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Conserved domains on  [gi|1370524933|ref|XP_024308207|]
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lysine-specific demethylase 6A isoform X11 [Homo sapiens]

Protein Classification

KDM6 family histone demethylase( domain architecture ID 11421451)

KDM6 family histone demethylase, similar to lysine-specific demethylase 6A (KDM6A), also called UTX (ubiquitously-transcribed TPR protein on the X chromosome) that specifically demethylates 'Lys-27' of histone H3, and UTY (ubiquitously-transcribed TPR protein on the Y chromosome) that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3

CATH:  1.25.40.10|2.60.120.10
EC:  1.14.11.-
Gene Ontology:  GO:0005515|GO:0032452|GO:0031490|GO:0046872
PubMed:  26059336|21153002|10517866|30708253|22404999|11165500|14697267|19478949
SCOP:  4001344|3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 1010-1118 8.11e-37

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


:

Pssm-ID: 396791  Cd Length: 114  Bit Score: 134.73  E-value: 8.11e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933 1010 QLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNN-------LNFLMGSWWPnlEDLYEANV 1082
Cdd:pfam02373    1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFggeqpddLLHLNTIISP--KQLRENGI 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1370524933 1083 PVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNV 1118
Cdd:pfam02373   79 PVYRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 2-268 4.53e-25

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 106.35  E-value: 4.53e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933    2 FKVNTDYESSLKHFQLALvDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVkatvLQQLGWMHHTV 81
Cdd:COG2956     18 YLLNGQPDKAIDLLEEAL-ELDP---ETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEA----LLELAQDYLKA 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   82 DLLgDKAtkesyaIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMD 161
Cdd:COG2956     90 GLL-DRA------EELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDE 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933  162 ALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNATRSKscSNTSALAARIKYLQAQLCNLPQG--SLQNKTK 239
Cdd:COG2956    163 AIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD--PDYLPALPRLAELYEKLGDPEEAleLLRKALE 240

                          250       260
                   ....*....|....*....|....*....
gi 1370524933  240 LLPSIEEAWSLpipAELTSRQGAMNTAQQ 268
Cdd:COG2956    241 LDPSDDLLLAL---ADLLERKEGLEAALA 266
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 976-1040 3.73e-08

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


:

Pssm-ID: 214721  Cd Length: 58  Bit Score: 51.10  E-value: 3.73e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370524933   976 QLHELTKLPafvrvvSAGNLLSHVGHTILGMNT-VQLYMKVPGSRTPGHQENNNfcSVNINIGPGD 1040
Cdd:smart00558    1 QLWNLAKLP------FKLNLLSDLPEDIPGPDVgPYLYMGMAGSTTPWHIDDYD--LVNYLHQGAG 58
 
Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 1010-1118 8.11e-37

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


Pssm-ID: 396791  Cd Length: 114  Bit Score: 134.73  E-value: 8.11e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933 1010 QLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNN-------LNFLMGSWWPnlEDLYEANV 1082
Cdd:pfam02373    1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFggeqpddLLHLNTIISP--KQLRENGI 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1370524933 1083 PVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNV 1118
Cdd:pfam02373   79 PVYRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 2-268 4.53e-25

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 106.35  E-value: 4.53e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933    2 FKVNTDYESSLKHFQLALvDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVkatvLQQLGWMHHTV 81
Cdd:COG2956     18 YLLNGQPDKAIDLLEEAL-ELDP---ETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEA----LLELAQDYLKA 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   82 DLLgDKAtkesyaIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMD 161
Cdd:COG2956     90 GLL-DRA------EELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDE 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933  162 ALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNATRSKscSNTSALAARIKYLQAQLCNLPQG--SLQNKTK 239
Cdd:COG2956    163 AIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD--PDYLPALPRLAELYEKLGDPEEAleLLRKALE 240

                          250       260
                   ....*....|....*....|....*....
gi 1370524933  240 LLPSIEEAWSLpipAELTSRQGAMNTAQQ 268
Cdd:COG2956    241 LDPSDDLLLAL---ADLLERKEGLEAALA 266
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 976-1040 3.73e-08

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


Pssm-ID: 214721  Cd Length: 58  Bit Score: 51.10  E-value: 3.73e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370524933   976 QLHELTKLPafvrvvSAGNLLSHVGHTILGMNT-VQLYMKVPGSRTPGHQENNNfcSVNINIGPGD 1040
Cdd:smart00558    1 QLWNLAKLP------FKLNLLSDLPEDIPGPDVgPYLYMGMAGSTTPWHIDDYD--LVNYLHQGAG 58
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 29-200 1.29e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.62  E-value: 1.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   29 NAEIQFHIAHLYETQRKYHSAKEAYEQLLQTE--NLSAqvkATVLQQLgwmhhtvDLLGDKATKesyAIQYLQKSLEADP 106
Cdd:TIGR02917  464 NASLHNLLGAIYLGKGDLAKAREAFEKALSIEpdFFPA---AANLARI-------DIQEGNPDD---AIQRFEKVLTIDP 530

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933  107 NSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTL 186
Cdd:TIGR02917  531 KNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRA 610

                          170
                   ....*....|....
gi 1370524933  187 YESCNQPQDAIKCY 200
Cdd:TIGR02917  611 QLAAGDLNKAVSSF 624
TPR_17 pfam13431
Tetratricopeptide repeat;
97-128 4.67e-03

Tetratricopeptide repeat;


Pssm-ID: 433201 [Multi-domain]  Cd Length: 34  Bit Score: 35.98  E-value: 4.67e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1370524933   97 YLQKSLEADPNSGQSWYFLGRCYSSIGKVQDA 128
Cdd:pfam13431    1 LYLKALELDPNNADAYYNLAVLLLELGQSETA 32
 
Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 1010-1118 8.11e-37

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


Pssm-ID: 396791  Cd Length: 114  Bit Score: 134.73  E-value: 8.11e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933 1010 QLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNN-------LNFLMGSWWPnlEDLYEANV 1082
Cdd:pfam02373    1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFggeqpddLLHLNTIISP--KQLRENGI 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1370524933 1083 PVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNV 1118
Cdd:pfam02373   79 PVYRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 2-268 4.53e-25

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 106.35  E-value: 4.53e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933    2 FKVNTDYESSLKHFQLALvDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVkatvLQQLGWMHHTV 81
Cdd:COG2956     18 YLLNGQPDKAIDLLEEAL-ELDP---ETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEA----LLELAQDYLKA 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   82 DLLgDKAtkesyaIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMD 161
Cdd:COG2956     90 GLL-DRA------EELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDE 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933  162 ALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNATRSKscSNTSALAARIKYLQAQLCNLPQG--SLQNKTK 239
Cdd:COG2956    163 AIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD--PDYLPALPRLAELYEKLGDPEEAleLLRKALE 240

                          250       260
                   ....*....|....*....|....*....
gi 1370524933  240 LLPSIEEAWSLpipAELTSRQGAMNTAQQ 268
Cdd:COG2956    241 LDPSDDLLLAL---ADLLERKEGLEAALA 266
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
29-200 4.89e-24

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 102.78  E-value: 4.89e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   29 NAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVkatvLQQLGWMHHtvdLLGDKATkesyAIQYLQKSLEADPNS 108
Cdd:COG0457      7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEA----LYNLGLAYL---RLGRYEE----ALADYEQALELDPDD 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933  109 GQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYE 188
Cdd:COG0457     76 AEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALE 155

                          170
                   ....*....|..
gi 1370524933  189 SCNQPQDAIKCY 200
Cdd:COG0457    156 KLGRYEEALELL 167
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
68-203 2.90e-21

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 94.69  E-value: 2.90e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   68 ATVLQQLGWMHHtvdLLGDKATkesyAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWC 147
Cdd:COG0457      8 AEAYNNLGLAYR---RLGRYEE----AIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1370524933  148 SIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 203
Cdd:COG0457     81 NLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERA 136
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 94-200 8.23e-20

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 86.60  E-value: 8.23e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   94 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 173
Cdd:COG4235      2 AIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALD 81

                           90       100
                   ....*....|....*....|....*..
gi 1370524933  174 HGHAAAWMDLGTLYESCNQPQDAIKCY 200
Cdd:COG4235     82 PDNPEALYLLGLAAFQQGDYAEAIAAW 108
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
7-166 1.75e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 86.60  E-value: 1.75e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933    7 DYESSLKHFQLALvDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQV---KATVLQQLGwmhhtvdl 83
Cdd:COG0457     23 RYEEAIEDYEKAL-ELDP---DDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEAlnnLGLALQALG-------- 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   84 lgdkatKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDAL 163
Cdd:COG0457     91 ------RYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEAL 164


                   ...
gi 1370524933  164 QAY 166
Cdd:COG0457    165 ELL 167
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
102-205 2.15e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 86.21  E-value: 2.15e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933  102 LEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWM 181
Cdd:COG0457      1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80

                           90       100
                   ....*....|....*....|....
gi 1370524933  182 DLGTLYESCNQPQDAIKCYLNATR 205
Cdd:COG0457     81 NLGLALQALGRYEEALEDYDKALE 104
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 27-203 3.06e-18

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 90.44  E-value: 3.06e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   27 LSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVKATVLQQLGwmhhtvdLLGDKATkesyAIQYLQKSLEADP 106
Cdd:COG3914     41 LGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQ-------ALGRYEE----ALALYRRALALNP 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933  107 NSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTL 186
Cdd:COG3914    110 DNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNA 189

                          170
                   ....*....|....*..
gi 1370524933  187 YESCNQPQDAIKCYLNA 203
Cdd:COG3914    190 LQDLGRLEEAIAAYRRA 206
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 94-203 9.03e-15

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 72.53  E-value: 9.03e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   94 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 173
Cdd:COG4783     23 AEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLD 102

                           90       100       110
                   ....*....|....*....|....*....|
gi 1370524933  174 HGHAAAWMDLGTLYESCNQPQDAIKCYLNA 203
Cdd:COG4783    103 PEHPEAYLRLARAYRALGRPDEAIAALEKA 132
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 35-300 1.70e-13

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 75.03  E-value: 1.70e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   35 HIAHLYETQRKYHSAKEAYEQLLQTENLSAQVKATVLQQLGWMHHTVDLLGDKATKESY--AIQYLQKSLEADPNSGQSW 112
Cdd:COG3914      2 AAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLalAAGEAAAAAAALLLLAALL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933  113 YFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQ 192
Cdd:COG3914     82 ELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGR 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933  193 PQDAIKCYLNATRSKScSNTSALAARIKYLQaQLCNLPQGslqnktklLPSIEEAWSLPiPAELTSRQGAMNTAQQACK- 271
Cdd:COG3914    162 LEEAIAALRRALELDP-DNAEALNNLGNALQ-DLGRLEEA--------IAAYRRALELD-PDNADAHSNLLFALRQACDw 230

                          250       260       270
                   ....*....|....*....|....*....|
gi 1370524933  272 -PHHPNTEPVLGLSQTPISQQSLPLHMIPS 300
Cdd:COG3914    231 eVYDRFEELLAALARGPSELSPFALLYLPD 260
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 30-173 1.73e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 69.07  E-value: 1.73e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   30 AEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVkatvLQQLGWMHHTvdlLGDKATkesyAIQYLQKSLEADPNSG 109
Cdd:COG4783      4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEA----FALLGEILLQ---LGDLDE----AIVLLHEALELDPDEP 72

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370524933  110 QSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 173
Cdd:COG4783     73 EARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
7-144 1.78e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.88  E-value: 1.78e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933    7 DYESSLKHFQLALvDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVkatvLQQLGWMHHtvdLLGD 86
Cdd:COG0457     57 RYEEALADYEQAL-ELDP---DDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEA----LYNLGLALL---ELGR 125

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370524933   87 KATkesyAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASAD 144
Cdd:COG0457    126 YDE----AIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALL 179
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
94-173 1.45e-10

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 59.03  E-value: 1.45e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   94 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAfISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 173
Cdd:COG3063     11 AEEYYEKALELDPDNADALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELD 89
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 7-200 3.07e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 64.63  E-value: 3.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933    7 DYESSLKHFQLALvDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQT--ENLSAQVK-ATVLQQLGwmhhtvdl 83
Cdd:COG3914     93 RYEEALALYRRAL-ALNP---DNAEALFNLGNLLLALGRLEEALAALRRALALnpDFAEAYLNlGEALRRLG-------- 160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   84 lgdkatKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKsEASADTWCSIGVLYQQQNQPMDAL 163
Cdd:COG3914    161 ------RLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALEL-DPDNADAHSNLLFALRQACDWEVY 233

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1370524933  164 QAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCY 200
Cdd:COG3914    234 DRFEELLAALARGPSELSPFALLYLPDDDPAELLALA 270
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
103-198 2.65e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 58.77  E-value: 2.65e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933  103 EADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMD 182
Cdd:COG4785     67 LALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLN 146

                           90
                   ....*....|....*.
gi 1370524933  183 LGTLYESCNQPQDAIK 198
Cdd:COG4785    147 RGIALYYLGRYELAIA 162
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 94-173 5.09e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 56.51  E-value: 5.09e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   94 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 173
Cdd:COG5010     73 SLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 7-139 6.57e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.58  E-value: 6.57e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933    7 DYESSLKHFQlALVDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQvkatVLQQLGWMHHtvdLLGD 86
Cdd:COG4783     19 DYDEAEALLE-KALELDP---DNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPE----ARLNLGLALL---KAGD 87

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1370524933   87 KATkesyAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKS 139
Cdd:COG4783     88 YDE----ALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 29-144 6.64e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 55.40  E-value: 6.64e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   29 NAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVKATVLQQLGWMHHTVDllgdkatkesyAIQYLQKSLEADPNS 108
Cdd:COG4235     16 DAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEE-----------AEELLERALALDPDN 84

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1370524933  109 GQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASAD 144
Cdd:COG4235     85 PEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAP 120
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 110-205 9.38e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.20  E-value: 9.38e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933  110 QSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYES 189
Cdd:COG4783      5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                           90
                   ....*....|....*.
gi 1370524933  190 CNQPQDAIKCYLNATR 205
Cdd:COG4783     85 AGDYDEALALLEKALK 100
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 111-225 1.87e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.05  E-value: 1.87e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933  111 SWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESC 190
Cdd:COG2956     10 GWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKA 89

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1370524933  191 NQPQDAIKCYLNATRSKScSNTSALAARIKYLQAQ 225
Cdd:COG2956     90 GLLDRAEELLEKLLELDP-DDAEALRLLAEIYEQE 123
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 94-203 2.92e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 54.58  E-value: 2.92e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   94 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 173
Cdd:COG5010     39 EDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALS 118

                           90       100       110
                   ....*....|....*....|....*....|
gi 1370524933  174 HGHAAAWMDLGTLYESCNQPQDAIKCYLNA 203
Cdd:COG5010    119 PDNPNAYSNLAALLLSLGQDDEAKAALQRA 148
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 976-1040 3.73e-08

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


Pssm-ID: 214721  Cd Length: 58  Bit Score: 51.10  E-value: 3.73e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370524933   976 QLHELTKLPafvrvvSAGNLLSHVGHTILGMNT-VQLYMKVPGSRTPGHQENNNfcSVNINIGPGD 1040
Cdd:smart00558    1 QLWNLAKLP------FKLNLLSDLPEDIPGPDVgPYLYMGMAGSTTPWHIDDYD--LVNYLHQGAG 58
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
118-200 6.30e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 51.71  E-value: 6.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933  118 CYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQaYICAVQLDHGHAAAWMDLGTLYESCNQPQDAI 197
Cdd:COG3063      1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEAL 79


                   ...
gi 1370524933  198 KCY 200
Cdd:COG3063     80 AYL 82
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 94-166 4.14e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 46.91  E-value: 4.14e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370524933   94 AIQYLQKSLEADPNS---GQSWYFLGRCYSSIGKVQDAFISYRQSID---KSEASADTWCSIGVLYQQQNQPMDALQAY 166
Cdd:COG1729     12 AIAAFKAFLKRYPNSplaPDALYWLGEAYYALGDYDEAAEAFEKLLKrypDSPKAPDALLKLGLSYLELGDYDKARATL 90
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 39-139 4.80e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 48.03  E-value: 4.80e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   39 LYETQRKYHSAKEAYEQLLQTENLSAQvkatVLQQLGWMHhtvDLLGDKATkesyAIQYLQKSLEADPNSGQSWYFLGRC 118
Cdd:COG5010     63 LYNKLGDFEESLALLEQALQLDPNNPE----LYYNLALLY---SRSGDKDE----AKEYYEKALALSPDNPNAYSNLAAL 131

                           90       100
                   ....*....|....*....|.
gi 1370524933  119 YSSIGKVQDAFISYRQSIDKS 139
Cdd:COG5010    132 LLSLGQDDEAKAALQRALGTS 152
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
39-139 8.28e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 45.55  E-value: 8.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   39 LYETQRKYHSAKEAYEQLLQtenLSAQVkATVLQQLGWMHHtvdLLGDKATkesyAIQYlQKSLEADPNSGQSWYFLGRC 118
Cdd:COG3063      1 LYLKLGDLEEAEEYYEKALE---LDPDN-ADALNNLGLLLL---EQGRYDE----AIAL-EKALKLDPNNAEALLNLAEL 68

                           90       100
                   ....*....|....*....|.
gi 1370524933  119 YSSIGKVQDAFISYRQSIDKS 139
Cdd:COG3063     69 LLELGDYDEALAYLERALELD 89
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 151-205 3.45e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 45.34  E-value: 3.45e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1370524933  151 VLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNATR 205
Cdd:COG5010     62 NLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALA 116
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 141-203 1.00e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.88  E-value: 1.00e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370524933  141 ASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 203
Cdd:COG2956      6 AAALGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKL 68
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 29-200 1.29e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.62  E-value: 1.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   29 NAEIQFHIAHLYETQRKYHSAKEAYEQLLQTE--NLSAqvkATVLQQLgwmhhtvDLLGDKATKesyAIQYLQKSLEADP 106
Cdd:TIGR02917  464 NASLHNLLGAIYLGKGDLAKAREAFEKALSIEpdFFPA---AANLARI-------DIQEGNPDD---AIQRFEKVLTIDP 530

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933  107 NSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTL 186
Cdd:TIGR02917  531 KNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRA 610

                          170
                   ....*....|....
gi 1370524933  187 YESCNQPQDAIKCY 200
Cdd:TIGR02917  611 QLAAGDLNKAVSSF 624
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 5-200 2.37e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 45.46  E-value: 2.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933    5 NTDYESSLKHFQlALVDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTE--NLSAQVkatVLQQLgwmhhtvd 82
Cdd:TIGR02917  614 AGDLNKAVSSFK-KLLALQP---DSALALLLLADAYAVMKNYAKAITSLKRALELKpdNTEAQI---GLAQL-------- 678

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   83 LLGDKATKESYAI-QYLQKsleADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIdKSEASADTWCSIGVLYQQQNQPMD 161
Cdd:TIGR02917  679 LLAAKRTESAKKIaKSLQK---QHPKAALGFELEGDLYLRQKDYPAAIQAYRKAL-KRAPSSQNAIKLHRALLASGNTAE 754

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1370524933  162 ALQAYIcAVQLDH-GHAAAWMDLGTLYESCNQPQDAIKCY 200
Cdd:TIGR02917  755 AVKTLE-AWLKTHpNDAVLRTALAELYLAQKDYDKAIKHY 793
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 29-175 3.16e-04

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 44.52  E-value: 3.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   29 NAEIQFHIAHLYETQRKYHSAkeayEQLLQtENLSAQVKATVLQQLGwmhhtvDLLGDKATKesyAIQYLQKSLEADPNS 108
Cdd:COG3071    192 DPELAAAYARALIALGDHDEA----ERLLR-EALKRQWDPRLVRLYG------RLQGGDPAK---QLKRAEKWLKKHPND 257

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933  109 GQSWYFLGR-CYSS--IGKVQDAFisyRQSIdKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHG 175
Cdd:COG3071    258 PDLLLALGRlCLRNqlWGKAREYL---EAAL-ALRPSAEAYAELARLLEQLGDPEEAAEHYRKALALALG 323
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 43-138 1.43e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 39.59  E-value: 1.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   43 QRKYHSAKEAYEQLLQtENLSAQVKATVLQQLGWMHHtvdLLGDKATkesyAIQYLQKSLEADPNS---GQSWYFLGRCY 119
Cdd:COG1729      6 AGDYDEAIAAFKAFLK-RYPNSPLAPDALYWLGEAYY---ALGDYDE----AAEAFEKLLKRYPDSpkaPDALLKLGLSY 77

                           90
                   ....*....|....*....
gi 1370524933  120 SSIGKVQDAFISYRQSIDK 138
Cdd:COG1729     78 LELGDYDKARATLEELIKK 96
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 7-108 2.44e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 39.20  E-value: 2.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933    7 DYESSLKHFQlALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVkATVLQQLGWMHHTvdlLGD 86
Cdd:COG1729      8 DYDEAIAAFK-AFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKA-PDALLKLGLSYLE---LGD 82

                           90       100
                   ....*....|....*....|..
gi 1370524933   87 KATkesyAIQYLQKSLEADPNS 108
Cdd:COG1729     83 YDK----ARATLEELIKKYPDS 100
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
7-107 2.52e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 38.61  E-value: 2.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933    7 DYESSLKHFQLALvDCNPctlSNAEIQFHIAHLYETQRKYHSAkEAYEQLLQTENLSAQVkatvLQQLGWMHHtvdLLGD 86
Cdd:COG3063      7 DLEEAEEYYEKAL-ELDP---DNADALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEA----LLNLAELLL---ELGD 74

                           90       100
                   ....*....|....*....|.
gi 1370524933   87 KATkesyAIQYLQKSLEADPN 107
Cdd:COG3063     75 YDE----ALAYLERALELDPS 91
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 7-106 2.68e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.94  E-value: 2.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933    7 DYESSLKHFQLALvDCNPctlSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVK---ATVLQQLGwmhhtvdl 83
Cdd:COG5010     69 DFEESLALLEQAL-QLDP---NNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYsnlAALLLSLG-------- 136

                           90       100
                   ....*....|....*....|...
gi 1370524933   84 lgdkatKESYAIQYLQKSLEADP 106
Cdd:COG5010    137 ------QDDEAKAALQRALGTSP 153
TPR_17 pfam13431
Tetratricopeptide repeat;
97-128 4.67e-03

Tetratricopeptide repeat;


Pssm-ID: 433201 [Multi-domain]  Cd Length: 34  Bit Score: 35.98  E-value: 4.67e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1370524933   97 YLQKSLEADPNSGQSWYFLGRCYSSIGKVQDA 128
Cdd:pfam13431    1 LYLKALELDPNNADAYYNLAVLLLELGQSETA 32
TPR COG0790
TPR repeat [General function prediction only];
30-189 4.80e-03

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 40.30  E-value: 4.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   30 AEIQFHIAHLYE----TQRKYHSAKEAYEQLLQTENLSAQVkatvlqQLGWMHHTvdllGdKATKESY--AIQYLQKSle 103
Cdd:COG0790     63 AEAQYNLGLMYAegrgVPKDYEKALEWFEKAAEQGDAEAQY------NLGLMYEE----G-LGVPQDYakALEWYEKA-- 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933  104 ADPNSGQSWYFLGRCYSS-IGKVQD---AFISYRQSIDKSEASADTwcSIGVLYQQ-QNQPMD---ALQAYICAVqlDHG 175
Cdd:COG0790    130 AEQGDADAQYNLGLLYLNgEGVPKDpakAAEWYRKAAEQGDADAQY--NLGVLYENgRGVPKDpakALEWYRKAA--EQG 205

                          170
                   ....*....|....
gi 1370524933  176 HAAAWMDLGTLYES 189
Cdd:COG0790    206 DADAQYNLGRLYLN 219
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 90-200 7.38e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.84  E-value: 7.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370524933   90 KESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICA 169
Cdd:TIGR02917  412 DPSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKA 491

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1370524933  170 VQLDHGHAAAWMDLGTLYESCNQPQDAIKCY 200
Cdd:TIGR02917  492 LSIEPDFFPAAANLARIDIQEGNPDDAIQRF 522
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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