NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1389914512|ref|XP_024921811|]
View 

transcription factor GATA-6 [Cynoglossus semilaevis]

Protein Classification

GATA-type transcription factor( domain architecture ID 12062858)

GATA-type transcription factor binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator

CATH:  3.30.50.10
Gene Ontology:  GO:0003700|GO:0006357|GO:0006355|GO:0008270|GO:0043565|GO:0000981
PubMed:  31574210
SCOP:  4003617

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GATA-N pfam05349
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
 112-283 1.27e-72

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


:

Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 227.70  E-value: 1.27e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389914512 112 YQTLAIAAAQSQTGYDSSSGGYMHSNPNSPVYVPSSRVGPMIPSLSYLQAGGSAQPGHAMSGHSVWSQTTPESPSYSTGS 191
Cdd:pfam05349   2 YQSLALAANHGQAAYDHDSGGFLHSAASSPVYVPTTRVPSMLPTLPYLQGCGSSQQSHPVSSHSGWAQAGAESSSYNPGS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389914512 192 PHTSSRFHYPPSPPMNNGTPRDSGYSNTLNMSN--RDQYG-LSRPLSGTYPSPYSPYVAPqlsQLPSPWSGGAFENTMLH 268
Cdd:pfam05349  82 PHPSPRFSYSHSPPGSNGTSRDAAYQSPLLISAggREQYGaLGRPLGGSYPSPYPAYVSP---EMAPSWTAGPFDSSVLH 158

                         170
                  ....*....|....*.
gi 1389914512 269 TLQSRSAPL-IRGPNG 283
Cdd:pfam05349 159 SLQGRGAPLpGRRPNL 174
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 350-401 2.47e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 81.26  E-value: 2.47e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1389914512 350 SCANCQTSTTTLWRRN-AEGEPVCNACGLYTKLHGVPRPLAMKKEG-IQTRKRK 401
Cdd:cd00202     1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 296-346 2.51e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 75.87  E-value: 2.51e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1389914512 296 ECVNCGSISTPLWRRDG-TGHFLCNACGLYSKMNGLSRPLIKPQKRTSTSRR 346
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
 
Name Accession Description Interval E-value
GATA-N pfam05349
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
 112-283 1.27e-72

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 227.70  E-value: 1.27e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389914512 112 YQTLAIAAAQSQTGYDSSSGGYMHSNPNSPVYVPSSRVGPMIPSLSYLQAGGSAQPGHAMSGHSVWSQTTPESPSYSTGS 191
Cdd:pfam05349   2 YQSLALAANHGQAAYDHDSGGFLHSAASSPVYVPTTRVPSMLPTLPYLQGCGSSQQSHPVSSHSGWAQAGAESSSYNPGS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389914512 192 PHTSSRFHYPPSPPMNNGTPRDSGYSNTLNMSN--RDQYG-LSRPLSGTYPSPYSPYVAPqlsQLPSPWSGGAFENTMLH 268
Cdd:pfam05349  82 PHPSPRFSYSHSPPGSNGTSRDAAYQSPLLISAggREQYGaLGRPLGGSYPSPYPAYVSP---EMAPSWTAGPFDSSVLH 158

                         170
                  ....*....|....*.
gi 1389914512 269 TLQSRSAPL-IRGPNG 283
Cdd:pfam05349 159 SLQGRGAPLpGRRPNL 174
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 350-401 2.47e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 81.26  E-value: 2.47e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1389914512 350 SCANCQTSTTTLWRRN-AEGEPVCNACGLYTKLHGVPRPLAMKKEG-IQTRKRK 401
Cdd:cd00202     1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 296-346 2.51e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 75.87  E-value: 2.51e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1389914512 296 ECVNCGSISTPLWRRDG-TGHFLCNACGLYSKMNGLSRPLIKPQKRTSTSRR 346
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
346-395 2.22e-16

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 72.84  E-value: 2.22e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1389914512  346 RIGLSCANCQTSTTTLWRRNAEGE-PVCNACGLYTKLHGVP-RPLAMKKEGI 395
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLkRPLSLKKDGI 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
292-342 3.17e-13

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 63.98  E-value: 3.17e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1389914512  292 GESRECVNCGSISTPLWRRDGTGH-FLCNACGLYSKMNGLSRPLIKPQKRTS 342
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLKRPLSLKKDGI 52
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 351-385 7.12e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 62.72  E-value: 7.12e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1389914512 351 CANCQTSTTTLWRRNAEGEP-VCNACGLYTKLHGVP 385
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 297-330 5.27e-12

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 60.02  E-value: 5.27e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1389914512 297 CVNCGSISTPLWRRDGTGH-FLCNACGLYSKMNGL 330
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNrTLCNACGLYYKKKGL 35
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
224-403 1.23e-06

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 51.03  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389914512 224 NRDQYGLSRPLSGTYPSPYSPYVAPQLSQLpspwsggafeNTMLHTLQSRSAPLIRGPNGVSDILDDLGES------REC 297
Cdd:COG5641    92 SSRQSSISSLSDFPISSSSSTSNAASPSTN----------YTDESNQQFSSYNTTLNPGGTSSLNPNNNQSdnsnqpHVC 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389914512 298 VNCGSISTPLWRRD-----GTGHFLCNACGLYSKMNGLSRPLIKPQKRTSTSRRIGLSCANCQTST-TTLWRRNAEGEPV 371
Cdd:COG5641   162 SNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNDSNGeNANTESIGNSSAS 241

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1389914512 372 CNACGLYTKLHGvpRPLAMKKEGIQTRKRKPK 403
Cdd:COG5641   242 KLTKSWEERPQG--RQLLSDAGSLSPRSNNPK 271
 
Name Accession Description Interval E-value
GATA-N pfam05349
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
 112-283 1.27e-72

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 227.70  E-value: 1.27e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389914512 112 YQTLAIAAAQSQTGYDSSSGGYMHSNPNSPVYVPSSRVGPMIPSLSYLQAGGSAQPGHAMSGHSVWSQTTPESPSYSTGS 191
Cdd:pfam05349   2 YQSLALAANHGQAAYDHDSGGFLHSAASSPVYVPTTRVPSMLPTLPYLQGCGSSQQSHPVSSHSGWAQAGAESSSYNPGS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389914512 192 PHTSSRFHYPPSPPMNNGTPRDSGYSNTLNMSN--RDQYG-LSRPLSGTYPSPYSPYVAPqlsQLPSPWSGGAFENTMLH 268
Cdd:pfam05349  82 PHPSPRFSYSHSPPGSNGTSRDAAYQSPLLISAggREQYGaLGRPLGGSYPSPYPAYVSP---EMAPSWTAGPFDSSVLH 158

                         170
                  ....*....|....*.
gi 1389914512 269 TLQSRSAPL-IRGPNG 283
Cdd:pfam05349 159 SLQGRGAPLpGRRPNL 174
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 350-401 2.47e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 81.26  E-value: 2.47e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1389914512 350 SCANCQTSTTTLWRRN-AEGEPVCNACGLYTKLHGVPRPLAMKKEG-IQTRKRK 401
Cdd:cd00202     1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 296-346 2.51e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 75.87  E-value: 2.51e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1389914512 296 ECVNCGSISTPLWRRDG-TGHFLCNACGLYSKMNGLSRPLIKPQKRTSTSRR 346
Cdd:cd00202     1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
346-395 2.22e-16

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 72.84  E-value: 2.22e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1389914512  346 RIGLSCANCQTSTTTLWRRNAEGE-PVCNACGLYTKLHGVP-RPLAMKKEGI 395
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLkRPLSLKKDGI 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
292-342 3.17e-13

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 63.98  E-value: 3.17e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1389914512  292 GESRECVNCGSISTPLWRRDGTGH-FLCNACGLYSKMNGLSRPLIKPQKRTS 342
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLKRPLSLKKDGI 52
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 351-385 7.12e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 62.72  E-value: 7.12e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1389914512 351 CANCQTSTTTLWRRNAEGEP-VCNACGLYTKLHGVP 385
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 297-330 5.27e-12

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 60.02  E-value: 5.27e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1389914512 297 CVNCGSISTPLWRRDGTGH-FLCNACGLYSKMNGL 330
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNrTLCNACGLYYKKKGL 35
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
224-403 1.23e-06

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 51.03  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389914512 224 NRDQYGLSRPLSGTYPSPYSPYVAPQLSQLpspwsggafeNTMLHTLQSRSAPLIRGPNGVSDILDDLGES------REC 297
Cdd:COG5641    92 SSRQSSISSLSDFPISSSSSTSNAASPSTN----------YTDESNQQFSSYNTTLNPGGTSSLNPNNNQSdnsnqpHVC 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389914512 298 VNCGSISTPLWRRD-----GTGHFLCNACGLYSKMNGLSRPLIKPQKRTSTSRRIGLSCANCQTST-TTLWRRNAEGEPV 371
Cdd:COG5641   162 SNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNDSNGeNANTESIGNSSAS 241

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1389914512 372 CNACGLYTKLHGvpRPLAMKKEGIQTRKRKPK 403
Cdd:COG5641   242 KLTKSWEERPQG--RQLLSDAGSLSPRSNNPK 271
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
299-402 4.48e-05

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 46.02  E-value: 4.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389914512 299 NCGSISTPLWRR-DGTGHFLCNACGLYSKMNGLSRPLikPQKRTSTSRRIGLSCANCQTSTTTLWRrnaEGEPVCNACGL 377
Cdd:COG5641   303 LTTSTATPLWRRtSDKSSFSCNASGSALKPPGSKRPL--LPKPDPNSKRSNATCMNCSSTPTNKIL---SPPTTSNSPGA 377

                          90       100
                  ....*....|....*....|....*
gi 1389914512 378 YTKLHGVPRPLAMKKEGIQTRKRKP 402
Cdd:COG5641   378 QVKLPNQTRSTGATKKKITRRRMNS 402
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH