ricin B-type lectin domain, beta-trefoil fold, found in doublecortin domain-containing protein 1 (DCDC1) and similar proteins; DCDC1, also called doublecortin domain-containing 5 protein (DCDC5), is a microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis. In addition to doublecortin-like domains, DCDC1 may also contain a ricin B-type lectin domain in the middle region. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a putative sugar-binding pocket.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267 1032 AKIQIFCSTHKIEALVLEVQSDIVSGSKLAVHKPVAifgeekqvtepeekqmqedplttenasseildshvrahlrmkac 1111
Cdd:cd23427      1 DQIRQYCALRNPEDLVLEVSGPLVAGSKLIVNKCVL-------------------------------------------- 36

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267 1112 htlpryawqetshdfdeddslpkktekglfenvepqkkhscspkhsklhkhcHQQFEYRDGQIISHAAPQLVLGVQGPNL 1191
Cdd:cd23427     37 ----------------------------------------------------LQQFVFEDGFISCCSNPNLVLGVQGSEL 64

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267 1192 RSGMEVVLVEKKSDGSHQRWIHQEDsrtFHLVSNP--DLVLAVSMTKTRNE-------VCGYPVIVQKYKPYNNGAANQK 1262
Cdd:cd23427     65 GRGAEVVLVKKKPDDINQRWILRED---GHIMSKPnyDLVLTVSMPSTTPGdsssplsYIGCAVILQKYKGYSYGRANQK 141

                   ....*
gi 1370459267 1263 WHYMK 1267
Cdd:cd23427    142 WHWDP 146

Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267  295 VRILFFKNGMGQDGHEITVGKETMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDISKVPLLEKCLQNSITPLRGLLWVSK 374
Cdd:cd17157      1 RRILVFKNGDGSEGYEIVADLDEFEQFLDACTSKLNLGSPARVLYDWEGKEIKDLSEAPKLDKCLQNSSTPVLGPLWVSK 80

                   ....*.
gi 1370459267  375 GEGFSP 380
Cdd:cd17157     81 GEGFSP 86

Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and is involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370459267  936 VRLRVLQNGEKNKNRSVTILGpdISPGRKTQCTEILNLPSAARRLYNEKGKEIFALKDLQRDELVYVSCGELWINPDL 1013
Cdd:cd17156      1 LRLRVLRNGEKDKNKAVTVVG--EFQLFLERCTTALNLPFAARRLFDEKGKEHFTLKDLKRDQLVYVSCGEAWIDPKL 76

first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins; This ubiquitin-like (Ubl) domain (Ubl1) is found at the N-terminus of coronavirus Nsp3, a large multi-functional multi-domain protein which is an essential component of the replication/transcription complex (RTC). The functions of Ubl1 in CoVs are related to single-stranded RNA (ssRNA) binding and to interacting with the nucleocapsid (N) protein. SARS-CoV Ubl1 has been shown to bind ssRNA having AUA patterns, and since the 5'-UTR of the SARS-CoV genome has a number of AUA repeats, it may bind there. In mouse hepatitis virus (MHV), this Ubl1 domain binds the cognate N protein. Adjacent to Ubl1 is a Glu-rich acidic region (also referred to as hypervariable region, HVR); Ubl1 together with HVR has been called Nsp3a. Currently, the function of HVR in CoVs is unknown. This model corresponds to one of two Ubl domains in Nsp3; the other is located N-terminal to the papain-like protease (PLpro) and is not represented by this model.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 1370459267  547 GLNYSSMRLFDENGQEIKNPLSLKNEQKIWVSYG 580
Cdd:cd17072     38 NLPFAARRLFDENGKEIFTLRDLERDQLVYVSCG 71

ricin B-type lectin domain, beta-trefoil fold, found in doublecortin domain-containing protein 1 (DCDC1) and similar proteins; DCDC1, also called doublecortin domain-containing 5 protein (DCDC5), is a microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis. In addition to doublecortin-like domains, DCDC1 may also contain a ricin B-type lectin domain in the middle region. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a putative sugar-binding pocket.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267 1032 AKIQIFCSTHKIEALVLEVQSDIVSGSKLAVHKPVAifgeekqvtepeekqmqedplttenasseildshvrahlrmkac 1111
Cdd:cd23427      1 DQIRQYCALRNPEDLVLEVSGPLVAGSKLIVNKCVL-------------------------------------------- 36

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267 1112 htlpryawqetshdfdeddslpkktekglfenvepqkkhscspkhsklhkhcHQQFEYRDGQIISHAAPQLVLGVQGPNL 1191
Cdd:cd23427     37 ----------------------------------------------------LQQFVFEDGFISCCSNPNLVLGVQGSEL 64

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267 1192 RSGMEVVLVEKKSDGSHQRWIHQEDsrtFHLVSNP--DLVLAVSMTKTRNE-------VCGYPVIVQKYKPYNNGAANQK 1262
Cdd:cd23427     65 GRGAEVVLVKKKPDDINQRWILRED---GHIMSKPnyDLVLTVSMPSTTPGdsssplsYIGCAVILQKYKGYSYGRANQK 141

                   ....*
gi 1370459267 1263 WHYMK 1267
Cdd:cd23427    142 WHWDP 146

Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267  295 VRILFFKNGMGQDGHEITVGKETMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDISKVPLLEKCLQNSITPLRGLLWVSK 374
Cdd:cd17157      1 RRILVFKNGDGSEGYEIVADLDEFEQFLDACTSKLNLGSPARVLYDWEGKEIKDLSEAPKLDKCLQNSSTPVLGPLWVSK 80

                   ....*.
gi 1370459267  375 GEGFSP 380
Cdd:cd17157     81 GEGFSP 86

Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and is involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370459267  936 VRLRVLQNGEKNKNRSVTILGpdISPGRKTQCTEILNLPSAARRLYNEKGKEIFALKDLQRDELVYVSCGELWINPDL 1013
Cdd:cd17156      1 LRLRVLRNGEKDKNKAVTVVG--EFQLFLERCTTALNLPFAARRLFDEKGKEHFTLKDLKRDQLVYVSCGEAWIDPKL 76

Ricin-type beta-trefoil lectin domain;

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267 1162 HCH-----QQFEYRDGQIISHAAPQLVLGVQGPNlrSGMEVVLVEKKSDGSHQRWIHQEDSRT-FHLVSNpdLVLAVSMT 1235
Cdd:pfam00652   30 PCHgsngnQLWTLTGDGTIRSVASDLCLDVGSTA--DGAKVVLWPCHPGNGNQRWRYDEDGTQiRNPQSG--KCLDVSGA 105

                           90       100
                   ....*....|....*....|....*...
gi 1370459267 1236 KTRNEvcgyPVIVQKYkpyNNGAANQKW 1263
Cdd:pfam00652  106 GTSNG----KVILWTC---DSGNPNQQW 126

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267  1598 QPNTKRVWIYLNGGRPEDG-----TYAWGKTISELLQDCSSRLKM--THPARALYTPSGEPIQSWDDIERDMVICVSMGH 1670
Cdd:smart00537    2 LVKPKRIRFYRNGDRFFKGvrlvvNRKRFKSFEALLQDLTEVVKLdlPHGVRKLYTLDGKKVTSLDELEDGGSYVASGTE 81

                    ....*.
gi 1370459267  1671 GFKTPK 1676
Cdd:smart00537   82 AFKKVD 87

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 1370459267  547 GLNYSSMRLFDENGQEIKNPLSLKNEQKIWVSYG 580
Cdd:cd17072     38 NLPFAARRLFDENGKEIFTLRDLERDQLVYVSCG 71

GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; Gellin proteins act as central effectors of wound-induced protoplasmic gelation. They possess ten related N-terminal beta-trefoil domains (Gll-1 to Gll-10) that contribute to distinct gelation-related activities. The beta-trefoil domains show low sequence similarity to members of the functionally diverse ricin B lectin domain family. They are characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain bears a potential sugar binding site. Gellin from M. circinelloides has been called GellinA (also known as GllA). The model corresponds to GllA-1 domain, which is a remote family member of the ricin B-type lectin domain.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1370459267  730 AAEGTSLEGYKLILQKRHSGDDS--QKWVFGTDGCIYSKAYPQFVLT 774
Cdd:cd23454     60 IQGGVVKSGTRLVQSPKKPSKDAnnQRWGLTADGYIYLLSNPSLVLG 106

ricin B-type lectin domain, beta-trefoil fold, found in doublecortin domain-containing protein 1 (DCDC1) and similar proteins; DCDC1, also called doublecortin domain-containing 5 protein (DCDC5), is a microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis. In addition to doublecortin-like domains, DCDC1 may also contain a ricin B-type lectin domain in the middle region. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a putative sugar-binding pocket.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267 1032 AKIQIFCSTHKIEALVLEVQSDIVSGSKLAVHKPVAifgeekqvtepeekqmqedplttenasseildshvrahlrmkac 1111
Cdd:cd23427      1 DQIRQYCALRNPEDLVLEVSGPLVAGSKLIVNKCVL-------------------------------------------- 36

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267 1112 htlpryawqetshdfdeddslpkktekglfenvepqkkhscspkhsklhkhcHQQFEYRDGQIISHAAPQLVLGVQGPNL 1191
Cdd:cd23427     37 ----------------------------------------------------LQQFVFEDGFISCCSNPNLVLGVQGSEL 64

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267 1192 RSGMEVVLVEKKSDGSHQRWIHQEDsrtFHLVSNP--DLVLAVSMTKTRNE-------VCGYPVIVQKYKPYNNGAANQK 1262
Cdd:cd23427     65 GRGAEVVLVKKKPDDINQRWILRED---GHIMSKPnyDLVLTVSMPSTTPGdsssplsYIGCAVILQKYKGYSYGRANQK 141

                   ....*
gi 1370459267 1263 WHYMK 1267
Cdd:cd23427    142 WHWDP 146

Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267  295 VRILFFKNGMGQDGHEITVGKETMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDISKVPLLEKCLQNSITPLRGLLWVSK 374
Cdd:cd17157      1 RRILVFKNGDGSEGYEIVADLDEFEQFLDACTSKLNLGSPARVLYDWEGKEIKDLSEAPKLDKCLQNSSTPVLGPLWVSK 80

                   ....*.
gi 1370459267  375 GEGFSP 380
Cdd:cd17157     81 GEGFSP 86

Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and is involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370459267  936 VRLRVLQNGEKNKNRSVTILGpdISPGRKTQCTEILNLPSAARRLYNEKGKEIFALKDLQRDELVYVSCGELWINPDL 1013
Cdd:cd17156      1 LRLRVLRNGEKDKNKAVTVVG--EFQLFLERCTTALNLPFAARRLFDEKGKEHFTLKDLKRDQLVYVSCGEAWIDPKL 76

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370459267 1602 KRVWIYLNGGR-PEDGTYAWGK--TISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDIERDMVICVSMG 1669
Cdd:cd17072      1 VRLRVLKNGERdLERAVYVVGPdlELQLFLDRCTERLNLPFAARRLFDENGKEIFTLRDLERDQLVYVSCG 71

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267  295 VRILFFKNGMG--QDGHEITVGKETMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDIskvpllekclqnSITPLRGLLWV 372
Cdd:cd17072      1 VRLRVLKNGERdlERAVYVVGPDLELQLFLDRCTERLNLPFAARRLFDENGKEIFTL------------RDLERDQLVYV 68

                   ...
gi 1370459267  373 SKG 375
Cdd:cd17072     69 SCG 71

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267 1365 SVAELLTECTEQLGLARAASKVYTKDGTPIftlrdlvlwaldesflqrdsekqkqdaapvgkeqiivesmeenprmkvkn 1444
Cdd:cd17158     23 TFPGLLDQCTHRLGLARAARRLYTADGTLI-------------------------------------------------- 52

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1370459267 1445 rlfaksvtsdsldgidkslLTLILRNPIAIWVSCGEPFLP 1484
Cdd:cd17158     53 -------------------LTLILRYPIEVWVSCGEPFIP 73

Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370459267  946 KNKNRSV--TILGPDIspgrKT---QCTEILNLPSAARRLYNEKGKEIFALKDLQRDELVYVSCGE 1006
Cdd:cd17155      7 KNGTRDVfaKVTAPNI----KIlleECTEKLGLNSAARRVFLADGTEVFEPKDIPRDADVYISTGE 68

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370459267  936 VRLRVLQNGEKNkNRSVTILGP----DISPGRKTQCTEILNL-PSAARRLYNEKGKEIFALKDLQRDElVYVSCG 1005
Cdd:cd01617      1 KRITVFRNGDKN-FKGVKVLVKprrfRTFDQLLDELTEKLGLpTGGVRKLYTPSGKLVKSLSDLEDGE-SYVVCG 73

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370459267  936 VRLRVLQNGEKNKNRSVTILGPDIsPGRKTQCTEILNLPSAARRLYNEKGKEIFALkDLQRDELVYVSCGELWI 1009
Cdd:cd17158      1 VKILAYKNGEGRLRDGVLIIGSTF-PGLLDQCTHRLGLARAARRLYTADGTLILTL-ILRYPIEVWVSCGEPFI 72

ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267 1164 HQQFEYRD-----GQIIShAAPQLVLGVQGPNLRSGMEVVLVEkKSDGSHQRW-IHQEDSRTFHLVS-NPDLVLAVSMTK 1236
Cdd:cd00161     37 NQQWTLTPvgdgyYTIRN-VASGKCLDVAGGSTANGANVQQWT-CNGGDNQQWrLEPVGDGYYRIVNkHSGKCLDVSGGS 114

                           90       100
                   ....*....|....*....|....*..
gi 1370459267 1237 TRNevcGYPVIVQKYkpynNGAANQKW 1263
Cdd:cd00161    115 TAN---GANVQQWTC----NGGANQQW 134

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370459267  175 KVTAYKNGS---RTVFARVTvpTITLLLEECTEKLNLNMAARRVFLADGKEALEPEDIPHEADVYVSTGEPFLN 245
Cdd:cd17159      2 RVLVYPNGGspeRAVYAWGK--SIEELLDSCTERLGLRKPAKYLYTPDGEQIQSWDDIERDMLLCVSTGEPFLT 73

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267  296 RILFFKNGmGQDGHEITVGKETMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDISKVpllEKCLqnsitplrgLLWVSKG 375
Cdd:cd17159      2 RVLVYPNG-GSPERAVYAWGKSIEELLDSCTERLGLRKPAKYLYTPDGEQIQSWDDI---ERDM---------LLCVSTG 68

                   ....
gi 1370459267  376 EGFS 379
Cdd:cd17159     69 EPFL 72

Ricin-type beta-trefoil lectin domain;

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267 1162 HCH-----QQFEYRDGQIISHAAPQLVLGVQGPNlrSGMEVVLVEKKSDGSHQRWIHQEDSRT-FHLVSNpdLVLAVSMT 1235
Cdd:pfam00652   30 PCHgsngnQLWTLTGDGTIRSVASDLCLDVGSTA--DGAKVVLWPCHPGNGNQRWRYDEDGTQiRNPQSG--KCLDVSGA 105

                           90       100
                   ....*....|....*....|....*...
gi 1370459267 1236 KTRNEvcgyPVIVQKYkpyNNGAANQKW 1263
Cdd:pfam00652  106 GTSNG----KVILWTC---DSGNPNQQW 126

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267  937 RLRVLQNGEkNKNRSVTILGPDISPGRKTqCTEILNLPSAARRLYNEKGKEIFALKDLQRDELVYVSCGE 1006
Cdd:cd17159      2 RVLVYPNGG-SPERAVYAWGKSIEELLDS-CTERLGLRKPAKYLYTPDGEQIQSWDDIERDMLLCVSTGE 69

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1370459267 1365 SVAELLTECTEQLGLARAASKVYTKDGTPIFTLRDL 1400
Cdd:cd17159     22 SIEELLDSCTERLGLRKPAKYLYTPDGEQIQSWDDI 57

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267  1598 QPNTKRVWIYLNGGRPEDG-----TYAWGKTISELLQDCSSRLKM--THPARALYTPSGEPIQSWDDIERDMVICVSMGH 1670
Cdd:smart00537    2 LVKPKRIRFYRNGDRFFKGvrlvvNRKRFKSFEALLQDLTEVVKLdlPHGVRKLYTLDGKKVTSLDELEDGGSYVASGTE 81

                    ....*.
gi 1370459267  1671 GFKTPK 1676
Cdd:smart00537   82 AFKKVD 87

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370459267  174 IKVTAYKNGSR----TVFA--RVTVPTITLLLEECTEKLNLNM-AARRVFLADGKEALEPEDIPHEADVYVS 238
Cdd:cd01617      1 KRITVFRNGDKnfkgVKVLvkPRRFRTFDQLLDELTEKLGLPTgGVRKLYTPSGKLVKSLSDLEDGESYVVC 72

ricin B-type lectin domain, beta-trefoil fold, found in the polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3)-like subfamily; The GALNT3-like subfamily includes GALNT3, GALNT4, GALNT6 and GALNT12. They act as GalNAc transferases (EC 2.4.1.41) that catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. GALNT3 has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. It probably glycosylates fibronectin in vivo as well as FGF23. It plays a central role in phosphate homeostasis. GALNT4 shows highest activity towards Muc7, EA2 and Muc2, with a lower activity compared to GALNT2. It glycosylates 'Thr-57' of SELPLG. GALNT6 may participate in the synthesis of oncofetal fibronectin. It has activity toward Muc1a, Muc2, EA2 and fibronectin peptides. GALNT12 has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with non-glycosylated Muc2 and Muc7. It displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. It may play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs. Members of this family comprise a glycosyltransferase region and a ricin B-type lectin domain. The glycosyltransferase region contains two conserved domains, domain A (also called GT1 motif) and domain B (also called Gal/GalNAc-T motif). This model corresponds to the ricin B-type lectin domain with a beta-trefoil fold, which are characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267 1162 HCH-----QQFEY-RDGQIISHAAPQLVLGVQGPNlrsgmEVVLVEKKSDG----SHQRWIHQEDSRTFHLVSNpdLVLA 1231
Cdd:cd23435     33 GCHglggnQYFEYtSKGEIRHNIGKELCLHASGSD-----EVILQHCTSKGkdvpPEQKWLFTQDGTIRNPASG--LCLH 105

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1370459267 1232 VSMTKTRNEVCgypvivqkykpyNNGAANQKW 1263
Cdd:cd23435    106 ASGYKVLLRTC------------NPSDDSQKW 125

Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370459267 1603 RVWIYLNG-GRPEDGTYAWGKTISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDI 1658
Cdd:cd17157      2 RILVFKNGdGSEGYEIVADLDEFEQFLDACTSKLNLGSPARVLYDWEGKEIKDLSEA 58

ricin B-type lectin domain, beta-trefoil fold, found in Lumbricus terrestris 29-kDa galactose-binding lectin (EW29) and similar proteins; EW29 is a galactose-binding lectin from the earthworm Lumbricus terrestris. It contains two ricin B-type lectin domains with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The second ricin B-type lectin domain may harbor two sugar-binding pockets in subdomains alpha and gamma. EW29 uses these two sugar-binding sites for its function as a single domain-type hemagglutinin.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459267 1175 ISHAAPQLVLGVQGPNLRSGMEVVLVEKK-SDGSHQRWIHQEDSRTFHLVSNpDLVLavsmtktrnEVCGYP-VIVQKYK 1252
Cdd:cd23449      5 IKSKLNGKVLDVEGANAKPGAKVIMWEKKgGAEDNQLWYEDEVTGTIRSKLN-DFCL---------DASGDKgLILNPYD 74

                           90
                   ....*....|....*.
gi 1370459267 1253 PYNNgaaNQKWHYMKN 1268
Cdd:cd23449     75 PSNP---KQQWKISGN 87