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Conserved domains on  [gi|1370462942|ref|XP_024304979|]
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cysteine/serine-rich nuclear protein 2 isoform X1 [Homo sapiens]

Protein Classification

cysteine/serine-rich nuclear protein( domain architecture ID 11240357)

cysteine/serine-rich nuclear protein (CSRNP) may bind to the consensus sequence 5'-AGAGTG-3' and have transcriptional activator activity, such as CSRNP1, also called AXUD1, that may have tumor-suppressor function and play a role in apoptosis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CSRNP_N pfam16019
Cysteine/serine-rich nuclear protein N-terminus; This presumed domain is found at the ...
 61-279 1.81e-146

Cysteine/serine-rich nuclear protein N-terminus; This presumed domain is found at the N-terminus of cysteine/serine-rich nuclear proteins. These proteins act as transcriptional activators.


:

Pssm-ID: 464977  Cd Length: 218  Bit Score: 419.78  E-value: 1.81e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462942  61 LRRKNVRFDQVTVYYFARRQGFTSVPSQGGSSLGMAQRHNSVRSYTLCEFAQEQEVNHREILREHLKEEKLHAKKMKLTK 140
Cdd:pfam16019   1 KKKKSVRFDQVTVFYFPRCQGFTCVPSQGGSTLGMARKHSAFRRFTLAEHAIEQRRRRREKLRERRREEKLEALKQKLSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462942 141 NGTVESVEADGLTLDDVSDEDIDveNVEVDDYFFLQPLPTKRRRALLRASGVHRIDAEEKQELRAIRLSREECGCDCRLY 220
Cdd:pfam16019  81 SGTISDSEEEPLTIDDISDSDLD--GAELDDYGFLQPVPTKQRRALLRAAGVRKIDSEEKDECRAIRLSREDCGCDCRGF 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370462942 221 CDPEACACSQAGIKCQVDRMSFPCGCSRDGCGNMAGRIEFNPIRVRTHYLHTIMKLELE 279
Cdd:pfam16019 159 CDPETCACSLAGIKCQVDRPSFPCGCTKDGCGNPQGRIEFNPTRVRTHFIHTLMRLELE 217
 
Name Accession Description Interval E-value
CSRNP_N pfam16019
Cysteine/serine-rich nuclear protein N-terminus; This presumed domain is found at the ...
 61-279 1.81e-146

Cysteine/serine-rich nuclear protein N-terminus; This presumed domain is found at the N-terminus of cysteine/serine-rich nuclear proteins. These proteins act as transcriptional activators.


Pssm-ID: 464977  Cd Length: 218  Bit Score: 419.78  E-value: 1.81e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462942  61 LRRKNVRFDQVTVYYFARRQGFTSVPSQGGSSLGMAQRHNSVRSYTLCEFAQEQEVNHREILREHLKEEKLHAKKMKLTK 140
Cdd:pfam16019   1 KKKKSVRFDQVTVFYFPRCQGFTCVPSQGGSTLGMARKHSAFRRFTLAEHAIEQRRRRREKLRERRREEKLEALKQKLSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462942 141 NGTVESVEADGLTLDDVSDEDIDveNVEVDDYFFLQPLPTKRRRALLRASGVHRIDAEEKQELRAIRLSREECGCDCRLY 220
Cdd:pfam16019  81 SGTISDSEEEPLTIDDISDSDLD--GAELDDYGFLQPVPTKQRRALLRAAGVRKIDSEEKDECRAIRLSREDCGCDCRGF 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370462942 221 CDPEACACSQAGIKCQVDRMSFPCGCSRDGCGNMAGRIEFNPIRVRTHYLHTIMKLELE 279
Cdd:pfam16019 159 CDPETCACSLAGIKCQVDRPSFPCGCTKDGCGNPQGRIEFNPTRVRTHFIHTLMRLELE 217
 
Name Accession Description Interval E-value
CSRNP_N pfam16019
Cysteine/serine-rich nuclear protein N-terminus; This presumed domain is found at the ...
 61-279 1.81e-146

Cysteine/serine-rich nuclear protein N-terminus; This presumed domain is found at the N-terminus of cysteine/serine-rich nuclear proteins. These proteins act as transcriptional activators.


Pssm-ID: 464977  Cd Length: 218  Bit Score: 419.78  E-value: 1.81e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462942  61 LRRKNVRFDQVTVYYFARRQGFTSVPSQGGSSLGMAQRHNSVRSYTLCEFAQEQEVNHREILREHLKEEKLHAKKMKLTK 140
Cdd:pfam16019   1 KKKKSVRFDQVTVFYFPRCQGFTCVPSQGGSTLGMARKHSAFRRFTLAEHAIEQRRRRREKLRERRREEKLEALKQKLSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370462942 141 NGTVESVEADGLTLDDVSDEDIDveNVEVDDYFFLQPLPTKRRRALLRASGVHRIDAEEKQELRAIRLSREECGCDCRLY 220
Cdd:pfam16019  81 SGTISDSEEEPLTIDDISDSDLD--GAELDDYGFLQPVPTKQRRALLRAAGVRKIDSEEKDECRAIRLSREDCGCDCRGF 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370462942 221 CDPEACACSQAGIKCQVDRMSFPCGCSRDGCGNMAGRIEFNPIRVRTHYLHTIMKLELE 279
Cdd:pfam16019 159 CDPETCACSLAGIKCQVDRPSFPCGCTKDGCGNPQGRIEFNPTRVRTHFIHTLMRLELE 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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