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Conserved domains on  [gi|1370476871|ref|XP_024308489|]
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protein N-lysine methyltransferase METTL21A isoform X3 [Homo sapiens]

Protein Classification

protein N-lysine methyltransferase family protein( domain architecture ID 10563300)

protein N-lysine methyltransferase family protein is a class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to human METTL21D that specifically trimethylates 'Lys-315' of VCP/p97

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
25-208 4.23e-70

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


:

Pssm-ID: 313513  Cd Length: 172  Bit Score: 212.19  E-value: 4.23e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476871  25 SFANHTIQIRQDWRHlGVAAVVWDAAIVLSTYLEM------GAVELRGRSAVELGAGTGLVGIVAALLalkssmkpllvh 98
Cdd:pfam10294   1 KLDNPGLRIEEDTGN-GIGGHVWDAAVVLSKYLEMkifkelGANNLSGLNVLELGSGTGLVGIAVALL------------ 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476871  99 cllfFSGAHVTITDRKVALEFLKSNVQANlppHIQTKTVVKELTWGQNLGS--FSPGEFDLILGADIIYLEETFTDLLQT 176
Cdd:pfam10294  68 ----LPGASVTITDLEEALELLKKNIELN---ALSSKVVVKVLDWGENLPPdlFDGHPVDLILAADCVYNEDSFPLLEKT 140
                         170       180       190
                  ....*....|....*....|....*....|..
gi 1370476871 177 LEHLCSNHSVILLACRIRYERDNNFLAMLERQ 208
Cdd:pfam10294 141 LKDLLGKESVILVAYKKRREAEKKFFKLLERF 172
 
Name Accession Description Interval E-value
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
25-208 4.23e-70

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 212.19  E-value: 4.23e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476871  25 SFANHTIQIRQDWRHlGVAAVVWDAAIVLSTYLEM------GAVELRGRSAVELGAGTGLVGIVAALLalkssmkpllvh 98
Cdd:pfam10294   1 KLDNPGLRIEEDTGN-GIGGHVWDAAVVLSKYLEMkifkelGANNLSGLNVLELGSGTGLVGIAVALL------------ 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476871  99 cllfFSGAHVTITDRKVALEFLKSNVQANlppHIQTKTVVKELTWGQNLGS--FSPGEFDLILGADIIYLEETFTDLLQT 176
Cdd:pfam10294  68 ----LPGASVTITDLEEALELLKKNIELN---ALSSKVVVKVLDWGENLPPdlFDGHPVDLILAADCVYNEDSFPLLEKT 140
                         170       180       190
                  ....*....|....*....|....*....|..
gi 1370476871 177 LEHLCSNHSVILLACRIRYERDNNFLAMLERQ 208
Cdd:pfam10294 141 LKDLLGKESVILVAYKKRREAEKKFFKLLERF 172
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
66-159 5.21e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 39.79  E-value: 5.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476871  66 GRSAVELGAGTGLVGIVAALLalkssmkpllvhcllfFSGAHVTITDR-KVALEFLKSNVQANLPPHIQTktvvkelTWG 144
Cdd:COG2813    50 GGRVLDLGCGYGVIGLALAKR----------------NPEARVTLVDVnARAVELARANAAANGLENVEV-------LWS 106
                          90
                  ....*....|....*
gi 1370476871 145 QNLGSFSPGEFDLIL 159
Cdd:COG2813   107 DGLSGVPDGSFDLIL 121
 
Name Accession Description Interval E-value
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
25-208 4.23e-70

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 212.19  E-value: 4.23e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476871  25 SFANHTIQIRQDWRHlGVAAVVWDAAIVLSTYLEM------GAVELRGRSAVELGAGTGLVGIVAALLalkssmkpllvh 98
Cdd:pfam10294   1 KLDNPGLRIEEDTGN-GIGGHVWDAAVVLSKYLEMkifkelGANNLSGLNVLELGSGTGLVGIAVALL------------ 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476871  99 cllfFSGAHVTITDRKVALEFLKSNVQANlppHIQTKTVVKELTWGQNLGS--FSPGEFDLILGADIIYLEETFTDLLQT 176
Cdd:pfam10294  68 ----LPGASVTITDLEEALELLKKNIELN---ALSSKVVVKVLDWGENLPPdlFDGHPVDLILAADCVYNEDSFPLLEKT 140
                         170       180       190
                  ....*....|....*....|....*....|..
gi 1370476871 177 LEHLCSNHSVILLACRIRYERDNNFLAMLERQ 208
Cdd:pfam10294 141 LKDLLGKESVILVAYKKRREAEKKFFKLLERF 172
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
66-159 5.21e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 39.79  E-value: 5.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370476871  66 GRSAVELGAGTGLVGIVAALLalkssmkpllvhcllfFSGAHVTITDR-KVALEFLKSNVQANLPPHIQTktvvkelTWG 144
Cdd:COG2813    50 GGRVLDLGCGYGVIGLALAKR----------------NPEARVTLVDVnARAVELARANAAANGLENVEV-------LWS 106
                          90
                  ....*....|....*
gi 1370476871 145 QNLGSFSPGEFDLIL 159
Cdd:COG2813   107 DGLSGVPDGSFDLIL 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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