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Conserved domains on  [gi|1370464937|ref|XP_024305336|]
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leucine-rich repeat-containing protein 9 isoform X3 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-236 2.36e-29

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 117.19  E-value: 2.36e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937   55 NLTSLTIVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIENLEKLIKLKVLWLNHNTIKN 134
Cdd:cd21340      3 RITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISV 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  135 IEGLQTLKNLKDL------------------------------NLAGNLINSIgRCLDSNEQLERLNLSGNQICSFKELT 184
Cdd:cd21340     83 VEGLENLTNLEELhienqrlppgekltfdprslaalsnslrvlNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELL 161

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1370464937  185 N-LTRLPCLKDLCLNDpqyttNPVCLLCNYSTHVLYHLPCLQRFDTLDVSAKQ 236
Cdd:cd21340    162 DlLSSWPSLRELDLTG-----NPVCKKPKYRDKIILASKSLEVLDGKEITDTE 209
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1072-1317 3.46e-24

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 102.17  E-value: 3.46e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1072 FRNVCNVNLQNNHLTSFSGLIYLPNVKVLCLNYNHIESImPRLKPQTHLTSRQLlyqkvpssgygqQG--ISKtnrdims 1149
Cdd:cd21340      1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYL------------QNnqIEK------- 60

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1150 senlppimhslevlhlgyngICNliqlqLNRLRNLKFLFLQGNEISQVEGLDNLVVLQELVVDHNRIRS-----FN-DSA 1223
Cdd:cd21340     61 --------------------IEN-----LENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPgekltFDpRSL 115

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1224 FAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEklDVIST---LRELTVYGNPICRKMLHRHMLIFR 1300
Cdd:cd21340    116 AALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELL--DLLSSwpsLRELDLTGNPVCKKPKYRDKIILA 193

                          250
                   ....*....|....*..
gi 1370464937 1301 LPNLQMLDGSPVNSDDR 1317
Cdd:cd21340    194 SKSLEVLDGKEITDTER 210
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 834-1022 4.86e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 93.31  E-value: 4.86e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  834 HLHLSGNCYLKITALN---------LDGQHLFEITNLEKLENLKWASFSNNNLTKMEGLESCINLEELTLDGNCISKIEG 904
Cdd:cd21340      6 HLYLNDKNITKIDNLSlcknlkvlyLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEG 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  905 ISKMTKLTRLSINNNLLTGWEEHTFDNML------HLHSLSLENNRITSLSGLQKSFTLVELYISNNYIavnQEMHN--- 975
Cdd:cd21340     86 LENLTNLEELHIENQRLPPGEKLTFDPRSlaalsnSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQI---SDLEElld 162

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1370464937  976 -LKGLCNLVILDMCGNIIIwNQENYRLFVIFHLPELKALDGIPIEPSE 1022
Cdd:cd21340    163 lLSSWPSLRELDLTGNPVC-KKPKYRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
587-972 5.29e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 5.29e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  587 SLFSVFNNVILEESKKNPEVSVFSKDLKFDDEVIKMEPRIKARPKLISLDDKTILSLAKTSVYSHIVSLNLHGNSLSKLR 666
Cdd:COG4886     11 KLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  667 DLSKLTGLRKLNISFNEftcldDVYHLYNLEYLDASHNHVITL-EGFRGLMKLKHLDLSWNQLKKSGNEINMLckhtTSL 745
Cdd:COG4886     91 DLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNL----TNL 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  746 LTLDIQHNpwqkpatlRLS----VIGRLKTLTHLNgvfiseeeataamkfIAGTRITQLSllrhsstkeerprilsiwps 821
Cdd:COG4886    162 KSLDLSNN--------QLTdlpeELGNLTNLKELD---------------LSNNQITDLP-------------------- 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  822 aKILTQVSKLGpHLHLSGNcylKITALNLdgqhlfEITNLEKLENLkwaSFSNNNLTKMEGLESCINLEELTLDGNCISK 901
Cdd:COG4886    199 -EPLGNLTNLE-ELDLSGN---QLTDLPE------PLANLTNLETL---DLSNNQLTDLPELGNLTNLEELDLSNNQLTD 264

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370464937  902 IEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKSFTLVELYISNNYIAVNQE 972
Cdd:COG4886    265 LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-236 2.36e-29

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 117.19  E-value: 2.36e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937   55 NLTSLTIVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIENLEKLIKLKVLWLNHNTIKN 134
Cdd:cd21340      3 RITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISV 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  135 IEGLQTLKNLKDL------------------------------NLAGNLINSIgRCLDSNEQLERLNLSGNQICSFKELT 184
Cdd:cd21340     83 VEGLENLTNLEELhienqrlppgekltfdprslaalsnslrvlNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELL 161

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1370464937  185 N-LTRLPCLKDLCLNDpqyttNPVCLLCNYSTHVLYHLPCLQRFDTLDVSAKQ 236
Cdd:cd21340    162 DlLSSWPSLRELDLTG-----NPVCKKPKYRDKIILASKSLEVLDGKEITDTE 209
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1072-1317 3.46e-24

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 102.17  E-value: 3.46e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1072 FRNVCNVNLQNNHLTSFSGLIYLPNVKVLCLNYNHIESImPRLKPQTHLTSRQLlyqkvpssgygqQG--ISKtnrdims 1149
Cdd:cd21340      1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYL------------QNnqIEK------- 60

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1150 senlppimhslevlhlgyngICNliqlqLNRLRNLKFLFLQGNEISQVEGLDNLVVLQELVVDHNRIRS-----FN-DSA 1223
Cdd:cd21340     61 --------------------IEN-----LENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPgekltFDpRSL 115

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1224 FAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEklDVIST---LRELTVYGNPICRKMLHRHMLIFR 1300
Cdd:cd21340    116 AALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELL--DLLSSwpsLRELDLTGNPVCKKPKYRDKIILA 193

                          250
                   ....*....|....*..
gi 1370464937 1301 LPNLQMLDGSPVNSDDR 1317
Cdd:cd21340    194 SKSLEVLDGKEITDTER 210
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 834-1022 4.86e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 93.31  E-value: 4.86e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  834 HLHLSGNCYLKITALN---------LDGQHLFEITNLEKLENLKWASFSNNNLTKMEGLESCINLEELTLDGNCISKIEG 904
Cdd:cd21340      6 HLYLNDKNITKIDNLSlcknlkvlyLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEG 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  905 ISKMTKLTRLSINNNLLTGWEEHTFDNML------HLHSLSLENNRITSLSGLQKSFTLVELYISNNYIavnQEMHN--- 975
Cdd:cd21340     86 LENLTNLEELHIENQRLPPGEKLTFDPRSlaalsnSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQI---SDLEElld 162

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1370464937  976 -LKGLCNLVILDMCGNIIIwNQENYRLFVIFHLPELKALDGIPIEPSE 1022
Cdd:cd21340    163 lLSSWPSLRELDLTGNPVC-KKPKYRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
587-972 5.29e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 5.29e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  587 SLFSVFNNVILEESKKNPEVSVFSKDLKFDDEVIKMEPRIKARPKLISLDDKTILSLAKTSVYSHIVSLNLHGNSLSKLR 666
Cdd:COG4886     11 KLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  667 DLSKLTGLRKLNISFNEftcldDVYHLYNLEYLDASHNHVITL-EGFRGLMKLKHLDLSWNQLKKSGNEINMLckhtTSL 745
Cdd:COG4886     91 DLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNL----TNL 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  746 LTLDIQHNpwqkpatlRLS----VIGRLKTLTHLNgvfiseeeataamkfIAGTRITQLSllrhsstkeerprilsiwps 821
Cdd:COG4886    162 KSLDLSNN--------QLTdlpeELGNLTNLKELD---------------LSNNQITDLP-------------------- 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  822 aKILTQVSKLGpHLHLSGNcylKITALNLdgqhlfEITNLEKLENLkwaSFSNNNLTKMEGLESCINLEELTLDGNCISK 901
Cdd:COG4886    199 -EPLGNLTNLE-ELDLSGN---QLTDLPE------PLANLTNLETL---DLSNNQLTDLPELGNLTNLEELDLSNNQLTD 264

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370464937  902 IEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKSFTLVELYISNNYIAVNQE 972
Cdd:COG4886    265 LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
979-1333 9.35e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 9.35e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  979 LCNLVILDMCGNIIIWNQENYRLFVIFHLPELKALDGIPIEPSETDSAKDLFGGRLTSDMIAERQGHSNFKQMQELNWTS 1058
Cdd:COG4886      2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1059 SSIRTVDLIPVDQFRNVCNVNLQNNhltsfSGLIYLPNVKVLCLNYNHIESIMPRLKPQTHLTSrqlLYqkvpssgygqq 1138
Cdd:COG4886     82 LSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLPEELANLTNLKE---LD----------- 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1139 gISKTN-RDIMSS-ENLPpimhSLEVLHLGYNGICNlIQLQLNRLRNLKFLFLQGNEISQV-EGLDNLVVLQELVVDHNR 1215
Cdd:COG4886    143 -LSNNQlTDLPEPlGNLT----NLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQ 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1216 IRSFNDSaFAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEKLdviSTLRELTVYGNPICRKMLHRH 1295
Cdd:COG4886    217 LTDLPEP-LANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANL---TNLKTLDLSNNQLTDLKLKEL 292

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 1370464937 1296 MLIFRLPNLQMLDGSPVNSDDRAKAEFHLAELQAKKNS 1333
Cdd:COG4886    293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLL 330
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 650-784 1.10e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.04  E-value: 1.10e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  650 SHIVSLNLHGNSLSKLRDLSKLTGLRKLNISFNEFTCLDDVYHLYNLE------------------------------YL 699
Cdd:cd21340     46 TNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVL 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  700 DASHNHVITLEGFRGLMKLKHLDLSWNQLkKSGNEINMLCKHTTSLLTLDIQHNPWQKPATLRLSVIGRLKTLTHLNGVF 779
Cdd:cd21340    126 NISGNNIDSLEPLAPLRNLEQLDASNNQI-SDLEELLDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKE 204


                   ....*
gi 1370464937  780 ISEEE 784
Cdd:cd21340    205 ITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-157 1.62e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 1.62e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937   35 SKLEMFFLGYPRIVGLSLF----PNLTSLTIVAQDIKEISG-LEPCLQLKELWIAECCIEKI-EGLQECRNLEKLYLYFN 108
Cdd:COG4886    159 TNLKSLDLSNNQLTDLPEElgnlTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNN 238

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1370464937  109 KISKIENLEKLIKLKVLWLNHNTIKNIEGLQTLKNLKDLNLAGNLINSI 157
Cdd:COG4886    239 QLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL 287
LRR_9 pfam14580
Leucine-rich repeat;
897-1041 5.39e-07

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 51.30  E-value: 5.39e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  897 NCISKIEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKsftlvelyisnnyiavnqeMHNL 976
Cdd:pfam14580   52 NEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLDP-------------------LASL 112

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370464937  977 KGLCNLVILDmcgNIIIwNQENYRLFVIFHLPELKALDGIPIEPSETDSAKDLFGGRLTSDMIAE 1041
Cdd:pfam14580  113 KKLTFLSLLR---NPVT-NKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQLAKE 173
LRR_9 pfam14580
Leucine-rich repeat;
1189-1321 1.92e-06

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 49.76  E-value: 1.92e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1189 LQGNEISQVEGLDNLVVLQELVVDHNRIrsfndsafakpssllaLHLEENrlreLGklQSLVKLEKLFLGYNKIQDITEL 1268
Cdd:pfam14580   49 FSDNEIRKLDGFPLLRRLKTLLLNNNRI----------------CRIGEG----LG--EALPNLTELILTNNNLQELGDL 106

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1370464937 1269 EKLDVISTLRELTVYGNPICRKMLHRHMLIFRLPNLQMLDGSPVNSDDRAKAE 1321
Cdd:pfam14580  107 DPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAE 159
LRR_8 pfam13855
Leucine rich repeat;
121-177 3.78e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 3.78e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  121 KLKVLWLNHNTIKNIEG--LQTLKNLKDLNLAGNLINSI-GRCLDSNEQLERLNLSGNQI 177
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
672-728 4.92e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 4.92e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370464937  672 TGLRKLNISFNEFTCLDDV--YHLYNLEYLDASHNHVITLEG--FRGLMKLKHLDLSWNQL 728
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-236 2.36e-29

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 117.19  E-value: 2.36e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937   55 NLTSLTIVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIENLEKLIKLKVLWLNHNTIKN 134
Cdd:cd21340      3 RITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISV 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  135 IEGLQTLKNLKDL------------------------------NLAGNLINSIgRCLDSNEQLERLNLSGNQICSFKELT 184
Cdd:cd21340     83 VEGLENLTNLEELhienqrlppgekltfdprslaalsnslrvlNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELL 161

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1370464937  185 N-LTRLPCLKDLCLNDpqyttNPVCLLCNYSTHVLYHLPCLQRFDTLDVSAKQ 236
Cdd:cd21340    162 DlLSSWPSLRELDLTG-----NPVCKKPKYRDKIILASKSLEVLDGKEITDTE 209
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1072-1317 3.46e-24

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 102.17  E-value: 3.46e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1072 FRNVCNVNLQNNHLTSFSGLIYLPNVKVLCLNYNHIESImPRLKPQTHLTSRQLlyqkvpssgygqQG--ISKtnrdims 1149
Cdd:cd21340      1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYL------------QNnqIEK------- 60

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1150 senlppimhslevlhlgyngICNliqlqLNRLRNLKFLFLQGNEISQVEGLDNLVVLQELVVDHNRIRS-----FN-DSA 1223
Cdd:cd21340     61 --------------------IEN-----LENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPgekltFDpRSL 115

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1224 FAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEklDVIST---LRELTVYGNPICRKMLHRHMLIFR 1300
Cdd:cd21340    116 AALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELL--DLLSSwpsLRELDLTGNPVCKKPKYRDKIILA 193

                          250
                   ....*....|....*..
gi 1370464937 1301 LPNLQMLDGSPVNSDDR 1317
Cdd:cd21340    194 SKSLEVLDGKEITDTER 210
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 834-1022 4.86e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 93.31  E-value: 4.86e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  834 HLHLSGNCYLKITALN---------LDGQHLFEITNLEKLENLKWASFSNNNLTKMEGLESCINLEELTLDGNCISKIEG 904
Cdd:cd21340      6 HLYLNDKNITKIDNLSlcknlkvlyLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEG 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  905 ISKMTKLTRLSINNNLLTGWEEHTFDNML------HLHSLSLENNRITSLSGLQKSFTLVELYISNNYIavnQEMHN--- 975
Cdd:cd21340     86 LENLTNLEELHIENQRLPPGEKLTFDPRSlaalsnSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQI---SDLEElld 162

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1370464937  976 -LKGLCNLVILDMCGNIIIwNQENYRLFVIFHLPELKALDGIPIEPSE 1022
Cdd:cd21340    163 lLSSWPSLRELDLTGNPVC-KKPKYRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
587-972 5.29e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 5.29e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  587 SLFSVFNNVILEESKKNPEVSVFSKDLKFDDEVIKMEPRIKARPKLISLDDKTILSLAKTSVYSHIVSLNLHGNSLSKLR 666
Cdd:COG4886     11 KLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  667 DLSKLTGLRKLNISFNEftcldDVYHLYNLEYLDASHNHVITL-EGFRGLMKLKHLDLSWNQLKKSGNEINMLckhtTSL 745
Cdd:COG4886     91 DLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNL----TNL 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  746 LTLDIQHNpwqkpatlRLS----VIGRLKTLTHLNgvfiseeeataamkfIAGTRITQLSllrhsstkeerprilsiwps 821
Cdd:COG4886    162 KSLDLSNN--------QLTdlpeELGNLTNLKELD---------------LSNNQITDLP-------------------- 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  822 aKILTQVSKLGpHLHLSGNcylKITALNLdgqhlfEITNLEKLENLkwaSFSNNNLTKMEGLESCINLEELTLDGNCISK 901
Cdd:COG4886    199 -EPLGNLTNLE-ELDLSGN---QLTDLPE------PLANLTNLETL---DLSNNQLTDLPELGNLTNLEELDLSNNQLTD 264

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370464937  902 IEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKSFTLVELYISNNYIAVNQE 972
Cdd:COG4886    265 LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
979-1333 9.35e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 9.35e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  979 LCNLVILDMCGNIIIWNQENYRLFVIFHLPELKALDGIPIEPSETDSAKDLFGGRLTSDMIAERQGHSNFKQMQELNWTS 1058
Cdd:COG4886      2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1059 SSIRTVDLIPVDQFRNVCNVNLQNNhltsfSGLIYLPNVKVLCLNYNHIESIMPRLKPQTHLTSrqlLYqkvpssgygqq 1138
Cdd:COG4886     82 LSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLPEELANLTNLKE---LD----------- 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1139 gISKTN-RDIMSS-ENLPpimhSLEVLHLGYNGICNlIQLQLNRLRNLKFLFLQGNEISQV-EGLDNLVVLQELVVDHNR 1215
Cdd:COG4886    143 -LSNNQlTDLPEPlGNLT----NLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQ 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1216 IRSFNDSaFAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEKLdviSTLRELTVYGNPICRKMLHRH 1295
Cdd:COG4886    217 LTDLPEP-LANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANL---TNLKTLDLSNNQLTDLKLKEL 292

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 1370464937 1296 MLIFRLPNLQMLDGSPVNSDDRAKAEFHLAELQAKKNS 1333
Cdd:COG4886    293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLL 330
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 650-784 1.10e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.04  E-value: 1.10e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  650 SHIVSLNLHGNSLSKLRDLSKLTGLRKLNISFNEFTCLDDVYHLYNLE------------------------------YL 699
Cdd:cd21340     46 TNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVL 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  700 DASHNHVITLEGFRGLMKLKHLDLSWNQLkKSGNEINMLCKHTTSLLTLDIQHNPWQKPATLRLSVIGRLKTLTHLNGVF 779
Cdd:cd21340    126 NISGNNIDSLEPLAPLRNLEQLDASNNQI-SDLEELLDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKE 204


                   ....*
gi 1370464937  780 ISEEE 784
Cdd:cd21340    205 ITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-157 1.62e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 1.62e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937   35 SKLEMFFLGYPRIVGLSLF----PNLTSLTIVAQDIKEISG-LEPCLQLKELWIAECCIEKI-EGLQECRNLEKLYLYFN 108
Cdd:COG4886    159 TNLKSLDLSNNQLTDLPEElgnlTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNN 238

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1370464937  109 KISKIENLEKLIKLKVLWLNHNTIKNIEGLQTLKNLKDLNLAGNLINSI 157
Cdd:COG4886    239 QLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1068-1287 3.23e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.72  E-value: 3.23e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1068 PVDQFRNVCNVNLQNNHLTSFSGLI-YLPNVKVLCLNYNHIESIMPRLKPQTHLTSRQLLYQKVPSSGYGQQGISKTNRD 1146
Cdd:COG4886    108 ELSNLTNLESLDLSGNQLTDLPEELaNLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKEL 187

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1147 IMSS---ENLPPI---MHSLEVLHLGYNGICNLiQLQLNRLRNLKFLFLQGNEISQVEGLDNLVVLQELVVDHNRIRSFN 1220
Cdd:COG4886    188 DLSNnqiTDLPEPlgnLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP 266

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370464937 1221 DSafAKPSSLLALHLEENRLRE--LGKLQSLVKLEKLFLGYNKIQDITELEKLDVISTLRELTVYGNPI 1287
Cdd:COG4886    267 PL--ANLTNLKTLDLSNNQLTDlkLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
654-851 5.18e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 5.18e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  654 SLNLHGNSLSKL-RDLSKLTGLRKLNISFNEFTCLDDVYHLYNLEYLDASHNHVITLEGFRGLMKLKHLDLSWNQLKKSG 732
Cdd:COG4886    209 ELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  733 NEINMLCKHTTSLLTLDIQHNPWQKPATLRLSVIGRLKTLTHLNGVFISEEEATAAMKFIAGTRITQLSLLRHSSTKEER 812
Cdd:COG4886    289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLT 368

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1370464937  813 PRILSIWPSAKILTQVSKLGPHLHLSGNCYLKITALNLD 851
Cdd:COG4886    369 LGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLAL 407
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
565-962 1.00e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 1.00e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  565 DHDLVLPEYVVEFEYITMVKAPSLFSVFNNVILEESKKNPEVSVFSKDLKFDDEVIKMEPRIKARPKLISLDDKTILSLA 644
Cdd:COG4886      5 LLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSL 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  645 KTSVYSHIVSL-NLHGNSLSKLRDLSKLTGLRKLNISFNEFTCL-DDVYHLYNLEYLDASHNHVITL-EGFRGLMKLKHL 721
Cdd:COG4886     85 LLLGLTDLGDLtNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSL 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  722 DLSWNQLKKSGNEINMLckhtTSLLTLDIQHNPWQK-PATLrlsviGRLKTLTHLNgvfISEEEATAAMKFIAgtRITQL 800
Cdd:COG4886    165 DLSNNQLTDLPEELGNL----TNLKELDLSNNQITDlPEPL-----GNLTNLEELD---LSGNQLTDLPEPLA--NLTNL 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  801 SLLRHSSTKEERPRILSIWPSAKIL----TQVSKLGP--------HLHLSGNcylKITALNLDGQHLFEITNLEKLENLK 868
Cdd:COG4886    231 ETLDLSNNQLTDLPELGNLTNLEELdlsnNQLTDLPPlanltnlkTLDLSNN---QLTDLKLKELELLLGLNSLLLLLLL 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  869 WASFSNNNLTKMEGLESCINLEELTLDGNCISKIEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSL 948
Cdd:COG4886    308 LNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLL 387

                          410
                   ....*....|....
gi 1370464937  949 SGLQKSFTLVELYI 962
Cdd:COG4886    388 TLLLLLLTTTAGVL 401
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 88-177 2.32e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 58.26  E-value: 2.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937   88 IEKIEGLQECRNLEKLYLYFNKISK------IENLEKLIKLKVLWLNHNTIKN------IEGLQTLKNLKDLNLAGNLI- 154
Cdd:COG5238    254 IALAEALKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGIg 333

                           90       100
                   ....*....|....*....|....*..
gi 1370464937  155 ----NSIGRCLDSNEQLERLNLSGNQI 177
Cdd:COG5238    334 aqgaIALAKALQENTTLHSLDLSDNQI 360
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
886-1269 5.22e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 5.22e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  886 CINLEELTLDGNCISKIEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKSFTLVELYISNN 965
Cdd:COG4886      2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  966 YIAVNQEMHNLKGLCNLVILDMCGNIIIwnqenyrlfviFHLPELKALDgipiepsetdsakdLFGGRLTS--DMIAerq 1043
Cdd:COG4886     82 LSLLLLGLTDLGDLTNLTELDLSGNEEL-----------SNLTNLESLD--------------LSGNQLTDlpEELA--- 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1044 ghsNFKQMQELNWTSSSIRTVDLiPVDQFRNVCNVNLQNNHLTSFS-GLIYLPNVKVLCLNYNHIESIMPRLkpqTHLTS 1122
Cdd:COG4886    134 ---NLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPeELGNLTNLKELDLSNNQITDLPEPL---GNLTN 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1123 RQLLYqkvpssgygqqgISKTN-RDImsSENLPPiMHSLEVLHLGYNGICNLIQLQlnRLRNLKFLFLQGNEISQVEGLD 1201
Cdd:COG4886    207 LEELD------------LSGNQlTDL--PEPLAN-LTNLETLDLSNNQLTDLPELG--NLTNLEELDLSNNQLTDLPPLA 269

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370464937 1202 NLVVLQELVVDHNRIRSFNDSAFAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELE 1269
Cdd:COG4886    270 NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337
LRR_9 pfam14580
Leucine-rich repeat;
897-1041 5.39e-07

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 51.30  E-value: 5.39e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  897 NCISKIEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKsftlvelyisnnyiavnqeMHNL 976
Cdd:pfam14580   52 NEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLDP-------------------LASL 112

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370464937  977 KGLCNLVILDmcgNIIIwNQENYRLFVIFHLPELKALDGIPIEPSETDSAKDLFGGRLTSDMIAE 1041
Cdd:pfam14580  113 KKLTFLSLLR---NPVT-NKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQLAKE 173
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-189 8.41e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 8.41e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937   50 LSLFPNLTSLTIVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIENLEKLIKLKVLWLNH 129
Cdd:COG4886     26 LLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG 105

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370464937  130 NtikniEGLQTLKNLKDLNLAGNLINSIGRCLDSNEQLERLNLSGNQI----CSFKELTNLTRL 189
Cdd:COG4886    106 N-----EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLtdlpEPLGNLTNLKSL 164
LRR_9 pfam14580
Leucine-rich repeat;
1189-1321 1.92e-06

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 49.76  E-value: 1.92e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1189 LQGNEISQVEGLDNLVVLQELVVDHNRIrsfndsafakpssllaLHLEENrlreLGklQSLVKLEKLFLGYNKIQDITEL 1268
Cdd:pfam14580   49 FSDNEIRKLDGFPLLRRLKTLLLNNNRI----------------CRIGEG----LG--EALPNLTELILTNNNLQELGDL 106

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1370464937 1269 EKLDVISTLRELTVYGNPICRKMLHRHMLIFRLPNLQMLDGSPVNSDDRAKAE 1321
Cdd:pfam14580  107 DPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAE 159
LRR_8 pfam13855
Leucine rich repeat;
1206-1262 2.68e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 2.68e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370464937 1206 LQELVVDHNRIRSFNDSAFAKPSSLLALHLEENRLRELGK--LQSLVKLEKLFLGYNKI 1262
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
121-177 3.78e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 3.78e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  121 KLKVLWLNHNTIKNIEG--LQTLKNLKDLNLAGNLINSI-GRCLDSNEQLERLNLSGNQI 177
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
672-728 4.92e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 4.92e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370464937  672 TGLRKLNISFNEFTCLDDV--YHLYNLEYLDASHNHVITLEG--FRGLMKLKHLDLSWNQL 728
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 99-138 2.36e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 42.62  E-value: 2.36e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1370464937   99 NLEKLYLYFNKISKIENLEKLIKLKVLWLNHNT-IKNIEGL 138
Cdd:pfam12799    2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDL 42
LRR_8 pfam13855
Leucine rich repeat;
888-945 1.14e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 1.14e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  888 NLEELTLDGNCISKIEGIS--KMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRI 945
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
909-967 1.20e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 1.20e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370464937  909 TKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGlqKSFT----LVELYISNNYI 967
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSP--GAFSglpsLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
650-706 2.84e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 2.84e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370464937  650 SHIVSLNLHGNSLSKLRD--LSKLTGLRKLNISFNEFTCLDDV--YHLYNLEYLDASHNHV 706
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGafSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
98-154 2.84e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 2.84e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370464937   98 RNLEKLYLYFNKISKI--ENLEKLIKLKVLWLNHNTIKNIEG--LQTLKNLKDLNLAGNLI 154
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 121-152 3.43e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.54  E-value: 3.43e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1370464937  121 KLKVLWLNHNTIKNIEGLQTLKNLKDLNLAGN 152
Cdd:pfam12799    2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 84-178 4.45e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 4.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937   84 AECCIEKIEGLQECRNLEKLYLYFNKISK------IENLEKLIKLKVLWLNHNTIKNI------EGLQTLKNLKDLNLAG 151
Cdd:cd00116    151 GASCEALAKALRANRDLKELNLANNGIGDagiralAEGLKANCNLEVLDLNNNGLTDEgasalaETLASLKSLEVLNLGD 230

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1370464937  152 NLINSIGRC------LDSNEQLERLNLSGNQIC 178
Cdd:cd00116    231 NNLTDAGAAalasalLSPNISLLTLSLSCNDIT 263
LRR_9 pfam14580
Leucine-rich repeat;
108-242 5.94e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 42.44  E-value: 5.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  108 NKISKIENLEKLIKLKVLWLNHNTIKNI-EGL-QTLKNLKDLNLAGNLINSIGrcldsneQLERLnlsgnqiCSFKELTN 185
Cdd:pfam14580   52 NEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLgEALPNLTELILTNNNLQELG-------DLDPL-------ASLKKLTF 117

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370464937  186 LTRLpclkdlclndpqytTNPVCLLCNYSTHVLYHLPCLQRFDTLDVSAKQIKELAD 242
Cdd:pfam14580  118 LSLL--------------RNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEK 160
LRR_8 pfam13855
Leucine rich repeat;
1159-1216 1.50e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 1.50e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1159 SLEVLHLGYNGICNLIQLQLNRLRNLKFLFLQGNEISQVEG--LDNLVVLQELVVDHNRI 1216
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
857-1285 2.52e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 2.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  857 EITNLEKLENLKWASFSNNNLTKMEGLESCINLEELTLDGNCISKIEGISKMTKLTRLSINNNLltgweehTFDNMLHLH 936
Cdd:COG4886     44 SLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLE 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  937 SLSLENNRITSLSGLQKSFT-LVELYISNNYIAVNQEmhNLKGLCNLVILDMCGNiiiwnqenyrlfvifhlpelkALDG 1015
Cdd:COG4886    117 SLDLSGNQLTDLPEELANLTnLKELDLSNNQLTDLPE--PLGNLTNLKSLDLSNN---------------------QLTD 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1016 IPIEpsetdsakdlfggrltsdmiaerqghsnFKQMQELNWtsssirtvdlipvdqfrnvcnVNLQNNHLTSFSGLIY-L 1094
Cdd:COG4886    174 LPEE----------------------------LGNLTNLKE---------------------LDLSNNQITDLPEPLGnL 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1095 PNVKVLCLNYNHIESIMPRLKPQTHLTSRQLLYQKVpssgygqqgisktnrdimssENLPPI--MHSLEVLHLGYNGICN 1172
Cdd:COG4886    205 TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL--------------------TDLPELgnLTNLEELDLSNNQLTD 264

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937 1173 LiqLQLNRLRNLKFLFLQGNEIS--QVEGLDNLVVLQELVVDHNRIRSFNDSAFAKPSSLLALHLEENRLRELGKLQSLV 1250
Cdd:COG4886    265 L--PPLANLTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 1370464937 1251 KLEKLFLGYNKIQDITELEKLDVISTLRELTVYGN 1285
Cdd:COG4886    343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEA 377
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-242 2.96e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.84  E-value: 2.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937   50 LSLFPNLTSLTIVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIeNLEKLIKLKVLWLNH 129
Cdd:COG4886    224 LANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL-KLKELELLLGLNSLL 302

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937  130 NTIKNIEGLQTLKNLKDLNLAgNLINSIGRCLDSNEQLERLNLSGNQICSFKELTNLTRLPCLKDLCLNDPQYTTNPVCL 209
Cdd:COG4886    303 LLLLLLNLLELLILLLLLTTL-LLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1370464937  210 LCNYSTHVLYHLPCLQRFDTLDVSAKQIKELAD 242
Cdd:COG4886    382 LALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 77-118 5.04e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 5.04e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1370464937   77 QLKELWIAECCIEKIEGLQECRNLEKLYLYFN-KISKIENLEK 118
Cdd:pfam12799    2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 888-919 8.50e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 8.50e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1370464937  888 NLEELTLDGNCISKIEGISKMTKLTRLSINNN 919
Cdd:pfam12799    2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 99-177 9.78e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.16  E-value: 9.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464937   99 NLEKLYLYFNKISKiENLEKLIK-------LKVLWLNHNTIKN------IEGLQTLKNLKDLNLAGNLIN-----SIGRC 160
Cdd:COG5238    181 SVETVYLGCNQIGD-EGIEELAEaltqnttVTTLWLKRNPIGDegaeilAEALKGNKSLTTLDLSNNQIGdegviALAEA 259

                           90
                   ....*....|....*..
gi 1370464937  161 LDSNEQLERLNLSGNQI 177
Cdd:COG5238    260 LKNNTTVETLYLSGNQI 276
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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