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Conserved domains on  [gi|1370459259|ref|XP_024304241|]
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doublecortin domain-containing protein 1 isoform X8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
beta-trefoil_Ricin_DCDC1 cd23427
ricin B-type lectin domain, beta-trefoil fold, found in doublecortin domain-containing protein ...
1032-1267 1.48e-48

ricin B-type lectin domain, beta-trefoil fold, found in doublecortin domain-containing protein 1 (DCDC1) and similar proteins; DCDC1, also called doublecortin domain-containing 5 protein (DCDC5), is a microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis. In addition to doublecortin-like domains, DCDC1 may also contain a ricin B-type lectin domain in the middle region. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a putative sugar-binding pocket.


:

Pssm-ID: 467305  Cd Length: 146  Bit Score: 169.79  E-value: 1.48e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259 1032 AKIQIFCSTHKIEALVLEVQSDIVSGSKLAVHKPVAifgeekqvtepeekqmqedplttenasseildshvrahlrmkac 1111
Cdd:cd23427      1 DQIRQYCALRNPEDLVLEVSGPLVAGSKLIVNKCVL-------------------------------------------- 36
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259 1112 htlpryawqetshdfdeddslpkktekglfenvepqkkhscspkhsklhkhcHQQFEYRDGQIISHAAPQLVLGVQGPNL 1191
Cdd:cd23427     37 ----------------------------------------------------LQQFVFEDGFISCCSNPNLVLGVQGSEL 64
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259 1192 RSGMEVVLVEKKSDGSHQRWIHQEDsrtFHLVSNP--DLVLAVSMTKTRNE-------VCGYPVIVQKYKPYNNGAANQK 1262
Cdd:cd23427     65 GRGAEVVLVKKKPDDINQRWILRED---GHIMSKPnyDLVLTVSMPSTTPGdsssplsYIGCAVILQKYKGYSYGRANQK 141

                   ....*
gi 1370459259 1263 WHYMK 1267
Cdd:cd23427    142 WHWDP 146
DCX_DCDC1 cd17155
Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); ...
174-245 8.01e-43

Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


:

Pssm-ID: 340675  Cd Length: 72  Bit Score: 150.62  E-value: 8.01e-43
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370459259  174 IKVTAYKNGSRTVFARVTVPTITLLLEECTEKLNLNMAARRVFLADGKEALEPEDIPHEADVYVSTGEPFLN 245
Cdd:cd17155      1 IKVTAFKNGTRDVFAKVTAPNIKILLEECTEKLGLNSAARRVFLADGTEVFEPKDIPRDADVYISTGEPFKD 72
DCX2_DCDC5 cd17157
Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
295-380 3.53e-41

Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


:

Pssm-ID: 340677  Cd Length: 86  Bit Score: 146.34  E-value: 3.53e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259  295 VRILFFKNGMGQDGHEITVGKETMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDISKVPLLEKCLQNSITPLRGLLWVSK 374
Cdd:cd17157      1 RRILVFKNGDGSEGYEIVADLDEFEQFLDACTSKLNLGSPARVLYDWEGKEIKDLSEAPKLDKCLQNSSTPVLGPLWVSK 80

                   ....*.
gi 1370459259  375 GEGFSP 380
Cdd:cd17157     81 GEGFSP 86
DCX4_DCDC5 cd17159
Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
1670-1742 2.81e-40

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


:

Pssm-ID: 340679  Cd Length: 73  Bit Score: 143.21  E-value: 2.81e-40
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370459259 1670 KRVWIYLNGGRPEDGTYAWGKTISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDIERDMVICVSMGHGFKT 1742
Cdd:cd17159      1 KRVLVYPNGGSPERAVYAWGKSIEELLDSCTERLGLRKPAKYLYTPDGEQIQSWDDIERDMLLCVSTGEPFLT 73
DCX1_DCDC5 cd17156
Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
936-1013 8.78e-39

Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and is involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


:

Pssm-ID: 340676  Cd Length: 76  Bit Score: 139.35  E-value: 8.78e-39
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370459259  936 VRLRVLQNGEKNKNRSVTILGpdISPGRKTQCTEILNLPSAARRLYNEKGKEIFALKDLQRDELVYVSCGELWINPDL 1013
Cdd:cd17156      1 LRLRVLRNGEKDKNKAVTVVG--EFQLFLERCTTALNLPFAARRLFDEKGKEHFTLKDLKRDQLVYVSCGEAWIDPKL 76
DCX3_DCDC5 cd17158
Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
1412-1552 1.13e-27

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


:

Pssm-ID: 340678  Cd Length: 73  Bit Score: 107.40  E-value: 1.13e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259 1412 VKIIAYKNGDGY-RNGKLIVAGTFPMLLTECTEQLGLARAASKVYTKDGTPIftlrdlvlwaldesflqrdsekqkqdaa 1490
Cdd:cd17158      1 VKILAYKNGEGRlRDGVLIIGSTFPGLLDQCTHRLGLARAARRLYTADGTLI---------------------------- 52
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370459259 1491 pvgkeqiivesmeenprmkvknrlfaksvtsdsldgidkslLTLILRNPIAIWVSCGEPFLP 1552
Cdd:cd17158     53 -----------------------------------------LTLILRYPIEVWVSCGEPFIP 73
Ubl1_cv_Nsp3_N-like super family cl28922
first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV ...
547-580 2.04e-03

first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins; This ubiquitin-like (Ubl) domain (Ubl1) is found at the N-terminus of coronavirus Nsp3, a large multi-functional multi-domain protein which is an essential component of the replication/transcription complex (RTC). The functions of Ubl1 in CoVs are related to single-stranded RNA (ssRNA) binding and to interacting with the nucleocapsid (N) protein. SARS-CoV Ubl1 has been shown to bind ssRNA having AUA patterns, and since the 5'-UTR of the SARS-CoV genome has a number of AUA repeats, it may bind there. In mouse hepatitis virus (MHV), this Ubl1 domain binds the cognate N protein. Adjacent to Ubl1 is a Glu-rich acidic region (also referred to as hypervariable region, HVR); Ubl1 together with HVR has been called Nsp3a. Currently, the function of HVR in CoVs is unknown. This model corresponds to one of two Ubl domains in Nsp3; the other is located N-terminal to the papain-like protease (PLpro) and is not represented by this model.


The actual alignment was detected with superfamily member cd17072:

Pssm-ID: 475130  Cd Length: 71  Bit Score: 38.41  E-value: 2.04e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1370459259  547 GLNYSSMRLFDENGQEIKNPLSLKNEQKIWVSYG 580
Cdd:cd17072     38 NLPFAARRLFDENGKEIFTLRDLERDQLVYVSCG 71
beta-trefoil_Ricin-like super family cl49609
ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a ...
730-774 3.51e-03

ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.


The actual alignment was detected with superfamily member cd23454:

Pssm-ID: 483949 [Multi-domain]  Cd Length: 136  Bit Score: 39.61  E-value: 3.51e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1370459259  730 AAEGTSLEGYKLILQKRHSGDDS--QKWVFGTDGCIYSKAYPQFVLT 774
Cdd:cd23454     60 IQGGVVKSGTRLVQSPKKPSKDAnnQRWGLTADGYIYLLSNPSLVLG 106
 
Name Accession Description Interval E-value
beta-trefoil_Ricin_DCDC1 cd23427
ricin B-type lectin domain, beta-trefoil fold, found in doublecortin domain-containing protein ...
1032-1267 1.48e-48

ricin B-type lectin domain, beta-trefoil fold, found in doublecortin domain-containing protein 1 (DCDC1) and similar proteins; DCDC1, also called doublecortin domain-containing 5 protein (DCDC5), is a microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis. In addition to doublecortin-like domains, DCDC1 may also contain a ricin B-type lectin domain in the middle region. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a putative sugar-binding pocket.


Pssm-ID: 467305  Cd Length: 146  Bit Score: 169.79  E-value: 1.48e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259 1032 AKIQIFCSTHKIEALVLEVQSDIVSGSKLAVHKPVAifgeekqvtepeekqmqedplttenasseildshvrahlrmkac 1111
Cdd:cd23427      1 DQIRQYCALRNPEDLVLEVSGPLVAGSKLIVNKCVL-------------------------------------------- 36
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259 1112 htlpryawqetshdfdeddslpkktekglfenvepqkkhscspkhsklhkhcHQQFEYRDGQIISHAAPQLVLGVQGPNL 1191
Cdd:cd23427     37 ----------------------------------------------------LQQFVFEDGFISCCSNPNLVLGVQGSEL 64
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259 1192 RSGMEVVLVEKKSDGSHQRWIHQEDsrtFHLVSNP--DLVLAVSMTKTRNE-------VCGYPVIVQKYKPYNNGAANQK 1262
Cdd:cd23427     65 GRGAEVVLVKKKPDDINQRWILRED---GHIMSKPnyDLVLTVSMPSTTPGdsssplsYIGCAVILQKYKGYSYGRANQK 141

                   ....*
gi 1370459259 1263 WHYMK 1267
Cdd:cd23427    142 WHWDP 146
DCX_DCDC1 cd17155
Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); ...
174-245 8.01e-43

Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340675  Cd Length: 72  Bit Score: 150.62  E-value: 8.01e-43
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370459259  174 IKVTAYKNGSRTVFARVTVPTITLLLEECTEKLNLNMAARRVFLADGKEALEPEDIPHEADVYVSTGEPFLN 245
Cdd:cd17155      1 IKVTAFKNGTRDVFAKVTAPNIKILLEECTEKLGLNSAARRVFLADGTEVFEPKDIPRDADVYISTGEPFKD 72
DCX2_DCDC5 cd17157
Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
295-380 3.53e-41

Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340677  Cd Length: 86  Bit Score: 146.34  E-value: 3.53e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259  295 VRILFFKNGMGQDGHEITVGKETMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDISKVPLLEKCLQNSITPLRGLLWVSK 374
Cdd:cd17157      1 RRILVFKNGDGSEGYEIVADLDEFEQFLDACTSKLNLGSPARVLYDWEGKEIKDLSEAPKLDKCLQNSSTPVLGPLWVSK 80

                   ....*.
gi 1370459259  375 GEGFSP 380
Cdd:cd17157     81 GEGFSP 86
DCX4_DCDC5 cd17159
Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
1670-1742 2.81e-40

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340679  Cd Length: 73  Bit Score: 143.21  E-value: 2.81e-40
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370459259 1670 KRVWIYLNGGRPEDGTYAWGKTISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDIERDMVICVSMGHGFKT 1742
Cdd:cd17159      1 KRVLVYPNGGSPERAVYAWGKSIEELLDSCTERLGLRKPAKYLYTPDGEQIQSWDDIERDMLLCVSTGEPFLT 73
DCX1_DCDC5 cd17156
Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
936-1013 8.78e-39

Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and is involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340676  Cd Length: 76  Bit Score: 139.35  E-value: 8.78e-39
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370459259  936 VRLRVLQNGEKNKNRSVTILGpdISPGRKTQCTEILNLPSAARRLYNEKGKEIFALKDLQRDELVYVSCGELWINPDL 1013
Cdd:cd17156      1 LRLRVLRNGEKDKNKAVTVVG--EFQLFLERCTTALNLPFAARRLFDEKGKEHFTLKDLKRDQLVYVSCGEAWIDPKL 76
DCX3_DCDC5 cd17158
Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
1412-1552 1.13e-27

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340678  Cd Length: 73  Bit Score: 107.40  E-value: 1.13e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259 1412 VKIIAYKNGDGY-RNGKLIVAGTFPMLLTECTEQLGLARAASKVYTKDGTPIftlrdlvlwaldesflqrdsekqkqdaa 1490
Cdd:cd17158      1 VKILAYKNGEGRlRDGVLIIGSTFPGLLDQCTHRLGLARAARRLYTADGTLI---------------------------- 52
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370459259 1491 pvgkeqiivesmeenprmkvknrlfaksvtsdsldgidkslLTLILRNPIAIWVSCGEPFLP 1552
Cdd:cd17158     53 -----------------------------------------LTLILRYPIEVWVSCGEPFIP 73
Ricin_B_lectin pfam00652
Ricin-type beta-trefoil lectin domain;
1162-1263 5.42e-06

Ricin-type beta-trefoil lectin domain;


Pssm-ID: 395527 [Multi-domain]  Cd Length: 126  Bit Score: 47.53  E-value: 5.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259 1162 HCH-----QQFEYRDGQIISHAAPQLVLGVQGPNlrSGMEVVLVEKKSDGSHQRWIHQEDSRT-FHLVSNpdLVLAVSMT 1235
Cdd:pfam00652   30 PCHgsngnQLWTLTGDGTIRSVASDLCLDVGSTA--DGAKVVLWPCHPGNGNQRWRYDEDGTQiRNPQSG--KCLDVSGA 105
                           90       100
                   ....*....|....*....|....*...
gi 1370459259 1236 KTRNEvcgyPVIVQKYkpyNNGAANQKW 1263
Cdd:pfam00652  106 GTSNG----KVILWTC---DSGNPNQQW 126
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
1407-1469 6.02e-05

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 43.40  E-value: 6.02e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259  1407 THQKAVKIIAYKNGDGYRNG-KLIV----AGTFPMLLTECTEQLGL--ARAASKVYTKDGTPIFTLRDLV 1469
Cdd:smart00537    1 SLVKPKRIRFYRNGDRFFKGvRLVVnrkrFKSFEALLQDLTEVVKLdlPHGVRKLYTLDGKKVTSLDELE 70
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
932-1014 2.08e-04

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 41.86  E-value: 2.08e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259   932 PYAPVRLRVLQNGEKNKNRSVTILGPDISPGRK---TQCTEI--LNLPSAARRLYNEKGKEIFALKDLQRDELVYVSCGE 1006
Cdd:smart00537    2 LVKPKRIRFYRNGDRFFKGVRLVVNRKRFKSFEallQDLTEVvkLDLPHGVRKLYTLDGKKVTSLDELEDGGSYVASGTE 81

                    ....*...
gi 1370459259  1007 LWINPDLS 1014
Cdd:smart00537   82 AFKKVDYG 89
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
1666-1744 2.46e-04

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 41.47  E-value: 2.46e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259  1666 QPNTKRVWIYLNGGRPEDG-----TYAWGKTISELLQDCSSRLKM--THPARALYTPSGEPIQSWDDIERDMVICVSMGH 1738
Cdd:smart00537    2 LVKPKRIRFYRNGDRFFKGvrlvvNRKRFKSFEALLQDLTEVVKLdlPHGVRKLYTLDGKKVTSLDELEDGGSYVASGTE 81

                    ....*.
gi 1370459259  1739 GFKTPK 1744
Cdd:smart00537   82 AFKKVD 87
RICIN smart00458
Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication.
1163-1263 6.02e-04

Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication.


Pssm-ID: 214672 [Multi-domain]  Cd Length: 118  Bit Score: 41.34  E-value: 6.02e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259  1163 CH-----QQFEYRDGQIISHAAPQLVLGVQGPNlrsGMEVVLVEKKSDGSHQRWIHQEDSRTFHLVSNpdLVLAVSMTKT 1237
Cdd:smart00458   24 CHgtggnQLWKLTSDGAIRIKDTDLCLTANGNT---GSTVTLYSCDGTNDNQYWEVNKDGTIRNPDSG--KCLDVKDGNT 98
                            90       100
                    ....*....|....*....|....*.
gi 1370459259  1238 RNEVCGYPvivqkykpyNNGAANQKW 1263
Cdd:smart00458   99 GTKVILWT---------CSGNPNQKW 115
DCX_DCDC5_like cd17072
Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar ...
547-580 2.04e-03

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340592  Cd Length: 71  Bit Score: 38.41  E-value: 2.04e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1370459259  547 GLNYSSMRLFDENGQEIKNPLSLKNEQKIWVSYG 580
Cdd:cd17072     38 NLPFAARRLFDENGKEIFTLRDLERDQLVYVSCG 71
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
170-252 2.70e-03

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 38.78  E-value: 2.70e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259   170 QPRVIKVTAYKNG------SRTVFARVTVPTITLLLEECTE--KLNLNMAARRVFLADGKEALEPEDIpHEADVYVSTGE 241
Cdd:smart00537    2 LVKPKRIRFYRNGdrffkgVRLVVNRKRFKSFEALLQDLTEvvKLDLPHGVRKLYTLDGKKVTSLDEL-EDGGSYVASGT 80
                            90
                    ....*....|.
gi 1370459259   242 pflNPFKKIKD 252
Cdd:smart00537   81 ---EAFKKVDY 88
beta-trefoil_Ricin_GllA-1 cd23454
GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; ...
730-774 3.51e-03

GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; Gellin proteins act as central effectors of wound-induced protoplasmic gelation. They possess ten related N-terminal beta-trefoil domains (Gll-1 to Gll-10) that contribute to distinct gelation-related activities. The beta-trefoil domains show low sequence similarity to members of the functionally diverse ricin B lectin domain family. They are characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain bears a potential sugar binding site. Gellin from M. circinelloides has been called GellinA (also known as GllA). The model corresponds to GllA-1 domain, which is a remote family member of the ricin B-type lectin domain.


Pssm-ID: 467332 [Multi-domain]  Cd Length: 136  Bit Score: 39.61  E-value: 3.51e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1370459259  730 AAEGTSLEGYKLILQKRHSGDDS--QKWVFGTDGCIYSKAYPQFVLT 774
Cdd:cd23454     60 IQGGVVKSGTRLVQSPKKPSKDAnnQRWGLTADGYIYLLSNPSLVLG 106
 
Name Accession Description Interval E-value
beta-trefoil_Ricin_DCDC1 cd23427
ricin B-type lectin domain, beta-trefoil fold, found in doublecortin domain-containing protein ...
1032-1267 1.48e-48

ricin B-type lectin domain, beta-trefoil fold, found in doublecortin domain-containing protein 1 (DCDC1) and similar proteins; DCDC1, also called doublecortin domain-containing 5 protein (DCDC5), is a microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis. In addition to doublecortin-like domains, DCDC1 may also contain a ricin B-type lectin domain in the middle region. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a putative sugar-binding pocket.


Pssm-ID: 467305  Cd Length: 146  Bit Score: 169.79  E-value: 1.48e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259 1032 AKIQIFCSTHKIEALVLEVQSDIVSGSKLAVHKPVAifgeekqvtepeekqmqedplttenasseildshvrahlrmkac 1111
Cdd:cd23427      1 DQIRQYCALRNPEDLVLEVSGPLVAGSKLIVNKCVL-------------------------------------------- 36
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259 1112 htlpryawqetshdfdeddslpkktekglfenvepqkkhscspkhsklhkhcHQQFEYRDGQIISHAAPQLVLGVQGPNL 1191
Cdd:cd23427     37 ----------------------------------------------------LQQFVFEDGFISCCSNPNLVLGVQGSEL 64
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259 1192 RSGMEVVLVEKKSDGSHQRWIHQEDsrtFHLVSNP--DLVLAVSMTKTRNE-------VCGYPVIVQKYKPYNNGAANQK 1262
Cdd:cd23427     65 GRGAEVVLVKKKPDDINQRWILRED---GHIMSKPnyDLVLTVSMPSTTPGdsssplsYIGCAVILQKYKGYSYGRANQK 141

                   ....*
gi 1370459259 1263 WHYMK 1267
Cdd:cd23427    142 WHWDP 146
DCX_DCDC1 cd17155
Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); ...
174-245 8.01e-43

Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340675  Cd Length: 72  Bit Score: 150.62  E-value: 8.01e-43
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370459259  174 IKVTAYKNGSRTVFARVTVPTITLLLEECTEKLNLNMAARRVFLADGKEALEPEDIPHEADVYVSTGEPFLN 245
Cdd:cd17155      1 IKVTAFKNGTRDVFAKVTAPNIKILLEECTEKLGLNSAARRVFLADGTEVFEPKDIPRDADVYISTGEPFKD 72
DCX2_DCDC5 cd17157
Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
295-380 3.53e-41

Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340677  Cd Length: 86  Bit Score: 146.34  E-value: 3.53e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259  295 VRILFFKNGMGQDGHEITVGKETMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDISKVPLLEKCLQNSITPLRGLLWVSK 374
Cdd:cd17157      1 RRILVFKNGDGSEGYEIVADLDEFEQFLDACTSKLNLGSPARVLYDWEGKEIKDLSEAPKLDKCLQNSSTPVLGPLWVSK 80

                   ....*.
gi 1370459259  375 GEGFSP 380
Cdd:cd17157     81 GEGFSP 86
DCX4_DCDC5 cd17159
Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
1670-1742 2.81e-40

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340679  Cd Length: 73  Bit Score: 143.21  E-value: 2.81e-40
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370459259 1670 KRVWIYLNGGRPEDGTYAWGKTISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDIERDMVICVSMGHGFKT 1742
Cdd:cd17159      1 KRVLVYPNGGSPERAVYAWGKSIEELLDSCTERLGLRKPAKYLYTPDGEQIQSWDDIERDMLLCVSTGEPFLT 73
DCX1_DCDC5 cd17156
Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
936-1013 8.78e-39

Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and is involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340676  Cd Length: 76  Bit Score: 139.35  E-value: 8.78e-39
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370459259  936 VRLRVLQNGEKNKNRSVTILGpdISPGRKTQCTEILNLPSAARRLYNEKGKEIFALKDLQRDELVYVSCGELWINPDL 1013
Cdd:cd17156      1 LRLRVLRNGEKDKNKAVTVVG--EFQLFLERCTTALNLPFAARRLFDEKGKEHFTLKDLKRDQLVYVSCGEAWIDPKL 76
DCX_DCDC5_like cd17072
Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar ...
936-1005 5.51e-30

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340592  Cd Length: 71  Bit Score: 113.91  E-value: 5.51e-30
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370459259  936 VRLRVLQNGEKNKNRSVTILGPDIS-PGRKTQCTEILNLPSAARRLYNEKGKEIFALKDLQRDELVYVSCG 1005
Cdd:cd17072      1 VRLRVLKNGERDLERAVYVVGPDLElQLFLDRCTERLNLPFAARRLFDENGKEIFTLRDLERDQLVYVSCG 71
DCX3_DCDC5 cd17158
Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
1412-1552 1.13e-27

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340678  Cd Length: 73  Bit Score: 107.40  E-value: 1.13e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259 1412 VKIIAYKNGDGY-RNGKLIVAGTFPMLLTECTEQLGLARAASKVYTKDGTPIftlrdlvlwaldesflqrdsekqkqdaa 1490
Cdd:cd17158      1 VKILAYKNGEGRlRDGVLIIGSTFPGLLDQCTHRLGLARAARRLYTADGTLI---------------------------- 52
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370459259 1491 pvgkeqiivesmeenprmkvknrlfaksvtsdsldgidkslLTLILRNPIAIWVSCGEPFLP 1552
Cdd:cd17158     53 -----------------------------------------LTLILRYPIEVWVSCGEPFIP 73
DCX_DCDC5_like cd17072
Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar ...
1670-1737 6.72e-24

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340592  Cd Length: 71  Bit Score: 96.57  E-value: 6.72e-24
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370459259 1670 KRVWIYLNGGR-PEDGTYAWGK--TISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDIERDMVICVSMG 1737
Cdd:cd17072      1 VRLRVLKNGERdLERAVYVVGPdlELQLFLDRCTERLNLPFAARRLFDENGKEIFTLRDLERDQLVYVSCG 71
DCX_DCDC5_like cd17072
Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar ...
174-240 2.24e-21

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340592  Cd Length: 71  Bit Score: 89.25  E-value: 2.24e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370459259  174 IKVTAYKNGSR--TVFARVTVP--TITLLLEECTEKLNLNMAARRVFLADGKEALEPEDIPHEADVYVSTG 240
Cdd:cd17072      1 VRLRVLKNGERdlERAVYVVGPdlELQLFLDRCTERLNLPFAARRLFDENGKEIFTLRDLERDQLVYVSCG 71
DCX_DCDC5_like cd17072
Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar ...
1412-1468 1.57e-16

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340592  Cd Length: 71  Bit Score: 75.77  E-value: 1.57e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259 1412 VKIIAYKNGDG-YRNGKLIVAG--TFPMLLTECTEQLGLARAASKVYTKDGTPIFTLRDL 1468
Cdd:cd17072      1 VRLRVLKNGERdLERAVYVVGPdlELQLFLDRCTERLNLPFAARRLFDENGKEIFTLRDL 60
DCX_DCDC5_like cd17072
Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar ...
295-375 3.25e-16

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340592  Cd Length: 71  Bit Score: 74.62  E-value: 3.25e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259  295 VRILFFKNGMG--QDGHEITVGKETMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDIskvpllekclqnSITPLRGLLWV 372
Cdd:cd17072      1 VRLRVLKNGERdlERAVYVVGPDLELQLFLDRCTERLNLPFAARRLFDENGKEIFTL------------RDLERDQLVYV 68

                   ...
gi 1370459259  373 SKG 375
Cdd:cd17072     69 SCG 71
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
1670-1736 1.32e-15

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340456  Cd Length: 73  Bit Score: 73.03  E-value: 1.32e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370459259 1670 KRVWIYLNGGRPEDGTYAWGK-----TISELLQDCSSRLKM-THPARALYTPSGEPIQSWDDIERDMVICVSM 1736
Cdd:cd01617      1 KRITVFRNGDKNFKGVKVLVKprrfrTFDQLLDELTEKLGLpTGGVRKLYTPSGKLVKSLSDLEDGESYVVCG 73
DCX1_DCDC5 cd17156
Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
174-246 1.21e-11

Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and is involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340676  Cd Length: 76  Bit Score: 61.92  E-value: 1.21e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370459259  174 IKVTAYKNGSRTVFARVTVPTIT-LLLEECTEKLNLNMAARRVFLADGKEALEPEDIPHEADVYVSTGEPFLNP 246
Cdd:cd17156      1 LRLRVLRNGEKDKNKAVTVVGEFqLFLERCTTALNLPFAARRLFDEKGKEHFTLKDLKRDQLVYVSCGEAWIDP 74
DCX_DCDC1 cd17155
Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); ...
946-1006 2.07e-11

Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340675  Cd Length: 72  Bit Score: 61.25  E-value: 2.07e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370459259  946 KNKNRSV--TILGPDIspgrKT---QCTEILNLPSAARRLYNEKGKEIFALKDLQRDELVYVSCGE 1006
Cdd:cd17155      7 KNGTRDVfaKVTAPNI----KIlleECTEKLGLNSAARRVFLADGTEVFEPKDIPRDADVYISTGE 68
DCX3_DCDC5 cd17158
Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
174-244 9.35e-11

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340678  Cd Length: 73  Bit Score: 59.25  E-value: 9.35e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370459259  174 IKVTAYKNGSRTVFARVTV--PTITLLLEECTEKLNLNMAARRVFLADGKEALePEDIPHEADVYVSTGEPFL 244
Cdd:cd17158      1 VKILAYKNGEGRLRDGVLIigSTFPGLLDQCTHRLGLARAARRLYTADGTLIL-TLILRYPIEVWVSCGEPFI 72
beta-trefoil_Ricin_GllA-1 cd23454
GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; ...
1164-1263 1.25e-09

GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; Gellin proteins act as central effectors of wound-induced protoplasmic gelation. They possess ten related N-terminal beta-trefoil domains (Gll-1 to Gll-10) that contribute to distinct gelation-related activities. The beta-trefoil domains show low sequence similarity to members of the functionally diverse ricin B lectin domain family. They are characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain bears a potential sugar binding site. Gellin from M. circinelloides has been called GellinA (also known as GllA). The model corresponds to GllA-1 domain, which is a remote family member of the ricin B-type lectin domain.


Pssm-ID: 467332 [Multi-domain]  Cd Length: 136  Bit Score: 58.09  E-value: 1.25e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259 1164 HQQFEYRDGQIIsHAAPQLVLGVQGPNLRSGMEVVLVEKKS--DGSHQRWIHQEDSrTFHLVSNPDLVLAVSMTKTRNev 1241
Cdd:cd23454     39 SQLWRYDDGYLV-NKASGLVLDIQGGVVKSGTRLVQSPKKPskDANNQRWGLTADG-YIYLLSNPSLVLGIKGNETRE-- 114
                           90       100
                   ....*....|....*....|..
gi 1370459259 1242 cGYPVIVQKYKPYNNgAANQKW 1263
Cdd:cd23454    115 -GARVILQERKLQKD-ALNQRW 134
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
936-1005 1.38e-09

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340456  Cd Length: 73  Bit Score: 56.08  E-value: 1.38e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370459259  936 VRLRVLQNGEKNkNRSVTILGP----DISPGRKTQCTEILNL-PSAARRLYNEKGKEIFALKDLQRDElVYVSCG 1005
Cdd:cd01617      1 KRITVFRNGDKN-FKGVKVLVKprrfRTFDQLLDELTEKLGLpTGGVRKLYTPSGKLVKSLSDLEDGE-SYVVCG 73
DCX_DCDC1 cd17155
Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); ...
1412-1468 1.68e-09

Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340675  Cd Length: 72  Bit Score: 55.86  E-value: 1.68e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370459259 1412 VKIIAYKNGDGYRNGKlIVAGTFPMLLTECTEQLGLARAASKVYTKDGTPIFTLRDL 1468
Cdd:cd17155      1 IKVTAFKNGTRDVFAK-VTAPNIKILLEECTEKLGLNSAARRVFLADGTEVFEPKDI 56
DCX3_DCDC5 cd17158
Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
936-1009 1.76e-08

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340678  Cd Length: 73  Bit Score: 52.70  E-value: 1.76e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370459259  936 VRLRVLQNGEKNKNRSVTILGPDIsPGRKTQCTEILNLPSAARRLYNEKGKEIFALkDLQRDELVYVSCGELWI 1009
Cdd:cd17158      1 VKILAYKNGEGRLRDGVLIIGSTF-PGLLDQCTHRLGLARAARRLYTADGTLILTL-ILRYPIEVWVSCGEPFI 72
DCX1_DCDC5 cd17156
Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
1412-1468 4.08e-08

Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and is involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340676  Cd Length: 76  Bit Score: 51.91  E-value: 4.08e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370459259 1412 VKIIAYKNGDGYRNGKLIVAGTFPMLLTECTEQLGLARAASKVYTKDGTPIFTLRDL 1468
Cdd:cd17156      1 LRLRVLRNGEKDKNKAVTVVGEFQLFLERCTTALNLPFAARRLFDEKGKEHFTLKDL 57
beta-trefoil_Ricin-like cd00161
ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a ...
1164-1263 4.43e-08

ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.


Pssm-ID: 467293 [Multi-domain]  Cd Length: 134  Bit Score: 53.53  E-value: 4.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259 1164 HQQFEYRD-----GQIIShAAPQLVLGVQGPNLRSGMEVVLVEkKSDGSHQRW-IHQEDSRTFHLVS-NPDLVLAVSMTK 1236
Cdd:cd00161     37 NQQWTLTPvgdgyYTIRN-VASGKCLDVAGGSTANGANVQQWT-CNGGDNQQWrLEPVGDGYYRIVNkHSGKCLDVSGGS 114
                           90       100
                   ....*....|....*....|....*..
gi 1370459259 1237 TRNevcGYPVIVQKYkpynNGAANQKW 1263
Cdd:cd00161    115 TAN---GANVQQWTC----NGGANQQW 134
DCX3_DCDC5 cd17158
Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
1671-1720 1.17e-07

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340678  Cd Length: 73  Bit Score: 50.39  E-value: 1.17e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1370459259 1671 RVWIYLNG-GRPEDGTYAWGKTISELLQDCSSRLKMTHPARALYTPSGEPI 1720
Cdd:cd17158      2 KILAYKNGeGRLRDGVLIIGSTFPGLLDQCTHRLGLARAARRLYTADGTLI 52
DCX4_DCDC5 cd17159
Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
175-245 5.11e-07

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340679  Cd Length: 73  Bit Score: 48.83  E-value: 5.11e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370459259  175 KVTAYKNGS---RTVFARVTvpTITLLLEECTEKLNLNMAARRVFLADGKEALEPEDIPHEADVYVSTGEPFLN 245
Cdd:cd17159      2 RVLVYPNGGspeRAVYAWGK--SIEELLDSCTERLGLRKPAKYLYTPDGEQIQSWDDIERDMLLCVSTGEPFLT 73
DCX3_DCDC5 cd17158
Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
295-380 6.65e-07

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340678  Cd Length: 73  Bit Score: 48.46  E-value: 6.65e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259  295 VRILFFKNGMG--QDGHEITVGkeTMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDIskvpllekCLQNSITplrglLWV 372
Cdd:cd17158      1 VKILAYKNGEGrlRDGVLIIGS--TFPGLLDQCTHRLGLARAARRLYTADGTLILTL--------ILRYPIE-----VWV 65

                   ....*...
gi 1370459259  373 SKGEGFSP 380
Cdd:cd17158     66 SCGEPFIP 73
DCX4_DCDC5 cd17159
Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
296-379 7.94e-07

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340679  Cd Length: 73  Bit Score: 48.06  E-value: 7.94e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259  296 RILFFKNGmGQDGHEITVGKETMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDISKVpllEKCLqnsitplrgLLWVSKG 375
Cdd:cd17159      2 RVLVYPNG-GSPERAVYAWGKSIEELLDSCTERLGLRKPAKYLYTPDGEQIQSWDDI---ERDM---------LLCVSTG 68

                   ....
gi 1370459259  376 EGFS 379
Cdd:cd17159     69 EPFL 72
DCX_DCDC1 cd17155
Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); ...
1671-1741 4.90e-06

Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340675  Cd Length: 72  Bit Score: 45.84  E-value: 4.90e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370459259 1671 RVWIYLNGGRPedgTYA--WGKTISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDIERDMVICVSMGHGFK 1741
Cdd:cd17155      2 KVTAFKNGTRD---VFAkvTAPNIKILLEECTEKLGLNSAARRVFLADGTEVFEPKDIPRDADVYISTGEPFK 71
Ricin_B_lectin pfam00652
Ricin-type beta-trefoil lectin domain;
1162-1263 5.42e-06

Ricin-type beta-trefoil lectin domain;


Pssm-ID: 395527 [Multi-domain]  Cd Length: 126  Bit Score: 47.53  E-value: 5.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259 1162 HCH-----QQFEYRDGQIISHAAPQLVLGVQGPNlrSGMEVVLVEKKSDGSHQRWIHQEDSRT-FHLVSNpdLVLAVSMT 1235
Cdd:pfam00652   30 PCHgsngnQLWTLTGDGTIRSVASDLCLDVGSTA--DGAKVVLWPCHPGNGNQRWRYDEDGTQiRNPQSG--KCLDVSGA 105
                           90       100
                   ....*....|....*....|....*...
gi 1370459259 1236 KTRNEvcgyPVIVQKYkpyNNGAANQKW 1263
Cdd:pfam00652  106 GTSNG----KVILWTC---DSGNPNQQW 126
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
1412-1469 1.17e-05

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340456  Cd Length: 73  Bit Score: 44.91  E-value: 1.17e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370459259 1412 VKIIAYKNGDGYRNGKLIV-----AGTFPMLLTECTEQLGL-ARAASKVYTKDGTPIFTLRDLV 1469
Cdd:cd01617      1 KRITVFRNGDKNFKGVKVLvkprrFRTFDQLLDELTEKLGLpTGGVRKLYTPSGKLVKSLSDLE 64
DCX4_DCDC5 cd17159
Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
937-1006 1.37e-05

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340679  Cd Length: 73  Bit Score: 44.59  E-value: 1.37e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259  937 RLRVLQNGEkNKNRSVTILGPDISPGRKTqCTEILNLPSAARRLYNEKGKEIFALKDLQRDELVYVSCGE 1006
Cdd:cd17159      2 RVLVYPNGG-SPERAVYAWGKSIEELLDS-CTERLGLRKPAKYLYTPDGEQIQSWDDIERDMLLCVSTGE 69
beta-trefoil_Ricin-like cd00161
ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a ...
1175-1265 2.01e-05

ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.


Pssm-ID: 467293 [Multi-domain]  Cd Length: 134  Bit Score: 45.82  E-value: 2.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259 1175 ISHAAPQLVLGVQGPNLRSGMEVVLVEKkSDGSHQRW-IHQEDSRTFHLVS-NPDLVLAVSMTKTRNevcGYPVIVQKYk 1252
Cdd:cd00161      5 IVNAASGKCLDVAGGSTANGAPVQQWTC-NGGANQQWtLTPVGDGYYTIRNvASGKCLDVAGGSTAN---GANVQQWTC- 79
                           90
                   ....*....|...
gi 1370459259 1253 pynNGAANQKWHY 1265
Cdd:cd00161     80 ---NGGDNQQWRL 89
DCX4_DCDC5 cd17159
Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
1413-1468 2.68e-05

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340679  Cd Length: 73  Bit Score: 43.82  E-value: 2.68e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370459259 1413 KIIAYKNGDGYRNGKLIVAGTFPMLLTECTEQLGLARAASKVYTKDGTPIFTLRDL 1468
Cdd:cd17159      2 RVLVYPNGGSPERAVYAWGKSIEELLDSCTERLGLRKPAKYLYTPDGEQIQSWDDI 57
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
1407-1469 6.02e-05

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 43.40  E-value: 6.02e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259  1407 THQKAVKIIAYKNGDGYRNG-KLIV----AGTFPMLLTECTEQLGL--ARAASKVYTKDGTPIFTLRDLV 1469
Cdd:smart00537    1 SLVKPKRIRFYRNGDRFFKGvRLVVnrkrFKSFEALLQDLTEVVKLdlPHGVRKLYTLDGKKVTSLDELE 70
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
932-1014 2.08e-04

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 41.86  E-value: 2.08e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259   932 PYAPVRLRVLQNGEKNKNRSVTILGPDISPGRK---TQCTEI--LNLPSAARRLYNEKGKEIFALKDLQRDELVYVSCGE 1006
Cdd:smart00537    2 LVKPKRIRFYRNGDRFFKGVRLVVNRKRFKSFEallQDLTEVvkLDLPHGVRKLYTLDGKKVTSLDELEDGGSYVASGTE 81

                    ....*...
gi 1370459259  1007 LWINPDLS 1014
Cdd:smart00537   82 AFKKVDYG 89
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
1666-1744 2.46e-04

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 41.47  E-value: 2.46e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259  1666 QPNTKRVWIYLNGGRPEDG-----TYAWGKTISELLQDCSSRLKM--THPARALYTPSGEPIQSWDDIERDMVICVSMGH 1738
Cdd:smart00537    2 LVKPKRIRFYRNGDRFFKGvrlvvNRKRFKSFEALLQDLTEVVKLdlPHGVRKLYTLDGKKVTSLDELEDGGSYVASGTE 81

                    ....*.
gi 1370459259  1739 GFKTPK 1744
Cdd:smart00537   82 AFKKVD 87
RICIN smart00458
Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication.
1163-1263 6.02e-04

Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication.


Pssm-ID: 214672 [Multi-domain]  Cd Length: 118  Bit Score: 41.34  E-value: 6.02e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259  1163 CH-----QQFEYRDGQIISHAAPQLVLGVQGPNlrsGMEVVLVEKKSDGSHQRWIHQEDSRTFHLVSNpdLVLAVSMTKT 1237
Cdd:smart00458   24 CHgtggnQLWKLTSDGAIRIKDTDLCLTANGNT---GSTVTLYSCDGTNDNQYWEVNKDGTIRNPDSG--KCLDVKDGNT 98
                            90       100
                    ....*....|....*....|....*.
gi 1370459259  1238 RNEVCGYPvivqkykpyNNGAANQKW 1263
Cdd:smart00458   99 GTKVILWT---------CSGNPNQKW 115
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
174-238 1.85e-03

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340456  Cd Length: 73  Bit Score: 38.75  E-value: 1.85e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370459259  174 IKVTAYKNGSR----TVFA--RVTVPTITLLLEECTEKLNLNM-AARRVFLADGKEALEPEDIPHEADVYVS 238
Cdd:cd01617      1 KRITVFRNGDKnfkgVKVLvkPRRFRTFDQLLDELTEKLGLPTgGVRKLYTPSGKLVKSLSDLEDGESYVVC 72
DCX_DCDC5_like cd17072
Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar ...
547-580 2.04e-03

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340592  Cd Length: 71  Bit Score: 38.41  E-value: 2.04e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1370459259  547 GLNYSSMRLFDENGQEIKNPLSLKNEQKIWVSYG 580
Cdd:cd17072     38 NLPFAARRLFDENGKEIFTLRDLERDQLVYVSCG 71
beta-trefoil_Ricin_GALNT3-like cd23435
ricin B-type lectin domain, beta-trefoil fold, found in the polypeptide ...
1162-1263 2.45e-03

ricin B-type lectin domain, beta-trefoil fold, found in the polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3)-like subfamily; The GALNT3-like subfamily includes GALNT3, GALNT4, GALNT6 and GALNT12. They act as GalNAc transferases (EC 2.4.1.41) that catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. GALNT3 has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. It probably glycosylates fibronectin in vivo as well as FGF23. It plays a central role in phosphate homeostasis. GALNT4 shows highest activity towards Muc7, EA2 and Muc2, with a lower activity compared to GALNT2. It glycosylates 'Thr-57' of SELPLG. GALNT6 may participate in the synthesis of oncofetal fibronectin. It has activity toward Muc1a, Muc2, EA2 and fibronectin peptides. GALNT12 has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with non-glycosylated Muc2 and Muc7. It displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. It may play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs. Members of this family comprise a glycosyltransferase region and a ricin B-type lectin domain. The glycosyltransferase region contains two conserved domains, domain A (also called GT1 motif) and domain B (also called Gal/GalNAc-T motif). This model corresponds to the ricin B-type lectin domain with a beta-trefoil fold, which are characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.


Pssm-ID: 467313 [Multi-domain]  Cd Length: 128  Bit Score: 40.01  E-value: 2.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259 1162 HCH-----QQFEY-RDGQIISHAAPQLVLGVQGPNlrsgmEVVLVEKKSDG----SHQRWIHQEDSRTFHLVSNpdLVLA 1231
Cdd:cd23435     33 GCHglggnQYFEYtSKGEIRHNIGKELCLHASGSD-----EVILQHCTSKGkdvpPEQKWLFTQDGTIRNPASG--LCLH 105
                           90       100       110
                   ....*....|....*....|....*....|..
gi 1370459259 1232 VSMTKTRNEVCgypvivqkykpyNNGAANQKW 1263
Cdd:cd23435    106 ASGYKVLLRTC------------NPSDDSQKW 125
DCX1_DCDC2_like cd17071
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and ...
1413-1468 2.60e-03

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and similar proteins; DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340591  Cd Length: 80  Bit Score: 38.36  E-value: 2.60e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370459259 1413 KIIAYKNGDGYRNGKLIV-----AGTFPMLLTECTEQLGLA-RAASKVYT-KDGTPIFTLRDL 1468
Cdd:cd17071      2 IIVVYKNGDPFFPGKKFVvnerqVRTFDAFLNEVTSGIKAPfGAVRSIYTpTGGHRVKDLDSL 64
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
170-252 2.70e-03

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 38.78  E-value: 2.70e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259   170 QPRVIKVTAYKNG------SRTVFARVTVPTITLLLEECTE--KLNLNMAARRVFLADGKEALEPEDIpHEADVYVSTGE 241
Cdd:smart00537    2 LVKPKRIRFYRNGdrffkgVRLVVNRKRFKSFEALLQDLTEvvKLDLPHGVRKLYTLDGKKVTSLDEL-EDGGSYVASGT 80
                            90
                    ....*....|.
gi 1370459259   242 pflNPFKKIKD 252
Cdd:smart00537   81 ---EAFKKVDY 88
DCX2_DCDC5 cd17157
Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
1671-1726 3.16e-03

Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340677  Cd Length: 86  Bit Score: 38.48  E-value: 3.16e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370459259 1671 RVWIYLNG-GRPEDGTYAWGKTISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDI 1726
Cdd:cd17157      2 RILVFKNGdGSEGYEIVADLDEFEQFLDACTSKLNLGSPARVLYDWEGKEIKDLSEA 58
beta-trefoil_Ricin_GllA-1 cd23454
GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; ...
730-774 3.51e-03

GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; Gellin proteins act as central effectors of wound-induced protoplasmic gelation. They possess ten related N-terminal beta-trefoil domains (Gll-1 to Gll-10) that contribute to distinct gelation-related activities. The beta-trefoil domains show low sequence similarity to members of the functionally diverse ricin B lectin domain family. They are characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain bears a potential sugar binding site. Gellin from M. circinelloides has been called GellinA (also known as GllA). The model corresponds to GllA-1 domain, which is a remote family member of the ricin B-type lectin domain.


Pssm-ID: 467332 [Multi-domain]  Cd Length: 136  Bit Score: 39.61  E-value: 3.51e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1370459259  730 AAEGTSLEGYKLILQKRHSGDDS--QKWVFGTDGCIYSKAYPQFVLT 774
Cdd:cd23454     60 IQGGVVKSGTRLVQSPKKPSKDAnnQRWGLTADGYIYLLSNPSLVLG 106
DCX2_DCDC5 cd17157
Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
1412-1468 4.53e-03

Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340677  Cd Length: 86  Bit Score: 38.10  E-value: 4.53e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370459259 1412 VKIIAYKNGDGyRNGKLIVAG--TFPMLLTECTEQLGLARAASKVYTKDGTPIFTLRDL 1468
Cdd:cd17157      1 RRILVFKNGDG-SEGYEIVADldEFEQFLDACTSKLNLGSPARVLYDWEGKEIKDLSEA 58
beta-trefoil_Ricin_EW29-like cd23449
ricin B-type lectin domain, beta-trefoil fold, found in Lumbricus terrestris 29-kDa ...
1175-1268 8.86e-03

ricin B-type lectin domain, beta-trefoil fold, found in Lumbricus terrestris 29-kDa galactose-binding lectin (EW29) and similar proteins; EW29 is a galactose-binding lectin from the earthworm Lumbricus terrestris. It contains two ricin B-type lectin domains with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The second ricin B-type lectin domain may harbor two sugar-binding pockets in subdomains alpha and gamma. EW29 uses these two sugar-binding sites for its function as a single domain-type hemagglutinin.


Pssm-ID: 467327 [Multi-domain]  Cd Length: 128  Bit Score: 38.04  E-value: 8.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459259 1175 ISHAAPQLVLGVQGPNLRSGMEVVLVEKK-SDGSHQRWIHQEDSRTFHLVSNpDLVLavsmtktrnEVCGYP-VIVQKYK 1252
Cdd:cd23449      5 IKSKLNGKVLDVEGANAKPGAKVIMWEKKgGAEDNQLWYEDEVTGTIRSKLN-DFCL---------DASGDKgLILNPYD 74
                           90
                   ....*....|....*.
gi 1370459259 1253 PYNNgaaNQKWHYMKN 1268
Cdd:cd23449     75 PSNP---KQQWKISGN 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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