT 235
Cdd:TIGR00870 201 ILTADSLGNT 210
|
|
| TRPV1 |
cd22196 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ... |
167-235 |
4.87e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411980 [Multi-domain] Cd Length: 649 Bit Score: 40.94 E-value: 4.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 167 GNTPLLFAINSRRQHMVEFLLKNQANIHAVDN---FKRTA-----------LILAVQHNLSSIVTLLLQ---QNIRISSQ 229
Cdd:cd22196 94 GQTALHIAIERRNMHLVELLVQNGADVHARASgefFKKKKggpgfyfgelpLSLAACTNQLDIVKFLLEnphSPADISAR 173
|
....*.
gi 1370514181 230 DMFGQT 235
Cdd:cd22196 174 DSMGNT 179
|
|
| TRPV1 |
cd22196 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ... |
134-204 |
5.63e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411980 [Multi-domain] Cd Length: 649 Bit Score: 40.94 E-value: 5.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 134 GNTALHYAVYNKGTSLAERLLSHHANIEA--------LNKEGN------TPLLFAINSRRQHMVEFLLKNQ---ANIHAV 196
Cdd:cd22196 94 GQTALHIAIERRNMHLVELLVQNGADVHArasgeffkKKKGGPgfyfgeLPLSLAACTNQLDIVKFLLENPhspADISAR 173
|
....*...
gi 1370514181 197 DNFKRTAL 204
Cdd:cd22196 174 DSMGNTVL 181
|
|
| CCDC22 |
pfam05667 |
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ... |
423-626 |
5.74e-03 |
|
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.
Pssm-ID: 461708 [Multi-domain] Cd Length: 600 Bit Score: 40.78 E-value: 5.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 423 HSSLATAINEYNEIVERKDLELVLWRADDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTL 502
Cdd:pfam05667 258 SAALAGTEATSGASRSAQDLAELLSSFSGSSTTDTGLTKGSRFTHTEKLQFTNEAPAATSSPPTKVETEEELQQQREEEL 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 503 AlgSVQLDLRQAQHRIKEMKqmhpnGEAKESQSIGKQnsLEERIRQQELENLLLERQLEDARK------EGDN-----KE 571
Cdd:pfam05667 338 E--ELQEQLEDLESSIQELE-----KEIKKLESSIKQ--VEEELEELKEQNEELEKQYKVKKKtldllpDAEEniaklQA 408
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1370514181 572 IVINIHRDCLENGKEdlLEERNKELMKEYNYLKEkllQCEKEKAEREVIVREFQE 626
Cdd:pfam05667 409 LVDASAQRLVELAGQ--WEKHRVPLIEEYRALKE---AKSNKEDESQRKLEEIKE 458
|
|
| TRPV1-4 |
cd22193 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ... |
166-235 |
5.84e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411977 [Multi-domain] Cd Length: 607 Bit Score: 40.93 E-value: 5.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 166 EGNTPLLFAINSRRQHMVEFLLKNQANIHAVDN--------------FKRTALILAVQHNLSSIVTLLLQ---QNIRISS 228
Cdd:cd22193 75 EGQTALHIAIERRQGDIVALLVENGADVHAHAKgrffqpkyqgegfyFGELPLSLAACTNQPDIVQYLLEnehQPADIEA 154
|
....*..
gi 1370514181 229 QDMFGQT 235
Cdd:cd22193 155 QDSRGNT 161
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
464-895 |
5.85e-03 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 40.87 E-value: 5.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 464 QLTDKNELLTEQVHKARVKFNTLKGKLRET---RDALREKTLALGSVQLDLR-QAQHRIKEMKQmhpnGEAKESQSIGKQ 539
Cdd:pfam15921 93 RLNESNELHEKQKFYLRQSVIDLQTKLQEMqmeRDAMADIRRRESQSQEDLRnQLQNTVHELEA----AKCLKEDMLEDS 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 540 NSLEERIRQ---------QELENLLLERQLEDARK--EGDNkeiVINIHRDCLENGKEDLLeernKELMKEYNYLKEKLL 608
Cdd:pfam15921 169 NTQIEQLRKmmlshegvlQEIRSILVDFEEASGKKiyEHDS---MSTMHFRSLGSAISKIL----RELDTEISYLKGRIF 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 609 ----QCEKEKAEREVIVREFQEELVDHLKTFsISESPLEGTShchinLNETWTSKKKLF-----QVEIQPEEKHEE---- 675
Cdd:pfam15921 242 pvedQLEALKSESQNKIELLLQQHQDRIEQL-ISEHEVEITG-----LTEKASSARSQAnsiqsQLEIIQEQARNQnsmy 315
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 676 FRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANE--DFSCHGDLNTDQLKMdiLFKKLKQKFNDL 753
Cdd:pfam15921 316 MRQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANSELTEARTErdQFSQESGNLDDQLQK--LLADLHKREKEL 393
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 754 VAEKEAvSSECVNLAKDNEVLHQEL---LSMRNVQekCEKLEKDKKMLEEEVlnlKTHMEKDMV-------ELGKLQEYK 823
Cdd:pfam15921 394 SLEKEQ-NKRLWDRDTGNSITIDHLrreLDDRNME--VQRLEALLKAMKSEC---QGQMERQMAaiqgkneSLEKVSSLT 467
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370514181 824 SELdERAVQEIEKLEEIHLQKQAEYEKQlEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFK 895
Cdd:pfam15921 468 AQL-ESTKEMLRKVVEELTAKKMTLESS-ERTVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQHLK 537
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
69-99 |
6.92e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 35.34 E-value: 6.92e-03
10 20 30
....*....|....*....|....*....|..
gi 1370514181 69 RTVLHLACAH-GRVQVVTLLLHRRCQIDICDR 99
Cdd:pfam00023 3 NTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
133-162 |
7.01e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 35.26 E-value: 7.01e-03
10 20 30
....*....|....*....|....*....|
gi 1370514181 133 YGNTALHYAVYNKGTSLAERLLSHHANIEA 162
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
390-899 |
7.60e-03 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 40.41 E-value: 7.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 390 QLNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLAtainEYNEivERKDLELVLWRADDVSrhekmgSNISQLTDKN 469
Cdd:PRK02224 207 RLNGLESELAELDEEIERYEEQREQARETRDEADEVLE----EHEE--RREELETLEAEIEDLR------ETIAETERER 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 470 ELLTEQVHKARVKFNTLkgklRETRDALREKTlALGSvqLDLRQAQHRIKEMkqmhpngEAKESQsigkqnsLEERIRQQ 549
Cdd:PRK02224 275 EELAEEVRDLRERLEEL----EEERDDLLAEA-GLDD--ADAEAVEARREEL-------EDRDEE-------LRDRLEEC 333
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 550 ELENLLLERQLEDARKEGDNkeivinihrdclengkedlLEERNKELMKEYNYLKEKLLQCEKEKAEREVIVREFQEELV 629
Cdd:PRK02224 334 RVAAQAHNEEAESLREDADD-------------------LEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIE 394
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 630 DHLKTFSISESPLEGTSHCHINLnetwtskkklfqveiqpEEKHEEFR-KLFELISLLNyTADQIRKKNRELEEEAtgyk 708
Cdd:PRK02224 395 ELRERFGDAPVDLGNAEDFLEEL-----------------REERDELReREAELEATLR-TARERVEEAEALLEAG---- 452
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 709 KCLEmtinmlnafanedfsCHGDLNtDQLKMDILFKKlKQKFNDLVAEKEAVSSECVNLAKDnevlHQELLSMRNVQEKC 788
Cdd:PRK02224 453 KCPE---------------CGQPVE-GSPHVETIEED-RERVEELEAELEDLEEEVEEVEER----LERAEDLVEAEDRI 511
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514181 789 EKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKqLEQLNKDNTAsLKKKEL 868
Cdd:PRK02224 512 ERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREE-VAELNSKLAE-LKERIE 589
|
490 500 510
....*....|....*....|....*....|.
gi 1370514181 869 TLKDVECKFSKMkTAYEEVTTELEEFKEAFA 899
Cdd:PRK02224 590 SLERIRTLLAAI-ADAEDEIERLREKREALA 619
|
|
| |
