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Conserved domains on  [gi|1370462066|ref|XP_024304777|]
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endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X1 [Homo sapiens]

Protein Classification

endoplasmic reticulum-Golgi intermediate compartment family protein( domain architecture ID 10620114)

endoplasmic reticulum-Golgi intermediate compartment (ERGIC) family protein is a constituent of COPII-coated ER-derived transport vesicles, playing a role in transport between the ER and Golgi, similar to vertebrate ERGIC protein and fungal ER-derived vesicles proteins

Gene Ontology:  GO:0030134|GO:0006888|GO:0016020
PubMed:  15308636|28444333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COPIIcoated_ERV pfam07970
Endoplasmic reticulum vesicle transporter; This family is conserved from plants and fungi to ...
 170-332 7.69e-60

Endoplasmic reticulum vesicle transporter; This family is conserved from plants and fungi to humans. Erv46 works in close conjunction with Erv41 and together they form a complex which cycles between the endoplasmic reticulum and Golgi complex. Erv46-41 interacts strongly with the endoplasmic reticulum glucosidase II. Mammalian glucosidase II comprises a catalytic alpha-subunit and a 58 kDa beta subunit, which is required for ER localization. All proteins identified biochemically as Erv41p-Erv46p interactors are localized to the early secretory pathway and are involved in protein maturation and processing in the ER and/or sorting into COPII vesicles for transport to the Golgi.


:

Pssm-ID: 462327  Cd Length: 225  Bit Score: 192.82  E-value: 7.69e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462066 170 CRIHGHLYVNKVAGNFHITVGKAIPHPRGHAH--LAALVNHESYNFSHRIDHLSFGELVPAI-INPLDGTEKIAIDHNQM 246
Cdd:pfam07970  55 CRIKGTLEVNKVAGNFHIAPGRSFQQGGMHVHdlSPYLKLPDKFNFSHTIHHLSFGPDIPGEkVNPLDGTKVQTDTGNYM 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462066 247 FQYFITVVPTKLHTYKISA-DTHQFSVTERERIINHAAGSH---GVSGIFMKYDLSSLMVTVTEEHMPFWQFFVRLCGIV 322
Cdd:pfam07970 135 FQYFLKVVPTRYEFLDGKKiETNQYSVTSHERPLTGGRDEHgrgGLPGVFFNYDISPMKVINTEQRRSFSHFLTSVCAII 214

                         170
                  ....*....|
gi 1370462066 323 GGIFSTTGML 332
Cdd:pfam07970 215 GGVFTVASLI 224
ERGIC_N pfam13850
Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC); This family is the N-terminal of ...
 13-95 7.48e-31

Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC); This family is the N-terminal of ERGIC proteins, ER-Golgi intermediate compartment clusters, otherwise known as Ervs, and is associated with family COPIIcoated_ERV, pfam07970.


:

Pssm-ID: 464000  Cd Length: 91  Bit Score: 112.94  E-value: 7.48e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462066  13 VKELDAFPKVPESYVETSASGGTVSLIAFTTMALLTIMEFSVYQDTWMKYEYEVDKDFSSKLRINIDITV-AMKCQYVGA 91
Cdd:pfam13850   1 LKSFDAFPKTPEDYRVRTSSGGIITIISILIILFLFLSELGSYLTGTVDPELVVDKSRGEKLQINLDITFpAMPCDLLSV 80


                  ....
gi 1370462066  92 DVLD 95
Cdd:pfam13850  81 DVMD 84
 
Name Accession Description Interval E-value
COPIIcoated_ERV pfam07970
Endoplasmic reticulum vesicle transporter; This family is conserved from plants and fungi to ...
 170-332 7.69e-60

Endoplasmic reticulum vesicle transporter; This family is conserved from plants and fungi to humans. Erv46 works in close conjunction with Erv41 and together they form a complex which cycles between the endoplasmic reticulum and Golgi complex. Erv46-41 interacts strongly with the endoplasmic reticulum glucosidase II. Mammalian glucosidase II comprises a catalytic alpha-subunit and a 58 kDa beta subunit, which is required for ER localization. All proteins identified biochemically as Erv41p-Erv46p interactors are localized to the early secretory pathway and are involved in protein maturation and processing in the ER and/or sorting into COPII vesicles for transport to the Golgi.


Pssm-ID: 462327  Cd Length: 225  Bit Score: 192.82  E-value: 7.69e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462066 170 CRIHGHLYVNKVAGNFHITVGKAIPHPRGHAH--LAALVNHESYNFSHRIDHLSFGELVPAI-INPLDGTEKIAIDHNQM 246
Cdd:pfam07970  55 CRIKGTLEVNKVAGNFHIAPGRSFQQGGMHVHdlSPYLKLPDKFNFSHTIHHLSFGPDIPGEkVNPLDGTKVQTDTGNYM 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462066 247 FQYFITVVPTKLHTYKISA-DTHQFSVTERERIINHAAGSH---GVSGIFMKYDLSSLMVTVTEEHMPFWQFFVRLCGIV 322
Cdd:pfam07970 135 FQYFLKVVPTRYEFLDGKKiETNQYSVTSHERPLTGGRDEHgrgGLPGVFFNYDISPMKVINTEQRRSFSHFLTSVCAII 214

                         170
                  ....*....|
gi 1370462066 323 GGIFSTTGML 332
Cdd:pfam07970 215 GGVFTVASLI 224
ERGIC_N pfam13850
Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC); This family is the N-terminal of ...
 13-95 7.48e-31

Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC); This family is the N-terminal of ERGIC proteins, ER-Golgi intermediate compartment clusters, otherwise known as Ervs, and is associated with family COPIIcoated_ERV, pfam07970.


Pssm-ID: 464000  Cd Length: 91  Bit Score: 112.94  E-value: 7.48e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462066  13 VKELDAFPKVPESYVETSASGGTVSLIAFTTMALLTIMEFSVYQDTWMKYEYEVDKDFSSKLRINIDITV-AMKCQYVGA 91
Cdd:pfam13850   1 LKSFDAFPKTPEDYRVRTSSGGIITIISILIILFLFLSELGSYLTGTVDPELVVDKSRGEKLQINLDITFpAMPCDLLSV 80


                  ....
gi 1370462066  92 DVLD 95
Cdd:pfam13850  81 DVMD 84
 
Name Accession Description Interval E-value
COPIIcoated_ERV pfam07970
Endoplasmic reticulum vesicle transporter; This family is conserved from plants and fungi to ...
 170-332 7.69e-60

Endoplasmic reticulum vesicle transporter; This family is conserved from plants and fungi to humans. Erv46 works in close conjunction with Erv41 and together they form a complex which cycles between the endoplasmic reticulum and Golgi complex. Erv46-41 interacts strongly with the endoplasmic reticulum glucosidase II. Mammalian glucosidase II comprises a catalytic alpha-subunit and a 58 kDa beta subunit, which is required for ER localization. All proteins identified biochemically as Erv41p-Erv46p interactors are localized to the early secretory pathway and are involved in protein maturation and processing in the ER and/or sorting into COPII vesicles for transport to the Golgi.


Pssm-ID: 462327  Cd Length: 225  Bit Score: 192.82  E-value: 7.69e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462066 170 CRIHGHLYVNKVAGNFHITVGKAIPHPRGHAH--LAALVNHESYNFSHRIDHLSFGELVPAI-INPLDGTEKIAIDHNQM 246
Cdd:pfam07970  55 CRIKGTLEVNKVAGNFHIAPGRSFQQGGMHVHdlSPYLKLPDKFNFSHTIHHLSFGPDIPGEkVNPLDGTKVQTDTGNYM 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462066 247 FQYFITVVPTKLHTYKISA-DTHQFSVTERERIINHAAGSH---GVSGIFMKYDLSSLMVTVTEEHMPFWQFFVRLCGIV 322
Cdd:pfam07970 135 FQYFLKVVPTRYEFLDGKKiETNQYSVTSHERPLTGGRDEHgrgGLPGVFFNYDISPMKVINTEQRRSFSHFLTSVCAII 214

                         170
                  ....*....|
gi 1370462066 323 GGIFSTTGML 332
Cdd:pfam07970 215 GGVFTVASLI 224
ERGIC_N pfam13850
Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC); This family is the N-terminal of ...
 13-95 7.48e-31

Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC); This family is the N-terminal of ERGIC proteins, ER-Golgi intermediate compartment clusters, otherwise known as Ervs, and is associated with family COPIIcoated_ERV, pfam07970.


Pssm-ID: 464000  Cd Length: 91  Bit Score: 112.94  E-value: 7.48e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462066  13 VKELDAFPKVPESYVETSASGGTVSLIAFTTMALLTIMEFSVYQDTWMKYEYEVDKDFSSKLRINIDITV-AMKCQYVGA 91
Cdd:pfam13850   1 LKSFDAFPKTPEDYRVRTSSGGIITIISILIILFLFLSELGSYLTGTVDPELVVDKSRGEKLQINLDITFpAMPCDLLSV 80


                  ....
gi 1370462066  92 DVLD 95
Cdd:pfam13850  81 DVMD 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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