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Conserved domains on  [gi|1694523173|ref|XP_029441235|]
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LOW QUALITY PROTEIN: zinc finger protein 665-like [Rhinatrema bivittatum]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB super family cl42959
krueppel associated box;
11-68 1.09e-13

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 66.46  E-value: 1.09e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1694523173   11 VTFRDVAAYFWEVEWDILGEWQKELYKKVIKEIHGVLMSRGYSILNPDVVFKIKKEDE 68
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEE 58
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
503-915 6.94e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 6.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 503 KPFKCSECDKCFTKKNSLKNHTTIHKGEKPFKCS--ECDKCFARMPELKNHKRRHTGEKPFKCSEC-----DKCFTCMST 575
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSlplsnSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 576 LKKHTRMhtgeKLFKCSECDKCFAQMSELKNHTRMHTgeKPFKCSECDKCFAKKSSLKSTQTIHTGEKPFKCSECDKCFv 655
Cdd:COG5048   112 SSSSNSN----DNNLLSSHSLPPSSRDPQLPDLLSIS--NLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNL- 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 656 qmtDLKNHKRMHTGEKpfkCSECDKCFTKKKQLKNHTTIHKGEKPFKCSVCDKCFARMPELKNHKRRHTGEKPFKCSECD 735
Cdd:COG5048   185 ---SLLISSNVSTSIP---SSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 736 KCFTCMSTLKKHTR---------MHTG-EKPFKCSECDKCFTQISQLNVHKRT--HTGE--KPFKCSE--CDKCFAQMSH 799
Cdd:COG5048   259 ESPRSSLPTASSQSsspnesdssSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDA 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 800 LNVHKRMHTGEKPFKC--SECDKCFAQISSLKSHKTIH-----TLEKPFKC--SECDRCFSEMLLLKRHKTVHTCEKP-- 868
Cdd:COG5048   339 LKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPyn 418

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 1694523173 869 FKCFECDKCFTKLSNLKRHIRVHTGEKPFKCSECDKcFTQLSTLKNH 915
Cdd:COG5048   419 CKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
11-68 1.09e-13

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 66.46  E-value: 1.09e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1694523173   11 VTFRDVAAYFWEVEWDILGEWQKELYKKVIKEIHGVLMSRGYSILNPDVVFKIKKEDE 68
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEE 58
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
503-915 6.94e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 6.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 503 KPFKCSECDKCFTKKNSLKNHTTIHKGEKPFKCS--ECDKCFARMPELKNHKRRHTGEKPFKCSEC-----DKCFTCMST 575
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSlplsnSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 576 LKKHTRMhtgeKLFKCSECDKCFAQMSELKNHTRMHTgeKPFKCSECDKCFAKKSSLKSTQTIHTGEKPFKCSECDKCFv 655
Cdd:COG5048   112 SSSSNSN----DNNLLSSHSLPPSSRDPQLPDLLSIS--NLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNL- 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 656 qmtDLKNHKRMHTGEKpfkCSECDKCFTKKKQLKNHTTIHKGEKPFKCSVCDKCFARMPELKNHKRRHTGEKPFKCSECD 735
Cdd:COG5048   185 ---SLLISSNVSTSIP---SSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 736 KCFTCMSTLKKHTR---------MHTG-EKPFKCSECDKCFTQISQLNVHKRT--HTGE--KPFKCSE--CDKCFAQMSH 799
Cdd:COG5048   259 ESPRSSLPTASSQSsspnesdssSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDA 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 800 LNVHKRMHTGEKPFKC--SECDKCFAQISSLKSHKTIH-----TLEKPFKC--SECDRCFSEMLLLKRHKTVHTCEKP-- 868
Cdd:COG5048   339 LKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPyn 418

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 1694523173 869 FKCFECDKCFTKLSNLKRHIRVHTGEKPFKCSECDKcFTQLSTLKNH 915
Cdd:COG5048   419 CKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 11-49 1.52e-10

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 56.79  E-value: 1.52e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1694523173  11 VTFRDVAAYFWEVEWDILGEWQKELYKKVIKEIHGVLMS 49
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 10-49 4.30e-10

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 55.55  E-value: 4.30e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1694523173  10 SVTFRDVAAYFWEVEWDILGEWQKELYKKVIKEIHGVLMS 49
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVS 40
zf-H2C2_2 pfam13465
Zinc-finger double domain;
883-908 3.76e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.76e-05
                          10        20
                  ....*....|....*....|....*.
gi 1694523173 883 NLKRHIRVHTGEKPFKCSECDKCFTQ 908
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
11-68 1.09e-13

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 66.46  E-value: 1.09e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1694523173   11 VTFRDVAAYFWEVEWDILGEWQKELYKKVIKEIHGVLMSRGYSILNPDVVFKIKKEDE 68
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEE 58
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
503-915 6.94e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 6.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 503 KPFKCSECDKCFTKKNSLKNHTTIHKGEKPFKCS--ECDKCFARMPELKNHKRRHTGEKPFKCSEC-----DKCFTCMST 575
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSlplsnSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 576 LKKHTRMhtgeKLFKCSECDKCFAQMSELKNHTRMHTgeKPFKCSECDKCFAKKSSLKSTQTIHTGEKPFKCSECDKCFv 655
Cdd:COG5048   112 SSSSNSN----DNNLLSSHSLPPSSRDPQLPDLLSIS--NLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNL- 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 656 qmtDLKNHKRMHTGEKpfkCSECDKCFTKKKQLKNHTTIHKGEKPFKCSVCDKCFARMPELKNHKRRHTGEKPFKCSECD 735
Cdd:COG5048   185 ---SLLISSNVSTSIP---SSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 736 KCFTCMSTLKKHTR---------MHTG-EKPFKCSECDKCFTQISQLNVHKRT--HTGE--KPFKCSE--CDKCFAQMSH 799
Cdd:COG5048   259 ESPRSSLPTASSQSsspnesdssSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDA 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 800 LNVHKRMHTGEKPFKC--SECDKCFAQISSLKSHKTIH-----TLEKPFKC--SECDRCFSEMLLLKRHKTVHTCEKP-- 868
Cdd:COG5048   339 LKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPyn 418

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 1694523173 869 FKCFECDKCFTKLSNLKRHIRVHTGEKPFKCSECDKcFTQLSTLKNH 915
Cdd:COG5048   419 CKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 11-49 1.52e-10

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 56.79  E-value: 1.52e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1694523173  11 VTFRDVAAYFWEVEWDILGEWQKELYKKVIKEIHGVLMS 49
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 10-49 4.30e-10

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 55.55  E-value: 4.30e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1694523173  10 SVTFRDVAAYFWEVEWDILGEWQKELYKKVIKEIHGVLMS 49
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVS 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
347-732 2.93e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 2.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 347 PMNTKLTTHAKDHLQKKPLKCTQCEQCFFFQAEMEGHVRIHSGERPFQC--PECEERFTEKSNLRKHKKIHRQDQPCKCS 424
Cdd:COG5048    16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 425 QCEKcfryrswLKVHQRSHKGEKSFIWSECDKDLCQKCSLGKHTN-----------------IHTGTKPFKCSECDKCFV 487
Cdd:COG5048    96 KSLP-------LSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRdpqlpdllsisnlrnnpLPGNNSSSVNTPQSNSLH 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 488 QMTDLKNHKRMHTGEKPF----------KCSECDKCFTKKNSLKNHTTIHKGEKPFKCSECDKCFARMPELKNHKRRHTG 557
Cdd:COG5048   169 PPLPANSLSKDPSSNLSLlissnvstsiPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 558 EKPFKCSECDKCFTCMSTLKKHTR---------MHTGEKL-FKCSECDKCFAQMSELKNHTRM--HTGE--KPFKCSE-- 621
Cdd:COG5048   249 SSSDSSSSASESPRSSLPTASSQSsspnesdssSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYsl 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 622 CDKCFAKKSSLKSTQTIHTGEKPFKC--SECDKCFVQMTDLKNHKRMH-----TGEKPFKC--SECDKCFTKKKQLKNHT 692
Cdd:COG5048   329 CGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHI 408

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1694523173 693 TIHKGEKP--FKCSVCDKCFARMPELKNHKRRHTGEKPFKCS 732
Cdd:COG5048   409 ITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
883-908 3.76e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.76e-05
                          10        20
                  ....*....|....*....|....*.
gi 1694523173 883 NLKRHIRVHTGEKPFKCSECDKCFTQ 908
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
643-921 4.66e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 4.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 643 KPFKCSECDKCFVQMTDLKNHKRMHTGEKPFKCS--ECDKCFTKKKQLKNHTTIHKGEKPFKCSvcDKCFARMPELKNHK 720
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 721 RRHTGEKPFKCSECDKC---------------FTCMSTLKKHTRMHTGEKPFKCS----------ECDKCFTQISQLNVH 775
Cdd:COG5048   110 LSSSSSNSNDNNLLSSHslppssrdpqlpdllSISNLRNNPLPGNNSSSVNTPQSnslhpplpanSLSKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 776 KRTHTGEKPFKCSECDKCFAQMSHLNVHKRMHTGEKPFKCSECDKCFAQISSLKSHKTIHTLEKPFKCSECDRCFSEMLL 855
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1694523173 856 LKRHKTVHTCE-------KPFKCFECDKCFTKLSNLKRHIR--VHTGE--KPFKCSE--CDKCFTQLSTLKNHKTVHTG 921
Cdd:COG5048   270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
547-572 1.70e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.70e-04
                          10        20
                  ....*....|....*....|....*.
gi 1694523173 547 ELKNHKRRHTGEKPFKCSECDKCFTC 572
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
715-740 1.70e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.70e-04
                          10        20
                  ....*....|....*....|....*.
gi 1694523173 715 ELKNHKRRHTGEKPFKCSECDKCFTC 740
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
744-768 2.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.45e-04
                          10        20
                  ....*....|....*....|....*
gi 1694523173 744 LKKHTRMHTGEKPFKCSECDKCFTQ 768
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
799-824 2.60e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.60e-04
                          10        20
                  ....*....|....*....|....*.
gi 1694523173 799 HLNVHKRMHTGEKPFKCSECDKCFAQ 824
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
491-516 3.32e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.32e-04
                          10        20
                  ....*....|....*....|....*.
gi 1694523173 491 DLKNHKRMHTGEKPFKCSECDKCFTK 516
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
659-684 3.32e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.32e-04
                          10        20
                  ....*....|....*....|....*.
gi 1694523173 659 DLKNHKRMHTGEKPFKCSECDKCFTK 684
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
772-796 4.68e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.68e-04
                          10        20
                  ....*....|....*....|....*
gi 1694523173 772 LNVHKRTHTGEKPFKCSECDKCFAQ 796
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
603-628 4.77e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.77e-04
                          10        20
                  ....*....|....*....|....*.
gi 1694523173 603 ELKNHTRMHTGEKPFKCSECDKCFAK 628
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 501-584 1.30e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 501 GEKPFKCS--ECDKCFTKKNSLKNHTtihkgekpfKCSECDKCFARMPELKNHKRRHTGEKPFKCSECDKCFTCMSTLKK 578
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1694523173 579 HtRMHT 584
Cdd:COG5189   417 H-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 696-780 1.44e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 696 KGEKPFKCSV--CDKCFARMPELKNHKrrhtgekpfKCSECDKCFTCMSTLKKHTRMHTGEKPFKCSECDKCFTQISQLN 773
Cdd:COG5189   345 KDGKPYKCPVegCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 1694523173 774 VHkRTHT 780
Cdd:COG5189   416 YH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 641-724 2.33e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 2.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694523173 641 GEKPFKCS--ECDKCFVQMTDLKNHKrmhtgekpfKCSECDKCFTKKKQLKNHTTIHKGEKPFKCSVCDKCFARMPELKN 718
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1694523173 719 HkRRHT 724
Cdd:COG5189   417 H-RKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 869-891 2.89e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.89e-03
                          10        20
                  ....*....|....*....|...
gi 1694523173 869 FKCFECDKCFTKLSNLKRHIRVH 891
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
576-600 3.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.43e-03
                          10        20
                  ....*....|....*....|....*
gi 1694523173 576 LKKHTRMHTGEKLFKCSECDKCFAQ 600
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
519-544 5.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.56e-03
                          10        20
                  ....*....|....*....|....*.
gi 1694523173 519 SLKNHTTIHKGEKPFKCSECDKCFAR 544
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
688-712 9.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 9.18e-03
                          10        20
                  ....*....|....*....|....*
gi 1694523173 688 LKNHTTIHKGEKPFKCSVCDKCFAR 712
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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