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Conserved domains on  [gi|1370461310|ref|XP_024304634|]
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uncharacterized protein C12orf50 isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF5571 pfam17732
Family of unknown function (DUF5571); This is a family of unknown function found in chordata. ...
66-414 0e+00

Family of unknown function (DUF5571); This is a family of unknown function found in chordata. Family members carry a zinc finger family on the N-terminal pfam15663.


:

Pssm-ID: 465475  Cd Length: 352  Bit Score: 594.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370461310  66 LKPQENISRPIHHPLVLKTNFE---EEEEVDEQNDASSLWTKTPEEIEEKRAIKEMCYKSGEYYRFHTPPDILSSKSMTP 142
Cdd:pfam17732   1 LKPQENISRPIHPPLVININFEeeeEEEEEEKENDASSLWTKTPEDIEEERAIKEMCYKSGEYYRFHTPPDHQSTKSVSP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370461310 143 TAEKQLEKPLENGSELQEGDSLTVPTKLSQYERQGEIKTSLHGKPKTDIAAFENGGGDCYVPQRVIFLGVDESEALTEEK 222
Cdd:pfam17732  81 SVEKELEKPLENGSDLQEGDGLTIPTKLNNFERQGETKISLDGKPRTDLAAFENGGGDCYVPQRIIFLGVDESEALTEEK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370461310 223 EITISKCSNTKDNKDSPHPKHSLTTRLVPTTHVLNATENISMKCREDPSSMNDVQPVKKPHFKGVKKRKWIYDEPQNFPN 302
Cdd:pfam17732 161 EPIMSKYSNVKDIKDSPHPKHSVTTRLVPTTHVLNATENINMKCREDPSSMNDSQPVRKPHFKGVKKKKWIYEEPKNSPN 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370461310 303 SGMQRAVQAPRPQNKMSYHRNNKNRNAENASYIHVQRDAVRTVALNAPSRSRPTHGSYNKVHANREPKPNLSPDKYTSTS 382
Cdd:pfam17732 241 PGTRKATQTPNPKNKMSYQRNDKNRNAENASYIHVVRQAVRNVYLNSPEPRRSANGFYNKVRVNKEPKFNLSPDKYSSTS 320
                         330       340       350
                  ....*....|....*....|....*....|..
gi 1370461310 383 YNDSAWRKRIPFSKTYSKSEKIYPEPRRNGSK 414
Cdd:pfam17732 321 YNAPTWRKRIPFSKTYSKFKKIYSEPRRNGSK 352
zf-CCCH_3 super family cl25863
Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically ...
1-45 1.38e-14

Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically between 155 and 169 amino acids in length.


The actual alignment was detected with superfamily member pfam15663:

Pssm-ID: 464787 [Multi-domain]  Cd Length: 110  Bit Score: 69.41  E-value: 1.38e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1370461310   1 MEMQQNCS-ISCFWETQPLGCVKISCIFYHSKPRNINGLFLPPSSN 45
Cdd:pfam15663  55 MEIDKNRKeIPCYWENQPGGCQKPHCAFHHTKPRYVDGLFLPPSKT 100
 
Name Accession Description Interval E-value
DUF5571 pfam17732
Family of unknown function (DUF5571); This is a family of unknown function found in chordata. ...
66-414 0e+00

Family of unknown function (DUF5571); This is a family of unknown function found in chordata. Family members carry a zinc finger family on the N-terminal pfam15663.


Pssm-ID: 465475  Cd Length: 352  Bit Score: 594.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370461310  66 LKPQENISRPIHHPLVLKTNFE---EEEEVDEQNDASSLWTKTPEEIEEKRAIKEMCYKSGEYYRFHTPPDILSSKSMTP 142
Cdd:pfam17732   1 LKPQENISRPIHPPLVININFEeeeEEEEEEKENDASSLWTKTPEDIEEERAIKEMCYKSGEYYRFHTPPDHQSTKSVSP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370461310 143 TAEKQLEKPLENGSELQEGDSLTVPTKLSQYERQGEIKTSLHGKPKTDIAAFENGGGDCYVPQRVIFLGVDESEALTEEK 222
Cdd:pfam17732  81 SVEKELEKPLENGSDLQEGDGLTIPTKLNNFERQGETKISLDGKPRTDLAAFENGGGDCYVPQRIIFLGVDESEALTEEK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370461310 223 EITISKCSNTKDNKDSPHPKHSLTTRLVPTTHVLNATENISMKCREDPSSMNDVQPVKKPHFKGVKKRKWIYDEPQNFPN 302
Cdd:pfam17732 161 EPIMSKYSNVKDIKDSPHPKHSVTTRLVPTTHVLNATENINMKCREDPSSMNDSQPVRKPHFKGVKKKKWIYEEPKNSPN 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370461310 303 SGMQRAVQAPRPQNKMSYHRNNKNRNAENASYIHVQRDAVRTVALNAPSRSRPTHGSYNKVHANREPKPNLSPDKYTSTS 382
Cdd:pfam17732 241 PGTRKATQTPNPKNKMSYQRNDKNRNAENASYIHVVRQAVRNVYLNSPEPRRSANGFYNKVRVNKEPKFNLSPDKYSSTS 320
                         330       340       350
                  ....*....|....*....|....*....|..
gi 1370461310 383 YNDSAWRKRIPFSKTYSKSEKIYPEPRRNGSK 414
Cdd:pfam17732 321 YNAPTWRKRIPFSKTYSKFKKIYSEPRRNGSK 352
zf-CCCH_3 pfam15663
Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically ...
1-45 1.38e-14

Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically between 155 and 169 amino acids in length.


Pssm-ID: 464787 [Multi-domain]  Cd Length: 110  Bit Score: 69.41  E-value: 1.38e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1370461310   1 MEMQQNCS-ISCFWETQPLGCVKISCIFYHSKPRNINGLFLPPSSN 45
Cdd:pfam15663  55 MEIDKNRKeIPCYWENQPGGCQKPHCAFHHTKPRYVDGLFLPPSKT 100
 
Name Accession Description Interval E-value
DUF5571 pfam17732
Family of unknown function (DUF5571); This is a family of unknown function found in chordata. ...
66-414 0e+00

Family of unknown function (DUF5571); This is a family of unknown function found in chordata. Family members carry a zinc finger family on the N-terminal pfam15663.


Pssm-ID: 465475  Cd Length: 352  Bit Score: 594.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370461310  66 LKPQENISRPIHHPLVLKTNFE---EEEEVDEQNDASSLWTKTPEEIEEKRAIKEMCYKSGEYYRFHTPPDILSSKSMTP 142
Cdd:pfam17732   1 LKPQENISRPIHPPLVININFEeeeEEEEEEKENDASSLWTKTPEDIEEERAIKEMCYKSGEYYRFHTPPDHQSTKSVSP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370461310 143 TAEKQLEKPLENGSELQEGDSLTVPTKLSQYERQGEIKTSLHGKPKTDIAAFENGGGDCYVPQRVIFLGVDESEALTEEK 222
Cdd:pfam17732  81 SVEKELEKPLENGSDLQEGDGLTIPTKLNNFERQGETKISLDGKPRTDLAAFENGGGDCYVPQRIIFLGVDESEALTEEK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370461310 223 EITISKCSNTKDNKDSPHPKHSLTTRLVPTTHVLNATENISMKCREDPSSMNDVQPVKKPHFKGVKKRKWIYDEPQNFPN 302
Cdd:pfam17732 161 EPIMSKYSNVKDIKDSPHPKHSVTTRLVPTTHVLNATENINMKCREDPSSMNDSQPVRKPHFKGVKKKKWIYEEPKNSPN 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370461310 303 SGMQRAVQAPRPQNKMSYHRNNKNRNAENASYIHVQRDAVRTVALNAPSRSRPTHGSYNKVHANREPKPNLSPDKYTSTS 382
Cdd:pfam17732 241 PGTRKATQTPNPKNKMSYQRNDKNRNAENASYIHVVRQAVRNVYLNSPEPRRSANGFYNKVRVNKEPKFNLSPDKYSSTS 320
                         330       340       350
                  ....*....|....*....|....*....|..
gi 1370461310 383 YNDSAWRKRIPFSKTYSKSEKIYPEPRRNGSK 414
Cdd:pfam17732 321 YNAPTWRKRIPFSKTYSKFKKIYSEPRRNGSK 352
zf-CCCH_3 pfam15663
Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically ...
1-45 1.38e-14

Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically between 155 and 169 amino acids in length.


Pssm-ID: 464787 [Multi-domain]  Cd Length: 110  Bit Score: 69.41  E-value: 1.38e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1370461310   1 MEMQQNCS-ISCFWETQPLGCVKISCIFYHSKPRNINGLFLPPSSN 45
Cdd:pfam15663  55 MEIDKNRKeIPCYWENQPGGCQKPHCAFHHTKPRYVDGLFLPPSKT 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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