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Conserved domains on  [gi|1720431918|ref|XP_030100277|]
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immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11471389)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-183 2.65e-22

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.39  E-value: 2.65e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918  51 ANVTTLSLSANKITVLRRgAFVNVTQVTSLWLAHSEVRTVESgALAVLSQLKNLDLSHNLISNFPwSDLRNLSALQLLKM 130
Cdd:COG4886   113 TNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDL 189

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720431918 131 NHNRLGSLPrDALGALPDLRSLRINNNRLRTLePGTFDALSALSHLQLYHNPF 183
Cdd:COG4886   190 SNNQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQL 240
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 154-228 3.15e-13

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 73.96  E-value: 3.15e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720431918  154 INNNRLRTLEPGTFDALSALSHLQLYHNPFHCSCGLVWLQAWAASTRVSLPEPDSIACASPPELQGVPVHRLPAL 228
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPLL 76
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 232-360 1.89e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


:

Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 40.63  E-value: 1.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918 232 PPSVRLSAEPPPEAPGTPLRaglafmLHCVAEGHPTPRLQWQLqipGGTVVLVPPVLSKEEDGGdkvedgegdgdedlpt 311
Cdd:pfam13927   1 KPVITVSPSSVTVREGETVT------LTCEATGSPPPTITWYK---NGEPISSGSTRSRSLSGS---------------- 55

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1720431918 312 qteaptptpapawpappatprflalaNGSLLVPLLSAKEAGIYTCRAHN 360
Cdd:pfam13927  56 --------------------------NSTLTISNVTRSDAGTYTCVASN 78
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 351-373 2.66e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member pfam07679:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 90  Bit Score: 37.62  E-value: 2.66e-03
                          10        20
                  ....*....|....*....|...
gi 1720431918 351 AGIYTCRAHNELGTNSTSLRVTV 373
Cdd:pfam07679  68 SGKYTCVATNSAGEAEASAELTV 90
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-183 2.65e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.39  E-value: 2.65e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918  51 ANVTTLSLSANKITVLRRgAFVNVTQVTSLWLAHSEVRTVESgALAVLSQLKNLDLSHNLISNFPwSDLRNLSALQLLKM 130
Cdd:COG4886   113 TNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDL 189

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720431918 131 NHNRLGSLPrDALGALPDLRSLRINNNRLRTLePGTFDALSALSHLQLYHNPF 183
Cdd:COG4886   190 SNNQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQL 240
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 154-228 3.15e-13

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 73.96  E-value: 3.15e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720431918  154 INNNRLRTLEPGTFDALSALSHLQLYHNPFHCSCGLVWLQAWAASTRVSLPEPDSIACASPPELQGVPVHRLPAL 228
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPLL 76
LRR_8 pfam13855
Leucine rich repeat;
99-159 1.45e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 1.45e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720431918  99 SQLKNLDLSHNLISNFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRL 159
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 52-181 1.42e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.95  E-value: 1.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918  52 NVTTLSLSANKITVLRrgAFVNVTQVTSLWLAHSEVRTVESgaLAVLSQLKNLDLSHNLISNFpwSDLRNLSALQLLKMN 131
Cdd:cd21340    25 NLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIE 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720431918 132 HNRLGS------LPRDALGALPDLRSLRINNNRLRTLEPgtFDALSALSHLQLYHN 181
Cdd:cd21340    99 NQRLPPgekltfDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNN 152
LRRCT smart00082
Leucine rich repeat C-terminal domain;
181-229 2.91e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 50.51  E-value: 2.91e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1720431918  181 NPFHCSCGLVWLQAWAASTRVsLPEPDSIACASPPELQGvPVHRLPALP 229
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEH-LQDPVDLRCASPSSLRG-PLLELLHSE 47
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 99-181 4.45e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.70  E-value: 4.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918  99 SQLKNLDLSHNLISNFPWSDLRNLSALQLLKMNHNRL-GSLPrDALGALPDLRSLRINNNRLRTLEPGTFDALSALSHLQ 177
Cdd:PLN00113  475 KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLsGEIP-DELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLD 553


                  ....
gi 1720431918 178 LYHN 181
Cdd:PLN00113  554 LSQN 557
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 232-360 1.89e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 40.63  E-value: 1.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918 232 PPSVRLSAEPPPEAPGTPLRaglafmLHCVAEGHPTPRLQWQLqipGGTVVLVPPVLSKEEDGGdkvedgegdgdedlpt 311
Cdd:pfam13927   1 KPVITVSPSSVTVREGETVT------LTCEATGSPPPTITWYK---NGEPISSGSTRSRSLSGS---------------- 55

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1720431918 312 qteaptptpapawpappatprflalaNGSLLVPLLSAKEAGIYTCRAHN 360
Cdd:pfam13927  56 --------------------------NSTLTISNVTRSDAGTYTCVASN 78
IgI_5_Robo cd20952
Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the ...
 248-373 2.24e-04

Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fifth Ig-like domain of Roundabout (Robo) homolog 1/2 and similar domains. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, -2, and -3), and three mammalian Slit homologs (Slit-1,-2, -3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, -2, and -3 are expressed by commissural neurons in the vertebrate spinal cord and Slits 1, -2, -3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of slit responsiveness, antagonizes slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. The fifth Ig-like domain of Robo 1 and 2 is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors


Pssm-ID: 409544 [Multi-domain]  Cd Length: 87  Bit Score: 40.56  E-value: 2.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918 248 TPLRAGLAFMLHCVAEGHPTPRLQWQlqipggtvvlvppvlskeEDGgdkvedgegdgdEDLPTQTEaptptpapawpap 327
Cdd:cd20952     9 QTVAVGGTVVLNCQATGEPVPTISWL------------------KDG------------VPLLGKDE------------- 45

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1720431918 328 patpRFLALANGSLLVPLLSAKEAGIYTCRAHNELGTNSTSLRVTV 373
Cdd:cd20952    46 ----RITTLENGSLQIKGAEKSDTGEYTCVALNLSGEATWSAVLDV 87
I-set pfam07679
Immunoglobulin I-set domain;
351-373 2.66e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 37.62  E-value: 2.66e-03
                          10        20
                  ....*....|....*....|...
gi 1720431918 351 AGIYTCRAHNELGTNSTSLRVTV 373
Cdd:pfam07679  68 SGKYTCVATNSAGEAEASAELTV 90
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-183 2.65e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.39  E-value: 2.65e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918  51 ANVTTLSLSANKITVLRRgAFVNVTQVTSLWLAHSEVRTVESgALAVLSQLKNLDLSHNLISNFPwSDLRNLSALQLLKM 130
Cdd:COG4886   113 TNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDL 189

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720431918 131 NHNRLGSLPrDALGALPDLRSLRINNNRLRTLePGTFDALSALSHLQLYHNPF 183
Cdd:COG4886   190 SNNQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-184 1.30e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.84  E-value: 1.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918  36 DCAYKELREVPE---GLPaNVTTLSLSANKITVLRrGAFVNVTQVTSLWLAHSEVRTVeSGALAVLSQLKNLDLSHNLIS 112
Cdd:COG4886   165 DLSNNQLTDLPEelgNLT-NLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLT 241

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720431918 113 NFPWsdLRNLSALQLLKMNHNRLGSLPrdALGALPDLRSLRINNNRLRTLEPGTFDALSALSHLQLYHNPFH 184
Cdd:COG4886   242 DLPE--LGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-183 1.37e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 1.37e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918  51 ANVTTLSLSANKITVLRRGAFVNVTQVTSLWLAHSEvrtvesgALAVLSQLKNLDLSHNLISNFPWSdLRNLSALQLLKM 130
Cdd:COG4886    72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDL 143

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720431918 131 NHNRLGSLPrDALGALPDLRSLRINNNRLRTLePGTFDALSALSHLQLYHNPF 183
Cdd:COG4886   144 SNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI 194
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 154-228 3.15e-13

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 73.96  E-value: 3.15e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720431918  154 INNNRLRTLEPGTFDALSALSHLQLYHNPFHCSCGLVWLQAWAASTRVSLPEPDSIACASPPELQGVPVHRLPAL 228
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPLL 76
LRR_8 pfam13855
Leucine rich repeat;
99-159 1.45e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 1.45e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720431918  99 SQLKNLDLSHNLISNFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRL 159
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
120-183 1.65e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 1.65e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720431918 120 RNLSALQLlkmNHNRLGSLPRDALGALPDLRSLRINNNRLRTLEPGTFDALSALSHLQLYHNPF 183
Cdd:pfam13855   1 PNLRSLDL---SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
52-135 1.21e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 1.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918  52 NVTTLSLSANKITVLRRGAFVNvtqvtslwlahsevrtvesgalavLSQLKNLDLSHNLISNFPWSDLRNLSALQLLKMN 131
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKG------------------------LSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 1720431918 132 HNRL 135
Cdd:pfam13855  58 GNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 52-181 1.42e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.95  E-value: 1.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918  52 NVTTLSLSANKITVLRrgAFVNVTQVTSLWLAHSEVRTVESgaLAVLSQLKNLDLSHNLISNFpwSDLRNLSALQLLKMN 131
Cdd:cd21340    25 NLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIE 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720431918 132 HNRLGS------LPRDALGALPDLRSLRINNNRLRTLEPgtFDALSALSHLQLYHN 181
Cdd:cd21340    99 NQRLPPgekltfDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNN 152
LRRCT smart00082
Leucine rich repeat C-terminal domain;
181-229 2.91e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 50.51  E-value: 2.91e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1720431918  181 NPFHCSCGLVWLQAWAASTRVsLPEPDSIACASPPELQGvPVHRLPALP 229
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEH-LQDPVDLRCASPSSLRG-PLLELLHSE 47
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-184 4.37e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 4.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918  36 DCAYKELREVPEGLPA--NVTTLSLSANKITVLRrgAFVNVTQVTSLWLAHSEVRTVESgaLAVLSQLKNLDLSHNLISN 113
Cdd:COG4886   211 DLSGNQLTDLPEPLANltNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTD 286

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720431918 114 FPWSDLRNLSALQLLKMNHNRLGSLPrdALGALPDLRSLRINNNRLRTLEPGTFDALSALSHLQLYHNPFH 184
Cdd:COG4886   287 LKLKELELLLGLNSLLLLLLLLNLLE--LLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLL 355
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 99-181 4.45e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.70  E-value: 4.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918  99 SQLKNLDLSHNLISNFPWSDLRNLSALQLLKMNHNRL-GSLPrDALGALPDLRSLRINNNRLRTLEPGTFDALSALSHLQ 177
Cdd:PLN00113  475 KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLsGEIP-DELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLD 553


                  ....
gi 1720431918 178 LYHN 181
Cdd:PLN00113  554 LSQN 557
PLN03150 PLN03150
hypothetical protein; Provisional
 98-170 2.99e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.50  E-value: 2.99e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720431918  98 LSQLKNLDLSHNLI-SNFPWSdLRNLSALQLLKMNHNRL-GSLPrDALGALPDLRSLRINNNRLRTLEPGTFDAL 170
Cdd:PLN03150  441 LRHLQSINLSGNSIrGNIPPS-LGSITSLEVLDLSYNSFnGSIP-ESLGQLTSLRILNLNGNSLSGRVPAALGGR 513
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 47-157 3.88e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 3.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918  47 EGLPaNVTTLSLSANKITVLrrGAFVNVTQVTSLWLAH-----SEVRTVESGALAVLSQ-LKNLDLSHNLISNFpwSDLR 120
Cdd:cd21340    65 ENLV-NLKKLYLGGNRISVV--EGLENLTNLEELHIENqrlppGEKLTFDPRSLAALSNsLRVLNISGNNIDSL--EPLA 139

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1720431918 121 NLSALQLLKMNHNRLGSLPR--DALGALPDLRSLRINNN 157
Cdd:cd21340   140 PLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_9 pfam14580
Leucine-rich repeat;
96-182 5.35e-05

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 44.37  E-value: 5.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918  96 AVLSQLKNLDLSHNLI---SNFPWsdlrnLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLepGTFDALSA 172
Cdd:pfam14580  39 ATLDQFDTIDFSDNEIrklDGFPL-----LRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQEL--GDLDPLAS 111

                          90
                  ....*....|...
gi 1720431918 173 LSHLQ---LYHNP 182
Cdd:pfam14580 112 LKKLTflsLLRNP 124
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 232-360 1.89e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 40.63  E-value: 1.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918 232 PPSVRLSAEPPPEAPGTPLRaglafmLHCVAEGHPTPRLQWQLqipGGTVVLVPPVLSKEEDGGdkvedgegdgdedlpt 311
Cdd:pfam13927   1 KPVITVSPSSVTVREGETVT------LTCEATGSPPPTITWYK---NGEPISSGSTRSRSLSGS---------------- 55

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1720431918 312 qteaptptpapawpappatprflalaNGSLLVPLLSAKEAGIYTCRAHN 360
Cdd:pfam13927  56 --------------------------NSTLTISNVTRSDAGTYTCVASN 78
IgI_5_Robo cd20952
Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the ...
 248-373 2.24e-04

Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fifth Ig-like domain of Roundabout (Robo) homolog 1/2 and similar domains. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, -2, and -3), and three mammalian Slit homologs (Slit-1,-2, -3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, -2, and -3 are expressed by commissural neurons in the vertebrate spinal cord and Slits 1, -2, -3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of slit responsiveness, antagonizes slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. The fifth Ig-like domain of Robo 1 and 2 is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors


Pssm-ID: 409544 [Multi-domain]  Cd Length: 87  Bit Score: 40.56  E-value: 2.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918 248 TPLRAGLAFMLHCVAEGHPTPRLQWQlqipggtvvlvppvlskeEDGgdkvedgegdgdEDLPTQTEaptptpapawpap 327
Cdd:cd20952     9 QTVAVGGTVVLNCQATGEPVPTISWL------------------KDG------------VPLLGKDE------------- 45

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1720431918 328 patpRFLALANGSLLVPLLSAKEAGIYTCRAHNELGTNSTSLRVTV 373
Cdd:cd20952    46 ----RITTLENGSLQIKGAEKSDTGEYTCVALNLSGEATWSAVLDV 87
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 48-172 2.61e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 2.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918  48 GLP-----ANVTTLSLSANKITVLRRGAFVNVTQVTSLWLAHSEVRTVESGALAVLSQLKNLDLSHNLISNFPWSDLRNL 122
Cdd:PLN00113  467 GLPdsfgsKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEM 546

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720431918 123 SALQLLKMNHNRL-GSLPRDaLGALPDLRSLRINNNRLRTLEP--GTFDALSA 172
Cdd:PLN00113  547 PVLSQLDLSQNQLsGEIPKN-LGNVESLVQVNISHNHLHGSLPstGAFLAINA 598
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 76-186 9.21e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 9.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918  76 QVTSLWLAHSEVRTVESGALAVLSQLKNLDLSHNLISNFPWSDLRNLSALQLLKMNHNRL-GSLPrDALGALPDLRSLRI 154
Cdd:PLN00113  476 RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLsGQIP-ASFSEMPVLSQLDL 554

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1720431918 155 NNNRLRTLEPGTFDALSALSHLQLYHNPFHCS 186
Cdd:PLN00113  555 SQNQLSGEIPKNLGNVESLVQVNISHNHLHGS 586
I-set pfam07679
Immunoglobulin I-set domain;
351-373 2.66e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 37.62  E-value: 2.66e-03
                          10        20
                  ....*....|....*....|...
gi 1720431918 351 AGIYTCRAHNELGTNSTSLRVTV 373
Cdd:pfam07679  68 SGKYTCVATNSAGEAEASAELTV 90
IgI_LRIG1-like cd05763
Immunoglobulin (Ig)-like ectodomain of the LRIG1 (Leucine-rich Repeats And Immunoglobulin-like ...
 250-373 2.93e-03

Immunoglobulin (Ig)-like ectodomain of the LRIG1 (Leucine-rich Repeats And Immunoglobulin-like Domains Protein 1) and similar proteins; member of the I-set of IgSF domains; The members here are composed of subgroup of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. The ectodomain of LRIG1 has two distinct regions: the proposed 15 LRRs and three Ig-like domains closer to the membrane. LRIG1 has been reported to interact with many receptor tyrosine kinases, GDNF/c-Ret, E-cadherin, JAK/STAT, c-Met, and the EGFR family signaling systems. Immunoglobulin Superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The structure of the LRIG1 extracellular Ig domain lacks a C" strand and thus is better described as a member of the I-set of IgSF domains.


Pssm-ID: 409420 [Multi-domain]  Cd Length: 91  Bit Score: 37.60  E-value: 2.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918 250 LRAGLAFMLHCVAEGHPTPRLQWQlqipggtvvlvppvlskeEDGGDKVEDGEGDGDEDLPTQTEaptptpapawpappa 329
Cdd:cd05763    11 IRAGSTARLECAATGHPTPQIAWQ------------------KDGGTDFPAARERRMHVMPEDDV--------------- 57

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1720431918 330 tprflalangsLLVPLLSAKEAGIYTCRAHNELGTNSTSLRVTV 373
Cdd:cd05763    58 -----------FFIVDVKIEDTGVYSCTAQNSAGSISANATLTV 90
Ig_DSCAM cd05734
Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM); The members ...
 253-373 4.61e-03

Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM); The members here are composed of the immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM). DSCAM is a cell adhesion molecule expressed largely in the developing nervous system. The gene encoding DSCAM is located at human chromosome 21q22, the locus associated with the intellectual disability phenotype of Down Syndrome. DSCAM is predicted to be the largest member of the IG superfamily. It has been demonstrated that DSCAM can mediate cation-independent homophilic intercellular adhesion.


Pssm-ID: 409397 [Multi-domain]  Cd Length: 97  Bit Score: 37.09  E-value: 4.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918 253 GLAFMLHCVAEGHPTPRLQWQLQIPGGTVVLVPPVLSkeedggdkvedgegdgdedlptqteaptptpapawpappaTPR 332
Cdd:cd05734    16 GKAVVLNCSADGYPPPTIVWKHSKGSGVPQFQHIVPL----------------------------------------NGR 55

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1720431918 333 FLALANGSLLVPLLSAKEAGIYTCRAHNELGTN-STSLRVTV 373
Cdd:cd05734    56 IQLLSNGSLLIKHVLEEDSGYYLCKVSNDVGADiSKSMYLTV 97
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 256-368 6.34e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 36.15  E-value: 6.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918 256 FMLHCVAEGHPTPRLQWQLqipGGTVVLVPPVLSKEEDGGdkvedgegdgdedlptqteaptptpapawpappatprfla 335
Cdd:cd00096     1 VTLTCSASGNPPPTITWYK---NGKPLPPSSRDSRRSELG---------------------------------------- 37

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1720431918 336 laNGSLLVPLLSAKEAGIYTCRAHNELGTNSTS 368
Cdd:cd00096    38 --NGTLTISNVTLEDSGTYTCVASNSAGGSASA 68
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 33-136 8.62e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.39  E-value: 8.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720431918  33 QFADCAYKELREVPEGLPAnVTTLSLSANKI---------TVLRRGafvnvTQVTSLWLAHSEVRtvESGA------LAV 97
Cdd:COG5238   219 PIGDEGAEILAEALKGNKS-LTTLDLSNNQIgdegvialaEALKNN-----TTVETLYLSGNQIG--AEGAialakaLQG 290

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1720431918  98 LSQLKNLDLSHNLISNFPW----SDLRNLSALQLLKMNHNRLG 136
Cdd:COG5238   291 NTTLTSLDLSVNRIGDEGAialaEGLQGNKTLHTLNLAYNGIG 333
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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