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Conserved domains on  [gi|1720428389|ref|XP_030099641|]
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probable cysteine--tRNA ligase, mitochondrial isoform X9 [Mus musculus]

Protein Classification

cysteine--tRNA ligase( domain architecture ID 1002819)

cysteine--tRNA ligase catalyzes the attachment of cysteine to tRNA(Cys)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PTZ00399 super family cl36555
cysteinyl-tRNA-synthetase; Provisional
79-311 4.25e-23

cysteinyl-tRNA-synthetase; Provisional


The actual alignment was detected with superfamily member PTZ00399:

Pssm-ID: 240402 [Multi-domain]  Cd Length: 651  Bit Score: 99.72  E-value: 4.25e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428389  79 KDFLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAKHLLLGLASFVEDARAYVKGQLTCGPVEEDV----LWERLTSTKK 154
Cdd:PTZ00399  327 RQALSKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVKIKLRESELTSPQKWTQhdfeLNELFEETKS 406
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428389 155 AVKAALANDFDTPRAVNTILDLVHHANRQLRAVSKeasgPRSPTVFgAIISYVEQFFETVGISLANRQC-VSGDSSTV-T 232
Cdd:PTZ00399  407 AVHAALLDNFDTPEALQALQKLISATNTYLNSGEQ----PSAPLLR-SVAQYVTKILSIFGLVEGSDGLgSQGQNSTSeN 481
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428389 233 LRCVVDELVRFRLKVRQYAldtpgAAGEARKRQLQERQPLLEACDTLR-QDLVTHGINVKDRGSAASTWELLDP----RT 307
Cdd:PTZ00399  482 FKPLLEALLRFRDEVRDAA-----KAEMKLISLDKKKKQLLQLCDKLRdEWLPNLGIRIEDKPDGPSVWKLDDKeelqRE 556

                  ....
gi 1720428389 308 RHQK 311
Cdd:PTZ00399  557 KEEK 560
 
Name Accession Description Interval E-value
PTZ00399 PTZ00399
cysteinyl-tRNA-synthetase; Provisional
79-311 4.25e-23

cysteinyl-tRNA-synthetase; Provisional


Pssm-ID: 240402 [Multi-domain]  Cd Length: 651  Bit Score: 99.72  E-value: 4.25e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428389  79 KDFLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAKHLLLGLASFVEDARAYVKGQLTCGPVEEDV----LWERLTSTKK 154
Cdd:PTZ00399  327 RQALSKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVKIKLRESELTSPQKWTQhdfeLNELFEETKS 406
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428389 155 AVKAALANDFDTPRAVNTILDLVHHANRQLRAVSKeasgPRSPTVFgAIISYVEQFFETVGISLANRQC-VSGDSSTV-T 232
Cdd:PTZ00399  407 AVHAALLDNFDTPEALQALQKLISATNTYLNSGEQ----PSAPLLR-SVAQYVTKILSIFGLVEGSDGLgSQGQNSTSeN 481
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428389 233 LRCVVDELVRFRLKVRQYAldtpgAAGEARKRQLQERQPLLEACDTLR-QDLVTHGINVKDRGSAASTWELLDP----RT 307
Cdd:PTZ00399  482 FKPLLEALLRFRDEVRDAA-----KAEMKLISLDKKKKQLLQLCDKLRdEWLPNLGIRIEDKPDGPSVWKLDDKeelqRE 556

                  ....
gi 1720428389 308 RHQK 311
Cdd:PTZ00399  557 KEEK 560
CysS COG0215
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ...
79-302 6.18e-23

Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439985 [Multi-domain]  Cd Length: 465  Bit Score: 98.25  E-value: 6.18e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428389  79 KDFLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAKHLLLGLASFVEDARAYVKgqltcgpvEEDVLWERLTSTKKAVKA 158
Cdd:COG0215   277 RDLLKKYDPEVLRFFLLSAHYRSPLDFSEEALEEAEKALERLYNALRRLEEALG--------AADSSAEEIEELREEFIA 348
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428389 159 ALANDFDTPRAVNTILDLVHHANRQLravskeaSGPRSPTVFGAIISYVEQFFETVGISLANRQCVSGDSSTVtlrcVVD 238
Cdd:COG0215   349 AMDDDFNTPEALAVLFELVREINKAL-------DEGEDKAALAALAALLRALGGVLGLLLLEPEAWQGAAEDE----LLD 417
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720428389 239 ELVRFRLKVRQyaldtpgaagEARKRQLQERqplleAcDTLRQDLVTHGINVKDrGSAASTWEL 302
Cdd:COG0215   418 ALIEALIEERA----------EARKAKDFAR-----A-DRIRDELAALGIVLED-TPDGTTWRR 464
DALR_2 pfam09190
DALR domain; This DALR domain is found in cysteinyl-tRNA-synthetases.
155-191 1.32e-03

DALR domain; This DALR domain is found in cysteinyl-tRNA-synthetases.


Pssm-ID: 462711 [Multi-domain]  Cd Length: 63  Bit Score: 36.41  E-value: 1.32e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1720428389 155 AVKAALANDFDTPRAVNTILDLVHHANRQLRAVSKEA 191
Cdd:pfam09190   1 KFIEAMDDDFNTPEALAVLFELAKEINRALKTNDAEA 37
 
Name Accession Description Interval E-value
PTZ00399 PTZ00399
cysteinyl-tRNA-synthetase; Provisional
79-311 4.25e-23

cysteinyl-tRNA-synthetase; Provisional


Pssm-ID: 240402 [Multi-domain]  Cd Length: 651  Bit Score: 99.72  E-value: 4.25e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428389  79 KDFLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAKHLLLGLASFVEDARAYVKGQLTCGPVEEDV----LWERLTSTKK 154
Cdd:PTZ00399  327 RQALSKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVKIKLRESELTSPQKWTQhdfeLNELFEETKS 406
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428389 155 AVKAALANDFDTPRAVNTILDLVHHANRQLRAVSKeasgPRSPTVFgAIISYVEQFFETVGISLANRQC-VSGDSSTV-T 232
Cdd:PTZ00399  407 AVHAALLDNFDTPEALQALQKLISATNTYLNSGEQ----PSAPLLR-SVAQYVTKILSIFGLVEGSDGLgSQGQNSTSeN 481
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428389 233 LRCVVDELVRFRLKVRQYAldtpgAAGEARKRQLQERQPLLEACDTLR-QDLVTHGINVKDRGSAASTWELLDP----RT 307
Cdd:PTZ00399  482 FKPLLEALLRFRDEVRDAA-----KAEMKLISLDKKKKQLLQLCDKLRdEWLPNLGIRIEDKPDGPSVWKLDDKeelqRE 556

                  ....
gi 1720428389 308 RHQK 311
Cdd:PTZ00399  557 KEEK 560
CysS COG0215
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ...
79-302 6.18e-23

Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439985 [Multi-domain]  Cd Length: 465  Bit Score: 98.25  E-value: 6.18e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428389  79 KDFLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAKHLLLGLASFVEDARAYVKgqltcgpvEEDVLWERLTSTKKAVKA 158
Cdd:COG0215   277 RDLLKKYDPEVLRFFLLSAHYRSPLDFSEEALEEAEKALERLYNALRRLEEALG--------AADSSAEEIEELREEFIA 348
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428389 159 ALANDFDTPRAVNTILDLVHHANRQLravskeaSGPRSPTVFGAIISYVEQFFETVGISLANRQCVSGDSSTVtlrcVVD 238
Cdd:COG0215   349 AMDDDFNTPEALAVLFELVREINKAL-------DEGEDKAALAALAALLRALGGVLGLLLLEPEAWQGAAEDE----LLD 417
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720428389 239 ELVRFRLKVRQyaldtpgaagEARKRQLQERqplleAcDTLRQDLVTHGINVKDrGSAASTWEL 302
Cdd:COG0215   418 ALIEALIEERA----------EARKAKDFAR-----A-DRIRDELAALGIVLED-TPDGTTWRR 464
cysS PRK14535
cysteinyl-tRNA synthetase; Provisional
76-200 2.50e-08

cysteinyl-tRNA synthetase; Provisional


Pssm-ID: 173001 [Multi-domain]  Cd Length: 699  Bit Score: 55.11  E-value: 2.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428389  76 FWSKDFLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAKHLLLGLASFVEDArayvkgqltcgPVEEDVLWERLTSTKKA 155
Cdd:PRK14535  517 FTIREVLKQYDPEVVRFFILRAHYRSPLNYSDAHLDDAKGALTRLYTTLKNT-----------PAAEFMLSENVNDYTRR 585
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720428389 156 VKAALANDFDTPRAVNTILDLVHHANR----QLRAVSKEASG-----PRSPTVF 200
Cdd:PRK14535  586 FYAAMNDDFGTVEAVAVLFELAGEVNKtndaQLAGCLKALGGiigllQRDPTEF 639
DALR_2 pfam09190
DALR domain; This DALR domain is found in cysteinyl-tRNA-synthetases.
155-191 1.32e-03

DALR domain; This DALR domain is found in cysteinyl-tRNA-synthetases.


Pssm-ID: 462711 [Multi-domain]  Cd Length: 63  Bit Score: 36.41  E-value: 1.32e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1720428389 155 AVKAALANDFDTPRAVNTILDLVHHANRQLRAVSKEA 191
Cdd:pfam09190   1 KFIEAMDDDFNTPEALAVLFELAKEINRALKTNDAEA 37
PRK12418 PRK12418
cysteinyl-tRNA synthetase; Provisional
87-173 1.70e-03

cysteinyl-tRNA synthetase; Provisional


Pssm-ID: 183518 [Multi-domain]  Cd Length: 384  Bit Score: 39.53  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428389  87 PDVFRLFCLRTNYRSAIEYSDSTLVEAKHLLlglasfvEDARAYVKgqLTCGPVEEDVLwerltstkKAVKAALANDFDT 166
Cdd:PRK12418  282 PAAIRLALLAGHYRADREWTDAVLAEAEARL-------ARWRAAAA--LPAGPDAADVV--------ARVRAALADDLDT 344

                  ....*..
gi 1720428389 167 PRAVNTI 173
Cdd:PRK12418  345 PGALAAV 351
cysS PRK14536
cysteinyl-tRNA synthetase; Provisional
49-177 2.80e-03

cysteinyl-tRNA synthetase; Provisional


Pssm-ID: 184731 [Multi-domain]  Cd Length: 490  Bit Score: 39.13  E-value: 2.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428389  49 RCDLHGGTTD--PVH--------------------ILHKGLLNRVTQLPFWSKDFL-------KTFSPDVFRLFCLRTNY 99
Cdd:PRK14536  233 QCDIHIGGVDhiRVHhtneiaqceaatgkpwvrywLHHEFLLMNKGKMSKSAGQFLtlsslqeKGFQPLDYRFFLLGGHY 312
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428389 100 RSAIEYSDSTLVEAK----HLLLGLASFVEDARAY---VKGQLTcgpveeDVLWERLTSTKKA--------VKAALANDF 164
Cdd:PRK14536  313 RSQLAFSWEALKTAKaarrSLVRRVARVVDAARATtgsVRGTLA------ECAAERVAESRASesellltdFRAALEDDF 386
                         170
                  ....*....|...
gi 1720428389 165 DTPRAVNTILDLV 177
Cdd:PRK14536  387 STPKALSELQKLV 399
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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