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Conserved domains on  [gi|1370522403|ref|XP_024308179|]
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collectrin isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Collectrin super family cl25227
Renal amino acid transporter; Collectrin is a single-pass transmembrane protein that is ...
 1-119 6.13e-58

Renal amino acid transporter; Collectrin is a single-pass transmembrane protein that is homologous to the C-terminal region of human angiotensin-converting enzyme 2, ACE2, SwissProt:Q9BYF1, found in Peptidase_M2 pfam01401. Collectrin is critical for normal amino acid reabsorption in the kidney.


The actual alignment was detected with superfamily member pfam16959:

Pssm-ID: 465322  Cd Length: 154  Bit Score: 178.22  E-value: 6.13e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370522403   1 MVAFSMRKVPNREATE-----ISHVLLCNVTQRVSFWFVVTDPSKNHTL-PAVEVQSAIRMNKNRINNAFFLNDQTLEFL 74
Cdd:pfam16959  30 SVAYAMRKYFSREKNQtvpfqIENVLVCNETPRVSFWFVVTSPNNPSDLiPKAEVEAAIRMSRNRINNAFLLDDSTLEFL 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1370522403  75 KIPSTLAPPMDPSVPIWIIIFGVIFCIIIVAIALLILSGIWQRRR 119
Cdd:pfam16959 110 GIPPTLAPPVEPPVPIWLIVFGVVMGLVVVGIVYLIVSGIRQRRR 154
 
Name Accession Description Interval E-value
Collectrin pfam16959
Renal amino acid transporter; Collectrin is a single-pass transmembrane protein that is ...
 1-119 6.13e-58

Renal amino acid transporter; Collectrin is a single-pass transmembrane protein that is homologous to the C-terminal region of human angiotensin-converting enzyme 2, ACE2, SwissProt:Q9BYF1, found in Peptidase_M2 pfam01401. Collectrin is critical for normal amino acid reabsorption in the kidney.


Pssm-ID: 465322  Cd Length: 154  Bit Score: 178.22  E-value: 6.13e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370522403   1 MVAFSMRKVPNREATE-----ISHVLLCNVTQRVSFWFVVTDPSKNHTL-PAVEVQSAIRMNKNRINNAFFLNDQTLEFL 74
Cdd:pfam16959  30 SVAYAMRKYFSREKNQtvpfqIENVLVCNETPRVSFWFVVTSPNNPSDLiPKAEVEAAIRMSRNRINNAFLLDDSTLEFL 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1370522403  75 KIPSTLAPPMDPSVPIWIIIFGVIFCIIIVAIALLILSGIWQRRR 119
Cdd:pfam16959 110 GIPPTLAPPVEPPVPIWLIVFGVVMGLVVVGIVYLIVSGIRQRRR 154
 
Name Accession Description Interval E-value
Collectrin pfam16959
Renal amino acid transporter; Collectrin is a single-pass transmembrane protein that is ...
 1-119 6.13e-58

Renal amino acid transporter; Collectrin is a single-pass transmembrane protein that is homologous to the C-terminal region of human angiotensin-converting enzyme 2, ACE2, SwissProt:Q9BYF1, found in Peptidase_M2 pfam01401. Collectrin is critical for normal amino acid reabsorption in the kidney.


Pssm-ID: 465322  Cd Length: 154  Bit Score: 178.22  E-value: 6.13e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370522403   1 MVAFSMRKVPNREATE-----ISHVLLCNVTQRVSFWFVVTDPSKNHTL-PAVEVQSAIRMNKNRINNAFFLNDQTLEFL 74
Cdd:pfam16959  30 SVAYAMRKYFSREKNQtvpfqIENVLVCNETPRVSFWFVVTSPNNPSDLiPKAEVEAAIRMSRNRINNAFLLDDSTLEFL 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1370522403  75 KIPSTLAPPMDPSVPIWIIIFGVIFCIIIVAIALLILSGIWQRRR 119
Cdd:pfam16959 110 GIPPTLAPPVEPPVPIWLIVFGVVMGLVVVGIVYLIVSGIRQRRR 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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