Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370459265  174 IKVTAYKNGSRTVFARVTVPTITLLLEECTEKLNLNMAARRVFLADGKEALEPEDIPHEADVYVSTGEPFLN 245
Cdd:cd17155      1 IKVTAFKNGTRDVFAKVTAPNIKILLEECTEKLGLNSAARRVFLADGTEVFEPKDIPRDADVYISTGEPFKD 72

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370459265 1625 KRVWIYLNGGRPEDGTYAWGKTISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDIERDMVICVSMGHGFKT 1697
Cdd:cd17159      1 KRVLVYPNGGSPERAVYAWGKSIEELLDSCTERLGLRKPAKYLYTPDGEQIQSWDDIERDMLLCVSTGEPFLT 73

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459265 1367 VKIIAYKNGDGY-RNGKLIVAGTFPMLLTECTEQLGLARAASKVYTKDGTPIftlrdlvlwaldesflqrdsekqkqdaa 1445
Cdd:cd17158      1 VKILAYKNGEGRlRDGVLIIGSTFPGLLDQCTHRLGLARAARRLYTADGTLI---------------------------- 52

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370459265 1446 pvgkeqiivesmeenprmkvknrlfaksvtsdsldgidkslLTLILRNPIAIWVSCGEPFLP 1507
Cdd:cd17158     53 -----------------------------------------LTLILRYPIEVWVSCGEPFIP 73

ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370459265  654 ENHFLQNK-TGMILSraitqgclaighpirvkAAEGTSLEGYKLILQKRHSGDDS--QKWVFGTDGCIYSKAYPQFVLT 729
Cdd:cd23454     45 DDGYLVNKaSGLVLD-----------------IQGGVVKSGTRLVQSPKKPSKDAnnQRWGLTADGYIYLLSNPSLVLG 106

Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370459265  174 IKVTAYKNGSRTVFARVTVPTITLLLEECTEKLNLNMAARRVFLADGKEALEPEDIPHEADVYVSTGEPFLN 245
Cdd:cd17155      1 IKVTAFKNGTRDVFAKVTAPNIKILLEECTEKLGLNSAARRVFLADGTEVFEPKDIPRDADVYISTGEPFKD 72

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370459265 1625 KRVWIYLNGGRPEDGTYAWGKTISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDIERDMVICVSMGHGFKT 1697
Cdd:cd17159      1 KRVLVYPNGGSPERAVYAWGKSIEELLDSCTERLGLRKPAKYLYTPDGEQIQSWDDIERDMLLCVSTGEPFLT 73

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459265 1367 VKIIAYKNGDGY-RNGKLIVAGTFPMLLTECTEQLGLARAASKVYTKDGTPIftlrdlvlwaldesflqrdsekqkqdaa 1445
Cdd:cd17158      1 VKILAYKNGEGRlRDGVLIIGSTFPGLLDQCTHRLGLARAARRLYTADGTLI---------------------------- 52

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370459265 1446 pvgkeqiivesmeenprmkvknrlfaksvtsdsldgidkslLTLILRNPIAIWVSCGEPFLP 1507
Cdd:cd17158     53 -----------------------------------------LTLILRYPIEVWVSCGEPFIP 73

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459265  1362 THQKAVKIIAYKNGDGYRNG-KLIV----AGTFPMLLTECTEQLGL--ARAASKVYTKDGTPIFTLRDLV 1424
Cdd:smart00537    1 SLVKPKRIRFYRNGDRFFKGvRLVVnrkrFKSFEALLQDLTEVVKLdlPHGVRKLYTLDGKKVTSLDELE 70

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459265  1621 QPNTKRVWIYLNGGRPEDG-----TYAWGKTISELLQDCSSRLKM--THPARALYTPSGEPIQSWDDIERDMVICVSMGH 1693
Cdd:smart00537    2 LVKPKRIRFYRNGDRFFKGvrlvvNRKRFKSFEALLQDLTEVVKLdlPHGVRKLYTLDGKKVTSLDELEDGGSYVASGTE 81

                    ....*.
gi 1370459265  1694 GFKTPK 1699
Cdd:smart00537   82 AFKKVD 87

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 1370459265  547 GLNYSSMRLFDENGQEIKNPLSLKNEQKIWVSYG 580
Cdd:cd17072     38 NLPFAARRLFDENGKEIFTLRDLERDQLVYVSCG 71

GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; Gellin proteins act as central effectors of wound-induced protoplasmic gelation. They possess ten related N-terminal beta-trefoil domains (Gll-1 to Gll-10) that contribute to distinct gelation-related activities. The beta-trefoil domains show low sequence similarity to members of the functionally diverse ricin B lectin domain family. They are characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain bears a potential sugar binding site. Gellin from M. circinelloides has been called GellinA (also known as GllA). The model corresponds to GllA-1 domain, which is a remote family member of the ricin B-type lectin domain.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370459265  654 ENHFLQNK-TGMILSraitqgclaighpirvkAAEGTSLEGYKLILQKRHSGDDS--QKWVFGTDGCIYSKAYPQFVLT 729
Cdd:cd23454     45 DDGYLVNKaSGLVLD-----------------IQGGVVKSGTRLVQSPKKPSKDAnnQRWGLTADGYIYLLSNPSLVLG 106

Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370459265  174 IKVTAYKNGSRTVFARVTVPTITLLLEECTEKLNLNMAARRVFLADGKEALEPEDIPHEADVYVSTGEPFLN 245
Cdd:cd17155      1 IKVTAFKNGTRDVFAKVTAPNIKILLEECTEKLGLNSAARRVFLADGTEVFEPKDIPRDADVYISTGEPFKD 72

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370459265 1625 KRVWIYLNGGRPEDGTYAWGKTISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDIERDMVICVSMGHGFKT 1697
Cdd:cd17159      1 KRVLVYPNGGSPERAVYAWGKSIEELLDSCTERLGLRKPAKYLYTPDGEQIQSWDDIERDMLLCVSTGEPFLT 73

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370459265  891 VRLRVLQNGEKNKNRSVTILGPDIS-PGRKTQCTEILNLPSAARRLYNEKGKEIFALKDLQRDELVYVSCG 960
Cdd:cd17072      1 VRLRVLKNGERDLERAVYVVGPDLElQLFLDRCTERLNLPFAARRLFDENGKEIFTLRDLERDQLVYVSCG 71

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370459265 1625 KRVWIYLNGGR-PEDGTYAWGK--TISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDIERDMVICVSMG 1692
Cdd:cd17072      1 VRLRVLKNGERdLERAVYVVGPdlELQLFLDRCTERLNLPFAARRLFDENGKEIFTLRDLERDQLVYVSCG 71

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459265 1367 VKIIAYKNGDG-YRNGKLIVAG--TFPMLLTECTEQLGLARAASKVYTKDGTPIFTLRDL 1423
Cdd:cd17072      1 VRLRVLKNGERdLERAVYVVGPdlELQLFLDRCTERLNLPFAARRLFDENGKEIFTLRDL 60

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370459265 1625 KRVWIYLNGGRPEDGTYAWGK-----TISELLQDCSSRLKM-THPARALYTPSGEPIQSWDDIERDMVICVSM 1691
Cdd:cd01617      1 KRITVFRNGDKNFKGVKVLVKprrfrTFDQLLDELTEKLGLpTGGVRKLYTPSGKLVKSLSDLEDGESYVVCG 73

Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370459265  901 KNKNRSV--TILGPDIspgrKT---QCTEILNLPSAARRLYNEKGKEIFALKDLQRDELVYVSCGE 961
Cdd:cd17155      7 KNGTRDVfaKVTAPNI----KIlleECTEKLGLNSAARRVFLADGTEVFEPKDIPRDADVYISTGE 68

GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; Gellin proteins act as central effectors of wound-induced protoplasmic gelation. They possess ten related N-terminal beta-trefoil domains (Gll-1 to Gll-10) that contribute to distinct gelation-related activities. The beta-trefoil domains show low sequence similarity to members of the functionally diverse ricin B lectin domain family. They are characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain bears a potential sugar binding site. Gellin from M. circinelloides has been called GellinA (also known as GllA). The model corresponds to GllA-1 domain, which is a remote family member of the ricin B-type lectin domain.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459265 1119 HQQFEYRDGQIIsHAAPQLVLGVQGPNLRSGMEVVLVEKKS--DGSHQRWIHQEDSrTFHLVSNPDLVLAVSMTKTRNev 1196
Cdd:cd23454     39 SQLWRYDDGYLV-NKASGLVLDIQGGVVKSGTRLVQSPKKPskDANNQRWGLTADG-YIYLLSNPSLVLGIKGNETRE-- 114

                           90       100
                   ....*....|....*....|..
gi 1370459265 1197 cGYPVIVQKYKPYNNgAANQKW 1218
Cdd:cd23454    115 -GARVILQERKLQKD-ALNQRW 134

Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370459265 1367 VKIIAYKNGDGYRNGKlIVAGTFPMLLTECTEQLGLARAASKVYTKDGTPIFTLRDL 1423
Cdd:cd17155      1 IKVTAFKNGTRDVFAK-VTAPNIKILLEECTEKLGLNSAARRVFLADGTEVFEPKDI 56

ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459265 1119 HQQFEYRD-----GQIIShAAPQLVLGVQGPNLRSGMEVVLVEkKSDGSHQRW-IHQEDSRTFHLVS-NPDLVLAVSMTK 1191
Cdd:cd00161     37 NQQWTLTPvgdgyYTIRN-VASGKCLDVAGGSTANGANVQQWT-CNGGDNQQWrLEPVGDGYYRIVNkHSGKCLDVSGGS 114

                           90       100
                   ....*....|....*....|....*..
gi 1370459265 1192 TRNevcGYPVIVQKYkpynNGAANQKW 1218
Cdd:cd00161    115 TAN---GANVQQWTC----NGGANQQW 134

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1370459265 1626 RVWIYLNG-GRPEDGTYAWGKTISELLQDCSSRLKMTHPARALYTPSGEPI 1675
Cdd:cd17158      2 KILAYKNGeGRLRDGVLIIGSTFPGLLDQCTHRLGLARAARRLYTADGTLI 52

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459265  295 VRILFFKNGMG--QDGHEITVGkeTMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDIskvpllekCLQNSITplrglLWV 372
Cdd:cd17158      1 VKILAYKNGEGrlRDGVLIIGS--TFPGLLDQCTHRLGLARAARRLYTADGTLILTL--------ILRYPIE-----VWV 65

                   ....*...
gi 1370459265  373 SKGEGFSP 380
Cdd:cd17158     66 SCGEPFIP 73

Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370459265 1626 RVWIYLNGGRPedgTYA--WGKTISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDIERDMVICVSMGHGFK 1696
Cdd:cd17155      2 KVTAFKNGTRD---VFAkvTAPNIKILLEECTEKLGLNSAARRVFLADGTEVFEPKDIPRDADVYISTGEPFK 71

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370459265 1367 VKIIAYKNGDGYRNGKLIV-----AGTFPMLLTECTEQLGL-ARAASKVYTKDGTPIFTLRDLV 1424
Cdd:cd01617      1 KRITVFRNGDKNFKGVKVLvkprrFRTFDQLLDELTEKLGLpTGGVRKLYTPSGKLVKSLSDLE 64

ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459265 1130 ISHAAPQLVLGVQGPNLRSGMEVVLVEKkSDGSHQRW-IHQEDSRTFHLVS-NPDLVLAVSMTKTRNevcGYPVIVQKYk 1207
Cdd:cd00161      5 IVNAASGKCLDVAGGSTANGAPVQQWTC-NGGANQQWtLTPVGDGYYTIRNvASGKCLDVAGGSTAN---GANVQQWTC- 79

                           90
                   ....*....|...
gi 1370459265 1208 pynNGAANQKWHY 1220
Cdd:cd00161     80 ---NGGDNQQWRL 89

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459265  1362 THQKAVKIIAYKNGDGYRNG-KLIV----AGTFPMLLTECTEQLGL--ARAASKVYTKDGTPIFTLRDLV 1424
Cdd:smart00537    1 SLVKPKRIRFYRNGDRFFKGvRLVVnrkrFKSFEALLQDLTEVVKLdlPHGVRKLYTLDGKKVTSLDELE 70

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459265  1621 QPNTKRVWIYLNGGRPEDG-----TYAWGKTISELLQDCSSRLKM--THPARALYTPSGEPIQSWDDIERDMVICVSMGH 1693
Cdd:smart00537    2 LVKPKRIRFYRNGDRFFKGvrlvvNRKRFKSFEALLQDLTEVVKLdlPHGVRKLYTLDGKKVTSLDELEDGGSYVASGTE 81

                    ....*.
gi 1370459265  1694 GFKTPK 1699
Cdd:smart00537   82 AFKKVD 87

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370459265  174 IKVTAYKNGSR----TVFA--RVTVPTITLLLEECTEKLNLNM-AARRVFLADGKEALEPEDIPHEADVYVS 238
Cdd:cd01617      1 KRITVFRNGDKnfkgVKVLvkPRRFRTFDQLLDELTEKLGLPTgGVRKLYTPSGKLVKSLSDLEDGESYVVC 72

ricin B-type lectin domain, beta-trefoil fold, found in the polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3)-like subfamily; The GALNT3-like subfamily includes GALNT3, GALNT4, GALNT6 and GALNT12. They act as GalNAc transferases (EC 2.4.1.41) that catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. GALNT3 has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. It probably glycosylates fibronectin in vivo as well as FGF23. It plays a central role in phosphate homeostasis. GALNT4 shows highest activity towards Muc7, EA2 and Muc2, with a lower activity compared to GALNT2. It glycosylates 'Thr-57' of SELPLG. GALNT6 may participate in the synthesis of oncofetal fibronectin. It has activity toward Muc1a, Muc2, EA2 and fibronectin peptides. GALNT12 has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with non-glycosylated Muc2 and Muc7. It displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. It may play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs. Members of this family comprise a glycosyltransferase region and a ricin B-type lectin domain. The glycosyltransferase region contains two conserved domains, domain A (also called GT1 motif) and domain B (also called Gal/GalNAc-T motif). This model corresponds to the ricin B-type lectin domain with a beta-trefoil fold, which are characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459265 1117 HCH-----QQFEY-RDGQIISHAAPQLVLGVQGPNlrsgmEVVLVEKKSDG----SHQRWIHQEDSRTFHLVSNpdLVLA 1186
Cdd:cd23435     33 GCHglggnQYFEYtSKGEIRHNIGKELCLHASGSD-----EVILQHCTSKGkdvpPEQKWLFTQDGTIRNPASG--LCLH 105

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1370459265 1187 VSMTKTRNEVCgypvivqkykpyNNGAANQKW 1218
Cdd:cd23435    106 ASGYKVLLRTC------------NPSDDSQKW 125

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459265   170 QPRVIKVTAYKNG------SRTVFARVTVPTITLLLEECTE--KLNLNMAARRVFLADGKEALEPEDIpHEADVYVSTGE 241
Cdd:smart00537    2 LVKPKRIRFYRNGdrffkgVRLVVNRKRFKSFEALLQDLTEvvKLDLPHGVRKLYTLDGKKVTSLDEL-EDGGSYVASGT 80

                            90
                    ....*....|.
gi 1370459265   242 pflNPFKKIKD 252
Cdd:smart00537   81 ---EAFKKVDY 88

Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370459265 1626 RVWIYLNG-GRPEDGTYAWGKTISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDI 1681
Cdd:cd17157      2 RILVFKNGdGSEGYEIVADLDEFEQFLDACTSKLNLGSPARVLYDWEGKEIKDLSEA 58

ricin B-type lectin domain, beta-trefoil fold, found in Lumbricus terrestris 29-kDa galactose-binding lectin (EW29) and similar proteins; EW29 is a galactose-binding lectin from the earthworm Lumbricus terrestris. It contains two ricin B-type lectin domains with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The second ricin B-type lectin domain may harbor two sugar-binding pockets in subdomains alpha and gamma. EW29 uses these two sugar-binding sites for its function as a single domain-type hemagglutinin.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459265 1130 ISHAAPQLVLGVQGPNLRSGMEVVLVEKK-SDGSHQRWIHQEDSRTFHLVSNpDLVLavsmtktrnEVCGYP-VIVQKYK 1207
Cdd:cd23449      5 IKSKLNGKVLDVEGANAKPGAKVIMWEKKgGAEDNQLWYEDEVTGTIRSKLN-DFCL---------DASGDKgLILNPYD 74

                           90
                   ....*....|....*.
gi 1370459265 1208 PYNNgaaNQKWHYMKN 1223
Cdd:cd23449     75 PSNP---KQQWKISGN 87