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Conserved domains on  [gi|1370466307|ref|XP_024305633|]
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protein FAM227B isoform X19 [Homo sapiens]

Protein Classification

FWWh domain-containing protein( domain architecture ID 10633045)

FWWh domain-containing protein similar to Homo sapiens FAM227A (family with sequence similarity 227 member A) and FAM227B

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FWWh pfam14922
Protein of unknown function; This is a family of eukaryotic proteins. Most members carry a ...
 136-257 3.72e-59

Protein of unknown function; This is a family of eukaryotic proteins. Most members carry a highly distinctive, conserved sequence motif of FWWh, where h represents a hydrophobic residue. The function of the family is not known.


:

Pssm-ID: 464378  Cd Length: 150  Bit Score: 185.53  E-value: 3.72e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466307 136 ERVFKIWKTHFLSEASIALLHDSFWWWFLHKFRPDRENQDCLFDRISESYVTLFMSIPLSR-KDAFFQIYPDCLAQAIYA 214
Cdd:pfam14922  28 PCYKKEWKKFFLSEASQAILLDSFWWFFLERYQPDKESQDKLFDRIAENYVKLLLTAPRPDyKDAFFKRYPDLLAQAVYT 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1370466307 215 TFHEAFPESSYLFNDEFKEDLGNNIFLWCSGLKPQKGFWIHWK 257
Cdd:pfam14922 108 AFCEAFPQSWSLFNEEFKSELCNLMSLWISGIKPSPRSWKKWN 150
 
Name Accession Description Interval E-value
FWWh pfam14922
Protein of unknown function; This is a family of eukaryotic proteins. Most members carry a ...
 136-257 3.72e-59

Protein of unknown function; This is a family of eukaryotic proteins. Most members carry a highly distinctive, conserved sequence motif of FWWh, where h represents a hydrophobic residue. The function of the family is not known.


Pssm-ID: 464378  Cd Length: 150  Bit Score: 185.53  E-value: 3.72e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466307 136 ERVFKIWKTHFLSEASIALLHDSFWWWFLHKFRPDRENQDCLFDRISESYVTLFMSIPLSR-KDAFFQIYPDCLAQAIYA 214
Cdd:pfam14922  28 PCYKKEWKKFFLSEASQAILLDSFWWFFLERYQPDKESQDKLFDRIAENYVKLLLTAPRPDyKDAFFKRYPDLLAQAVYT 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1370466307 215 TFHEAFPESSYLFNDEFKEDLGNNIFLWCSGLKPQKGFWIHWK 257
Cdd:pfam14922 108 AFCEAFPQSWSLFNEEFKSELCNLMSLWISGIKPSPRSWKKWN 150
 
Name Accession Description Interval E-value
FWWh pfam14922
Protein of unknown function; This is a family of eukaryotic proteins. Most members carry a ...
 136-257 3.72e-59

Protein of unknown function; This is a family of eukaryotic proteins. Most members carry a highly distinctive, conserved sequence motif of FWWh, where h represents a hydrophobic residue. The function of the family is not known.


Pssm-ID: 464378  Cd Length: 150  Bit Score: 185.53  E-value: 3.72e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370466307 136 ERVFKIWKTHFLSEASIALLHDSFWWWFLHKFRPDRENQDCLFDRISESYVTLFMSIPLSR-KDAFFQIYPDCLAQAIYA 214
Cdd:pfam14922  28 PCYKKEWKKFFLSEASQAILLDSFWWFFLERYQPDKESQDKLFDRIAENYVKLLLTAPRPDyKDAFFKRYPDLLAQAVYT 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1370466307 215 TFHEAFPESSYLFNDEFKEDLGNNIFLWCSGLKPQKGFWIHWK 257
Cdd:pfam14922 108 AFCEAFPQSWSLFNEEFKSELCNLMSLWISGIKPSPRSWKKWN 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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