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Conserved domains on  [gi|1370486554|ref|XP_024309721|]
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protein sel-1 homolog 3 isoform X1 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11434433)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
526-717 1.22e-35

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 135.44  E-value: 1.22e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486554 526 WLKHEATRGNAAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAA 605
Cdd:COG0790    53 AAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAA-EQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAA 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486554 606 SKGLHQAVNGLGWYYHK---FKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGHM 682
Cdd:COG0790   131 EQGDADAQYNLGLLYLNgegVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGR--GVP-KDPAKALEWYRKAAEQGDA 207

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1370486554 683 EGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEK 717
Cdd:COG0790   208 DAQYNLGRLYLNG--EGVEKDLEKALRWLRKAAEQ 240
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
526-717 1.22e-35

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 135.44  E-value: 1.22e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486554 526 WLKHEATRGNAAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAA 605
Cdd:COG0790    53 AAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAA-EQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAA 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486554 606 SKGLHQAVNGLGWYYHK---FKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGHM 682
Cdd:COG0790   131 EQGDADAQYNLGLLYLNgegVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGR--GVP-KDPAKALEWYRKAAEQGDA 207

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1370486554 683 EGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEK 717
Cdd:COG0790   208 DAQYNLGRLYLNG--EGVEKDLEKALRWLRKAAEQ 240
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 578-608 2.23e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 39.43  E-value: 2.23e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1370486554 578 YDYAIVLFKGQGVKKNRRLALELMKKAASKG 608
Cdd:pfam08238   5 YRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 643-681 2.22e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 36.38  E-value: 2.22e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1370486554  643 PDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGH 681
Cdd:smart00671   1 AEAQYNLGQMYEYGL--GVP-KDLEKALEYYKKAAELGN 36
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
526-717 1.22e-35

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 135.44  E-value: 1.22e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486554 526 WLKHEATRGNAAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAA 605
Cdd:COG0790    53 AAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAA-EQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAA 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486554 606 SKGLHQAVNGLGWYYHK---FKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGHM 682
Cdd:COG0790   131 EQGDADAQYNLGLLYLNgegVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGR--GVP-KDPAKALEWYRKAAEQGDA 207

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1370486554 683 EGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEK 717
Cdd:COG0790   208 DAQYNLGRLYLNG--EGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
524-678 2.80e-30

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 120.03  E-value: 2.80e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486554 524 FMWLKHEATRGNAAAQQRLAQMLFWGqQGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKK 603
Cdd:COG0790    87 LEWFEKAAEQGDAEAQYNLGLMYEEG-LGVPQDYAKALEWYEKAA-EQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRK 164

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370486554 604 AASKGLHQAVNGLGWYYHK---FKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQ 678
Cdd:COG0790   165 AAEQGDADAQYNLGVLYENgrgVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGE--GVE-KDLEKALRWLRKAAE 239
TPR COG0790
TPR repeat [General function prediction only];
525-749 4.22e-27

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 110.79  E-value: 4.22e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486554 525 MWLKHEATRGNAAAQQRLAQMLFWGQQGVAKNPEAAIEWYAKGALETEDPALiYDYAIVLFKGQGVKKNRRLALELMKKA 604
Cdd:COG0790    15 AAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQ-YNLGLMYAEGRGVPKDYEKALEWFEKA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486554 605 ASKGLHQAVNGLGWYYHK---FKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGH 681
Cdd:COG0790    94 AEQGDAEAQYNLGLMYEEglgVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGE--GVP-KDPAKAAEWYRKAAEQGD 170

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370486554 682 MEGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEKN-----GYLGHVIRKGLnaYLEGSWHEALLYYVLAAE 749
Cdd:COG0790   171 ADAQYNLGVLYENG--RGVPKDPAKALEWYRKAAEQGdadaqYNLGRLYLNGE--GVEKDLEKALRWLRKAAE 239
TPR COG0790
TPR repeat [General function prediction only];
548-774 1.51e-19

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 88.83  E-value: 1.51e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486554 548 WGQQGVAKNPEAAIEWYAKGALETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAASKGLHQAVNGLGWYYHK---FK 624
Cdd:COG0790     1 LALAAAAAAAAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEgrgVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486554 625 KNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGHMEGTLWCSLYYITGnlETFPRDP 704
Cdd:COG0790    81 KDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGL--GVP-QDYAKALEWYEKAAEQGDADAQYNLGLLYLNG--EGVPKDP 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486554 705 EKAVVWAKHVAEKN-----GYLGHVIRKGLnaYLEGSWHEALLYYVLAAETGIEVSQTNLAHI------CEERPDLARRY 773
Cdd:COG0790   156 AKAAEWYRKAAEQGdadaqYNLGVLYENGR--GVPKDPAKALEWYRKAAEQGDADAQYNLGRLylngegVEKDLEKALRW 233


                  .
gi 1370486554 774 L 774
Cdd:COG0790   234 L 234
TPR COG0790
TPR repeat [General function prediction only];
595-848 6.38e-10

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 60.71  E-value: 6.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486554 595 RLALELMKKAASKGLHQAVNGLGWYYHKFKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFH 674
Cdd:COG0790    15 AAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGR--GVP-KDYEKALEWFE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486554 675 KAAQGGHMEGTLWCSLYYITGnlETFPRDPEKAVVWakhvaekngylghvirkglnaylegswheallyYVLAAETGIEV 754
Cdd:COG0790    92 KAAEQGDAEAQYNLGLMYEEG--LGVPQDYAKALEW---------------------------------YEKAAEQGDAD 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486554 755 SQTNLahiceerpdlarrylgvncvwryynfsvfqidapsfaylkmGDLYYYGHQNQsQDLELSVQMYAQAALDGDSQGF 834
Cdd:COG0790   137 AQYNL-----------------------------------------GLLYLNGEGVP-KDPAKAAEWYRKAAEQGDADAQ 174

                         250
                  ....*....|....
gi 1370486554 835 FNLALLIEEGTIIP 848
Cdd:COG0790   175 YNLGVLYENGRGVP 188
TPR COG0790
TPR repeat [General function prediction only];
415-605 4.28e-08

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 55.32  E-value: 4.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486554 415 GYHKASYYLAVFYETGLNVPRDQLQGmlyslvggqgserlssmnlgykhyqgidnypldwelsyayysniatktpldqht 494
Cdd:COG0790   133 GDADAQYNLGLLYLNGEGVPKDPAKA------------------------------------------------------ 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486554 495 lqgdqayvetirlkddeilkvqtkedgdvFMWLKHEATRGNAAAQQRLAQMLFWGqQGVAKNPEAAIEWYAKGAlETEDP 574
Cdd:COG0790   159 -----------------------------AEWYRKAAEQGDADAQYNLGVLYENG-RGVPKDPAKALEWYRKAA-EQGDA 207

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1370486554 575 ALIYDYAIVLFKGQGVKKNRRLALELMKKAA 605
Cdd:COG0790   208 DAQYNLGRLYLNGEGVEKDLEKALRWLRKAA 238
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 534-645 2.91e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 47.31  E-value: 2.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486554 534 GNAAAQQRLAQMLFWgqqgvAKNPEAAIEWYAKG-ALETEDPALIYDYAIVLFKGQGVKKnrrlALELMKKAASK--GLH 610
Cdd:COG4235    15 NDAEGWLLLGRAYLR-----LGRYDEALAAYEKAlRLDPDNADALLDLAEALLAAGDTEE----AEELLERALALdpDNP 85

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1370486554 611 QAVNGLGWYYHKfKKNYAKAAKYWLKAEEMGNPDA 645
Cdd:COG4235    86 EALYLLGLAAFQ-QGDYAEAIAAWQKLLALLPADA 119
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 578-608 2.23e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 39.43  E-value: 2.23e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1370486554 578 YDYAIVLFKGQGVKKNRRLALELMKKAASKG 608
Cdd:pfam08238   5 YRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 536-568 1.52e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 37.12  E-value: 1.52e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1370486554 536 AAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGA 568
Cdd:pfam08238   1 AEAQYRLGYLYLYGL-GVPKDPEKALEWYEKAA 32
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 643-681 2.22e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 36.38  E-value: 2.22e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1370486554  643 PDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGH 681
Cdd:smart00671   1 AEAQYNLGQMYEYGL--GVP-KDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 643-680 4.80e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 35.58  E-value: 4.80e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1370486554 643 PDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGG 680
Cdd:pfam08238   1 AEAQYRLGYLYLYGL--GVP-KDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 578-608 5.22e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 35.61  E-value: 5.22e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1370486554  578 YDYAIVLFKGQGVKKNRRLALELMKKAASKG 608
Cdd:smart00671   5 YNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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