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Conserved domains on  [gi|1370480841|ref|XP_024307734|]
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cadherin-22 isoform X3 [Homo sapiens]

Protein Classification

cadherin( domain architecture ID 10638918)

cadherin is a glycoprotein involved in Ca2+-mediated cell-cell adhesion

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 280-374 1.74e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.93  E-value: 1.74e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841 280 LEVQEDAQVGSLVGVVTARDPDA-ANRPVRYAIDRESDlDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQ 358
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                          90
                  ....*....|....*.
gi 1370480841 359 LSRASLRIRILDVNDN 374
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 51-152 1.48e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.98  E-value: 1.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841  51 PYIGSVAELSPTGTSVMQVMASDADDptyGSSARLVYSVLDG--EHHFTVDPKTGVIRTAVPdLDRESQERYEVVIQATD 128
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGneDGLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....
gi 1370480841 129 MAGQlgGLSGSTTVTIVVTDVNDN 152
Cdd:cd11304    77 GGGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 161-269 1.47e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 1.47e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841 161 YQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLkdESSSGGDVFKVttdsDTQEAIIVVQKRLDFESQPVHTVILEAL 240
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*....
gi 1370480841 241 NKFVDPRFAdlgtfrdQAIVRVAVTDVDE 269
Cdd:cd11304    76 DGGGPPLSS-------TATVTITVLDVND 97
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 637-696 3.42e-19

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 81.81  E-value: 3.42e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841 637 ADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALYA 696
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 381-479 9.18e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.20  E-value: 9.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841 381 PYEAAVCEDAKPGQLIQTISVVDRDEPQGGhRFYFRLVPEAPSNpHFSlldIQDNTAAVHTQHvGFNRQEQDVFFLPILV 460
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDG-LFS---IDPSTGEITTAK-PLDREEQSSYTLTVTA 74

                          90
                  ....*....|....*....
gi 1370480841 461 VDSGPPTLSSTGTLTIRIC 479
Cdd:cd11304    75 TDGGGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3-45 4.33e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.03  E-value: 4.33e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1370480841    3 RLDREQKTFYTLRAQARDRATNRlLEPESEFIIKVQDINDSEP 45
Cdd:smart00112  40 PLDREEQPEYTLTVEATDGGGPP-LSSTATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 280-374 1.74e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.93  E-value: 1.74e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841 280 LEVQEDAQVGSLVGVVTARDPDA-ANRPVRYAIDRESDlDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQ 358
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                          90
                  ....*....|....*.
gi 1370480841 359 LSRASLRIRILDVNDN 374
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 51-152 1.48e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.98  E-value: 1.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841  51 PYIGSVAELSPTGTSVMQVMASDADDptyGSSARLVYSVLDG--EHHFTVDPKTGVIRTAVPdLDRESQERYEVVIQATD 128
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGneDGLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....
gi 1370480841 129 MAGQlgGLSGSTTVTIVVTDVNDN 152
Cdd:cd11304    77 GGGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 161-269 1.47e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 1.47e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841 161 YQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLkdESSSGGDVFKVttdsDTQEAIIVVQKRLDFESQPVHTVILEAL 240
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*....
gi 1370480841 241 NKFVDPRFAdlgtfrdQAIVRVAVTDVDE 269
Cdd:cd11304    76 DGGGPPLSS-------TATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 296-376 2.25e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 2.25e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841  296 TARDPDA-ANRPVRYAIDRESDlDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDN 374
Cdd:smart00112   1 SATDADSgENGKVTYSILSGND-DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 1370480841  375 PP 376
Cdd:smart00112  80 AP 81
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 637-696 3.42e-19

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 81.81  E-value: 3.42e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841 637 ADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALYA 696
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
52-132 8.65e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 8.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841  52 YIGSVAELSPTGTSVMQVMASDADDPTygsSARLVYSVLDGE--HHFTVDPKTGVIRTAVPdLDRESQERYEVVIQATDM 129
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP---NGRIFYSILGGGpgGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATDS 76


                  ...
gi 1370480841 130 AGQ 132
Cdd:pfam00028  77 GGP 79
Cadherin pfam00028
Cadherin domain;
281-369 1.56e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.11  E-value: 1.56e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841 281 EVQEDAQVGSLVGVVTARDPD-AANRPVRYAIdRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQL 359
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDlGPNGRIFYSI-LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                          90
                  ....*....|
gi 1370480841 360 SRASLRIRIL 369
Cdd:pfam00028  83 STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 381-479 9.18e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.20  E-value: 9.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841 381 PYEAAVCEDAKPGQLIQTISVVDRDEPQGGhRFYFRLVPEAPSNpHFSlldIQDNTAAVHTQHvGFNRQEQDVFFLPILV 460
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDG-LFS---IDPSTGEITTAK-PLDREEQSSYTLTVTA 74

                          90
                  ....*....|....*....
gi 1370480841 461 VDSGPPTLSSTGTLTIRIC 479
Cdd:cd11304    75 TDGGGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 71-154 9.83e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.99  E-value: 9.83e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841   71 ASDADDptyGSSARLVYSVLDGE--HHFTVDPKTGVIRTAVPdLDRESQERYEVVIQATDMAGQlgGLSGSTTVTIVVTD 148
Cdd:smart00112   2 ATDADS---GENGKVTYSILSGNddGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGP--PLSSTATVTITVLD 75


                   ....*.
gi 1370480841  149 VNDNPP 154
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
382-479 3.49e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 3.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841 382 YEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLvpEAPSNPHFSlldIQDNTAAVHTQHVgFNRQEQDVFFLPILVV 461
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFR---IDPDTGDISTTKP-LDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 1370480841 462 DSGPPTLSSTGTLTIRIC 479
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
161-249 3.10e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.01  E-value: 3.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841 161 YQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKdeSSSGGDVFKVTTDSDTqeaiIVVQKRLDFESQPVHTVILEAL 240
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGD----ISTTKPLDRESIGEYELTVEAT 74


                  ....*....
gi 1370480841 241 NKFVDPRFA 249
Cdd:pfam00028  75 DSGGPPLSS 83
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 179-271 1.50e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.74  E-value: 1.50e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841  179 KAEDSDVGENTDMTYHLkdESSSGGDVFKVTTDSDtqeaIIVVQKRLDFESQPVHTVILEALNKFVDPRFAdlgtfrdQA 258
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSS-------TA 67

                           90
                   ....*....|....
gi 1370480841  259 IVRVAVTDV-DEPP 271
Cdd:smart00112  68 TVTITVLDVnDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 400-482 5.66e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.51  E-value: 5.66e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841  400 SVVDRDEPQGGhRFYFRLVPEAPSNpHFSlldIQDNTAAVHTQHVgFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRIC 479
Cdd:smart00112   1 SATDADSGENG-KVTYSILSGNDDG-LFS---IDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ...
gi 1370480841  480 GCD 482
Cdd:smart00112  75 DVN 77
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3-45 4.33e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.03  E-value: 4.33e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1370480841    3 RLDREQKTFYTLRAQARDRATNRlLEPESEFIIKVQDINDSEP 45
Cdd:smart00112  40 PLDREEQPEYTLTVEATDGGGPP-LSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2-42 4.30e-05

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 42.69  E-value: 4.30e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1370480841   2 ERLDREQKTFYTLRAQARDRATNRlLEPESEFIIKVQDIND 42
Cdd:cd11304    58 KPLDREEQSSYTLTVTATDGGGPP-LSSTATVTITVLDVND 97
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 280-374 1.74e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.93  E-value: 1.74e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841 280 LEVQEDAQVGSLVGVVTARDPDA-ANRPVRYAIDRESDlDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQ 358
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                          90
                  ....*....|....*.
gi 1370480841 359 LSRASLRIRILDVNDN 374
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 51-152 1.48e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.98  E-value: 1.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841  51 PYIGSVAELSPTGTSVMQVMASDADDptyGSSARLVYSVLDG--EHHFTVDPKTGVIRTAVPdLDRESQERYEVVIQATD 128
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGneDGLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....
gi 1370480841 129 MAGQlgGLSGSTTVTIVVTDVNDN 152
Cdd:cd11304    77 GGGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 161-269 1.47e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 1.47e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841 161 YQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLkdESSSGGDVFKVttdsDTQEAIIVVQKRLDFESQPVHTVILEAL 240
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*....
gi 1370480841 241 NKFVDPRFAdlgtfrdQAIVRVAVTDVDE 269
Cdd:cd11304    76 DGGGPPLSS-------TATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 296-376 2.25e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 2.25e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841  296 TARDPDA-ANRPVRYAIDRESDlDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDN 374
Cdd:smart00112   1 SATDADSgENGKVTYSILSGND-DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 1370480841  375 PP 376
Cdd:smart00112  80 AP 81
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 637-696 3.42e-19

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 81.81  E-value: 3.42e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841 637 ADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGSSGSEQDFAYLSSWGPRFRPLAALYA 696
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
52-132 8.65e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 8.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841  52 YIGSVAELSPTGTSVMQVMASDADDPTygsSARLVYSVLDGE--HHFTVDPKTGVIRTAVPdLDRESQERYEVVIQATDM 129
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP---NGRIFYSILGGGpgGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATDS 76


                  ...
gi 1370480841 130 AGQ 132
Cdd:pfam00028  77 GGP 79
Cadherin pfam00028
Cadherin domain;
281-369 1.56e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.11  E-value: 1.56e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841 281 EVQEDAQVGSLVGVVTARDPD-AANRPVRYAIdRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQL 359
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDlGPNGRIFYSI-LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                          90
                  ....*....|
gi 1370480841 360 SRASLRIRIL 369
Cdd:pfam00028  83 STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 381-479 9.18e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.20  E-value: 9.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841 381 PYEAAVCEDAKPGQLIQTISVVDRDEPQGGhRFYFRLVPEAPSNpHFSlldIQDNTAAVHTQHvGFNRQEQDVFFLPILV 460
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDG-LFS---IDPSTGEITTAK-PLDREEQSSYTLTVTA 74

                          90
                  ....*....|....*....
gi 1370480841 461 VDSGPPTLSSTGTLTIRIC 479
Cdd:cd11304    75 TDGGGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 71-154 9.83e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.99  E-value: 9.83e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841   71 ASDADDptyGSSARLVYSVLDGE--HHFTVDPKTGVIRTAVPdLDRESQERYEVVIQATDMAGQlgGLSGSTTVTIVVTD 148
Cdd:smart00112   2 ATDADS---GENGKVTYSILSGNddGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGP--PLSSTATVTITVLD 75


                   ....*.
gi 1370480841  149 VNDNPP 154
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
382-479 3.49e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 3.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841 382 YEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLvpEAPSNPHFSlldIQDNTAAVHTQHVgFNRQEQDVFFLPILVV 461
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFR---IDPDTGDISTTKP-LDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 1370480841 462 DSGPPTLSSTGTLTIRIC 479
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
161-249 3.10e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.01  E-value: 3.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841 161 YQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKdeSSSGGDVFKVTTDSDTqeaiIVVQKRLDFESQPVHTVILEAL 240
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGD----ISTTKPLDRESIGEYELTVEAT 74


                  ....*....
gi 1370480841 241 NKFVDPRFA 249
Cdd:pfam00028  75 DSGGPPLSS 83
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 179-271 1.50e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.74  E-value: 1.50e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841  179 KAEDSDVGENTDMTYHLkdESSSGGDVFKVTTDSDtqeaIIVVQKRLDFESQPVHTVILEALNKFVDPRFAdlgtfrdQA 258
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSS-------TA 67

                           90
                   ....*....|....
gi 1370480841  259 IVRVAVTDV-DEPP 271
Cdd:smart00112  68 TVTITVLDVnDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 400-482 5.66e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.51  E-value: 5.66e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370480841  400 SVVDRDEPQGGhRFYFRLVPEAPSNpHFSlldIQDNTAAVHTQHVgFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRIC 479
Cdd:smart00112   1 SATDADSGENG-KVTYSILSGNDDG-LFS---IDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ...
gi 1370480841  480 GCD 482
Cdd:smart00112  75 DVN 77
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3-45 4.33e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.03  E-value: 4.33e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1370480841    3 RLDREQKTFYTLRAQARDRATNRlLEPESEFIIKVQDINDSEP 45
Cdd:smart00112  40 PLDREEQPEYTLTVEATDGGGPP-LSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2-42 4.30e-05

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 42.69  E-value: 4.30e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1370480841   2 ERLDREQKTFYTLRAQARDRATNRlLEPESEFIIKVQDIND 42
Cdd:cd11304    58 KPLDREEQSSYTLTVTATDGGGPP-LSSTATVTITVLDVND 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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