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Conserved domains on  [gi|1394673790|ref|XP_025034347|]
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polymeric immunoglobulin receptor [Pelodiscus sinensis]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10146027)

immunoglobulin (Ig) domain-containing protein with one or more Ig domains, which adopt a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition; similar to polymeric immunoglobulin receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 137-237 4.43e-27

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 105.17  E-value: 4.43e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790 137 PEGAELYYKELGGSVTMNCVFGTQYASVRKYLCKMGKTGCSTVIDTYGNVNPtykGRALLSPQETPGSFVIYMTQLRKED 216
Cdd:cd05716     1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKED 77

                          90       100
                  ....*....|....*....|.
gi 1394673790 217 SGLYLCGVGEYGETGESKELD 237
Cdd:cd05716    78 AGWYWCGVGDDGDRGLTVQVK 98
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 355-452 2.02e-26

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 103.25  E-value: 2.02e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790 355 LTGLKEVNAVIGTRVTLSCSYPCKYYSYQKYWCKWNNRGCKPLVSYEQNQTSP--AVNCDEENKTLYLTFNQVTQTNQGW 432
Cdd:cd05716     1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPGGriSLTDDPDNGVFTVTLNQLRKEDAGW 80

                          90       100
                  ....*....|....*....|
gi 1394673790 433 YWCGVSHSGHYGETMAVFLR 452
Cdd:cd05716    81 YWCGVGDDGDRGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 247-348 2.91e-26

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 102.86  E-value: 2.91e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790 247 PQGRHTINGVIGGSVSVECRYDPRRNYTLKYLCKWRKNGCTQLITNLImmiDSYEGRIVMHDNPKNGTFTIIMNQLVAED 326
Cdd:cd05716     1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEG---VVPGGRISLTDDPDNGVFTVTLNQLRKED 77

                          90       100
                  ....*....|....*....|..
gi 1394673790 327 AGYYWCMTDGDVERKSSKELKI 348
Cdd:cd05716    78 AGWYWCGVGDDGDRGLTVQVKL 99
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 28-128 5.00e-23

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 93.62  E-value: 5.00e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790  28 GPRQVTGLLGGSVTVKCFYPRTNvnRHDRKYWCKESTRQCATVISSNGYIAqdfAGRATITDFPEQGIFIMELSKLGLKD 107
Cdd:cd05716     3 GPEVVTGVEGGSVTIQCPYPPKY--ASSRKYWCKWGSEGCQTLVSSEGVVP---GGRISLTDDPDNGVFTVTLNQLRKED 77

                          90       100
                  ....*....|....*....|..
gi 1394673790 108 IGFYKCGIGLN-DRGLSFEVKL 128
Cdd:cd05716    78 AGWYWCGVGDDgDRGLTVQVKL 99
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 137-237 4.43e-27

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 105.17  E-value: 4.43e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790 137 PEGAELYYKELGGSVTMNCVFGTQYASVRKYLCKMGKTGCSTVIDTYGNVNPtykGRALLSPQETPGSFVIYMTQLRKED 216
Cdd:cd05716     1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKED 77

                          90       100
                  ....*....|....*....|.
gi 1394673790 217 SGLYLCGVGEYGETGESKELD 237
Cdd:cd05716    78 AGWYWCGVGDDGDRGLTVQVK 98
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 355-452 2.02e-26

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 103.25  E-value: 2.02e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790 355 LTGLKEVNAVIGTRVTLSCSYPCKYYSYQKYWCKWNNRGCKPLVSYEQNQTSP--AVNCDEENKTLYLTFNQVTQTNQGW 432
Cdd:cd05716     1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPGGriSLTDDPDNGVFTVTLNQLRKEDAGW 80

                          90       100
                  ....*....|....*....|
gi 1394673790 433 YWCGVSHSGHYGETMAVFLR 452
Cdd:cd05716    81 YWCGVGDDGDRGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 247-348 2.91e-26

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 102.86  E-value: 2.91e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790 247 PQGRHTINGVIGGSVSVECRYDPRRNYTLKYLCKWRKNGCTQLITNLImmiDSYEGRIVMHDNPKNGTFTIIMNQLVAED 326
Cdd:cd05716     1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEG---VVPGGRISLTDDPDNGVFTVTLNQLRKED 77

                          90       100
                  ....*....|....*....|..
gi 1394673790 327 AGYYWCMTDGDVERKSSKELKI 348
Cdd:cd05716    78 AGWYWCGVGDDGDRGLTVQVKL 99
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 28-128 5.00e-23

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 93.62  E-value: 5.00e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790  28 GPRQVTGLLGGSVTVKCFYPRTNvnRHDRKYWCKESTRQCATVISSNGYIAqdfAGRATITDFPEQGIFIMELSKLGLKD 107
Cdd:cd05716     3 GPEVVTGVEGGSVTIQCPYPPKY--ASSRKYWCKWGSEGCQTLVSSEGVVP---GGRISLTDDPDNGVFTVTLNQLRKED 77

                          90       100
                  ....*....|....*....|..
gi 1394673790 108 IGFYKCGIGLN-DRGLSFEVKL 128
Cdd:cd05716    78 AGWYWCGVGDDgDRGLTVQVKL 99
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 28-130 7.87e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 56.31  E-value: 7.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790  28 GPRQVTGLLGGSVTVKCFYPRTNVNRHDRKYWCKEST---RQCATVISSNGYIAQDFAGRATITDFPEQGIFIMELSKLG 104
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEASTSVYWYRQPPgkgPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLT 81

                          90       100
                  ....*....|....*....|....*..
gi 1394673790 105 LKDIGFYKCGIGLNDRG-LSFEVKLDV 130
Cdd:pfam07686  82 LSDSGTYTCAVIPSGEGvFGKGTRLTV 108
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 132-241 8.35e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 53.62  E-value: 8.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790 132 QGPKVPEGAElyykelGGSVTMNCVFGTQY--ASVRKYLCKM-GKTGCSTVIDTYGNVNPTYKGRALLSPQETP--GSFV 206
Cdd:pfam07686   1 QTPREVTVAL------GGSVTLPCTYSSSMseASTSVYWYRQpPGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPsnGDGS 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1394673790 207 IYMTQLRKEDSGLYLCGVGEYGETGESKELDMHVY 241
Cdd:pfam07686  75 LTIQNLTLSDSGTYTCAVIPSGEGVFGKGTRLTVL 109
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 359-453 2.39e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 46.68  E-value: 2.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790 359 KEVNAVIGTRVTLSCSYP--CKYYSYQKYWCKWN-NRGCKPLV-----SYEQNQTSPAV--NCDEENKTLYLTFNQVTQT 428
Cdd:pfam07686   4 REVTVALGGSVTLPCTYSssMSEASTSVYWYRQPpGKGPTFLIayysnGSEEGVKKGRFsgRGDPSNGDGSLTIQNLTLS 83

                          90       100
                  ....*....|....*....|....*
gi 1394673790 429 NQGWYWCGVSHSGHYGETMAVFLRV 453
Cdd:pfam07686  84 DSGTYTCAVIPSGEGVFGKGTRLTV 108
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 251-348 5.25e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 45.53  E-value: 5.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790 251 HTINGVIGGSVSVECRYDPRRNYTLkYLCKWRKNGCTQLITNLI------MMIDSYEGRIVMHDNPKNGTFTIIMNQLVA 324
Cdd:pfam07686   4 REVTVALGGSVTLPCTYSSSMSEAS-TSVYWYRQPPGKGPTFLIayysngSEEGVKKGRFSGRGDPSNGDGSLTIQNLTL 82

                          90       100
                  ....*....|....*....|....
gi 1394673790 325 EDAGYYWCMTDGDVERKSSKELKI 348
Cdd:pfam07686  83 SDSGTYTCAVIPSGEGVFGKGTRL 106
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 252-333 2.80e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.88  E-value: 2.80e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790  252 TINGVIGGSVSVECRYDPRRNYTLKylckWRKNGCTQLItnlimmidsYEGRIVMHDNPKNGTFTIimNQLVAEDAGYYW 331
Cdd:smart00410   3 SVTVKEGESVTLSCEASGSPPPEVT----WYKQGGKLLA---------ESGRFSVSRSGSTSTLTI--SNVTPEDSGTYT 67


                   ..
gi 1394673790  332 CM 333
Cdd:smart00410  68 CA 69
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 359-453 6.50e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.72  E-value: 6.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790  359 KEVNAVIGTRVTLSCSYPckyySYQKYWCKWNNRGCKPLvsyeqnQTSPAVNCDEENKTLYLTFNQVTQTNQGWYWCGVS 438
Cdd:smart00410   2 PSVTVKEGESVTLSCEAS----GSPPPEVTWYKQGGKLL------AESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAAT 71

                           90
                   ....*....|....*
gi 1394673790  439 hSGHYGETMAVFLRV 453
Cdd:smart00410  72 -NSSGSASSGTTLTV 85
IGv smart00406
Immunoglobulin V-Type;
187-224 3.15e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 36.98  E-value: 3.15e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1394673790  187 NPTYKGRALLSPQETPGSFVIYMTQLRKEDSGLYLCGV 224
Cdd:smart00406  44 QESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYCAV 81
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 29-130 5.12e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.33  E-value: 5.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790   29 PRQVTGLLGGSVTVKCfypRTNVNRHDRKYWckesTRQCATVISSNgyiaqdfaGRATITdfPEQGIFIMELSKLGLKDI 108
Cdd:smart00410   1 PPSVTVKEGESVTLSC---EASGSPPPEVTW----YKQGGKLLAES--------GRFSVS--RSGSTSTLTISNVTPEDS 63

                           90       100
                   ....*....|....*....|..
gi 1394673790  109 GFYKCGIGLNDRGLSFEVKLDV 130
Cdd:smart00410  64 GTYTCAATNSSGSASSGTTLTV 85
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 137-237 4.43e-27

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 105.17  E-value: 4.43e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790 137 PEGAELYYKELGGSVTMNCVFGTQYASVRKYLCKMGKTGCSTVIDTYGNVNPtykGRALLSPQETPGSFVIYMTQLRKED 216
Cdd:cd05716     1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKED 77

                          90       100
                  ....*....|....*....|.
gi 1394673790 217 SGLYLCGVGEYGETGESKELD 237
Cdd:cd05716    78 AGWYWCGVGDDGDRGLTVQVK 98
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 355-452 2.02e-26

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 103.25  E-value: 2.02e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790 355 LTGLKEVNAVIGTRVTLSCSYPCKYYSYQKYWCKWNNRGCKPLVSYEQNQTSP--AVNCDEENKTLYLTFNQVTQTNQGW 432
Cdd:cd05716     1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPGGriSLTDDPDNGVFTVTLNQLRKEDAGW 80

                          90       100
                  ....*....|....*....|
gi 1394673790 433 YWCGVSHSGHYGETMAVFLR 452
Cdd:cd05716    81 YWCGVGDDGDRGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 247-348 2.91e-26

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 102.86  E-value: 2.91e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790 247 PQGRHTINGVIGGSVSVECRYDPRRNYTLKYLCKWRKNGCTQLITNLImmiDSYEGRIVMHDNPKNGTFTIIMNQLVAED 326
Cdd:cd05716     1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEG---VVPGGRISLTDDPDNGVFTVTLNQLRKED 77

                          90       100
                  ....*....|....*....|..
gi 1394673790 327 AGYYWCMTDGDVERKSSKELKI 348
Cdd:cd05716    78 AGWYWCGVGDDGDRGLTVQVKL 99
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 28-128 5.00e-23

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 93.62  E-value: 5.00e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790  28 GPRQVTGLLGGSVTVKCFYPRTNvnRHDRKYWCKESTRQCATVISSNGYIAqdfAGRATITDFPEQGIFIMELSKLGLKD 107
Cdd:cd05716     3 GPEVVTGVEGGSVTIQCPYPPKY--ASSRKYWCKWGSEGCQTLVSSEGVVP---GGRISLTDDPDNGVFTVTLNQLRKED 77

                          90       100
                  ....*....|....*....|..
gi 1394673790 108 IGFYKCGIGLN-DRGLSFEVKL 128
Cdd:cd05716    78 AGWYWCGVGDDgDRGLTVQVKL 99
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 28-130 7.87e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 56.31  E-value: 7.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790  28 GPRQVTGLLGGSVTVKCFYPRTNVNRHDRKYWCKEST---RQCATVISSNGYIAQDFAGRATITDFPEQGIFIMELSKLG 104
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEASTSVYWYRQPPgkgPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLT 81

                          90       100
                  ....*....|....*....|....*..
gi 1394673790 105 LKDIGFYKCGIGLNDRG-LSFEVKLDV 130
Cdd:pfam07686  82 LSDSGTYTCAVIPSGEGvFGKGTRLTV 108
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 132-241 8.35e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 53.62  E-value: 8.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790 132 QGPKVPEGAElyykelGGSVTMNCVFGTQY--ASVRKYLCKM-GKTGCSTVIDTYGNVNPTYKGRALLSPQETP--GSFV 206
Cdd:pfam07686   1 QTPREVTVAL------GGSVTLPCTYSSSMseASTSVYWYRQpPGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPsnGDGS 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1394673790 207 IYMTQLRKEDSGLYLCGVGEYGETGESKELDMHVY 241
Cdd:pfam07686  75 LTIQNLTLSDSGTYTCAVIPSGEGVFGKGTRLTVL 109
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 359-453 2.39e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 46.68  E-value: 2.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790 359 KEVNAVIGTRVTLSCSYP--CKYYSYQKYWCKWN-NRGCKPLV-----SYEQNQTSPAV--NCDEENKTLYLTFNQVTQT 428
Cdd:pfam07686   4 REVTVALGGSVTLPCTYSssMSEASTSVYWYRQPpGKGPTFLIayysnGSEEGVKKGRFsgRGDPSNGDGSLTIQNLTLS 83

                          90       100
                  ....*....|....*....|....*
gi 1394673790 429 NQGWYWCGVSHSGHYGETMAVFLRV 453
Cdd:pfam07686  84 DSGTYTCAVIPSGEGVFGKGTRLTV 108
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 251-348 5.25e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 45.53  E-value: 5.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790 251 HTINGVIGGSVSVECRYDPRRNYTLkYLCKWRKNGCTQLITNLI------MMIDSYEGRIVMHDNPKNGTFTIIMNQLVA 324
Cdd:pfam07686   4 REVTVALGGSVTLPCTYSSSMSEAS-TSVYWYRQPPGKGPTFLIayysngSEEGVKKGRFSGRGDPSNGDGSLTIQNLTL 82

                          90       100
                  ....*....|....*....|....
gi 1394673790 325 EDAGYYWCMTDGDVERKSSKELKI 348
Cdd:pfam07686  83 SDSGTYTCAVIPSGEGVFGKGTRL 106
Ig_Versican cd05901
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), ...
 32-131 7.58e-06

Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican; The members here are composed of the immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican. In CSPGs, the Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, the CSPG aggrecan (not included in this group) forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Like aggrecan, versican has a wide distribution in connective tissue and extracellular matrices. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409482  Cd Length: 128  Bit Score: 45.72  E-value: 7.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790  32 VTGLLGGSVTVKCFY-------PRTNV-NRHDRKYWCK-------ESTRQCATVISSNGYI--AQDFAGRATITDFPE-Q 93
Cdd:cd05901     7 VHGSLSGSVVLPCRFstlptlpPSYNItSEFLRIKWTKiqvdkngKDHKETTVLVAQNGIIkiGQEYMGRVSVPSHPEdQ 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1394673790  94 GIFIMELSKLGLKDIGFYKCGI--GLNDRGLSfeVKLDVS 131
Cdd:cd05901    87 GDASLTIVKLRASDAGVYRCEVmhGIEDTQDT--VSLDVS 124
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 252-333 2.80e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.88  E-value: 2.80e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790  252 TINGVIGGSVSVECRYDPRRNYTLKylckWRKNGCTQLItnlimmidsYEGRIVMHDNPKNGTFTIimNQLVAEDAGYYW 331
Cdd:smart00410   3 SVTVKEGESVTLSCEASGSPPPEVT----WYKQGGKLLA---------ESGRFSVSRSGSTSTLTI--SNVTPEDSGTYT 67


                   ..
gi 1394673790  332 CM 333
Cdd:smart00410  68 CA 69
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 359-453 6.50e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.72  E-value: 6.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790  359 KEVNAVIGTRVTLSCSYPckyySYQKYWCKWNNRGCKPLvsyeqnQTSPAVNCDEENKTLYLTFNQVTQTNQGWYWCGVS 438
Cdd:smart00410   2 PSVTVKEGESVTLSCEAS----GSPPPEVTWYKQGGKLL------AESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAAT 71

                           90
                   ....*....|....*
gi 1394673790  439 hSGHYGETMAVFLRV 453
Cdd:smart00410  72 -NSSGSASSGTTLTV 85
IgV_CRIg cd16089
Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin ...
 248-348 3.19e-04

Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin superfamily (CRIg); The members here are composed of the immunoglobulin variable (IgV) region of the complement receptor of the immunoglobulin superfamily (CRIg). The N-terminal domain of CRIg (also known as Z39Ig and V-set and Ig domain-containing 4 (VSIG4) belongs to the IgV family of immunoglobulin-like domains while the C-terminal domain of CRIg belongs to the IgC family of immunoglobulin-like domains. Like all members of this family, the CRIg domain contains two beta-sheets: one composed of strands A', G, F, C, C' and C", and the other of strands B, E and D. The complement system is an important part of the innate immune system and is required for removal of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convertases. CRIg, a complement receptor expressed on macrophages, binds to C3b and iC3b mediating phagocytosis of the particles. It is also a potent inhibitor of the alternative pathway convertases and a negative regulator of T cell activation. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409510  Cd Length: 117  Bit Score: 40.59  E-value: 3.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790 248 QGRHTINGVIGGSVSVECRYDPRRNYTlKYLCKWRKNGCTQLITnlIMMIDS---------YEGRI-VMHDNPknGTFTI 317
Cdd:cd16089     4 EGPESITGPWKGSVNLPCTYVPEEGYT-QVLVKWLVQRDSDPVT--IFLRDSsgdhiqqakYRGRLeVSKDTP--GDVSL 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1394673790 318 IMNQLVAEDAGYY-----WCMTDGD-VERKSSKELKI 348
Cdd:cd16089    79 QLDTLEMDDRGHYtcqvtWQTPDGNlIVREKTTELRV 115
Ig_Aggrecan_like cd05878
Immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core ...
 28-129 4.16e-04

Immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core protein (CSPG); The members here are composed of the immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core proteins (CSPGs). Included in this group are the Ig domains of other CSPGs: versican, and neurocan. In CSPGs, this Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggrecan and versican have a wide distribution in connective tissue and extracellular matrices. Neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409462  Cd Length: 125  Bit Score: 40.68  E-value: 4.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790  28 GPRQVTGLLGGSVTVKCFY-------PRTNVNRHDRKYWCKEST-----RQCATVISSNGY--IAQDFAGRATITDFPEQ 93
Cdd:cd05878     3 QSSPVRVLLGTSVTLPCYFidpphpvTPSTAPLAPRIKWSKVSVdgkkeKEVVLLVATEGRvrVNSAYQGRVSLPNYPAI 82

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1394673790  94 -GIFIMELSKLGLKDIGFYKCGI--GLNDRGLSFEVKLD 129
Cdd:cd05878    83 pSDATLEVQSLRASDSGLYRCEVmhGIEDSQDTVELVVK 121
IGv smart00406
Immunoglobulin V-Type;
187-224 3.15e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 36.98  E-value: 3.15e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1394673790  187 NPTYKGRALLSPQETPGSFVIYMTQLRKEDSGLYLCGV 224
Cdd:smart00406  44 QESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYCAV 81
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 29-130 5.12e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.33  E-value: 5.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790   29 PRQVTGLLGGSVTVKCfypRTNVNRHDRKYWckesTRQCATVISSNgyiaqdfaGRATITdfPEQGIFIMELSKLGLKDI 108
Cdd:smart00410   1 PPSVTVKEGESVTLSC---EASGSPPPEVTW----YKQGGKLLAES--------GRFSVS--RSGSTSTLTISNVTPEDS 63

                           90       100
                   ....*....|....*....|..
gi 1394673790  109 GFYKCGIGLNDRGLSFEVKLDV 130
Cdd:smart00410  64 GTYTCAATNSSGSASSGTTLTV 85
Ig_CSPGs_LP_like cd05714
Immunoglobulin (Ig)-like domain of chondroitin sulfate proteoglycans (CSPGs), human cartilage ...
 32-119 5.32e-03

Immunoglobulin (Ig)-like domain of chondroitin sulfate proteoglycans (CSPGs), human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in chondroitin sulfate proteoglycans (CSPGs) and human cartilage link protein (LP). Included in this group are the CSPGs aggrecan, versican, and neurocan. In CSPGs, this Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggrecan and versican have a wide distribution in connective tissue and extracellular matrices. Neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. There is considerable evidence that HA-binding CSPGs are involved in developmental processes in the central nervous system. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409379  Cd Length: 123  Bit Score: 37.19  E-value: 5.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790  32 VTGLLGGSVTVKC-FY--PRTNVNRHD--RKYWCKEST----RQCATVISSNG---YIAQDFAGRATITDFPEQ-GIFIM 98
Cdd:cd05714     7 VFSHLGGNVTLPCkFYrdPTAFGSGIHkiRIKWTKLTSdsgyLKEVDVLVAMGnvvYHKKTYGGRVSVPLKPGSdSDASL 86

                          90       100
                  ....*....|....*....|...
gi 1394673790  99 ELSKLGLKDIGFYKCGI--GLND 119
Cdd:cd05714    87 VITDLTASDYGLYRCEVieGIED 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 143-233 7.58e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.94  E-value: 7.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394673790  143 YYKELGGSVTMNC-VFGTQYASVRKYlckmgKTGCSTVIdtygnvnptYKGRALLSPQETPGSFVIymTQLRKEDSGLYL 221
Cdd:smart00410   4 VTVKEGESVTLSCeASGSPPPEVTWY-----KQGGKLLA---------ESGRFSVSRSGSTSTLTI--SNVTPEDSGTYT 67

                           90
                   ....*....|..
gi 1394673790  222 CGVGEYGETGES 233
Cdd:smart00410  68 CAATNSSGSASS 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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