LOW QUALITY PROTEIN: ubiquitin-associated protein 2 [Rhinatrema bivittatum]
Protein Classification
lingerer family protein( domain architecture ID 10198271)
lingerer family protein similar to Drosophila pseudoobscura protein lingerer that acts in the nervous system to mediate the control of copulatory organs during courtship
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| UBA_UBP2_like | cd14277 | UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins; The family contains ... |
51-88 | 3.33e-18 | ||
UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins; The family contains some uncharacterized ubiquitin-associated proteins, including UBAP-2 and its homolog, UBAP2-like [UBP2L, also called protein NICE-4 (for newly identified cDNA from the epidermal differentiation complex EDC)], both of which contain an N-terminal ubiquitin-associated (UBA) domain along with a highly conserved, but function unknown domain (DUF3697). : Pssm-ID: 270463 Cd Length: 38 Bit Score: 78.76 E-value: 3.33e-18
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| DUF3697 | pfam12478 | Ubiquitin-associated protein 2; This domain family is found in eukaryotes, and is ... |
485-514 | 8.15e-08 | ||
Ubiquitin-associated protein 2; This domain family is found in eukaryotes, and is approximately 30 amino acids in length. The family is found in association with pfam00627. There are two conserved sequence motifs: AVEMPG and QFG. : Pssm-ID: 372135 [Multi-domain] Cd Length: 32 Bit Score: 48.97 E-value: 8.15e-08
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| Name | Accession | Description | Interval | E-value | ||
| UBA_UBP2_like | cd14277 | UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins; The family contains ... |
51-88 | 3.33e-18 | ||
UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins; The family contains some uncharacterized ubiquitin-associated proteins, including UBAP-2 and its homolog, UBAP2-like [UBP2L, also called protein NICE-4 (for newly identified cDNA from the epidermal differentiation complex EDC)], both of which contain an N-terminal ubiquitin-associated (UBA) domain along with a highly conserved, but function unknown domain (DUF3697). Pssm-ID: 270463 Cd Length: 38 Bit Score: 78.76 E-value: 3.33e-18
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| DUF3697 | pfam12478 | Ubiquitin-associated protein 2; This domain family is found in eukaryotes, and is ... |
485-514 | 8.15e-08 | ||
Ubiquitin-associated protein 2; This domain family is found in eukaryotes, and is approximately 30 amino acids in length. The family is found in association with pfam00627. There are two conserved sequence motifs: AVEMPG and QFG. Pssm-ID: 372135 [Multi-domain] Cd Length: 32 Bit Score: 48.97 E-value: 8.15e-08
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| UBA | smart00165 | Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 ... |
52-88 | 3.70e-06 | ||
Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 is known to bind ubiquitin. Pssm-ID: 197551 [Multi-domain] Cd Length: 37 Bit Score: 44.40 E-value: 3.70e-06
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| UBA_4 | pfam14555 | UBA-like domain; |
52-85 | 2.12e-03 | ||
UBA-like domain; Pssm-ID: 464207 Cd Length: 43 Bit Score: 37.05 E-value: 2.12e-03
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| Name | Accession | Description | Interval | E-value | ||
| UBA_UBP2_like | cd14277 | UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins; The family contains ... |
51-88 | 3.33e-18 | ||
UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins; The family contains some uncharacterized ubiquitin-associated proteins, including UBAP-2 and its homolog, UBAP2-like [UBP2L, also called protein NICE-4 (for newly identified cDNA from the epidermal differentiation complex EDC)], both of which contain an N-terminal ubiquitin-associated (UBA) domain along with a highly conserved, but function unknown domain (DUF3697). Pssm-ID: 270463 Cd Length: 38 Bit Score: 78.76 E-value: 3.33e-18
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| DUF3697 | pfam12478 | Ubiquitin-associated protein 2; This domain family is found in eukaryotes, and is ... |
485-514 | 8.15e-08 | ||
Ubiquitin-associated protein 2; This domain family is found in eukaryotes, and is approximately 30 amino acids in length. The family is found in association with pfam00627. There are two conserved sequence motifs: AVEMPG and QFG. Pssm-ID: 372135 [Multi-domain] Cd Length: 32 Bit Score: 48.97 E-value: 8.15e-08
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| UBA | smart00165 | Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 ... |
52-88 | 3.70e-06 | ||
Ubiquitin associated domain; Present in Rad23, SNF1-like kinases. The newly-found UBA in p62 is known to bind ubiquitin. Pssm-ID: 197551 [Multi-domain] Cd Length: 37 Bit Score: 44.40 E-value: 3.70e-06
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| UBA_like_SF | cd00194 | UBA domain-like superfamily; The ubiquitin-associated (UBA) domain-like superfamily contains ... |
58-85 | 1.22e-05 | ||
UBA domain-like superfamily; The ubiquitin-associated (UBA) domain-like superfamily contains alpha-helical structural homology ubiquitin-binding domains, including UBA domains and coupling of ubiquitin conjugation to endoplasmic reticulum degradation (CUE) domains which share a common three-helical bundle architecture. UBA domains are commonly occurring sequence motifs found in proteins involved in ubiquitin-mediated proteolysis. They contribute to ubiquitin (Ub) binding or ubiquitin-like (UbL) domain binding. However, some kinds of UBA domains can only bind the UbL domain, but not the Ub domain. UBA domains are normally comprised of compact three-helix bundles which contain a conserved GF/Y-loop. They can bind polyubiquitin with high affinity. They also bind monoubiquitin and other proteins. Most UBA domain-containing proteins have one UBA domain, but some harbor two or three UBA domains. CUE domain containing proteins are characterized by an FP and a di-leucine-like sequence and bind to monoubiquitin with varying affinities. Some higher eukaryotic CUE domain proteins do not bind monoubiquitin efficiently, since they carry LP, rather than FP among CUE domains. This superfamily also includes many UBA-like domains found in AMP-activated protein kinase (AMPK) related kinases, the NXF family of mRNA nuclear export factors, elongation factor Ts (EF-Ts), nascent polypeptide-associated complex subunit alpha (NACA) and similar proteins. Although many UBA-like domains may have a conserved TG but not GF/Y-loop, they still show a high level of structural and sequence similarity with three-helical ubiquitin binding domains. Pssm-ID: 270455 Cd Length: 28 Bit Score: 42.78 E-value: 1.22e-05
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| UBA_UBAC2 | cd14305 | UBA domain found in ubiquitin-associated domain-containing protein 2 (UBAC2) and similar ... |
52-88 | 1.92e-04 | ||
UBA domain found in ubiquitin-associated domain-containing protein 2 (UBAC2) and similar proteins; UBAC2, also called phosphoglycerate dehydrogenase-like protein 1, is a ubiquitin-associated domain (UBA)-domain containing protein encoded by gene UBAC2 (or PHGDHL1), a risk gene for Behcet's disease (BD). It may play an important role in the development of BD through its transcriptional modulation. Members in this family contain an N-terminal rhomboid-like domain and a C-terminal UBA domain. Pssm-ID: 270490 Cd Length: 38 Bit Score: 39.64 E-value: 1.92e-04
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| UBA_4 | pfam14555 | UBA-like domain; |
52-85 | 2.12e-03 | ||
UBA-like domain; Pssm-ID: 464207 Cd Length: 43 Bit Score: 37.05 E-value: 2.12e-03
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| UBA_Gts1p_like | cd14400 | UBA domain found in Saccharomyces cerevisiae protein GTS1 (Gts1p) and similar proteins; Gts1p, ... |
50-88 | 2.36e-03 | ||
UBA domain found in Saccharomyces cerevisiae protein GTS1 (Gts1p) and similar proteins; Gts1p, also called protein LSR1, is encoded by a pleiotropic gene GTS1 in budding yeast. The formation of Gts1p-mediated protein aggregates may induce reactive oxygen species (ROS) production and apoptosis. Gts1p also plays an important role in the regulation of heat and other stress responses under glucose-limited or -depleted conditions in either batch or continuous culture. Gts1p contains an N-terminal zinc finger motif similar to that of GATA-transcription factors, a ubiquitin-associated (UBA) domain and a C-terminal glutamine-rich strand. The zinc finger is responsible for the binding to the glycolytic enzyme glyceraldehydes-3-phosphate dehydrogenase (GAPDH) which is required for the maintenance of the metabolic oscillations of budding yeast. The polyglutamine sequence is indispensable for the pleiotropy and nuclear localization of Gts1p. It is essential for the transcriptional activation, whereas Gts1p lacks DNA binding activity. Pssm-ID: 270583 Cd Length: 39 Bit Score: 36.84 E-value: 2.36e-03
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| UBA_scDdi1_like | cd14309 | UBA domain found in Saccharomyces cerevisiae DNA-damage response protein Ddi1 and similar ... |
52-88 | 6.16e-03 | ||
UBA domain found in Saccharomyces cerevisiae DNA-damage response protein Ddi1 and similar proteins; Ddi1, also called v-SNARE-master 1 (Vsm1), is a ubiquitin receptor involved in regulation of the cell cycle and late secretory pathway in Saccharomyces cerevisiae. It functions as a ubiquitin association domain (UBA)- ubiquitin-like-domain (UBL) shuttle protein that is required for the proteasome to enable ubiquitin-dependent degradation of its ligands. For instance, Ddi1 plays an essential role in the final stages of proteasomal degradation of Ho endonuclease and of its cognate FBP, Ufo1. Moreover, Ddi1 and its associated protein Rad23p play a cooperative role as negative regulators in yeast PHO pathway. Ddi1 contains an N-terminal UBL domain and a C-terminal UBA domain. It also harbors a central retroviral aspartyl-protease-like domain (RVP) which may be important in cell-cycle control. At this point, Ddi1 may function proteolytically during regulated protein turnover in the cell. This family also includes mammalian regulatory solute carrier protein family 1 member 1 (RSC1A1), also called transporter regulator RS1 (RS1) which mediates transcriptional and post-transcriptional regulation of Na(+)-D-glucose cotransporter SGLT1. Pssm-ID: 270494 Cd Length: 36 Bit Score: 35.58 E-value: 6.16e-03
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| UBA_AeNAC | cd14359 | UBA-like domain found in archaeal nascent polypeptide-associated complex homolog from ... |
52-84 | 7.55e-03 | ||
UBA-like domain found in archaeal nascent polypeptide-associated complex homolog from Methanothermobacter marburgensis (AeNAC) and similar proteins; AeNAC is a functional archaeal homolog of eukaryotic nascent polypeptide-associated complex (NAC). Both AeNAC and eukaryotic NAC function as the cytosolic chaperone that can bind to ribosomal RNA, interact with the nascent polypeptide chains as they emerge from the ribosome, and assist in post-translational processes. They all contain a NAC domain and an ubiquitin-associated (UBA) domain in the C-terminus. However, unlike eukaryotic NAC, AeNAC forms a ribosome associated homodimer, but not heterodimer. The NAC domain of AeNAC is responsible for the homodimer formation. Pssm-ID: 270542 [Multi-domain] Cd Length: 40 Bit Score: 35.28 E-value: 7.55e-03
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| UBA_VP13D | cd14306 | UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar ... |
55-90 | 7.98e-03 | ||
UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar proteins; VP13D is a chorea-acanthocytosis (CHAC)-similar protein encoded by gene VPS13D. it contains two putative domains, ubiquitin-associated (UBA) domain and lectin domain of ricin B chain profile (ricin-B-lectin), suggesting it may interact with, and be involved in the trafficking of, proteins modified with ubiquitin and/or carbohydrate molecules. Further investigation is required. Pssm-ID: 270491 Cd Length: 36 Bit Score: 35.11 E-value: 7.98e-03
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| UBA1_NUB1_like | cd14291 | UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also called ... |
52-85 | 9.40e-03 | ||
UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins; NUB1, also called negative regulator of ubiquitin-like proteins 1, renal carcinoma antigen NY-REN-18, or protein BS4, is a NEDD8-interacting protein that can be induced by interferon. It functions as a strong post-transcriptional down-regulator of the NEDD8 expression and plays critical roles in regulating many biological events, such as cell growth, NF-kappaB signaling, and biological responses to hypoxia. NUB1 can also interact with aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) which may function in the regulation of cell cycle progression. NUB1 contains three ubiquitin-associated domains (UBA), a bipartite nuclear localization signal (NLS) and a PEST motif. This model corresponds to UBA1 domain. Pssm-ID: 270477 [Multi-domain] Cd Length: 36 Bit Score: 34.73 E-value: 9.40e-03
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