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Conserved domains on  [gi|1370463049|ref|XP_024304998|]
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dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase isoform X1 [Homo sapiens]

Protein Classification

Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase( domain architecture ID 10522737)

Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation, and transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DIE2_ALG10 pfam04922
DIE2/ALG10 family; The ALG10 protein from Saccharomyces cerevisiae encodes the alpha-1,2 ...
 1-367 2.84e-131

DIE2/ALG10 family; The ALG10 protein from Saccharomyces cerevisiae encodes the alpha-1,2 glucosyltransferase of the endoplasmic reticulum. This protein has been characterized in rat as potassium channel regulator 1.


:

Pssm-ID: 461481  Cd Length: 383  Bit Score: 382.29  E-value: 2.84e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463049   1 MITTLPGLYLVSIGVIKPAIWifGWSEHVVCSIGMLRFVNLLFSVgnfYLLYLLFCKVQPRNKAASSIQ-RVLSTLTLAV 79
Cdd:pfam04922  29 KITTPPGLYLLSYLLLKPLKL--GCSGSVLCSLAILRLTNLLGGL---LLLPLILRRLLKRLKPNSLPNaATLSAINLAL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463049  80 FPTLYFFNFLYYTEAGSMFFTLFAYLMCLYGNHKTSAFLGFCGFMFRQTNIIWAVFCAGNVIAQKLTEAWKTELQKKedr 159
Cdd:pfam04922 104 FPLLYFFSFLYYTDVWSTTFVLLSYLFSLRGSHWLSALLGLISLLFRQTNIVWVAFIAGLSVLDTLRRAWRKKQFND--- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463049 160 lppikgpFAEFRKILQFLLAYSMSF-KNLSMLLLLTWPYILLGFLFCAFVVVNGGIVIGDRSSHEACLHFPQLFYFFSFT 238
Cdd:pfam04922 181 -------STGFNDYLKFLLSLLSSFlNVLLKILRKFWPYAIVLVLFAAFVVWNGGIVLGDKSNHVATLHLPQLFYFFLFI 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463049 239 LFFSFPHLLSPSKIKTFLSLVWKRRILFFVVTLVSVFLVWKFTYAHKYLLADNRHYTFYVWKRVFQRYETVKYLLVPAYI 318
Cdd:pfam04922 254 AFFSWPLLLSPLLLRRFLKLYRKRLLLSLLLLALILLIVHFFTIVHPFLLADNRHYTFYIWRRIIGRHPLIRYLLVPVYL 333

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1370463049 319 FAGWSIADSL-KSKSIFWNLMFFICLFTVIVPQKLLEFRYFILPYVIYRL 367
Cdd:pfam04922 334 FSGWAILESLgKSQSVLWVLAFLLATALTLVPSPLLEPRYFIIPYVIWRL 383
 
Name Accession Description Interval E-value
DIE2_ALG10 pfam04922
DIE2/ALG10 family; The ALG10 protein from Saccharomyces cerevisiae encodes the alpha-1,2 ...
 1-367 2.84e-131

DIE2/ALG10 family; The ALG10 protein from Saccharomyces cerevisiae encodes the alpha-1,2 glucosyltransferase of the endoplasmic reticulum. This protein has been characterized in rat as potassium channel regulator 1.


Pssm-ID: 461481  Cd Length: 383  Bit Score: 382.29  E-value: 2.84e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463049   1 MITTLPGLYLVSIGVIKPAIWifGWSEHVVCSIGMLRFVNLLFSVgnfYLLYLLFCKVQPRNKAASSIQ-RVLSTLTLAV 79
Cdd:pfam04922  29 KITTPPGLYLLSYLLLKPLKL--GCSGSVLCSLAILRLTNLLGGL---LLLPLILRRLLKRLKPNSLPNaATLSAINLAL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463049  80 FPTLYFFNFLYYTEAGSMFFTLFAYLMCLYGNHKTSAFLGFCGFMFRQTNIIWAVFCAGNVIAQKLTEAWKTELQKKedr 159
Cdd:pfam04922 104 FPLLYFFSFLYYTDVWSTTFVLLSYLFSLRGSHWLSALLGLISLLFRQTNIVWVAFIAGLSVLDTLRRAWRKKQFND--- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463049 160 lppikgpFAEFRKILQFLLAYSMSF-KNLSMLLLLTWPYILLGFLFCAFVVVNGGIVIGDRSSHEACLHFPQLFYFFSFT 238
Cdd:pfam04922 181 -------STGFNDYLKFLLSLLSSFlNVLLKILRKFWPYAIVLVLFAAFVVWNGGIVLGDKSNHVATLHLPQLFYFFLFI 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463049 239 LFFSFPHLLSPSKIKTFLSLVWKRRILFFVVTLVSVFLVWKFTYAHKYLLADNRHYTFYVWKRVFQRYETVKYLLVPAYI 318
Cdd:pfam04922 254 AFFSWPLLLSPLLLRRFLKLYRKRLLLSLLLLALILLIVHFFTIVHPFLLADNRHYTFYIWRRIIGRHPLIRYLLVPVYL 333

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1370463049 319 FAGWSIADSL-KSKSIFWNLMFFICLFTVIVPQKLLEFRYFILPYVIYRL 367
Cdd:pfam04922 334 FSGWAILESLgKSQSVLWVLAFLLATALTLVPSPLLEPRYFIIPYVIWRL 383
 
Name Accession Description Interval E-value
DIE2_ALG10 pfam04922
DIE2/ALG10 family; The ALG10 protein from Saccharomyces cerevisiae encodes the alpha-1,2 ...
 1-367 2.84e-131

DIE2/ALG10 family; The ALG10 protein from Saccharomyces cerevisiae encodes the alpha-1,2 glucosyltransferase of the endoplasmic reticulum. This protein has been characterized in rat as potassium channel regulator 1.


Pssm-ID: 461481  Cd Length: 383  Bit Score: 382.29  E-value: 2.84e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463049   1 MITTLPGLYLVSIGVIKPAIWifGWSEHVVCSIGMLRFVNLLFSVgnfYLLYLLFCKVQPRNKAASSIQ-RVLSTLTLAV 79
Cdd:pfam04922  29 KITTPPGLYLLSYLLLKPLKL--GCSGSVLCSLAILRLTNLLGGL---LLLPLILRRLLKRLKPNSLPNaATLSAINLAL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463049  80 FPTLYFFNFLYYTEAGSMFFTLFAYLMCLYGNHKTSAFLGFCGFMFRQTNIIWAVFCAGNVIAQKLTEAWKTELQKKedr 159
Cdd:pfam04922 104 FPLLYFFSFLYYTDVWSTTFVLLSYLFSLRGSHWLSALLGLISLLFRQTNIVWVAFIAGLSVLDTLRRAWRKKQFND--- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463049 160 lppikgpFAEFRKILQFLLAYSMSF-KNLSMLLLLTWPYILLGFLFCAFVVVNGGIVIGDRSSHEACLHFPQLFYFFSFT 238
Cdd:pfam04922 181 -------STGFNDYLKFLLSLLSSFlNVLLKILRKFWPYAIVLVLFAAFVVWNGGIVLGDKSNHVATLHLPQLFYFFLFI 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463049 239 LFFSFPHLLSPSKIKTFLSLVWKRRILFFVVTLVSVFLVWKFTYAHKYLLADNRHYTFYVWKRVFQRYETVKYLLVPAYI 318
Cdd:pfam04922 254 AFFSWPLLLSPLLLRRFLKLYRKRLLLSLLLLALILLIVHFFTIVHPFLLADNRHYTFYIWRRIIGRHPLIRYLLVPVYL 333

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1370463049 319 FAGWSIADSL-KSKSIFWNLMFFICLFTVIVPQKLLEFRYFILPYVIYRL 367
Cdd:pfam04922 334 FSGWAILESLgKSQSVLWVLAFLLATALTLVPSPLLEPRYFIIPYVIWRL 383
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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