|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
15-458 |
0e+00 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 770.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 15 DGGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGL 94
Cdd:TIGR00892 13 DGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGGL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 95 LCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGW 174
Cdd:TIGR00892 93 LASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFGW 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 175 KGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKkiKTKKSTWEKVNKYLDFSLFKHRGFLIYLSGN 254
Cdd:TIGR00892 173 RGSFLILGGLLLHCCVCGALMRPVGPSQRVSKSKSKEGLPPDGSTKK--LSKKSTAEKINRFLDFSLFTHRGFLVYLSGN 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 255 VIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLA 334
Cdd:TIGR00892 251 VIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIRPHVQYLFSFALLFNGLTHLLCALA 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 335 QDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIV 414
Cdd:TIGR00892 331 GDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIV 410
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1370463222 415 VAASVWLLIGNAINYRLLAKERKEENARQKTRESEPL-SKSKHSE 458
Cdd:TIGR00892 411 VSAGLFLAIGNYINYRLLAKEQKAALEREGARDKKDAeGDSRESE 455
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
19-425 |
0e+00 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 646.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCL 98
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 99 GMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSF 178
Cdd:cd17427 81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 179 LILGSLLLNACVAGSLMRPLGPnqttsksknktgkteddsspkkiktkkstwekvnkyldfsLFKHRGFLIYLSGNVIMF 258
Cdd:cd17427 161 LILGGLLLNCCVAGSLMRPLGP----------------------------------------LFKHRGFLIYLSGNVIMF 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 259 LGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYT 338
Cdd:cd17427 201 LGFFAPIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPRIQYFFSFAVMYNGVCHLLCPLAEDYT 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 339 SLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAAS 418
Cdd:cd17427 281 GLVIYAVFFGFAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVAS 360
|
....*..
gi 1370463222 419 VWLLIGN 425
Cdd:cd17427 361 IWLFIGN 367
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
19-424 |
0e+00 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 528.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCL 98
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 99 GMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSF 178
Cdd:cd17426 81 GLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 179 LILGSLLLNACVAGSLMRPLGPnqttsksknktgkteddsspkkiktkkstwekvNKYLDFSLFKHRGFLIYLSGNVIMF 258
Cdd:cd17426 161 LILGGLLLNCCVAGSLMRPIGP---------------------------------KPFLDLTLFTHRGFLLYLSGNVIMF 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 259 LGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYT 338
Cdd:cd17426 208 FGLFAPLVFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMGIVANTKWVRPRIQYFFAASVLYNGVCHLLAPLSTSYV 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 339 SLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAAS 418
Cdd:cd17426 288 GFCIYAIFFGFAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISS 367
|
....*.
gi 1370463222 419 VWLLIG 424
Cdd:cd17426 368 IYLFIG 373
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
19-425 |
6.10e-154 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 442.25 E-value: 6.10e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCL 98
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 99 GMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSF 178
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 179 LILGSLLLNACVAGSLMRPlgpnqttsksknktgkteddsspkkiktkkstwekvnkyLDFSLFKHRGFLIYLSGNVIMF 258
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRP---------------------------------------LDFSVFRDRGFVIYTIAKFIMV 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 259 LGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYT 338
Cdd:cd17430 202 LGLFVPPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFARPACGVVAGLKWVRPRVVYLFSFAMLFNGLTDLCSATAADYG 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 339 SLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAAS 418
Cdd:cd17430 282 GLVVFCVFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSA 361
|
....*..
gi 1370463222 419 VWLLIGN 425
Cdd:cd17430 362 LFLALGN 368
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
19-423 |
1.27e-123 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 364.57 E-value: 1.27e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCL 98
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 99 GMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSF 178
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 179 LILGSLLLNACVAGSLMRplgpnqttsksknktgkteddsspkkiktkkstwekvnkyldfsLFKHRGFLIYLSGNVIMF 258
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR--------------------------------------------LLKDPTFVLLALGVSFAM 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 259 LGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIrpRIQYFFSFAIMFNGVCHLLCPLAQDYT 338
Cdd:cd17352 197 LGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRI--GRLYLYIFTLLILGLSLLAFPLATTYV 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 339 SLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAAS 418
Cdd:cd17352 275 GLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSG 354
|
....*
gi 1370463222 419 VWLLI 423
Cdd:cd17352 355 VLLFL 359
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
19-423 |
4.86e-110 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 330.20 E-value: 4.86e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCL 98
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 99 GMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSF 178
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 179 LILGSLLLNACVAGSLMRPlgpnqttsksknktgkteddsspkkiktkkstwekvnkyldfsLFKHRGFLIYLSGNVIMF 258
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRP-------------------------------------------FCSNTRYQIYTLGVTWMV 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 259 LGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYT 338
Cdd:cd17425 198 LGFVLPLIYLVPYATSNGMDESKAALLLSILGFINIFMRPLAGLLSGLPVFKGRRIYLFSLALLLNGLSNLICAISASFP 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 339 SLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAAS 418
Cdd:cd17425 278 VLLVYCLLYSISMSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAA 357
|
....*
gi 1370463222 419 VWLLI 423
Cdd:cd17425 358 LFMGL 362
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
19-422 |
1.65e-92 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 285.83 E-value: 1.65e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCL 98
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 99 GMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSF 178
Cdd:cd17423 81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 179 LILGSLLLNACVAGSLMRPLGpnqttsksknktgkTEDDSSpkkiktkkSTWEKVNKYLDFSLFKHRGFLIYLSGNVIMF 258
Cdd:cd17423 161 LLLSALSLHLVPCGALLRPLA--------------LPGDPP--------APPRSLSAAFGLSLLTHRAFLRYALATTLIN 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 259 LGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPriQYFFSFAIMFNGVCHLLCPLAQDYT 338
Cdd:cd17423 219 TGYFIPYVHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRL--LHLLVLWTALTGLSLLLLPLAKVYG 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 339 SLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAAS 418
Cdd:cd17423 297 SLLALAVAYGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGS 376
|
....
gi 1370463222 419 VWLL 422
Cdd:cd17423 377 LILL 380
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
19-421 |
4.02e-81 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 255.83 E-value: 4.02e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCL 98
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 99 GMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSF 178
Cdd:cd17422 81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 179 LILGSLLLNACVAGSLMRplgpnqttsksknktgkteddsspkkiktkkstwekvnkyldfsLFKHRGFLIYLSGNVIMF 258
Cdd:cd17422 161 LVVGALQLNIVVCGALLR--------------------------------------------VLKEPGFICYALFGLFAT 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 259 LGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRpRIQYFFSFAIMFnGVCHLLCPLAQDYT 338
Cdd:cd17422 197 LGFFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIR-KIYIELICVILL-CVVLLLFPFAYGFW 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 339 SLVLYAVFFGLGFGSVSSVLFETLM--DLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVA 416
Cdd:cd17422 275 SLLVCSIFYGFMFGTVAGTHIPLLAedDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMAL 354
|
....*
gi 1370463222 417 ASVWL 421
Cdd:cd17422 355 GAVFL 359
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
19-421 |
1.95e-61 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 204.66 E-value: 1.95e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCL 98
Cdd:cd17424 1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 99 GMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSF 178
Cdd:cd17424 81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 179 LILGSLLLNACVAGSLMRplgpnqttsksknktgkteddsspkkiktkkstwekvnkyldFSLFKhrGFLIYLSGNVIMF 258
Cdd:cd17424 161 LILGGFVLNLCVCGALMR------------------------------------------FLLMP--DFLVLAVSVLFLA 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 259 LGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYT 338
Cdd:cd17424 197 YGCSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKYRYFCYLFAVGMDGLCCLFLPILKTFP 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 339 SLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAAS 418
Cdd:cd17424 277 LLVPFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSS 356
|
...
gi 1370463222 419 VWL 421
Cdd:cd17424 357 LLL 359
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
19-423 |
1.83e-51 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 178.48 E-value: 1.83e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCL 98
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 99 GMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLsSLAPFNQYLFNTFGWKGSF 178
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLTF-ALAPFTQLLLDEYDWQGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 179 LILGSLLLNACVAGSLMRPlgpnqttsksknktgkteddsspkkiktkkstwekvnkyLDFSLFKHRGFLIYLSGNVIMF 258
Cdd:cd17421 160 LIFGGIMLNLVASGMLLRP---------------------------------------IDFSLLKDPFFCIYTWSFVFSQ 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 259 LGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRpRIQYFFSFAIMFnGVCHLLCPLAQDYT 338
Cdd:cd17421 201 LAYFIPYFHLVARARTLGIDPMDASFIISVAGITETVAQLASGWIADQNWIK-KYHYHKAYLILC-GVTNLLAPLATTYP 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 339 SLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAAS 418
Cdd:cd17421 279 LLMTYAVFFAIFCGGYLALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSS 358
|
....*
gi 1370463222 419 VWLLI 423
Cdd:cd17421 359 VSFFL 363
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
19-403 |
9.39e-39 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 144.98 E-value: 9.39e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHT-----TYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGG 93
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTKlgdpeASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 94 LLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFG 173
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 174 WKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKnktgkteddssPKKIKTKKSTWEKVNKYLDFSLFKHRGFLIYLSG 253
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKSK-----------PGRRTLHSRINLFLRKIFNVEIFKRKRYVIWALG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 254 NVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIqYFFSFAIMFNGVCHLLCPL 333
Cdd:cd17420 230 IPLALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMPPGVKKM-YLQVLSFVSIGLMSMMIPL 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 334 AQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEY 403
Cdd:cd17420 309 CNSFGILISVCLVMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSY 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-423 |
1.24e-37 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 141.94 E-value: 1.24e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 20 WIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLG 99
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 100 MVLASFSSSVVQLyLTMGFITGLGLAFNLQPALTIIGKYFY-RKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSF 178
Cdd:COG2223 84 LLLLALAVSYWLL-LLLGLLLGIGGGGSFAVGIALVSKWFPpDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 179 LILGSLLLNACVAGSLMrplgpnqttsksknktGKTEDDSSPKKIKTKKSTWekvnkyldFSLFKHRGFLIYLSGNVIMF 258
Cdd:COG2223 163 LILGILLLVVAVLAWLF----------------LRDPPAGAAAAAKASLRDQ--------LEALRDPRFWLLSLLYFGTF 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 259 LGFFAPIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLIANskYIRPRIQYFFSFAIMfnGVCHLLCPLAQ-D 336
Cdd:COG2223 219 GSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSD--RIGGRRVLLIVFALM--ALGLLLLALALgS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 337 YTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVA 416
Cdd:COG2223 295 LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALV 374
|
....*..
gi 1370463222 417 ASVWLLI 423
Cdd:COG2223 375 ALVLTLL 381
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
19-423 |
2.70e-37 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 140.35 E-value: 2.70e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCL 98
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 99 GMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSF 178
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 179 LILGSLLLNACVAGSLMRplgpnqttsksknktgkteddsspkkiktkkstwekvnkyldfsLFKHRGFLIYLSGNVIMF 258
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR--------------------------------------------LFTNKVFVAFIFWALFAY 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 259 LGFFAPIIFLAPYAKDQGIDEYSAAF-LLSVMAFVDMFARPSVGLIANSKYIrpRIQYFFSFAIMFNGVCHLLCPLAQDY 337
Cdd:cd17429 197 CSFVIPFIHLPEIVKLYGLSEQNDKFpLTSIIAIVHIFGKVILGIICDLPCI--SVWNVFILANFTLGVCILILPLMHTY 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 338 TSLVLYAVFFGL--GFGSVSSVLFEtlmDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVV 415
Cdd:cd17429 275 TGLAIVCALIGFssGYFSLMPVVTE---DLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYM 351
|
....*...
gi 1370463222 416 AASVWLLI 423
Cdd:cd17429 352 VGIICLLL 359
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-424 |
2.60e-36 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 137.69 E-value: 2.60e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 16 GGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLL 95
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 96 CCLGMVLASFSSSVVQLYLTMgFITGLGLAFNLQPALTIIGKYFYRK-RPMANGLAMAGSPVFLSSLAPFNQYLFNTFGW 174
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFPPKeRGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 175 KGSFLILGSLLLNACVAgslmrplgpnqttsksknktgkteddsspkkiktkkstwekvnkyldfslfkhrGFLIYLSGN 254
Cdd:COG2271 164 RAAFLILGLPGLLLALL------------------------------------------------------RFWLLALAY 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 255 VIMFLGFFAPIIFLAPYAKD-QGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMfnGVCHLLCPL 333
Cdd:COG2271 190 FLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLA--ALALLLLAL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 334 AQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAI 413
Cdd:COG2271 268 LPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALA 347
|
410
....*....|.
gi 1370463222 414 VVAASVWLLIG 424
Cdd:COG2271 348 LLAALLALLLL 358
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
19-422 |
1.15e-33 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 130.85 E-value: 1.15e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCL 98
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 99 GMVLASFSSSVVQLYLTMGFITGLGLAFNLQPA-LTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGS 177
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 178 FLILGSLLLNACVAGSLMRPlgpnqttsksknktgkteDDSSPKKIKTKKSTWEKVNKYLDFSLFKHRGFLIYLSGNVIM 257
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLR------------------RRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLC 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 258 FLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANsKYIRPRIqyffSFAIMFNGVCHLLCPLA--Q 335
Cdd:cd17355 223 GFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGD-RYSPRRL----LAASYALRALGLALLLLlpF 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 336 DYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVV 415
Cdd:cd17355 298 PPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGL 377
|
....*..
gi 1370463222 416 AASVWLL 422
Cdd:cd17355 378 IAALLVL 384
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
19-403 |
6.94e-33 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 128.76 E-value: 6.94e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSE-----IAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGG 93
Cdd:cd17464 1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGSKDDAqmrfkTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 94 LLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFG 173
Cdd:cd17464 81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 174 WKGSFLILGSLLLNACVAGSLMRPLGPNQttsksknktgkteDDSSPKKIKTKKSTwekVNKYLDFSLFKHRGFLIYLSG 253
Cdd:cd17464 161 LFNTLRVLCIFMFVLFLAGFTYKPLVPMK-------------KDKEGKKRKFKCPP---LKKIFNFNIWKSTGYRIWAFG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 254 NVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANskYIrPRIQ--YFFSFAIMFNGVCHLLC 331
Cdd:cd17464 225 IPAALFGYFVPYVHLMNHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVAD--YI-PGVKkvYLQVSSFFFIGLMSMMI 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370463222 332 PLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEY 403
Cdd:cd17464 302 PLCHVFGGLIAVCLFMGLFDGCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSY 373
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
19-423 |
1.06e-30 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 121.85 E-value: 1.06e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCL 98
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 99 GMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSF 178
Cdd:cd17428 81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 179 LILGSLLLNACVAGSLMRplgpnqttsksknktgkteddsspkkiktkkstwekvnkyldfsLFKHRGFLIYLSGNVIMF 258
Cdd:cd17428 161 LIVGALALNLLACGSLMR--------------------------------------------LFKNRVFSALFIAILLFD 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 259 LGFFAPIIFLAPYAKDQGIDEYSAAF-LLSVMAFVDMFARPSVGLIANSKYIRPriQYFFSFAIMFNGVCHLLCPLAQDY 337
Cdd:cd17428 197 IGAFPPSLLMEDVARSENIIEEIALIpLVSIIGITTAIGKLILGVLADFKWVNS--LYLYVLTLIGMGAALLAIPFAKSY 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 338 TSLVLYAVFFGLGFGSVSSVLFETlMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAA 417
Cdd:cd17428 275 LTLAVLSAILGFLSGNWSIFPYVT-TKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLG 353
|
....*.
gi 1370463222 418 SVWLLI 423
Cdd:cd17428 354 GFLLLL 359
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
17-427 |
1.47e-30 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 122.29 E-value: 1.47e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 17 GWGWIVVGAAFISIGFSYAFPkAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLC 96
Cdd:COG2807 15 GRWLLLLAIVLVALNLRPAIT-SVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 97 CLGMVLASFSSSVVQLYLTMGFItGLGLAFnLQPALT-IIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWK 175
Cdd:COG2807 94 AAGLLLRSLAPSVALLLAGTALI-GAGIAV-GNVLLPgLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWR 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 176 GSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKteddsspkkiktkkstwekvnkyldfSLFKHRGFLIYLSGNV 255
Cdd:COG2807 172 GALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLR--------------------------SLWRSPLAWLLTLFFG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 256 IMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIAnSKYIRPRIQYFFSFAIMFNGVCHLLcpLAQ 335
Cdd:COG2807 226 LQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLA-DRLGDRRPLLLLLGLLGLAGLLGLL--LAP 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 336 DyTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPR-FSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKY--MYMSCGA 412
Cdd:COG2807 303 G-SLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAeAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAalLLLAALA 381
|
410
....*....|....*
gi 1370463222 413 IVVAASVWLLIGNAI 427
Cdd:COG2807 382 VLMLVAGLLAGRPYV 396
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
21-390 |
1.91e-28 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 115.21 E-value: 1.91e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 21 IVVGAAFISIGFSYAFPkavtVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGM 100
Cdd:pfam07690 1 LFLAAFLAALGRSLLGP----ALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 101 VLASFSSSVVQLYLtMGFITGLGLAFNLQPALTIIGKYFYRK-RPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFL 179
Cdd:pfam07690 77 LLLLFASSLWLLLV-LRVLQGLGAGALFPAALALIADWFPPEeRGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 180 ILGSLLLNACVAGSLMRPlgpnqttsksknktgkteddsSPKKIKTKKSTWEKVNKYLDFSLFKHRGFLIYLSGNVIMFL 259
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRP---------------------PPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGF 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 260 GFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFnGVCHLLCPLAQDYTS 339
Cdd:pfam07690 215 AFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA-ALGLLLLSLTLSSLW 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1370463222 340 LVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGP 390
Cdd:pfam07690 294 LLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
20-381 |
3.24e-28 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 114.69 E-value: 3.24e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 20 WIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLG 99
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 100 MVLASFSSSVVQLYLtMGFITGLGLAFNLQPALTIIGKYF-YRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSF 178
Cdd:COG2814 89 SLLCALAPSLWLLLA-ARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 179 LILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTgkteddsspkkiktkkstwekvnkyldFSLFKHRGFLIYLSGNVIMF 258
Cdd:COG2814 168 LVNAVLALLALLLLLRLLPESRPAARARLRGSL---------------------------RELLRRPRLLLLLLLAFLLG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 259 LGFFAPIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIqyFFSFAIMfnGVCHLLCPLAQDY 337
Cdd:COG2814 221 FGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLL--LIGLLLL--ALGLLLLALAGSL 296
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1370463222 338 TSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIV 381
Cdd:COG2814 297 WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
20-423 |
1.38e-24 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 105.00 E-value: 1.38e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 20 WIVVGAAFI---SIGFSYAFpkavTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLC 96
Cdd:cd17353 3 WLVLLGAVLmhlILGYQYAW----SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 97 CLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGspVFLSSL--APFNQYLFNTFGW 174
Cdd:cd17353 79 GLGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAG--FGLGSLifSPLIAYLINTVGV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 175 KGSFLILGSL-LLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSpkkiktKKSTWEkvnkyldfSLFKHRGFLIYLSg 253
Cdd:cd17353 157 PTTFLILGIIfLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPR------DYTPRE--------MLRTPTFWLLWLM- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 254 nviMFLGFFAPIIF---LAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLIanSKYIRPRIQYFFSFAImfNGVCHL 329
Cdd:cd17353 222 ---FFLNATAGLMLigqAKPIGQEFaGLDAGIAALAVSILSIFNGGGRPFWGWL--SDKIGRKNTLSIAFLI--QGVAMF 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 330 LCPLAQDYTSL-VLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGkLVDLTGEYKYMYM 408
Cdd:cd17353 295 LLPFIGSVAVLfVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAA-YVLYTGGYNAAFI 373
|
410
....*....|....*
gi 1370463222 409 SCGAIVVAASVWLLI 423
Cdd:cd17353 374 IAAALSLVALALALL 388
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
19-424 |
9.83e-24 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 102.49 E-value: 9.83e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCL 98
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 99 GMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSF 178
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 179 LILGSLLLNACVAGSLMRPlgpnqttsksknktgKTEDDSSPKKIKTKKSTWEKVnkyldfSLFKHRGFLIYLSGNVIMF 258
Cdd:cd17314 161 TILGILAAIVLSVVSLLGF---------------KEPPDNQARLHVQKKKTQTMG------EIFRDKVFWILFIAIFLVL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 259 LGFFAPIIFLAPYAKDQGIDEYS-AAFLLSVMAFVDMFARPSVGLIANsKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDY 337
Cdd:cd17314 220 IGGFLFIANMASLVRSLQLDAPSfVTKLMSIYGLFNAFGRLLWGIVAD-FFGGRLSTLSILLTILGLGLCAFLFLLKMTP 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 338 TSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAA 417
Cdd:cd17314 299 VGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLA 378
|
....*..
gi 1370463222 418 SVWLLIG 424
Cdd:cd17314 379 SAILLAV 385
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
39-419 |
6.80e-22 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 97.11 E-value: 6.80e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 39 AVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMgF 118
Cdd:cd06174 14 LISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGR-F 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 119 ITGLGLAFNLQPALTIIGKYFYRK-RPMANGLAMAGSPVFLSSLAPFNQYLF--NTFGWKGSFLILGSLLLNACVAGSLM 195
Cdd:cd06174 93 LLGLGSGLIDPAVLALIADLFPEReRGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAALALLAAILLLLV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 196 RPLGPNQTTSKSKNKTGKTeddsspkkikTKKSTWEkvnkyldfsLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQ 275
Cdd:cd06174 173 VPDPPESARAKNEEASSKS----------VLKLLKR---------VLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 276 G-IDEYSAAFLLSVMAFVDMFARPSVGLIAnSKYIRPRIQYFFSFAIMfnGVCHLLCPLAQDYTSLVLYAVFFGLGFGSV 354
Cdd:cd06174 234 GgLSVAVAGLLLSLFGLAGALGSLLLGLLS-DRLIGRKPLLLIGLLLM--ALGLALLLLAPSLLLLLLLLLLLGFGLGGL 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370463222 355 SSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASV 419
Cdd:cd06174 311 LPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAI 375
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
19-403 |
6.84e-21 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 94.09 E-value: 6.84e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQ-----QIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGG 93
Cdd:cd17465 1 GWVVVFAATWCNGSIFGIQNSFGILYVMLLneqedQKDQAVQFKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 94 LLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFG 173
Cdd:cd17465 81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 174 WKGSFLILGSLLLNACVAGslmrplgpnqttsksknktgkteddsspkkiktkkstwekvnkyLDFSLFKHRGFLIYLSG 253
Cdd:cd17465 161 LAHTFQVLSLFMFIQIFLS--------------------------------------------LTYKVFRRKTYRIWAFG 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 254 NVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANS----KYIRPRIQYFFSFAIMfngvcHL 329
Cdd:cd17465 197 IATAVLGYFVPYVHLMKYVEEEFKENKREWVLLVCIGASSGIGRLMSGKIGDLipglKKIYLQVASFLLLGIM-----SM 271
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370463222 330 LCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEY 403
Cdd:cd17465 272 MIPLCQVFEGVIVVCLFLGLCDGCFITIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSY 345
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
49-424 |
7.33e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 91.10 E-value: 7.33e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 49 QIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMgFITGLGLAFNL 128
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLAR-FLQGLASAAVW 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 129 QPALTIIGKYF-YRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPlgpnqTTSKS 207
Cdd:cd17325 103 PAAMALIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLP-----EPRPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 208 KNKTGKTEDDSSPKKIKtkkstwekvnkyldfsLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQ-GIDEYSAAFLL 286
Cdd:cd17325 178 PNKRAVSAARLRSGLRL----------------LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 287 SVMAFVDMFARPSVGLIANskYIRPRIQYFFSFAIMfnGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLV 366
Cdd:cd17325 242 GAQGLASALSQPPAGKLSD--RIGRKPLILIGLLLS--AVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1370463222 367 GAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSCGAIVVAASVWLLIG 424
Cdd:cd17325 318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
73-423 |
9.97e-16 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 78.38 E-value: 9.97e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 73 GPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSvvqLYLTMG--FITGLGLAFNLQPALTIIGKYF---YRKRPMA- 146
Cdd:cd17473 52 APLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDS---LYALLAsrALLGIGVAGIMTLATALIGDYFegeERAKMLGl 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 147 NGLAMAGSPVFLSSLAPFnqylFNTFGWKGSFLI-LGSLLLNACVAGSLMRPlgpnQTTSKSKNKTGKTEDDSSPKKikt 225
Cdd:cd17473 129 QSAAMSLGGVVFLLLGGA----LAEIGWRAPFLVyLLALPVLILVLLFLPEP----ARKSKSAASPGAATAAALPWK--- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 226 kkstwekvnkyldfslfkhRGFLIYLSGNVIMFLgFFAPIIFLAPYAKDQGI-DEYSAAFLLSVMAFVDMFARPSVGLIa 304
Cdd:cd17473 198 -------------------RVLPIYFLAFLAMLL-FYVIPIQLPFLLQERGGgSAALIGLALAIASLAGAIGALLFGRL- 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 305 nSKYIRPRIQYFFSFAIMfnGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECG 384
Cdd:cd17473 257 -KRRLGKRRLLAIGFALM--ALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFL 333
|
330 340 350
....*....|....*....|....*....|....*....
gi 1370463222 385 PVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLI 423
Cdd:cd17473 334 GQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
44-419 |
2.27e-15 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 77.61 E-value: 2.27e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 44 FKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLyLTMGFITGLG 123
Cdd:cd17474 22 LPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL-LAGRALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 124 LAFNLQPALTIIGKYF-YRKRP-------MANGLAMAGSPVFLSSLApfnqylfnTFGWKGSFLILGSLLLNACVAGSLM 195
Cdd:cd17474 101 AAGLGPLALTLIGDLFeGGERAkamglyeAALGLGIAVGPLLGGLLA--------AISWRYPFFLLAALIPVAFLAILFL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 196 rplgpnqttsksKNKTGKTEDDSSPKKIKTKKstwekvnkyldfSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKD- 274
Cdd:cd17474 173 ------------LPEPKEKAKSSSATKLRDLK------------KALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELl 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 275 QGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIqYFFSFAIMfnGVCHLLCPLAQDYTSLVLYAVFFGLGFGSV 354
Cdd:cd17474 229 YGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRI-LVIGLLLY--ALSLLLLGFVPSLALLLIAIVLFGLGLGLN 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370463222 355 SSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSCGAIVVAASV 419
Cdd:cd17474 306 LPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG-LSAPFLVGAAIALAAAV 369
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
21-421 |
6.72e-15 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 76.05 E-value: 6.72e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 21 IVVGAAFISIGFSYAfpkAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGM 100
Cdd:COG0738 11 IAIYLLFFLWGFATA---LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 101 VLASFSSSVVqLYLTMGFITGLGLAF---NLQPALTIIGKYFYRKR-PMA---NGLAMAGSPVFLSSLAPFNqylfNTFG 173
Cdd:COG0738 88 LLFALAPSYP-LLLLALFLLGLGLGLldvAANPYVAALGPETAASRlNLLhafFSLGALLGPLLGGLLILLG----LSLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 174 WKGSFLILGSLLLNACVAgslmrplgpnqtTSKSKNKTGKTEDDSSPKKIKTKKstwekvnkyldfSLFKHRGFLIYLsg 253
Cdd:COG0738 163 WHLPYLILAVLLLLLALL------------FLRSKLPEIEEEEEEAAGSAASLK------------SLLKNPRLLLGG-- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 254 nVIMFLGFFA---PIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLIAnsKYIRPRIQYFFSFAIMFNGVchL 329
Cdd:COG0738 217 -LAIFLYVGAegaIGDWLPLYLKDVlGLSEATAALGLSLFWGGMTIGRFLGGFLL--KRFGPVRLLRLSALLAAVGL--L 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 330 LCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRfSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMS 409
Cdd:COG0738 292 LALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVP 370
|
410
....*....|....
gi 1370463222 410 --CGAIVVAASVWL 421
Cdd:COG0738 371 lvCYLLILLLALAL 384
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
47-422 |
7.63e-15 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 75.74 E-value: 7.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 47 IQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMgFITGLGLAf 126
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLL-FLVGAGYG- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 127 NLQPALT--IIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLM--RPLGPNQ 202
Cdd:cd17475 100 SVQPGGGraIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFyrEPPAASA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 203 TTSKSknktgktedDSSPKKIKtkkstwekvnkyldfSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQ-GIDEYS 281
Cdd:cd17475 180 ATESA---------STLLRSLK---------------EVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHlGLSVVA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 282 AAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVS--SVLF 359
Cdd:cd17475 236 AGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGwnGLYL 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370463222 360 ETLMDLVGAPRFSSAVGL-VTIVECGpVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLL 422
Cdd:cd17475 316 TLVAESAGPEQAGTALGLaNTINFIG-IAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
61-422 |
1.71e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 74.55 E-value: 1.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 61 ISSIMLAVMYAGgPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLtMGFITGLGLAFNLQPALTIIGKYFY 140
Cdd:cd17489 37 VGLFTLAALLAR-PFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLV-LRLIHGIGWGAFTTAAATLVADIIP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 141 RKRpMANGLAMAGSPVFLSSL--APFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMrplgpnqttsksknktgktedds 218
Cdd:cd17489 115 PSR-RGEGIGYYGLATTLAMAlgPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLV----------------------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 219 spKKIKTKKSTWEKVNKYLDFSLFKHRGFLIYLSGNViMFLGFFAPIIFLAPYAKDQGIDeySAAFLLSVMAFVDMFARP 298
Cdd:cd17489 171 --KDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFL-ASIAYGAISTFLPLYAAERGIS--NAGLFFTVYAIALLLSRP 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 299 SVGLIANskyiRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLV 378
Cdd:cd17489 246 FSGKLSD----RKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTF 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1370463222 379 TIVECGPVLLGPPLAGKLVDLTGeYKYMYMSCGAIVVAASVWLL 422
Cdd:cd17489 322 FIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
46-422 |
3.00e-13 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 71.04 E-value: 3.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 46 EIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLyLTMGFITGLGLA 125
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALL-LLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 126 FNLQPALTIIGKYF-YRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGslLLNACVAGSLMRPLGPNQTT 204
Cdd:cd17324 103 GFWAIAAAYAADLVpPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA--VLALLAALLLWRLLPSLPPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 205 SKSKNKTGKTEddsspkkiktkkstwekvnkyldFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQ-GIDEYSAA 283
Cdd:cd17324 181 KPGSLGLLSSL-----------------------LLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVpGFSSSAII 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 284 FLLSVMAFVDMFARPSVGLIANsKYIRPRIqYFFSFAIMFNGVchLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLM 363
Cdd:cd17324 238 GLLLLFGVAGVVGSPLAGRLAD-RGGRRAL-LIALLLLAAALL--LLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 364 DLVGAPRfSSAVGL-VTIVECGpVLLGPPLAGKLVDLTGeYKYMYMSCGAIVVAASVWLL 422
Cdd:cd17324 314 RLAPEAR-GLASSLyLAAYNLG-GALGAALGGLVLDHGG-WAGVGWVGAALLLLALLLAL 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
240-452 |
8.06e-13 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 69.62 E-value: 8.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 240 SLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPriqyFFSF 319
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRR----VLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 320 AIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDL 399
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1370463222 400 TGeYKYMYMSCGAIVVAASVWLlignainYRLLAKERKEENARQKTRESEPLS 452
Cdd:COG2814 161 FG-WRWVFLVNAVLALLALLLL-------LRLLPESRPAARARLRGSLRELLR 205
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
18-180 |
1.92e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 64.83 E-value: 1.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 18 WGWIVVGAAFISIGFSYAfpkAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCC 97
Cdd:COG0477 14 RALLALALGTFLEGLDFT---IVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 98 LGMVLASFSSSVVQLYLtMGFITGLGLAFNLQPALTIIGKYF-YRKRPMANGLAMAGSPVFLsSLAPF-NQYLFNTFGWK 175
Cdd:COG0477 91 LASLLCGLAPSPELLIA-ARALQGIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLGL-ALGPLlGGLLVAALGWR 168
|
....*
gi 1370463222 176 GSFLI 180
Cdd:COG0477 169 WIFLI 173
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
20-423 |
5.48e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 60.66 E-value: 5.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 20 WIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLG 99
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 100 MVLASFSSSVVQLYLtMGFITGLGLAFNLQPALTIIGKYF-YRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSF 178
Cdd:cd17319 82 TALTGFATSLTSLYV-LRFLLGVAEAGFFPGAIKALAEWFpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 179 LILGslllnacVAGSLMRPLgpnqttsksknktgkteddsspkkiktkkstWekvnkyldfsLFKHRGFLIYLSGNVIMF 258
Cdd:cd17319 161 IIEG-------LLGLLLAVL-------------------------------W----------WFYLRQVWGLALGYFGIN 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 259 LGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYT 338
Cdd:cd17319 193 YALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPV 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 339 SLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAAS 418
Cdd:cd17319 273 VAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAA 352
|
....*
gi 1370463222 419 VWLLI 423
Cdd:cd17319 353 LLVLL 357
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
251-419 |
9.78e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 60.30 E-value: 9.78e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 251 LSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANskYIRPRIQYFFSFAIMfnGVCHLL 330
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLD--RFGRKRLLLIGLLIF--ALATLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 331 CPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSC 410
Cdd:cd17489 78 YLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG-FAVLFIVA 156
|
....*....
gi 1370463222 411 GAIVVAASV 419
Cdd:cd17489 157 AVLALLALL 165
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
256-423 |
1.45e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.51 E-value: 1.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 256 IMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANsKYIRPRIqYFFSFAIMfnGVCHLLCPLAQ 335
Cdd:cd17325 7 LDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSD-RFGRKRL-LLLGLLLL--AVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 336 DYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSCGAIVV 415
Cdd:cd17325 83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVCAALAL 161
|
....*...
gi 1370463222 416 AASVWLLI 423
Cdd:cd17325 162 LALVLALL 169
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
54-419 |
3.25e-09 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 58.47 E-value: 3.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 54 TYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMgFITGLGLAFNLQPALT 133
Cdd:cd06180 32 SYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALR-FLAGAASAFVFVFGSN 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 134 IIGKYFYR-KRPMANGLAMAGSPV--FLSSLApfnQYLFNTFG--WKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSK 208
Cdd:cd06180 111 LVLHHATAaGRGHLIGLLFAGVGLgiALSGLL---VPAGLGGGlsWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 209 NKTGkteddsspkkiktkkstwekvnkyldfsLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLlsv 288
Cdd:cd06180 188 AESA----------------------------PGLNRPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLL--- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 289 MAFVDMFARPSVGLianSKYIRPRIQYFFSFAIMF--NGVCHLLCPLAQDYTSLVLYAVFFGLGF-GSVSSVLFETLMdl 365
Cdd:cd06180 237 WSLFGLAAVPSCFL---WGALSDRWGTRRALAANLlvQAVGVLLPLLSPGPAGLVLSAVLFGGTFmAITALVMALARE-- 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1370463222 366 VGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASV 419
Cdd:cd06180 312 LAPPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAAL 365
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
39-352 |
3.51e-09 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 58.36 E-value: 3.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 39 AVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLyLTMGF 118
Cdd:cd17503 14 IVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASL-IIFRI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 119 ITGLGLAFNLQPALTIIGKYFYR-KRPMAngLAMAGSPVflsSLAP-----FNQYLFNTFGWKGSFLIlgslLLNACVAG 192
Cdd:cd17503 93 LQGFGGGVLIPLAQTILLRIYPPeKRGAA--MGLVGLVI---LLAPaigptLGGWLTDNLSWRWIFYI----NLPIGILA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 193 SLMRPLgpnqttsksknktgkteddsspkkiktkkstwekvnkyLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYA 272
Cdd:cd17503 164 LLLAPL--------------------------------------LDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYL 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 273 kdQGIDEYSA---AFLLSVMAFVDMFARPSVGLIanSKYIRPRIQYFFSFAIMFnGVCHLLCPLAQDYTSLVLYAVFFGL 349
Cdd:cd17503 206 --QNVLGYSAfesGLVLAPGGLASAILSPLVGRL--LDKFGPRLLLLAGLLLLA-LGTLLLAFLTPDTSLWLIILPLFIR 280
|
...
gi 1370463222 350 GFG 352
Cdd:cd17503 281 GLG 283
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
56-195 |
6.50e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 57.60 E-value: 6.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 56 SEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLtMGFITGLGLAFNLQPALTII 135
Cdd:cd17365 34 AQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL-LRFLTGLGLGAAMPNAITLV 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370463222 136 GKYF-YRKRPMANGLAMAGSPV------FLSSLapfnqyLFNTFGWKGSFLILGS--LLLNACVAGSLM 195
Cdd:cd17365 113 SEYApARRRSLAVTLMFCGYPLgaalggFLAAA------LIPAFGWRSVFLLGGVppLILLPLLRGTLL 175
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
44-367 |
4.97e-08 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 54.89 E-value: 4.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 44 FKEIQQIFHTTYSEIAWISSIMLAVMYAG----GPVSSvlvnKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLyLTMGFI 119
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGqllyGPLSD----RFGRRPVLLAGLLLFILASLLCALASSIEQL-LIARFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 120 TGLGLAFNLQPALTII-GKYFYRKRPMANGLAMAG---SPVflssLAP-FNQYLFNTFGWKGSFLILGSLLLnACVAGSL 194
Cdd:cd17320 97 QGLGAAAGSVVARAIVrDLYSGAELAKIFSLLMMIlaiAPA----LAPlLGGLLLLFFGWRAIFVFLALLGL-LLLLLVL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 195 MRPlgpnqttsksknKTGKTEDDSSPKKIKTKKSTwekvnkyldFSLFKHRGFLIYLSGNVIMFLGFF-----APIIFLA 269
Cdd:cd17320 172 LFL------------PETLPEEKRKPLLSSLLRAY---------KRVLKNRRFLGYALALGLSFAGLFaylaaAPFIYIE 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 270 PYakDQGIDEYSAAFLLSVMAFVdmfarpsVGLIANSKYIR----PRIQYFFSFAIMFNGVCHLLCPLAQD--YTSLVLY 343
Cdd:cd17320 231 QL--GLSPAQFGLLFALNAIALI-------LGSLLNGRLVRrfgpRRLLRLGLLLLLAAALVLLLAALLGGlsLWPLVAP 301
|
330 340
....*....|....*....|....
gi 1370463222 344 AVFFGLGFGSVSSVLFETLMDLVG 367
Cdd:cd17320 302 LFLIFFGFGLIFPNATSLALEPFP 325
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
19-182 |
5.79e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 54.67 E-value: 5.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 19 GWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCL 98
Cdd:TIGR00895 15 QWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 99 GMVLASFSSSVVQLyLTMGFITGLGLAFNLQPALTIIGKYF-YRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGS 177
Cdd:TIGR00895 95 FTLLCALATNVTQL-LILRFLAGLGLGGLMPNLNALVSEYApKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSL 173
|
....*
gi 1370463222 178 FLILG 182
Cdd:TIGR00895 174 FYVGG 178
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
21-442 |
7.88e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.52 E-value: 7.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 21 IVVGAAFISIGFSYAFPKAVTVFFkeiqqifhttYSEIAWISSIMLAVMYAGGPVSSVLVN------------KYGSR-P 87
Cdd:COG2211 13 LAYGLGDLGLNLAFGLLSAYLLYF----------YTDVLGLSAALVGLILLVARLWDAITDpligalsdrtrtRWGRRrP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 88 VVIAGGLLCCLGMVLASFSSSVVQ-----LYLTMGFITGLGLAFNLQPALTIIGKYF--YRKRPMANGLAMAGSPV--FL 158
Cdd:COG2211 83 WILIGAIPLALSFVLLFTAPDLSPtgkliYALVTYLLLGLAYTLVNIPYSALGAELTpdYEERTRLSSWRFAFAGLggLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 159 SSLAPFnqYLFNTF------GWKGSFLILGSLLLnACVAGSLMRplgpnqttsksknktgkTEDDSSPKKikTKKSTWEK 232
Cdd:COG2211 163 ASVLPP--PLVAAFggdaalGYRLTALIFAVLGL-LAFLLTFFG-----------------TKERPVPEE--EKVSLKES 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 233 VnkyldFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLIAnsKYIRP 311
Cdd:COG2211 221 L-----KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLA--KRFGK 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 312 RIQYFFSFAIMfnGVCHLLCPLAQ--DYTSLVLYAVFFGLGFGSVSSVLFETLMDLV-------GAPRFSSAVGLVTIVE 382
Cdd:COG2211 294 KKAFIIGLLLA--ALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktGRRREGLYFGIFTFAI 371
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370463222 383 CGPVLLGPPLAGKLVDLTG-------------EYKYMYMSCGAIVVAASVWLLIGNAINYRLLAKERKEENAR 442
Cdd:COG2211 372 KLGQALAGALAGLLLALFGyvagaaqspsaltGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAAR 444
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
256-422 |
1.32e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 53.32 E-value: 1.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 256 IMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAImfngVCHLLCPLAQ 335
Cdd:cd17324 10 AIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFI----LGNLLAALAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 336 DYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSCGAIVV 415
Cdd:cd17324 86 SFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAAFLAIAVLAL 164
|
....*..
gi 1370463222 416 AASVWLL 422
Cdd:cd17324 165 LAALLLW 171
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-197 |
2.11e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 52.95 E-value: 2.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 20 WIVVGAAFISIGFSYAFpkaVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSR--PVVIAGGLLCC 97
Cdd:COG2271 183 WLLALAYFLVYFALYGF---LTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 98 LGMVLASFSSSVVQLYLTMgFITGLGLAFNLQPALTIIGKYFYRK-RPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKG 176
Cdd:COG2271 260 LALLLLALLPSPALAIALL-FLAGFGLGGAFGLLWALAAELFPKKaRGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|.
gi 1370463222 177 SFLILGSLLLNACVAGSLMRP 197
Cdd:COG2271 339 AFLLLAALALLAALLALLLLR 359
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
46-379 |
6.06e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 51.40 E-value: 6.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 46 EIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLyLTMGFITGLGLA 125
Cdd:cd17321 21 TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL-IAARALQGIGAA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 126 FNLQPALTIIGKYFY-RKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLnacvagslmrplgpnqtt 204
Cdd:cd17321 100 AIMPASLALIAATFPgERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGL------------------ 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 205 sksknktgkteddsspkkiktkkstwekvnkyldFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKD-QGIDEYSAA 283
Cdd:cd17321 162 ----------------------------------VALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGvLGYSPLQAG 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 284 FLLSVMAFVDMFARPSVGLIANSkyIRPRIQYFFSFAIMFNGVCHL-LCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETL 362
Cdd:cd17321 208 LALLPLALAMLVAAPLAGRLADR--FGPRLVLVAGLLLTAVGLLLLaLLGADSSVWLLLPGLVLLGLGLGLFATPLTNAA 285
|
330
....*....|....*..
gi 1370463222 363 MDLVGAPRFSSAVGLVT 379
Cdd:cd17321 286 LSSVPKEKAGAASGILN 302
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
20-423 |
1.03e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 50.69 E-value: 1.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 20 WIVVGAAFISIGFSYAFPkAVTVFFKeiqQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLG 99
Cdd:cd17329 3 VLLIGSFLNRLGFFMVWP-FMAIYLH---QQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 100 MVLASFSSSVVqLYLTMGFITGLGLAFNLQPALTIIG--------KYFYRKRPMANGLAMAGSPVFLSSLApfnQYLFNT 171
Cdd:cd17329 79 FALLGFAHSPW-LFAIALVLTGFGGGLFEPASEAMIAdvttpenrTRAFSLLYWAINLGVAIGPLLGGLLL---LYSFRL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 172 FgwkgsFLILGSLLLNACVAgsLMRPLGPNQTTSKSKNKTGkteddsSPKKIKTKkstwekvnkyldfslFKHRGFLIYL 251
Cdd:cd17329 155 L-----FLAAAVLFLLAALV--LLFLLPETRPKRRAAEKTE------ILRGYKIV---------------LRDRAFLLFL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 252 SGNVIMFLGFFAPIIFLAPYAKDQGIDEYSA-AFLLSVMAFVDMFARPSVGLIANSKYIRPRIqyffSFAIMFNGVCHLL 330
Cdd:cd17329 207 LASFLISLIYFQLESTLPVYVVEILGLGESLlGLLLALNALLIVLLQFPVARLVERFRLRKIL----MIGILLFAIGFAV 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 331 CPLAQDYTSLVLYAVFFGLG---FGSVSSVLFETLMDLVGAPRFSSAVGLVTIVEcgpVLLGPPLAGKLVDLTGeYKYMY 407
Cdd:cd17329 283 LAFANTLAVLILAMIVLTLGemlVFPAVQTLVAALAPPDKRGSYMGFYALAWGLG---RAIGPLVGGLLLDLLG-PGLPW 358
|
410
....*....|....*.
gi 1370463222 408 MSCGAIVVAASVWLLI 423
Cdd:cd17329 359 LILAALGLIAAALLLG 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
251-423 |
1.64e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.11 E-value: 1.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 251 LSGNVIMFLGFFAPIIFLAPY-AKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIanSKYIRPRIQYFFSFAIMfnGVCHL 329
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRL--SDRFGRRRVLLIGLLLF--ALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 330 LCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMS 409
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLI 156
|
170
....*....|....
gi 1370463222 410 CGAIVVAASVWLLI 423
Cdd:pfam07690 157 LAILSLLAAVLLLL 170
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
47-419 |
1.68e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 49.86 E-value: 1.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 47 IQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLyLTMGFITGLGLAF 126
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLL-LLLVALAGIGSAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 127 NLQPALTIIGKYFYRKRPMANGLAMAG-------SPVFLSslapfnqYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLG 199
Cdd:cd17478 101 FHPEGARLASQAAGGRRGLAMSIFSVGgnlgfalGPLIAA-------ALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 200 PNQTTSKsknktgktedDSSPKKIKTKKSTWekvnkyldfslfkhRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDE 279
Cdd:cd17478 174 KPEAKKA----------AAKSSARSTLKGVW--------------RALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 280 YSAAFLLSVMAFVDMFARPSVGLIanSKYIRPRIQYFFSFAIMFngVCHLLCPLAQDYTSLVLYAV--FFGLGFGSVSSV 357
Cdd:cd17478 230 VFAGLLLSLFLFAGAIGTLIGGPL--SDRFGRRRVIIASLLLAA--PFLLLFLLTPGIWSYILLVLagFLLFASFPVTVV 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370463222 358 LFETLMdlvgaPRFSSAV-GLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSCGAIVVAASV 419
Cdd:cd17478 306 LAQELL-----PGNVGLAsGLMMGLSFGLGGIGAPVLGALADAFG-LESVLLILALLPLLGAL 362
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
247-423 |
1.95e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 50.05 E-value: 1.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 247 FLIYL-SGNVIMFLGFFAPIIflapyAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANsKYIRPRIqyfFSFAIMFNG 325
Cdd:TIGR00895 23 FLIMLmDGYDLAAMGFAAPAI-----SAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLAD-RIGRRRV---LLWSILLFS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 326 VCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKY 405
Cdd:TIGR00895 94 VFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFG-WRS 172
|
170
....*....|....*...
gi 1370463222 406 MYMsCGAIVVAASVWLLI 423
Cdd:TIGR00895 173 LFY-VGGIAPLLLLLLLM 189
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
46-354 |
2.24e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 49.56 E-value: 2.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 46 EIQQIFHTTYSEIAWissiMLAVMYAGGPVSSV----LVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITG 121
Cdd:cd17341 24 VIRDDLGLSTSQIGL----LVAIPVLAGALLRLpygfLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 122 LGLAfNLQPALTIIGKYFYRKRP-----MANGLAMAGSPV---FLSSLAPFNQYLFNTFGWKGSFLILGSLLLnacVAGS 193
Cdd:cd17341 100 FAGA-NFASGQPWASFWFPKEKIggaagGIAGAGNMGVAVsqlLAPLIAGAIVFDGGFVGWRNAFFVPGILLA---IAAV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 194 LMRPLGPNQTTSKSKNKTGKTEddssPKKIKTKKSTWEkvnkyldFSLFkhrgfliYlsgnVIMFLGFFAPIIFLAPYAK 273
Cdd:cd17341 176 LVLLFGDDLPTGKASALEFLKV----QLAVLKNYRTWI-------LSLL-------Y----GVTFGSFVGFSNVLPTYFK 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 274 DQ-GIDEYSAAFLLSVMAFVDMFARPSVGLIANskYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFF----- 347
Cdd:cd17341 234 TRfGLPLVTAGILAALFPLAGALARPAGGWLSD--RFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFvalgl 311
|
....*....
gi 1370463222 348 --GLGFGSV 354
Cdd:cd17341 312 gaGAGNGSV 320
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
48-186 |
2.26e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 49.50 E-value: 2.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 48 QQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMgFITGLGLAFN 127
Cdd:cd17325 227 AELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLL-ALLGLGLGLV 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370463222 128 LQPALTIIGKYF-YRKRPMANG-------LAMAGSPVFLSslapfnqYLFNTFGWKGSFLILGSLLL 186
Cdd:cd17325 306 FPATLALLADIVpPEGRGTAMGlfntafsLGMVLGPLLGG-------FLYDAFGFATPFLAAAALLL 365
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
73-184 |
4.69e-06 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 46.10 E-value: 4.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 73 GPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLtMGFITGLGLAFNLQPALTIIGKYFYR-KRPMANGLAM 151
Cdd:TIGR00880 15 SPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLII-ARFLQGFGAAFALVAGAALIADIYPPeERGVALGLMS 93
|
90 100 110
....*....|....*....|....*....|...
gi 1370463222 152 AGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSL 184
Cdd:TIGR00880 94 AGIALGPLLGPPLGGVLAQFLGWRAPFLFLAIL 126
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
253-427 |
5.21e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 48.33 E-value: 5.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 253 GNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANskYIRPRIqyFFSFAIMFNGVCHLLCP 332
Cdd:COG2271 18 AYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLAD--RFGRRR--VLAIGLLLWGLATLLFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 333 LAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIveCGPV--LLGPPLAGKLVDLTGeYKYMYMSC 410
Cdd:COG2271 94 FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNA--GGPLggALAPPLLGWLLAAFG-WRAAFLIL 170
|
170
....*....|....*..
gi 1370463222 411 GAIVVAASVWLLIGNAI 427
Cdd:COG2271 171 GLPGLLLALLRFWLLAL 187
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
17-135 |
8.72e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 47.94 E-value: 8.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 17 GWGWI-----------------VVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVL 79
Cdd:cd17321 148 GWRWIflinvpiglvalllartFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRL 227
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1370463222 80 VNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMG--FITGLGLAFNLQPALTII 135
Cdd:cd17321 228 ADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPglVLLGLGLGLFATPLTNAA 285
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
21-420 |
9.88e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 47.55 E-value: 9.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 21 IVVGAAFISIGFSYAFPkAVTVFFKEIqqifHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGM 100
Cdd:cd17477 1 LLLSVALLGLGSGLLLP-LLSLRLERE----GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 101 VLASFSSSVVqLYLTMGFITGLGLAFNL---QPAL----------TIIGKYFyrkrpMANGLAMAGSPVFLSslapfnqy 167
Cdd:cd17477 76 LLLALTDSPW-VWFLLRFVMGIGLAGLFvvsESWLnalatnenrgRVLGLYS-----TVLGLGFALGPLLLA-------- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 168 LFNTFGWKgSFLILGSLLLNACVAGSLMRPLGPNQttsksknktgKTEDDSSPKKIKtkkstwekvnkyldfslfkhRGF 247
Cdd:cd17477 142 LVGTAGAL-PFLIAAVLLLLALVPLLLTRRAAPEI----------EEAESISLRRLL--------------------RIA 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 248 LIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANsKYIRPRIQYFFSFAIMfngVC 327
Cdd:cd17477 191 PLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLAD-RFDRRRVLLGCALLGA---LA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 328 HLLCPLAqDYTSLVLYAVFF--GLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKY 405
Cdd:cd17477 267 ALLLPLV-PGLPLALLVLLFlwGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGL 345
|
410
....*....|....*
gi 1370463222 406 MYMSCGAIVVAASVW 420
Cdd:cd17477 346 FLFLAAVALLFLLFL 360
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
49-423 |
1.27e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.22 E-value: 1.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 49 QIFHTTYSE--IAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASF-----SSSVVQLYLTMgFITG 121
Cdd:cd06173 25 LVLQLTGSAllVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALlallgSLSLWLLLVLA-FLLG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 122 LGLAFNlQPALT-----IIGKyfyRKRPMANGL---AMAGSPVFLSSLAPFnqyLFNTFGWKGSFLILGSLLLNACVAGS 193
Cdd:cd06173 104 IASAFF-GPARQallpeLVPK---EQLVRANALnslATQLARIIGPALGGL---LVALLGPGGAFAINALSFLLSALLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 194 LMRPLGPNQTTSKSKNKTGKTEDdsspkkiktkkstwekvnkylDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAP-YA 272
Cdd:cd06173 177 FIRRPPPAAPGESSSLLLRDLRE---------------------GLRYLRRSPLLRLLLLALALFALLGGALTVLLPlLA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 273 KDQGIDEYSAAFLLSVMAFVDMFArpsVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFG 352
Cdd:cd06173 236 KEVLGGGAAGYGLLLAAFGVGALL---GALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370463222 353 sVSSVLFETLMDLVGAPRFSSAV-GLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSCGAIVVAASVWLLI 423
Cdd:cd06173 313 -LFNVPLNTLLQLRVPDELRGRVfSVYNALNSGAMPLGALLAGLLADALG-LSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
39-422 |
1.66e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 46.93 E-value: 1.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 39 AVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVqLYLTMGF 118
Cdd:cd17333 14 LLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIY-LFVVLMF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 119 ITGLGLAFNLQPALTIIGKYFYRKRPMAN-------GLAMAGSPVFLSSLapfnqyLFNTFGWKGSFLILGSLLLnaCVA 191
Cdd:cd17333 93 LAGLGAGILDTGANTFVGALFEESSATRLnvlhgffGLGALIGPLIATSL------LTSELSWSWAYLIIGLIYL--LLA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 192 GSLMRPLGPNqtTSKSKNKTGKTEDDSSPKKIKTKKSTWekvnkyLDFSLFkhrgFLIYLSGNVIMflgffapIIFLAPY 271
Cdd:cd17333 165 ILILLTLFPE--LPSARNPQQSVGAFSASASRLLRNPSI------ILGALA----LFLYVGAETAF-------SSWVPSY 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 272 AKD-QGIDEYSAAFLLSVMAFVDMFARPSVGLIANSkyIRPRIQYFFSFAimfnGVCHLLCPLAQDYTSLVLYAVFFGLG 350
Cdd:cd17333 226 LVEkKHVSDGLAGYLLSGFWVGITIGRLLGGPISRR--IKPHTLLVLSGS----GALLGLLILLLAPTLVVGLVATALLG 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370463222 351 FGsvSSVLFETLMDLvGAPRFSSAVGLVT--IVECGPV--LLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLL 422
Cdd:cd17333 300 LF--MAALFPTILSL-GISNLPYAKGKGTsvLLAAGSIggAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
44-266 |
2.00e-05 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 46.81 E-value: 2.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 44 FKEIQQIFHTTYSEIAWISSIMLAVMYAG----GPvssvLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLyLTMGFI 119
Cdd:PRK11043 29 FKAIQADLQTSASAVSASLSLFLAGFALGqllwGP----LSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQL-LVLRFV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 120 TGLGL---AFNLQpALTIigKYFYRKRpmANGLAMAGSP-VFLS-SLAP-FNQYLFNTFGWKGSFLILgslllnACVAGS 193
Cdd:PRK11043 104 QAVGVcsaAVIWQ-ALVI--DRYPAQK--ANRVFATIMPlVALSpALAPlLGAWLLNHFGWQAIFATL------FAITLL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 194 LMRPlgpnqtTSKSKNKTGKTEDDSSPKKIKTkkstwekvnkyldfsLFKHRGFliylSGNVIMF----LGFFA-----P 264
Cdd:PRK11043 173 LILP------TLRLKPSKKARKQSQDALTFKQ---------------LLKSKTY----LGNVLIFaacsAAFFAwltgsP 227
|
..
gi 1370463222 265 II 266
Cdd:PRK11043 228 FI 229
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
47-419 |
4.44e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 45.65 E-value: 4.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 47 IQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGfITGLGLAF 126
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRA-LQGIGGAV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 127 nLQPALTIIGKYFYRKR-PMANGLaMAGSPVFLSSLA-PFNQYLFNTFGWKGSFLILGSLllnaCVAGSLMRPLgpnqtt 204
Cdd:cd17504 101 -FPLAFALVREEFPPERvPVAQGI-LSATFGIGAGIGlPLGGWIVQHLGWRWIFWTAAPV----AVLLAALVPL------ 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 205 sksknktgkteddsspkkiktkkstwekvnkyLDFSLFKHRGFLIYLSGNVIMFLGFFA-----PIIFLAPYAKDQGIDE 279
Cdd:cd17504 169 --------------------------------IDLRLLRRRNVLLANITALLAGFGMFMvfqllPQLLQLPTPTGFGLGI 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 280 YSAAFLLSVMAFVDMFARPSVGLIANSkyIRPRIQYFFSFAIMFNGVChLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLF 359
Cdd:cd17504 217 TEAGLLLLPGALVMLIAGPLAGRLIAR--VGPRRVLLIGLVISAVGLL-LLALLHSSLWALVVALLLIGIGLGLAFASLP 293
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370463222 360 ETLMDLVGAPRFSSAVGLVTIVE-----CGPVLLG-------PPLAGKLVDLTGEYKYMYMSCGAIVVAASV 419
Cdd:cd17504 294 NIVVESVPPDRTGIATGMNTVLRtigsaIGPAIAGailttytVSITSGGVPTEGAYVLAFLIGAALALAALL 365
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
20-119 |
1.27e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 44.19 E-value: 1.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 20 WIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAvMYAGGP-VSSVLVNKYGSRPVVIAGGLLCCL 98
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLI-AYAVGKfISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100
....*....|....*....|.
gi 1370463222 99 GMVLASFSSSVVQLYLTMGFI 119
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLN 101
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
73-196 |
2.86e-04 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 42.97 E-value: 2.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 73 GPVSsvlvNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLyLTMGFITGLGLAFNLQPALTII-GKYFYRKRPMANGLAM 151
Cdd:PRK11652 64 GPLS----DRVGRRPVILVGMSIFILGTLVALFAHSLTVL-IAASAIQGLGTGVGGVMARTLPrDLYEGTQLRHANSLLN 138
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1370463222 152 AGSpVFLSSLAPF-NQYLFNTFGWKGSFLILgsLLLNACVAGSLMR 196
Cdd:PRK11652 139 MGI-LVSPLLAPLiGGLLTTLFGWRACYLFL--LLLGAGVTFSMAR 181
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
46-401 |
3.59e-04 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 42.56 E-value: 3.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 46 EIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTmgFITGLGLA 125
Cdd:cd17339 24 EIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIALLFLGT--ALAGAGIA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 126 FN--LQPALtiIGKYFYRKRPMANGL---AMAGSPVFLSSLA-PFNQYLFntFGWKGSFLILGSL-LLNACVAGSLMRPL 198
Cdd:cd17339 102 VGnvLLPSL--IKRDFPRRVGLMTGLyttSMNLGAALASGLSvPLAQALG--GGWRGALAIWALPaLLALLIWLPQLRRR 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 199 GPNQTTSKSKnktgkteddsSPKKIKTKKSTWEkvnkyldfslfkhrgfliylsgnVIMFLG-----FFAPIIFLAPYAK 273
Cdd:cd17339 178 KRAAAAAAPL----------TKISVWRSPLAWQ-----------------------VTLFMGlqsllFYTLMAWLPTILI 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 274 DQGIDEYSAAFLLSVMAFVDMFARPSVGLIAnSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQdytSLVLYAVFFGLGFGS 353
Cdd:cd17339 225 DAGLSAATAGWLLSLFQLVGIPASLLVPILA-TRLKNQRPIVVLLAVLFIIGVLGLLFAPTA---LALLWAVLLGLGGGA 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1370463222 354 vssvLFETLMDLVG--APRFSSAVGLVTIVECGPVLL---GPPLAGKLVDLTG 401
Cdd:cd17339 301 ----AFSLALTLISlrSSDPAEAAALSGMAQSVGYLLaalGPLLFGVLHDLTG 349
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
23-358 |
4.33e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 42.64 E-value: 4.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 23 VGAAFISIGFSYAFPkAVTVFfkeIQQIFHTTYSEIAWISSIMLA----VMYAGGPVSSVLVNKYGSRPVVIAGGLLCCL 98
Cdd:cd17391 3 LGNFFTGIGFSLIAP-FLPLY---IEQLGVTSGGLVELWSGLAFSstflVSAIFSPIWGRLADRYGRKPMLLRASLGMAI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 99 GMVLASFSSSVVQLY---LTMGFITGLGLAfnlqpALTIIGKYFYRKRP-MANGLAMAGSpVFLSSLAPF-NQYLFNTFG 173
Cdd:cd17391 79 VIGLMAFVTNVWQLLilrLLQGVFSGYVPN-----ATALIASQTPKEKSgWALGTLSTGV-VAGTLIGPLlGGFLADLFG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 174 WKGSFLILGSLLLNAcvagSLMRPLGpnqttsksknktgkTEDDSSPKKIKTKKST---WEKV-NKYLDFSLFKHRgFLI 249
Cdd:cd17391 153 IRNVFFITGGLLFLA----FLLTLFF--------------VKEDFKPVEKKKMVSTkevWNSVpNPSLLISLFVTT-FII 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 250 YLSGNVImflgffAPIifLAPYAKDQGIDEYSAAFL----LSVMAFVDMFARPSVGLIANsKYIRPRIQYFFSFaimFNG 325
Cdd:cd17391 214 QLANQSI------EPI--LTLYIRQLMGDASNLAFIsglvFSATGVSSLLSAPRLGKLGD-RIGHHRILLGALL---ASA 281
|
330 340 350
....*....|....*....|....*....|....*..
gi 1370463222 326 VCHLLCPLAQDYTSLVLYAVFFGLGFG----SVSSVL 358
Cdd:cd17391 282 LLYIPQAFVQTPWQLGILRFLLGLATGgllpAINSLL 318
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
21-164 |
4.37e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 42.61 E-value: 4.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 21 IVVGAAFISIGFSYAFPKAVTVFfkeIQQIFHTTySEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGM 100
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPF---IVADLGPS-SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGS 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370463222 101 VLASFSSSVVQLYLTMGFItglGLAFNLQPALT-IIGKYFYRK-RPMANGLAMAGSPVFlSSLAPF 164
Cdd:cd06179 77 IVAGTAKSVNMLIGGQALI---GIGAGTQGLGAaVASELVPNKyRGLVQGVVNLVASPG-SALGPL 138
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
16-421 |
4.89e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 42.20 E-value: 4.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 16 GGWGWIVVGAAFISIGFSYAFPKAVtvffkeiqQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLL 95
Cdd:cd17316 4 AGLGWFFDAYDFFLIGFVAPVLAAE--------FSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 96 CCLGMVLASFSSSVVQLyLTMGFITGLGLAFNLQPALTIIGKYFYRKRP-----MANGLAMAGSPVFLSSLAPFNQYLFN 170
Cdd:cd17316 76 FGLATLLIGLLPTPILL-LVLRFLQGIGIGGEYPGASTYVAEFAPSKRRgfalgLLQSGWALGALLAALVASLLIPLLSG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 171 TFGWKGSFLILGSLLLnacvagslmrplgpnqttsksknktgkteddsspkkiktkkstwekvnkyldFSLFKHRGFLIY 250
Cdd:cd17316 155 DWGWRILFLIGALPAL----------------------------------------------------LALLLRRRTLLL 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 251 LSGNVIMFLGFFAPIIFLAPY-AKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANskYIRPRIQYFFSFAIMfnGVCHL 329
Cdd:cd17316 183 ILLWFFISFGYYGLTTFLPTYlQTVLGLSPATSSLYLLLISLGALVGALIAGLLSD--RIGRKKTLVIGLILS--GILAL 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 330 LCPLAQDYTSLVLYAVFFGLGF--GSVSSVLFETLMDLVGAPRFSSAVGLVT-IVECGPVLLGPPLAGKLVDLTGEYKYM 406
Cdd:cd17316 259 PLFYLLSGSPTLLLLLLFILSFfvGGVWGALYAYLAELFPTEVRATGVGLSYnLGRLGGGGAPPLIALLLASTGGTGVPA 338
|
410
....*....|....*
gi 1370463222 407 YMSCGAIVVAASVWL 421
Cdd:cd17316 339 LILALLAIVALIVAL 353
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
20-354 |
6.51e-04 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 41.90 E-value: 6.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 20 WIVVGAAFISIGFSYAFPkAVTVFfkEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLG 99
Cdd:TIGR00886 4 FFSWFGFFLSFLVWFAFS-PLAVF--LIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 100 MVLASFSSSVVQLYLTMGFITGLGLAfNLQPALTIIGkYFYRKRPM--ANGLA-----MAGSPVFLSSLAPFNQYLFNT- 171
Cdd:TIGR00886 81 CLWAGLAVQSYSVLLLIRLFIGIAGG-SFASCMPWIS-FFFPKKIQgtALGLAagwgnMGGGVAQFVMPPIIGSLIFGGg 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 172 ------FGWKGSFLILGSLLLNACVAGSLMRPLGPNqttskskNKTGKTEDDSSPKKIKTKKSTWekvnkyldfsLFkhr 245
Cdd:TIGR00886 159 qpahlaWGWAFVIVPAGILLLPALLIFFVGADTPPG-------KPATGKLSFKEALKVFGNRHTW----------IL--- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 246 gFLIYlsgnVIMFLGFFAPIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLIANsKYIRPRIqYFFSFAIMFN 324
Cdd:TIGR00886 219 -ALLY----SVTFGSFLGVSSIFAMLFKDQfGLSKVQAGAYASLGGFLGSLARPAGGAISD-RLGGARK-LLMNFLGVAM 291
|
330 340 350
....*....|....*....|....*....|....*.
gi 1370463222 325 GVCHLL------CPLAQDYTSLVLYAVFFGLGFGSV 354
Cdd:TIGR00886 292 GAFLVVlglvsdGSLAAFIVLFVALFFFAGAGNGST 327
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
59-135 |
9.54e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 41.41 E-value: 9.54e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370463222 59 AWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSvVQLYLTMGFITGLGLAFNLQPALTII 135
Cdd:cd17317 28 ALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPS-YELFLVLRFLVGVTSAGIFTVGFVLG 103
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
46-129 |
9.71e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 41.47 E-value: 9.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 46 EIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTM---GFITGL 122
Cdd:cd17393 24 AIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALflfGAANGA 103
|
....*...
gi 1370463222 123 G-LAFNLQ 129
Cdd:cd17393 104 LdVAMNAQ 111
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
20-417 |
1.50e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 40.69 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 20 WIVVGAAFISIGFSYAFPKA-VTVFFKEIQqifhttySEIAWISSIMLAVMYAG-------GPVSSVLVNKYGSR-PVVI 90
Cdd:cd17313 1 LFLLGFGFFGIEFGWALENSyVPPILQTLG-------LSHALIGFVWTLGPILGlfvqplvGSLSDRCNSRIGRRrPFIL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 91 AGGLLCCLGMVLASFSSSVVQLY----------LTMGFITGLGLAFNL--QPALTIIGKYFYRK-RPMANGLA--MAGSP 155
Cdd:cd17313 74 VGAPLAALGLILIPNAADIGLALgdgprtwalvLFVLGIVLLDFAMNVcqGPVRALLPDLVPPEqRSKANGIInfMGGLG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 156 VFLSSLAPFNQYLFNTFGW------KGSFLIlGSLLLNACVAGSLmrplgpnqTTSKSKNKTGKTEDDSSPKKIKTKKST 229
Cdd:cd17313 154 GVLGYLLGAILWDHNWFGFalggnlKVPFYI-GAIILLVCVLVTL--------FFVKEPPLSPEAGEHSENPSLGEVLKS 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 230 WEKVNKYLDFSLFK----HrgFLIYLSGNVIM--FLGFFAPIIFLAPYAKDQGID--EYSAAFLLSVMAFVDMFARPSVG 301
Cdd:cd17313 225 LLKLLKIMPRSLLRlllvI--FFWWIAFFPFElfFTDYMGEEVYHGTSAASSHYGagVRMGAWGLLIFSLAFLIFSLPIG 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 302 LIAnsKYIRPRIQYFFSFAIMfnGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPR--FSSAVGLVT 379
Cdd:cd17313 303 KLG--KKIGRKKVYLIGLVLF--AVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGrgQGTDTGLLN 378
|
410 420 430
....*....|....*....|....*....|....*...
gi 1370463222 380 IVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAA 417
Cdd:cd17313 379 LAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSL 416
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
56-135 |
3.54e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.50 E-value: 3.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 56 SEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTmGFITGLGLAFnLQPALTII 135
Cdd:cd17489 227 SNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLA-AVLYGLGFGL-LFPALQAL 304
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
262-422 |
6.41e-03 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 38.75 E-value: 6.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 262 FAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKyirPRIQYFFSFAIMFNGVChLLCPLAQDYTSLV 341
Cdd:PRK10213 37 FLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQAT---DRRYVVILFAVLLTLSC-LLVSFANSFSLLL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 342 LYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSCGAIVVAASVWL 421
Cdd:PRK10213 113 IGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIG-WRNVFNAAAVMGVLCIFWI 191
|
.
gi 1370463222 422 L 422
Cdd:PRK10213 192 I 192
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
23-163 |
7.62e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 38.78 E-value: 7.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 23 VGAAFISI---GFSYAFPKAVTVFFKE-IQQIFHTTY------SEIAWISSIMLAVMYAGG----PVSSVLVNKYGSRPV 88
Cdd:cd17357 2 VIVAFGGSfqfGYNIGVVNAPQEVFKEfINDTLVDRYglnlsdSELDLLWSLIVSIFFIGGaigsFISAFLANRFGRKNG 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370463222 89 VIAGGLLCCLG--MVLASFSSSVVQLYLTMGFITGLglafnlqpaltiigkyfyrkrpmANGLAMAGSPVFLSSLAP 163
Cdd:cd17357 82 LLISNALLVVSslLMFLSKSAKSPELLIFGRFLVGI-----------------------ACGLSTGFVPMYLQEISP 135
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
65-132 |
7.62e-03 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 38.56 E-value: 7.62e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370463222 65 MLAVMYA---GGPVSSVLVNKYGSRPVVIAGGLLCCL---GMVLASFSSSVVQLYLTMGFitglgLAFNLQPAL 132
Cdd:PRK14995 301 MLPVMVAsgfSGPIAGILVSRLGLRLVATGGMALSALsfyGLAMTDFSTQQWQAWGLMAL-----LGFSAASAL 369
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
86-423 |
9.51e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.36 E-value: 9.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 86 RPVVIAGGLLCCLGMVLASFSSSVVQLYLTMgFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPV--FLSSLap 163
Cdd:cd17490 62 KLFIIIGLLFTVLASLIMILFPSPWGLLIAR-FLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLgqLIAFL-- 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 164 FNQYLFNTFGWKGSFLIlgslllnACVAGSLMRPLgpnqttsksknkTGKTEDDSSPKKIKTKKstwekvNKYLdFSLFK 243
Cdd:cd17490 139 IGGLIAEHFGMRAPFLL-------AALAGVLGFIL------------SLFIKEERREKKPVLTE------LKEL-LSVLK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 244 HRgFLIYLS--GNVIMFLGFFAPIIFLAPYAKDQGideySAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQY---FFS 318
Cdd:cd17490 193 DK-KLLFFSllAILQQMITFSTTFGFTPLIAKQLG----ASSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERntiIIG 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463222 319 FAIMfnGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVD 398
Cdd:cd17490 268 FLLL--GAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISE 345
|
330 340
....*....|....*....|....*
gi 1370463222 399 LTGeYKYMYMSCGAIVVAASVWLLI 423
Cdd:cd17490 346 AFG-LQTGFFVIGVIALLAAILSLA 369
|
|
| |
