NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1720428379|ref|XP_030099636|]
View 

probable cysteine--tRNA ligase, mitochondrial isoform X5 [Mus musculus]

Protein Classification

cysteine--tRNA ligase( domain architecture ID 1002819)

cysteine--tRNA ligase catalyzes the attachment of cysteine to tRNA(Cys)

EC:  6.1.1.16
Gene Ontology:  GO:0005524|GO:0006423|GO:0004817|GO:0046872|GO:0000049

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PTZ00399 super family cl36555
cysteinyl-tRNA-synthetase; Provisional
 8-498 1.95e-125

cysteinyl-tRNA-synthetase; Provisional


The actual alignment was detected with superfamily member PTZ00399:

Pssm-ID: 240402 [Multi-domain]  Cd Length: 651  Bit Score: 380.14  E-value: 1.95e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379   8 LASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYStATGSVYFDLHA-RGDK--YGKL----VNTV 80
Cdd:PTZ00399  128 LARKWEKEFFEDMKALNVRPPDVITRVSEYVPEIVDFIQKIIDNGFAYE-SNGSVYFDVEAfRKAGhvYPKLepesVADE 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379  81 pSATAEPAGD-----SDKRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHEN 155
Cdd:PTZ00399  207 -DRIAEGEGAlgkvsGEKRSPNDFALWKASKPGEPSWDSPWGKGRPGWHIECSAMASNILGDPIDIHSGGIDLKFPHHDN 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 156 EIAQSEVFHQCQQWGNYFLHSGHLHVKGteEKMSKSLKNYITIKDCrlsgrslldsclhccfdsiaepsrgpkgkqdlpl 235
Cdd:PTZ00399  286 ELAQSEAYFDKHQWVNYFLHSGHLHIKG--LKMSKSLKNFITIRQA---------------------------------- 329

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 236 rcdlhggttdpvhilhkgllnrvtqlpfwskdfLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAKHLLLGLASFVEDAR 315
Cdd:PTZ00399  330 ---------------------------------LSKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVK 376

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 316 AYVKGQLTCGPVEEDV----LWERLTSTKKAVKAALANDFDTPRAVNTILDLVHHANRQLRAVSKeasgPRSPTVFgAII 391
Cdd:PTZ00399  377 IKLRESELTSPQKWTQhdfeLNELFEETKSAVHAALLDNFDTPEALQALQKLISATNTYLNSGEQ----PSAPLLR-SVA 451

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 392 SYVEQFFETVGISLANRQC-VSGDSSTV-TLRCVVDELVRFRLKVRQYAldtpgAAGEARKRQLQERQPLLEACDTLR-Q 468
Cdd:PTZ00399  452 QYVTKILSIFGLVEGSDGLgSQGQNSTSeNFKPLLEALLRFRDEVRDAA-----KAEMKLISLDKKKKQLLQLCDKLRdE 526

                         490       500       510
                  ....*....|....*....|....*....|....
gi 1720428379 469 DLVTHGINVKDRGSAASTWELLDP----RTRHQK 498
Cdd:PTZ00399  527 WLPNLGIRIEDKPDGPSVWKLDDKeelqREKEEK 560
 
Name Accession Description Interval E-value
PTZ00399 PTZ00399
cysteinyl-tRNA-synthetase; Provisional
 8-498 1.95e-125

cysteinyl-tRNA-synthetase; Provisional


Pssm-ID: 240402 [Multi-domain]  Cd Length: 651  Bit Score: 380.14  E-value: 1.95e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379   8 LASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYStATGSVYFDLHA-RGDK--YGKL----VNTV 80
Cdd:PTZ00399  128 LARKWEKEFFEDMKALNVRPPDVITRVSEYVPEIVDFIQKIIDNGFAYE-SNGSVYFDVEAfRKAGhvYPKLepesVADE 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379  81 pSATAEPAGD-----SDKRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHEN 155
Cdd:PTZ00399  207 -DRIAEGEGAlgkvsGEKRSPNDFALWKASKPGEPSWDSPWGKGRPGWHIECSAMASNILGDPIDIHSGGIDLKFPHHDN 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 156 EIAQSEVFHQCQQWGNYFLHSGHLHVKGteEKMSKSLKNYITIKDCrlsgrslldsclhccfdsiaepsrgpkgkqdlpl 235
Cdd:PTZ00399  286 ELAQSEAYFDKHQWVNYFLHSGHLHIKG--LKMSKSLKNFITIRQA---------------------------------- 329

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 236 rcdlhggttdpvhilhkgllnrvtqlpfwskdfLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAKHLLLGLASFVEDAR 315
Cdd:PTZ00399  330 ---------------------------------LSKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVK 376

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 316 AYVKGQLTCGPVEEDV----LWERLTSTKKAVKAALANDFDTPRAVNTILDLVHHANRQLRAVSKeasgPRSPTVFgAII 391
Cdd:PTZ00399  377 IKLRESELTSPQKWTQhdfeLNELFEETKSAVHAALLDNFDTPEALQALQKLISATNTYLNSGEQ----PSAPLLR-SVA 451

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 392 SYVEQFFETVGISLANRQC-VSGDSSTV-TLRCVVDELVRFRLKVRQYAldtpgAAGEARKRQLQERQPLLEACDTLR-Q 468
Cdd:PTZ00399  452 QYVTKILSIFGLVEGSDGLgSQGQNSTSeNFKPLLEALLRFRDEVRDAA-----KAEMKLISLDKKKKQLLQLCDKLRdE 526

                         490       500       510
                  ....*....|....*....|....*....|....
gi 1720428379 469 DLVTHGINVKDRGSAASTWELLDP----RTRHQK 498
Cdd:PTZ00399  527 WLPNLGIRIEDKPDGPSVWKLDDKeelqREKEEK 560
CysS COG0215
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ...
 2-489 3.33e-122

Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439985 [Multi-domain]  Cd Length: 465  Bit Score: 365.58  E-value: 3.33e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379   2 NVTPASLASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYsTATGSVYFDLhARGDKYGKLVNTVP 81
Cdd:COG0215    82 GESIWELAERYIAAFHEDMDALGVLPPDIEPRATEHIPEMIELIERLIEKGHAY-EADGDVYFDV-RSFPDYGKLSGRNL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379  82 S---ATAEPAGDSDKRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIA 158
Cdd:COG0215   160 DdlrAGARVEVDEEKRDPLDFALWKAAKPGEPSWDSPWGRGRPGWHIECSAMSTKYLGETFDIHGGGIDLIFPHHENEIA 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 159 QSEVFHqCQQWGNYFLHSGHLHVKGteEKMSKSLKNYITIkdcrlsgrslldsclhccfdsiaepsrgpkgkqdlplrcd 238
Cdd:COG0215   240 QSEAAT-GKPFARYWMHNGFLTVNG--EKMSKSLGNFFTV---------------------------------------- 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 239 lhggttdpvhilhkgllnrvtqlpfwsKDFLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAKHLLLGLASFVEDARAYV 318
Cdd:COG0215   277 ---------------------------RDLLKKYDPEVLRFFLLSAHYRSPLDFSEEALEEAEKALERLYNALRRLEEAL 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 319 KgqltcgpvEEDVLWERLTSTKKAVKAALANDFDTPRAVNTILDLVHHANRQLravskeaSGPRSPTVFGAIISYVEQFF 398
Cdd:COG0215   330 G--------AADSSAEEIEELREEFIAAMDDDFNTPEALAVLFELVREINKAL-------DEGEDKAALAALAALLRALG 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 399 ETVGISLANRQCVSGDSSTVtlrcVVDELVRFRLKVRQyaldtpgaagEARKRQLQERqplleAcDTLRQDLVTHGINVK 478
Cdd:COG0215   395 GVLGLLLLEPEAWQGAAEDE----LLDALIEALIEERA----------EARKAKDFAR-----A-DRIRDELAALGIVLE 454

                         490
                  ....*....|.
gi 1720428379 479 DrGSAASTWEL 489
Cdd:COG0215   455 D-TPDGTTWRR 464
tRNA-synt_1e pfam01406
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ...
 8-301 1.70e-90

tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.


Pssm-ID: 396128 [Multi-domain]  Cd Length: 301  Bit Score: 278.48  E-value: 1.70e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379   8 LASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYSTATGSVYFDLHArGDKYGKLVNTVPS---AT 84
Cdd:pfam01406  75 LAARFIEAYTKDMDALNVLPPDLEPRVTEHIDEIIEFIERLIKKGYAYVSDNGDVYFDVSS-FPDYGKLSGQNLEqleAG 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379  85 AEPAGDSDKRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIAQSEVFH 164
Cdd:pfam01406 154 ARGEVSEGKRDPLDFALWKASKEGEPSWDSPWGKGRPGWHIECSAMARKYLGDQIDIHGGGIDLAFPHHENEIAQSEAAF 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 165 QcQQWGNYFLHSGHLHVKGteEKMSKSLKNYITIkdcrlsgrslldsclhccfdsiaepsrgpkgkqdlplrcdlhggtt 244
Cdd:pfam01406 234 D-KQLANYWLHNGHVMIDG--EKMSKSLGNFFTI---------------------------------------------- 264

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720428379 245 dpvhilhkgllnrvtqlpfwsKDFLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAK 301
Cdd:pfam01406 265 ---------------------RDVLKRYDPEILRYFLLSVHYRSPLDFSEELLEQAK 300
cysS TIGR00435
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not ...
 2-368 4.95e-90

cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not from all species. The enzyme from one archaeal species, Archaeoglobus fulgidus, is found but the equivalent enzymes from some other Archaea, including Methanococcus jannaschii, are not found, although biochemical evidence suggests that tRNA(Cys) in these species are charged directly with Cys rather than through a misacylation and correction pathway as for tRNA(Gln). [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273076 [Multi-domain]  Cd Length: 464  Bit Score: 283.12  E-value: 4.95e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379   2 NVTPASLASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYSTATGSVYFDLHARgDKYGKLVN-TV 80
Cdd:TIGR00435  81 GESVYEVSERFIEAYFEDMKALNVLPPDLEPRATEHIDEIIEFIEQLIEKGYAYVSDNGDVYFDVSKF-KDYGKLSKqDL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379  81 PSATAEPAGDSD--KRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIA 158
Cdd:TIGR00435 160 DQLEAGARVDVDeaKRNKLDFVLWKSSKEGEPKWDSPWGKGRPGWHIECSAMNDKYLGDQIDIHGGGVDLIFPHHENEIA 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 159 QSEVFHQcQQWGNYFLHSGHLHVKGteEKMSKSLKNYITIkdcrlsgrslldsclhccfdsiaepsrgpkgkqdlplrcd 238
Cdd:TIGR00435 240 QSEAAFG-KQLAKYWMHNGFLMIDN--EKMSKSLGNFFTV---------------------------------------- 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 239 lhggttdpvhilhkgllnrvtqlpfwsKDFLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAK----HLLLGLASFVEDA 314
Cdd:TIGR00435 277 ---------------------------RDVLKNYDPEILRYFLLSVHYRSPLDFSEELLEAAKnaleRLYKALRVLDTSL 329

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720428379 315 rAYVKGQ-LTCGPVEEDVlwerltstKKAVKAALANDFDTPRAVNTILDLVHHAN 368
Cdd:TIGR00435 330 -AYSGNQsLNKFPDEKEF--------EARFVEAMDDDLNTANALAVLFELAKSIN 375
CysRS_core cd00672
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ...
 1-293 1.87e-49

catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173899 [Multi-domain]  Cd Length: 213  Bit Score: 168.91  E-value: 1.87e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379   1 MNVTPASLASLFEEEFKQDMAALKVLPPTVYLRVtenipqiiafiegiiahghaystatgsvyfdlhargdkygklvntv 80
Cdd:cd00672    79 EGLSWKEVADYYTKEFFEDMKALNVLPPDVVPRV---------------------------------------------- 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379  81 psataepagdsdkrhssdfalwkaakpqevfwaspwgdgrpgWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIAQS 160
Cdd:cd00672   113 ------------------------------------------WHIECSAMAMKYLGETFDIHGGGVDLIFPHHENEIAQS 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 161 EVFHQCqQWGNYFLHSGHLHVKGteEKMSKSLKNYITIkdcrlsgrslldsclhccfdsiaepsrgpkgkqdlplrcdlh 240
Cdd:cd00672   151 EAATGK-PFARYWLHTGHLTIDG--EKMSKSLGNFITV------------------------------------------ 185

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720428379 241 ggttdpvhilhkgllnrvtqlpfwsKDFLKTFSPDVFRLFCLRTNYRSAIEYS 293
Cdd:cd00672   186 -------------------------RDALKKYDPEVLRLALLSSHYRSPLDFS 213
 
Name Accession Description Interval E-value
PTZ00399 PTZ00399
cysteinyl-tRNA-synthetase; Provisional
 8-498 1.95e-125

cysteinyl-tRNA-synthetase; Provisional


Pssm-ID: 240402 [Multi-domain]  Cd Length: 651  Bit Score: 380.14  E-value: 1.95e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379   8 LASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYStATGSVYFDLHA-RGDK--YGKL----VNTV 80
Cdd:PTZ00399  128 LARKWEKEFFEDMKALNVRPPDVITRVSEYVPEIVDFIQKIIDNGFAYE-SNGSVYFDVEAfRKAGhvYPKLepesVADE 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379  81 pSATAEPAGD-----SDKRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHEN 155
Cdd:PTZ00399  207 -DRIAEGEGAlgkvsGEKRSPNDFALWKASKPGEPSWDSPWGKGRPGWHIECSAMASNILGDPIDIHSGGIDLKFPHHDN 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 156 EIAQSEVFHQCQQWGNYFLHSGHLHVKGteEKMSKSLKNYITIKDCrlsgrslldsclhccfdsiaepsrgpkgkqdlpl 235
Cdd:PTZ00399  286 ELAQSEAYFDKHQWVNYFLHSGHLHIKG--LKMSKSLKNFITIRQA---------------------------------- 329

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 236 rcdlhggttdpvhilhkgllnrvtqlpfwskdfLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAKHLLLGLASFVEDAR 315
Cdd:PTZ00399  330 ---------------------------------LSKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVK 376

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 316 AYVKGQLTCGPVEEDV----LWERLTSTKKAVKAALANDFDTPRAVNTILDLVHHANRQLRAVSKeasgPRSPTVFgAII 391
Cdd:PTZ00399  377 IKLRESELTSPQKWTQhdfeLNELFEETKSAVHAALLDNFDTPEALQALQKLISATNTYLNSGEQ----PSAPLLR-SVA 451

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 392 SYVEQFFETVGISLANRQC-VSGDSSTV-TLRCVVDELVRFRLKVRQYAldtpgAAGEARKRQLQERQPLLEACDTLR-Q 468
Cdd:PTZ00399  452 QYVTKILSIFGLVEGSDGLgSQGQNSTSeNFKPLLEALLRFRDEVRDAA-----KAEMKLISLDKKKKQLLQLCDKLRdE 526

                         490       500       510
                  ....*....|....*....|....*....|....
gi 1720428379 469 DLVTHGINVKDRGSAASTWELLDP----RTRHQK 498
Cdd:PTZ00399  527 WLPNLGIRIEDKPDGPSVWKLDDKeelqREKEEK 560
CysS COG0215
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ...
 2-489 3.33e-122

Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439985 [Multi-domain]  Cd Length: 465  Bit Score: 365.58  E-value: 3.33e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379   2 NVTPASLASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYsTATGSVYFDLhARGDKYGKLVNTVP 81
Cdd:COG0215    82 GESIWELAERYIAAFHEDMDALGVLPPDIEPRATEHIPEMIELIERLIEKGHAY-EADGDVYFDV-RSFPDYGKLSGRNL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379  82 S---ATAEPAGDSDKRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIA 158
Cdd:COG0215   160 DdlrAGARVEVDEEKRDPLDFALWKAAKPGEPSWDSPWGRGRPGWHIECSAMSTKYLGETFDIHGGGIDLIFPHHENEIA 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 159 QSEVFHqCQQWGNYFLHSGHLHVKGteEKMSKSLKNYITIkdcrlsgrslldsclhccfdsiaepsrgpkgkqdlplrcd 238
Cdd:COG0215   240 QSEAAT-GKPFARYWMHNGFLTVNG--EKMSKSLGNFFTV---------------------------------------- 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 239 lhggttdpvhilhkgllnrvtqlpfwsKDFLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAKHLLLGLASFVEDARAYV 318
Cdd:COG0215   277 ---------------------------RDLLKKYDPEVLRFFLLSAHYRSPLDFSEEALEEAEKALERLYNALRRLEEAL 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 319 KgqltcgpvEEDVLWERLTSTKKAVKAALANDFDTPRAVNTILDLVHHANRQLravskeaSGPRSPTVFGAIISYVEQFF 398
Cdd:COG0215   330 G--------AADSSAEEIEELREEFIAAMDDDFNTPEALAVLFELVREINKAL-------DEGEDKAALAALAALLRALG 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 399 ETVGISLANRQCVSGDSSTVtlrcVVDELVRFRLKVRQyaldtpgaagEARKRQLQERqplleAcDTLRQDLVTHGINVK 478
Cdd:COG0215   395 GVLGLLLLEPEAWQGAAEDE----LLDALIEALIEERA----------EARKAKDFAR-----A-DRIRDELAALGIVLE 454

                         490
                  ....*....|.
gi 1720428379 479 DrGSAASTWEL 489
Cdd:COG0215   455 D-TPDGTTWRR 464
tRNA-synt_1e pfam01406
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ...
 8-301 1.70e-90

tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.


Pssm-ID: 396128 [Multi-domain]  Cd Length: 301  Bit Score: 278.48  E-value: 1.70e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379   8 LASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYSTATGSVYFDLHArGDKYGKLVNTVPS---AT 84
Cdd:pfam01406  75 LAARFIEAYTKDMDALNVLPPDLEPRVTEHIDEIIEFIERLIKKGYAYVSDNGDVYFDVSS-FPDYGKLSGQNLEqleAG 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379  85 AEPAGDSDKRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIAQSEVFH 164
Cdd:pfam01406 154 ARGEVSEGKRDPLDFALWKASKEGEPSWDSPWGKGRPGWHIECSAMARKYLGDQIDIHGGGIDLAFPHHENEIAQSEAAF 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 165 QcQQWGNYFLHSGHLHVKGteEKMSKSLKNYITIkdcrlsgrslldsclhccfdsiaepsrgpkgkqdlplrcdlhggtt 244
Cdd:pfam01406 234 D-KQLANYWLHNGHVMIDG--EKMSKSLGNFFTI---------------------------------------------- 264

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720428379 245 dpvhilhkgllnrvtqlpfwsKDFLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAK 301
Cdd:pfam01406 265 ---------------------RDVLKRYDPEILRYFLLSVHYRSPLDFSEELLEQAK 300
cysS TIGR00435
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not ...
 2-368 4.95e-90

cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not from all species. The enzyme from one archaeal species, Archaeoglobus fulgidus, is found but the equivalent enzymes from some other Archaea, including Methanococcus jannaschii, are not found, although biochemical evidence suggests that tRNA(Cys) in these species are charged directly with Cys rather than through a misacylation and correction pathway as for tRNA(Gln). [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273076 [Multi-domain]  Cd Length: 464  Bit Score: 283.12  E-value: 4.95e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379   2 NVTPASLASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYSTATGSVYFDLHARgDKYGKLVN-TV 80
Cdd:TIGR00435  81 GESVYEVSERFIEAYFEDMKALNVLPPDLEPRATEHIDEIIEFIEQLIEKGYAYVSDNGDVYFDVSKF-KDYGKLSKqDL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379  81 PSATAEPAGDSD--KRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIA 158
Cdd:TIGR00435 160 DQLEAGARVDVDeaKRNKLDFVLWKSSKEGEPKWDSPWGKGRPGWHIECSAMNDKYLGDQIDIHGGGVDLIFPHHENEIA 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 159 QSEVFHQcQQWGNYFLHSGHLHVKGteEKMSKSLKNYITIkdcrlsgrslldsclhccfdsiaepsrgpkgkqdlplrcd 238
Cdd:TIGR00435 240 QSEAAFG-KQLAKYWMHNGFLMIDN--EKMSKSLGNFFTV---------------------------------------- 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 239 lhggttdpvhilhkgllnrvtqlpfwsKDFLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAK----HLLLGLASFVEDA 314
Cdd:TIGR00435 277 ---------------------------RDVLKNYDPEILRYFLLSVHYRSPLDFSEELLEAAKnaleRLYKALRVLDTSL 329

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720428379 315 rAYVKGQ-LTCGPVEEDVlwerltstKKAVKAALANDFDTPRAVNTILDLVHHAN 368
Cdd:TIGR00435 330 -AYSGNQsLNKFPDEKEF--------EARFVEAMDDDLNTANALAVLFELAKSIN 375
PLN02946 PLN02946
cysteine-tRNA ligase
 5-199 2.99e-57

cysteine-tRNA ligase


Pssm-ID: 178532 [Multi-domain]  Cd Length: 557  Bit Score: 199.39  E-value: 2.99e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379   5 PASLASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYSTAtGSVYFDLHaRGDKYGKLVNTV---P 81
Cdd:PLN02946  143 PISLSRRYCEEFLSDMAYLHCLPPSVEPRVSDHIPQIIDMIKQILDNGCAYRVD-GDVYFSVD-KFPEYGKLSGRKledN 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379  82 SATAEPAGDSDKRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIAQSE 161
Cdd:PLN02946  221 RAGERVAVDSRKKNPADFALWKAAKEGEPFWDSPWGPGRPGWHIECSAMSAAYLGHSFDIHGGGMDLVFPHHENEIAQSC 300

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1720428379 162 VfHQCQQWGNYFLHSGHLHVKgtEEKMSKSLKNYITIK 199
Cdd:PLN02946  301 A-ACCDSNISYWIHNGFVTVD--SEKMSKSLGNFFTIR 335
cysS PRK14535
cysteinyl-tRNA synthetase; Provisional
 4-387 1.26e-53

cysteinyl-tRNA synthetase; Provisional


Pssm-ID: 173001 [Multi-domain]  Cd Length: 699  Bit Score: 192.24  E-value: 1.26e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379   4 TPASLASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYSTATGSVYF---DLHARGDKYGKLVNTV 80
Cdd:PRK14535  310 TIGELTARFIQAMHEDADALGVLRPDIEPKATENIPQMIAMIETLIQNGKAYPAANGDVYYavrEFAAYGQLSGKSLDDL 389

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379  81 pSATAEPAGDSDKRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIAQS 160
Cdd:PRK14535  390 -RAGERVEVDGFKRDPLDFVLWKAAKAGEPAWESPWGNGRPGWHIECSAMSENLFGDTFDIHGGGADLQFPHHENEIAQS 468

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 161 --EVFHQCQQWG-------------NYFLHSGHLHVKGteEKMSKSLKNYITIKDCrlsgrslldsclhccfdsiaepsr 225
Cdd:PRK14535  469 vgATGHTCGHHHaqthhgqsiashvKYWLHNGFIRVDG--EKMSKSLGNFFTIREV------------------------ 522

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 226 gpkgkqdlplrcdlhggttdpvhilhkgllnrvtqlpfwskdfLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAKHLLL 305
Cdd:PRK14535  523 -------------------------------------------LKQYDPEVVRFFILRAHYRSPLNYSDAHLDDAKGALT 559

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 306 GLASFVEDArayvkgqltcgPVEEDVLWERLTSTKKAVKAALANDFDTPRAVNTILDLVHHANR----QLRAVSKEASG- 380
Cdd:PRK14535  560 RLYTTLKNT-----------PAAEFMLSENVNDYTRRFYAAMNDDFGTVEAVAVLFELAGEVNKtndaQLAGCLKALGGi 628

                         410
                  ....*....|.
gi 1720428379 381 ----PRSPTVF 387
Cdd:PRK14535  629 igllQRDPTEF 639
CysRS_core cd00672
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ...
 1-293 1.87e-49

catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173899 [Multi-domain]  Cd Length: 213  Bit Score: 168.91  E-value: 1.87e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379   1 MNVTPASLASLFEEEFKQDMAALKVLPPTVYLRVtenipqiiafiegiiahghaystatgsvyfdlhargdkygklvntv 80
Cdd:cd00672    79 EGLSWKEVADYYTKEFFEDMKALNVLPPDVVPRV---------------------------------------------- 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379  81 psataepagdsdkrhssdfalwkaakpqevfwaspwgdgrpgWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIAQS 160
Cdd:cd00672   113 ------------------------------------------WHIECSAMAMKYLGETFDIHGGGVDLIFPHHENEIAQS 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 161 EVFHQCqQWGNYFLHSGHLHVKGteEKMSKSLKNYITIkdcrlsgrslldsclhccfdsiaepsrgpkgkqdlplrcdlh 240
Cdd:cd00672   151 EAATGK-PFARYWLHTGHLTIDG--EKMSKSLGNFITV------------------------------------------ 185

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720428379 241 ggttdpvhilhkgllnrvtqlpfwsKDFLKTFSPDVFRLFCLRTNYRSAIEYS 293
Cdd:cd00672   186 -------------------------RDALKKYDPEVLRLALLSSHYRSPLDFS 213
PRK12418 PRK12418
cysteinyl-tRNA synthetase; Provisional
 16-360 1.62e-47

cysteinyl-tRNA synthetase; Provisional


Pssm-ID: 183518 [Multi-domain]  Cd Length: 384  Bit Score: 168.96  E-value: 1.62e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379  16 FKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAY---STATGSVYFDLHARGDkYGKLVN----TVPSATAEPA 88
Cdd:PRK12418   83 FREDMEALRVLPPRDYVGAVESIPEVVELVEKLLASGAAYvvdDEEYPDVYFSVDATPQ-FGYESGydraTMLELFAERG 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379  89 GDSD---KRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIAQSEVFHQ 165
Cdd:PRK12418  162 GDPDrpgKRDPLDALLWRAARPGEPSWPSPFGPGRPGWHIECSAIALNRLGSGFDIQGGGSDLIFPHHEFSAAHAEAATG 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 166 CQQWGNYFLHSGHLHVKGteEKMSKSLKNYITIKDCRLSGrslldsclhccfdsiaepsrgpkgkqdlplrcdlhggtTD 245
Cdd:PRK12418  242 ERRFARHYVHAGMIGLDG--EKMSKSRGNLVFVSRLRAAG--------------------------------------VD 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 246 PVHIlhkgllnrvtqlpfwskdflktfspdvfRLFCLRTNYRSAIEYSDSTLVEAKHLLlglasfvEDARAYVKgqLTCG 325
Cdd:PRK12418  282 PAAI----------------------------RLALLAGHYRADREWTDAVLAEAEARL-------ARWRAAAA--LPAG 324

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1720428379 326 PVEEDVLwerltstkKAVKAALANDFDTPRAVNTI 360
Cdd:PRK12418  325 PDAADVV--------ARVRAALADDLDTPGALAAV 351
mycothiol_MshC TIGR03447
cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Members of this ...
 16-205 2.71e-45

cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Members of this protein family are MshC, l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, an enzyme that uses ATP to ligate a Cys residue to a mycothiol precursor molecule, in the second to last step in mycothiol biosynthesis. This enzyme shows considerable homology to Cys--tRNA ligases, and many instances are misannotated as such. Mycothiol is found in Mycobacterium tuberculosis, Corynebacterium glutamicum, Streptomyces coelicolor, and various other members of the Actinobacteria. Mycothiol is an analog to glutathione. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 132488 [Multi-domain]  Cd Length: 411  Bit Score: 163.74  E-value: 2.71e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379  16 FKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAY---STATGSVYFDLHArGDKYGKLVN----TVPSATAEPA 88
Cdd:TIGR03447 110 FREDMEALRVLPPRDYIGAVESIDEVVEMVEKLLASGAAYiveGPEYPDVYFSIDA-TEQFGYESGydraTMLELFAERG 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379  89 GDSD---KRHSSDFALWKAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIAQSEVFHQ 165
Cdd:TIGR03447 189 GDPDrpgKRDPLDALLWRAAREGEPSWDSPFGRGRPGWHIECSAIALNRLGAGFDIQGGGSDLIFPHHEFSAAHAEAATG 268

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1720428379 166 CQQWGNYFLHSGHLHVKGteEKMSKSLKNYITIKDCRLSG 205
Cdd:TIGR03447 269 VRRMARHYVHAGMIGLDG--EKMSKSLGNLVFVSKLRAAG 306
cysS PRK14536
cysteinyl-tRNA synthetase; Provisional
 8-364 3.99e-41

cysteinyl-tRNA synthetase; Provisional


Pssm-ID: 184731 [Multi-domain]  Cd Length: 490  Bit Score: 153.92  E-value: 3.99e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379   8 LASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYsTATGSVYFDLHARGDkYGKLVNTVPS---AT 84
Cdd:PRK14536   99 IAAHYTAAFFRDTARLNIERPSIVCNATEHIQDMIALIKRLEARGHTY-CAGGNVYFDIRTFPS-YGSLASAAVEdlqAG 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379  85 AEPAGDSDKRHSSDFALW---KAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIAQSE 161
Cdd:PRK14536  177 ARIEHDTNKRNPHDFVLWftrSKFENHALTWDSPWGRGYPGWHIECSAMSMKYLGEQCDIHIGGVDHIRVHHTNEIAQCE 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 162 VFhQCQQWGNYFLHSGHLHVKgtEEKMSKSLKNYITIKDcrlsgrslldsclhccfdsiaepsrgpkgkqdlplrcdlhg 241
Cdd:PRK14536  257 AA-TGKPWVRYWLHHEFLLMN--KGKMSKSAGQFLTLSS----------------------------------------- 292

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379 242 gttdpvhILHKGllnrvtqlpfwskdflktFSPDVFRLFCLRTNYRSAIEYSDSTLVEAK----HLLLGLASFVEDARAY 317
Cdd:PRK14536  293 -------LQEKG------------------FQPLDYRFFLLGGHYRSQLAFSWEALKTAKaarrSLVRRVARVVDAARAT 347

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720428379 318 ---VKGQLTcgpveeDVLWERLTSTKKA--------VKAALANDFDTPRAVNTILDLV 364
Cdd:PRK14536  348 tgsVRGTLA------ECAAERVAESRASesellltdFRAALEDDFSTPKALSELQKLV 399
cysS PRK14534
cysteinyl-tRNA synthetase; Provisional
 3-210 2.67e-34

cysteinyl-tRNA synthetase; Provisional


Pssm-ID: 173000 [Multi-domain]  Cd Length: 481  Bit Score: 134.59  E-value: 2.67e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379   3 VTPASLASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYsTATGSVYFDLhARGDKYGK-----LV 77
Cdd:PRK14534   92 LTVYEISRFFTEAFFDDCKKLNIVYPDKVLVASEYIPIMIEVVKVLEENGFTY-FVNGNVYFDT-SCFKSYGQmaginLN 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428379  78 NTVPSATAEPAGDSDKRHSSDFALW---KAAKPQEVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHE 154
Cdd:PRK14534  170 DFKDMSVSRVEIDKSKRNKSDFVLWftnSKFKDQEMKWDSPWGFGYPSWHLECAAMNLEYFKSTLDIHLGGVDHIGVHHI 249

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720428379 155 NEIAQSEVFHQcQQWGNYFLHSGHLHVKgtEEKMSKSLKNYITIKDCRLSGRSLLD 210
Cdd:PRK14534  250 NEIAIAECYLN-KKWCDMFVHGEFLIME--YEKMSKSNNNFITIKDLEDQGFSPLD 302
class_I_aaRS_core cd00802
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ...
 122-192 1.35e-04

catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173901 [Multi-domain]  Cd Length: 143  Bit Score: 42.08  E-value: 1.35e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720428379 122 GWHIECSTMASEVFGSHLDIHTGGIDLAFpHHENEIAQSEVFHqcQQWGNYFLHSGHLHVKGTeEKMSKSL 192
Cdd:cd00802    77 EYMFLQAADFLLLYETECDIHLGGSDQLG-HIELGLELLKKAG--GPARPFGLTFGRVMGADG-TKMSKSK 143
DALR_2 pfam09190
DALR domain; This DALR domain is found in cysteinyl-tRNA-synthetases.
 342-378 2.15e-03

DALR domain; This DALR domain is found in cysteinyl-tRNA-synthetases.


Pssm-ID: 462711 [Multi-domain]  Cd Length: 63  Bit Score: 36.41  E-value: 2.15e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1720428379 342 AVKAALANDFDTPRAVNTILDLVHHANRQLRAVSKEA 378
Cdd:pfam09190   1 KFIEAMDDDFNTPEALAVLFELAKEINRALKTNDAEA 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH