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Conserved domains on  [gi|1370464953|ref|XP_024305343|]
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leucine-rich repeat-containing protein 9 isoform X11 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 18077502)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-236 4.51e-30

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 118.35  E-value: 4.51e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953  55 NLTSLTIVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIENLEKLIKLKVLWLNHNTIKN 134
Cdd:cd21340     3 RITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953 135 IEGLQTLKNLKDL------------------------------NLAGNLINSIgRCLDSNEQLERLNLSGNQICSFKELT 184
Cdd:cd21340    83 VEGLENLTNLEELhienqrlppgekltfdprslaalsnslrvlNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELL 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370464953 185 N-LTRLPCLKDLCLNDpqyttNPVCLLCNYSTHVLYHLPCLQRFDTLDVSAKQ 236
Cdd:cd21340   162 DlLSSWPSLRELDLTG-----NPVCKKPKYRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
694-798 4.10e-11

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 4.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953 694 SHIVSLNLHGNSLSKL-RDLSKLTGLRKLNISFNEFTCL-DDVYHLYNLEYLDASHNHVITLEGFRGLMKLKHLDLSWNQ 771
Cdd:COG4886   182 TNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQ 261

                          90       100
                  ....*....|....*....|....*..
gi 1370464953 772 LKKSGNEINMlckhtTSLLTLDIQHNP 798
Cdd:COG4886   262 LTDLPPLANL-----TNLKTLDLSNNQ 283
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-236 4.51e-30

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 118.35  E-value: 4.51e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953  55 NLTSLTIVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIENLEKLIKLKVLWLNHNTIKN 134
Cdd:cd21340     3 RITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953 135 IEGLQTLKNLKDL------------------------------NLAGNLINSIgRCLDSNEQLERLNLSGNQICSFKELT 184
Cdd:cd21340    83 VEGLENLTNLEELhienqrlppgekltfdprslaalsnslrvlNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELL 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370464953 185 N-LTRLPCLKDLCLNDpqyttNPVCLLCNYSTHVLYHLPCLQRFDTLDVSAKQ 236
Cdd:cd21340   162 DlLSSWPSLRELDLTG-----NPVCKKPKYRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-157 7.02e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 7.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953  35 SKLEMFFLGYPRIVGLSLF----PNLTSLTIVAQDIKEISG-LEPCLQLKELWIAECCIEKI-EGLQECRNLEKLYLYFN 108
Cdd:COG4886   159 TNLKSLDLSNNQLTDLPEElgnlTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNN 238

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1370464953 109 KISKIENLEKLIKLKVLWLNHNTIKNIEGLQTLKNLKDLNLAGNLINSI 157
Cdd:COG4886   239 QLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
694-798 4.10e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 4.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953 694 SHIVSLNLHGNSLSKL-RDLSKLTGLRKLNISFNEFTCL-DDVYHLYNLEYLDASHNHVITLEGFRGLMKLKHLDLSWNQ 771
Cdd:COG4886   182 TNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQ 261

                          90       100
                  ....*....|....*....|....*..
gi 1370464953 772 LKKSGNEINMlckhtTSLLTLDIQHNP 798
Cdd:COG4886   262 LTDLPPLANL-----TNLKTLDLSNNQ 283
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 694-803 3.54e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.57  E-value: 3.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953 694 SHIVSLNLHGNSLSKLRDLSKLTGLRKLNISFNEFTCLDDVYHLYNLE------------------------------YL 743
Cdd:cd21340    46 TNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVL 125

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953 744 DASHNHVITLEGFRGLMKLKHLDLSWNQLkKSGNEINMLCKHTTSLLTLDIQHNPWQKPH 803
Cdd:cd21340   126 NISGNNIDSLEPLAPLRNLEQLDASNNQI-SDLEELLDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
121-177 4.24e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 4.24e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953 121 KLKVLWLNHNTIKNIEG--LQTLKNLKDLNLAGNLINSI-GRCLDSNEQLERLNLSGNQI 177
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
716-772 5.85e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 5.85e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370464953 716 TGLRKLNISFNEFTCLDDV--YHLYNLEYLDASHNHVITLEG--FRGLMKLKHLDLSWNQL 772
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-236 4.51e-30

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 118.35  E-value: 4.51e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953  55 NLTSLTIVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIENLEKLIKLKVLWLNHNTIKN 134
Cdd:cd21340     3 RITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953 135 IEGLQTLKNLKDL------------------------------NLAGNLINSIgRCLDSNEQLERLNLSGNQICSFKELT 184
Cdd:cd21340    83 VEGLENLTNLEELhienqrlppgekltfdprslaalsnslrvlNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELL 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370464953 185 N-LTRLPCLKDLCLNDpqyttNPVCLLCNYSTHVLYHLPCLQRFDTLDVSAKQ 236
Cdd:cd21340   162 DlLSSWPSLRELDLTG-----NPVCKKPKYRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-157 7.02e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 7.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953  35 SKLEMFFLGYPRIVGLSLF----PNLTSLTIVAQDIKEISG-LEPCLQLKELWIAECCIEKI-EGLQECRNLEKLYLYFN 108
Cdd:COG4886   159 TNLKSLDLSNNQLTDLPEElgnlTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNN 238

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1370464953 109 KISKIENLEKLIKLKVLWLNHNTIKNIEGLQTLKNLKDLNLAGNLINSI 157
Cdd:COG4886   239 QLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
694-798 4.10e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 4.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953 694 SHIVSLNLHGNSLSKL-RDLSKLTGLRKLNISFNEFTCL-DDVYHLYNLEYLDASHNHVITLEGFRGLMKLKHLDLSWNQ 771
Cdd:COG4886   182 TNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQ 261

                          90       100
                  ....*....|....*....|....*..
gi 1370464953 772 LKKSGNEINMlckhtTSLLTLDIQHNP 798
Cdd:COG4886   262 LTDLPPLANL-----TNLKTLDLSNNQ 283
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 694-803 3.54e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.57  E-value: 3.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953 694 SHIVSLNLHGNSLSKLRDLSKLTGLRKLNISFNEFTCLDDVYHLYNLE------------------------------YL 743
Cdd:cd21340    46 TNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVL 125

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953 744 DASHNHVITLEGFRGLMKLKHLDLSWNQLkKSGNEINMLCKHTTSLLTLDIQHNPWQKPH 803
Cdd:cd21340   126 NISGNNIDSLEPLAPLRNLEQLDASNNQI-SDLEELLDLLSSWPSLRELDLTGNPVCKKP 184
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
694-797 1.63e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.72  E-value: 1.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953 694 SHIVSLNLHGNSLSKL-RDLSKLTGLRKLNISFNEFTCL-DDVYHLYNLEYLDASHNHVITL-EGFRGLMKLKHLDLSWN 770
Cdd:COG4886   113 TNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNN 192

                          90       100
                  ....*....|....*....|....*..
gi 1370464953 771 QLKKSGNEINMLckhtTSLLTLDIQHN 797
Cdd:COG4886   193 QITDLPEPLGNL----TNLEELDLSGN 215
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 88-177 2.44e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 60.19  E-value: 2.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953  88 IEKIEGLQECRNLEKLYLYFNKISK------IENLEKLIKLKVLWLNHNTIKN------IEGLQTLKNLKDLNLAGNLI- 154
Cdd:COG5238   254 IALAEALKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGIg 333

                          90       100
                  ....*....|....*....|....*..
gi 1370464953 155 ----NSIGRCLDSNEQLERLNLSGNQI 177
Cdd:COG5238   334 aqgaIALAKALQENTTLHSLDLSDNQI 360
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
698-773 3.68e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.56  E-value: 3.68e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370464953 698 SLNLHGNSLSKL-RDLSKLTGLRKLNISFNEFTCLDDVYHLYNLEYLDASHNHVITLEGFRGLMKLKHLDLSWNQLK 773
Cdd:COG4886   209 ELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLT 285
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 677-797 2.51e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.18  E-value: 2.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953 677 ISLDDKTILSLAKTSVYSHIVSLNLHGNSLSKLRDLSKLTGLRKLNISFNEFTCLDDVYHLYNLEYLDASHNHVITLEGF 756
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1370464953 757 RGLMKLKHLDLSwNQLKKSGNEI----NMLCKHTTSLLTLDIQHN 797
Cdd:cd21340    87 ENLTNLEELHIE-NQRLPPGEKLtfdpRSLAALSNSLRVLNISGN 130
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
609-798 2.81e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 2.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953 609 DHDLVLPEYVVEFEYITMVKAPSLFSVFNNVILEESKKNPEVSVFSKDLKFDDEVIKMEPRIKARPKLISLDDKTILSLA 688
Cdd:COG4886     5 LLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953 689 KTSVYSHIVSL-NLHGNSLSKLRDLSKLTGLRKLNISFNEFTCL-DDVYHLYNLEYLDASHNHVITL-EGFRGLMKLKHL 765
Cdd:COG4886    85 LLLGLTDLGDLtNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSL 164

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1370464953 766 DLSWNQLKKSGNEINMLckhtTSLLTLDIQHNP 798
Cdd:COG4886   165 DLSNNQLTDLPEELGNL----TNLKELDLSNNQ 193
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-282 5.59e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.10  E-value: 5.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953  50 LSLFPNLTSLTIVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIENLEKLIKLKVLWLNH 129
Cdd:COG4886    26 LLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953 130 NtikniEGLQTLKNLKDLNLAGNLINSIGRCLDSNEQLERLNLSGNQICSFKEltNLTRLPCLKDLCLNDPQYTTNPvcl 209
Cdd:COG4886   106 N-----EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLDLSNNQLTDLP--- 175

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370464953 210 lcnystHVLYHLPCLQrfdTLDVSAKQIKELADT----TAMKKIMYYNMRIKTLQRHLKE--DLEKLNDQKCKLQKLPE 282
Cdd:COG4886   176 ------EELGNLTNLK---ELDLSNNQITDLPEPlgnlTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPE 245
LRR_8 pfam13855
Leucine rich repeat;
121-177 4.24e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 4.24e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953 121 KLKVLWLNHNTIKNIEG--LQTLKNLKDLNLAGNLINSI-GRCLDSNEQLERLNLSGNQI 177
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
716-772 5.85e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 5.85e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370464953 716 TGLRKLNISFNEFTCLDDV--YHLYNLEYLDASHNHVITLEG--FRGLMKLKHLDLSWNQL 772
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
694-798 5.15e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.55  E-value: 5.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953 694 SHIVSLNLHGNSLSKLRDLSKLTGLRKLNISFNEFTCLDDVYHLYNLEYLDASHNHV--ITLEGFRGLMKLKHLDLSWNQ 771
Cdd:COG4886   228 TNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLtdLKLKELELLLGLNSLLLLLLL 307

                          90       100
                  ....*....|....*....|....*..
gi 1370464953 772 LKKSGNEINMLCKHTTSLLTLDIQHNP 798
Cdd:COG4886   308 LNLLELLILLLLLTTLLLLLLLLKGLL 334
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 99-138 5.57e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 43.77  E-value: 5.57e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1370464953  99 NLEKLYLYFNKISKIENLEKLIKLKVLWLNHNT-IKNIEGL 138
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDL 42
LRR_8 pfam13855
Leucine rich repeat;
98-154 3.68e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 3.68e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370464953  98 RNLEKLYLYFNKISKI--ENLEKLIKLKVLWLNHNTIKNIEG--LQTLKNLKDLNLAGNLI 154
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
694-750 3.87e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 3.87e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370464953 694 SHIVSLNLHGNSLSKLRD--LSKLTGLRKLNISFNEFTCLDDV--YHLYNLEYLDASHNHV 750
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGafSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 121-152 9.43e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.31  E-value: 9.43e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1370464953 121 KLKVLWLNHNTIKNIEGLQTLKNLKDLNLAGN 152
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 84-178 1.68e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.65  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953  84 AECCIEKIEGLQECRNLEKLYLYFNKISK------IENLEKLIKLKVLWLNHNTIKNI------EGLQTLKNLKDLNLAG 151
Cdd:cd00116   151 GASCEALAKALRANRDLKELNLANNGIGDagiralAEGLKANCNLEVLDLNNNGLTDEgasalaETLASLKSLEVLNLGD 230

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1370464953 152 NLINSIGRC------LDSNEQLERLNLSGNQIC 178
Cdd:cd00116   231 NNLTDAGAAalasalLSPNISLLTLSLSCNDIT 263
LRR_9 pfam14580
Leucine-rich repeat;
108-242 2.77e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 42.44  E-value: 2.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953 108 NKISKIENLEKLIKLKVLWLNHNTIKNI-EGL-QTLKNLKDLNLAGNLINSIGrcldsneQLERLnlsgnqiCSFKELTN 185
Cdd:pfam14580  52 NEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLgEALPNLTELILTNNNLQELG-------DLDPL-------ASLKKLTF 117

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370464953 186 LTRLpclkdlclndpqytTNPVCLLCNYSTHVLYHLPCLQRFDTLDVSAKQIKELAD 242
Cdd:pfam14580 118 LSLL--------------RNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEK 160
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-242 4.19e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.77  E-value: 4.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953  50 LSLFPNLTSLTIVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIeNLEKLIKLKVLWLNH 129
Cdd:COG4886   224 LANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL-KLKELELLLGLNSLL 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953 130 NTIKNIEGLQTLKNLKDLNLAgNLINSIGRCLDSNEQLERLNLSGNQICSFKELTNLTRLPCLKDLCLNDPQYTTNPVCL 209
Cdd:COG4886   303 LLLLLLNLLELLILLLLLTTL-LLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1370464953 210 LCNYSTHVLYHLPCLQRFDTLDVSAKQIKELAD 242
Cdd:COG4886   382 LALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 77-118 1.36e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 1.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1370464953  77 QLKELWIAECCIEKIEGLQECRNLEKLYLYFN-KISKIENLEK 118
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 99-177 1.38e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.08  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953  99 NLEKLYLYFNKISKiENLEKLIK-------LKVLWLNHNTIKN------IEGLQTLKNLKDLNLAGNLIN-----SIGRC 160
Cdd:COG5238   181 SVETVYLGCNQIGD-EGIEELAEaltqnttVTTLWLKRNPIGDegaeilAEALKGNKSLTTLDLSNNQIGdegviALAEA 259

                          90
                  ....*....|....*..
gi 1370464953 161 LDSNEQLERLNLSGNQI 177
Cdd:COG5238   260 LKNNTTVETLYLSGNQI 276
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-283 3.20e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.69  E-value: 3.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953  55 NLTSLTIVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIENLEKLIKLKVLWLNHNTIKN 134
Cdd:COG4886     9 TLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370464953 135 IEGLQTLKNLKDLNLAGNLInsigrcLDSNEQLERLNLSGNQICSFKEltNLTRLPCLKDLCLNDPQYTTNPVcllcnys 214
Cdd:COG4886    89 LTDLGDLTNLTELDLSGNEE------LSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPE------- 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370464953 215 thVLYHLPCLQrfdTLDVSAKQIK----ELADTTAMKK-IMYYNmRIKTLQRHLKE--DLEKLNDQKCKLQKLPEE 283
Cdd:COG4886   154 --PLGNLTNLK---SLDLSNNQLTdlpeELGNLTNLKElDLSNN-QITDLPEPLGNltNLEELDLSGNQLTDLPEP 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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