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Conserved domains on  [gi|1720362070|ref|XP_030101103|]
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host cell factor 2 isoform X3 [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 13286889)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-332 4.59e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 87.90  E-value: 4.59e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070  14 SFTGPVPRARHGHRAVAIRELMIIFGGGNEG-IADELHVYNTVTNQWflpaVRGDIPPGCAAHGFVC--DGTRILVFGGM 90
Cdd:COG3055     4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGsASNSFEVYDPATNTW----SELAPLPGPPRHHAAAvaQDGKLYVFGGF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070  91 VEYGRYSN-----ELYELQASRWlwkkvkpqpPPSGFPPCPRLGHSFSLYGNKCYLFGGlanesedsnNNVPRYLNDFYE 165
Cdd:COG3055    80 TGANPSSTplndvYVYDPATNTW---------TKLAPMPTPRGGATALLLDGKIYVVGG---------WDDGGNVAWVEV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 166 LELQHGSgvvgWSipaTKGVVPSPRESHTAIIyckkdSASPKMYVFGGMCGARLDDLWqldletmswskpETKGTVPLPR 245
Cdd:COG3055   142 YDPATGT----WT---QLAPLPTPRDHLAAAV-----LPDGKILVIGGRNGSGFSNTW------------TTLAPLPTAR 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 246 SLHTASVIGNKMYIFGGwvphkgenpETSPHDCEWRctssfsyLNLDTAEWTTLvsdsqedkkNSRPRPRAGHCAVAIGT 325
Cdd:COG3055   198 AGHAAAVLGGKILVFGG---------ESGFSDEVEA-------YDPATNTWTAL---------GELPTPRHGHAAVLTDG 252


                  ....*..
gi 1720362070 326 RLYFWSG 332
Cdd:COG3055   253 KVYVIGG 259
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 547-601 2.20e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.64  E-value: 2.20e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720362070 547 PKGKQSMSKVGNADVPDYSLlKKQDLVPGTVYKFRVAAINGCGIGPLSKVSEFKT 601
Cdd:cd00063    40 EKGSGDWKEVEVTPGSETSY-TLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 607-707 4.36e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.87  E-value: 4.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 607 PGAPSTVRISK-NVDGIHLSWEPPTSPSGNILEYSaylaIRTAQMQDNPSQLVfmRIYCGLKTSCTVTagQLaNAHIDYT 685
Cdd:cd00063     1 PSPPTNLRVTDvTSTSVTLSWTPPEDDGGPITGYV----VEYREKGSGDWKEV--EVTPGSETSYTLT--GL-KPGTEYE 71

                          90       100
                  ....*....|....*....|..
gi 1720362070 686 srpaivFRISAKNEKGYGPATQ 707
Cdd:cd00063    72 ------FRVRAVNGGGESPPSE 87
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
385-633 2.31e-04

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.61  E-value: 2.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 385 GYLLQLNTDLTYQATSSDSSAAPSVLGGRMDPHRQGSNSTLHNSVSDTVNSTKTEHTAVRGTSLRSKPDSRAVDSSAALH 464
Cdd:COG3401     4 SYLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 465 SPLAPNTSNNSSWVTdMLRKNEVDEICALPATKISRVEVHAAATPFSKETPSNPVAILK---AEQWCDVGIFKNNTALVS 541
Cdd:COG3401    84 VAAAPPTATGLTTLT-GSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYalgAGLYGVDGANASGTTASS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 542 QFYL------LPKGKQSMSKVGNADVPDYSLLKKQDLVPGTVYKFRVAAINGCGIGPLSKVSEFKTCTPgFPGAPSTVRI 615
Cdd:COG3401   163 VAGAgvvvspDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTT-PPSAPTGLTA 241

                         250
                  ....*....|....*....
gi 1720362070 616 SKNVDG-IHLSWEPPTSPS 633
Cdd:COG3401   242 TADTPGsVTLSWDPVTESD 260
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 312-355 1.31e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


:

Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 36.77  E-value: 1.31e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1720362070 312 PRPRAGHCAVAIGTRLYFWSGRDGYkkalNSQVcCKDLWYLDTE 355
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGG----EGQP-SDDVYVLSLP 39
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-332 4.59e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 87.90  E-value: 4.59e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070  14 SFTGPVPRARHGHRAVAIRELMIIFGGGNEG-IADELHVYNTVTNQWflpaVRGDIPPGCAAHGFVC--DGTRILVFGGM 90
Cdd:COG3055     4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGsASNSFEVYDPATNTW----SELAPLPGPPRHHAAAvaQDGKLYVFGGF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070  91 VEYGRYSN-----ELYELQASRWlwkkvkpqpPPSGFPPCPRLGHSFSLYGNKCYLFGGlanesedsnNNVPRYLNDFYE 165
Cdd:COG3055    80 TGANPSSTplndvYVYDPATNTW---------TKLAPMPTPRGGATALLLDGKIYVVGG---------WDDGGNVAWVEV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 166 LELQHGSgvvgWSipaTKGVVPSPRESHTAIIyckkdSASPKMYVFGGMCGARLDDLWqldletmswskpETKGTVPLPR 245
Cdd:COG3055   142 YDPATGT----WT---QLAPLPTPRDHLAAAV-----LPDGKILVIGGRNGSGFSNTW------------TTLAPLPTAR 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 246 SLHTASVIGNKMYIFGGwvphkgenpETSPHDCEWRctssfsyLNLDTAEWTTLvsdsqedkkNSRPRPRAGHCAVAIGT 325
Cdd:COG3055   198 AGHAAAVLGGKILVFGG---------ESGFSDEVEA-------YDPATNTWTAL---------GELPTPRHGHAAVLTDG 252


                  ....*..
gi 1720362070 326 RLYFWSG 332
Cdd:COG3055   253 KVYVIGG 259
PLN02193 PLN02193
nitrile-specifier protein
 2-262 4.09e-12

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 69.21  E-value: 4.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070   2 AAPSLL-NWRRV-SSFTGPVPRARHGHRAVAIRelMIIFGGG---NEGIADELHVYNTVTNQWFLPAVRGDIPP-GCAAH 75
Cdd:PLN02193  145 STPKLLgKWIKVeQKGEGPGLRCSHGIAQVGNK--IYSFGGEftpNQPIDKHLYVFDLETRTWSISPATGDVPHlSCLGV 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070  76 GFVCDGTRILVFGGMvEYGRYSNELYELQASRWLWKKVkpqpPPSGFPPCPRLGHSFSLYGNKCYLFGGLANESE----D 151
Cdd:PLN02193  223 RMVSIGSTLYVFGGR-DASRQYNGFYSFDTTTNEWKLL----TPVEEGPTPRSFHSMAADEENVYVFGGVSATARlktlD 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 152 SNNNVPRylndfyelelqhgsgvvGWSIPATkgvvpsPRESHTAIIYCKKDSASPKMYVFGGMCGARLDDLWQLDLETMS 231
Cdd:PLN02193  298 SYNIVDK-----------------KWFHCST------PGDSFSIRGGAGLEVVQGKVWVVYGFNGCEVDDVHYYDPVQDK 354

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1720362070 232 WSKPETKGTVPLPRSLHTASVIGNKMYIFGG 262
Cdd:PLN02193  355 WTQVETFGVRPSERSVFASAAVGKHIVIFGG 385
Kelch_3 pfam13415
Galactose oxidase, central domain;
207-253 1.63e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 45.36  E-value: 1.63e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720362070 207 KMYVFGGMC---GARLDDLWQLDLETMSWSKPetkGTVPLPRSLHTASVI 253
Cdd:pfam13415   3 KLYIFGGLGfdgQTRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 547-601 2.20e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.64  E-value: 2.20e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720362070 547 PKGKQSMSKVGNADVPDYSLlKKQDLVPGTVYKFRVAAINGCGIGPLSKVSEFKT 601
Cdd:cd00063    40 EKGSGDWKEVEVTPGSETSY-TLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 607-707 4.36e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.87  E-value: 4.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 607 PGAPSTVRISK-NVDGIHLSWEPPTSPSGNILEYSaylaIRTAQMQDNPSQLVfmRIYCGLKTSCTVTagQLaNAHIDYT 685
Cdd:cd00063     1 PSPPTNLRVTDvTSTSVTLSWTPPEDDGGPITGYV----VEYREKGSGDWKEV--EVTPGSETSYTLT--GL-KPGTEYE 71

                          90       100
                  ....*....|....*....|..
gi 1720362070 686 srpaivFRISAKNEKGYGPATQ 707
Cdd:cd00063    72 ------FRVRAVNGGGESPPSE 87
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
385-633 2.31e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.61  E-value: 2.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 385 GYLLQLNTDLTYQATSSDSSAAPSVLGGRMDPHRQGSNSTLHNSVSDTVNSTKTEHTAVRGTSLRSKPDSRAVDSSAALH 464
Cdd:COG3401     4 SYLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 465 SPLAPNTSNNSSWVTdMLRKNEVDEICALPATKISRVEVHAAATPFSKETPSNPVAILK---AEQWCDVGIFKNNTALVS 541
Cdd:COG3401    84 VAAAPPTATGLTTLT-GSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYalgAGLYGVDGANASGTTASS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 542 QFYL------LPKGKQSMSKVGNADVPDYSLLKKQDLVPGTVYKFRVAAINGCGIGPLSKVSEFKTCTPgFPGAPSTVRI 615
Cdd:COG3401   163 VAGAgvvvspDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTT-PPSAPTGLTA 241

                         250
                  ....*....|....*....
gi 1720362070 616 SKNVDG-IHLSWEPPTSPS 633
Cdd:COG3401   242 TADTPGsVTLSWDPVTESD 260
fn3 pfam00041
Fibronectin type III domain;
570-594 9.41e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.55  E-value: 9.41e-04
                          10        20
                  ....*....|....*....|....*
gi 1720362070 570 QDLVPGTVYKFRVAAINGCGIGPLS 594
Cdd:pfam00041  61 TGLKPGTEYEVRVQAVNGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
608-706 1.12e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.55  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 608 GAPSTVRIS-KNVDGIHLSWEPPTSPSGNILEYSaylaIRTAQMQDNPSQLVFMRiyCGLKTSCTVTagQLaNAHIDYTs 686
Cdd:pfam00041   1 SAPSNLTVTdVTSTSLTVSWTPPPDGNGPITGYE----VEYRPKNSGEPWNEITV--PGTTTSVTLT--GL-KPGTEYE- 70

                          90       100
                  ....*....|....*....|
gi 1720362070 687 rpaivFRISAKNEKGYGPAT 706
Cdd:pfam00041  71 -----VRVQAVNGGGEGPPS 85
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 312-355 1.31e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 36.77  E-value: 1.31e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1720362070 312 PRPRAGHCAVAIGTRLYFWSGRDGYkkalNSQVcCKDLWYLDTE 355
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGG----EGQP-SDDVYVLSLP 39
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
14-332 4.59e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 87.90  E-value: 4.59e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070  14 SFTGPVPRARHGHRAVAIRELMIIFGGGNEG-IADELHVYNTVTNQWflpaVRGDIPPGCAAHGFVC--DGTRILVFGGM 90
Cdd:COG3055     4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGsASNSFEVYDPATNTW----SELAPLPGPPRHHAAAvaQDGKLYVFGGF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070  91 VEYGRYSN-----ELYELQASRWlwkkvkpqpPPSGFPPCPRLGHSFSLYGNKCYLFGGlanesedsnNNVPRYLNDFYE 165
Cdd:COG3055    80 TGANPSSTplndvYVYDPATNTW---------TKLAPMPTPRGGATALLLDGKIYVVGG---------WDDGGNVAWVEV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 166 LELQHGSgvvgWSipaTKGVVPSPRESHTAIIyckkdSASPKMYVFGGMCGARLDDLWqldletmswskpETKGTVPLPR 245
Cdd:COG3055   142 YDPATGT----WT---QLAPLPTPRDHLAAAV-----LPDGKILVIGGRNGSGFSNTW------------TTLAPLPTAR 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 246 SLHTASVIGNKMYIFGGwvphkgenpETSPHDCEWRctssfsyLNLDTAEWTTLvsdsqedkkNSRPRPRAGHCAVAIGT 325
Cdd:COG3055   198 AGHAAAVLGGKILVFGG---------ESGFSDEVEA-------YDPATNTWTAL---------GELPTPRHGHAAVLTDG 252


                  ....*..
gi 1720362070 326 RLYFWSG 332
Cdd:COG3055   253 KVYVIGG 259
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
9-264 6.03e-18

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 84.82  E-value: 6.03e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070   9 WRRVSSFTGPvprARHGHRAVAIRELMIIFGG-----GNEGIADELHVYNTVTNQWFlpaVRGDIPPGCAAHGFVCDGTR 83
Cdd:COG3055    50 WSELAPLPGP---PRHHAAAVAQDGKLYVFGGftganPSSTPLNDVYVYDPATNTWT---KLAPMPTPRGGATALLLDGK 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070  84 ILVFGGMVEYGRYSN-ELYELQASRWlwkkvkpqpPPSGFPPCPRLGHS-FSLYGNKCYLFGGlANESEDSNNnvpryln 161
Cdd:COG3055   124 IYVVGGWDDGGNVAWvEVYDPATGTW---------TQLAPLPTPRDHLAaAVLPDGKILVIGG-RNGSGFSNT------- 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 162 dfyelelqhgsgvvgWSIPATKgvvPSPRESHTAIIYckkdsaSPKMYVFGGMCGArLDDLWQLDLETMSWSkpeTKGTV 241
Cdd:COG3055   187 ---------------WTTLAPL---PTARAGHAAAVL------GGKILVFGGESGF-SDEVEAYDPATNTWT---ALGEL 238

                         250       260
                  ....*....|....*....|...
gi 1720362070 242 PLPRSLHTASVIGNKMYIFGGWV 264
Cdd:COG3055   239 PTPRHGHAAVLTDGKVYVIGGET 261
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
134-335 4.25e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 79.04  E-value: 4.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 134 LYGNKCYLFGGLANESedsnnnvprYLNDFYELELQHGSgvvgWSipaTKGVVPSPRESHTAiiyckkdSASP--KMYVF 211
Cdd:COG3055    20 LLDGKVYVAGGLSGGS---------ASNSFEVYDPATNT----WS---ELAPLPGPPRHHAA-------AVAQdgKLYVF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 212 GGMCGAR-----LDDLWQLDLETMSWSKpetKGTVPLPRSLHTASVIGNKMYIFGGWVPHKGenpetsphdcewrcTSSF 286
Cdd:COG3055    77 GGFTGANpsstpLNDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGGN--------------VAWV 139

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720362070 287 SYLNLDTAEWTTLVSDsqedkknsrPRPRAGHCA-VAIGTRLYFWSGRDG 335
Cdd:COG3055   140 EVYDPATGTWTQLAPL---------PTPRDHLAAaVLPDGKILVIGGRNG 180
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
66-336 6.91e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 78.66  E-value: 6.91e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070  66 GDIP-PGCAAHGFVCDGtRILVFGGMvEYGRYSN--ELYELQASRWlwkkvkpqpPPSGFPPCPRLGHSFS-LYGNKCYL 141
Cdd:COG3055     7 PDLPtPRSEAAAALLDG-KVYVAGGL-SGGSASNsfEVYDPATNTW---------SELAPLPGPPRHHAAAvAQDGKLYV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 142 FGGLaneseDSNNNVPRYLNDFYELELQHGSgvvgWSipaTKGVVPSPRESHTAIIYckkdsaSPKMYVFGGMCGA-RLD 220
Cdd:COG3055    76 FGGF-----TGANPSSTPLNDVYVYDPATNT----WT---KLAPMPTPRGGATALLL------DGKIYVVGGWDDGgNVA 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 221 DLWQLDLETMSWSkpeTKGTVPLPRSLHTASVIGN-KMYIFGGwvphkgenpetsphdcewrcTSSFSYLNldtaEWTTL 299
Cdd:COG3055   138 WVEVYDPATGTWT---QLAPLPTPRDHLAAAVLPDgKILVIGG--------------------RNGSGFSN----TWTTL 190

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1720362070 300 vsdsqedkkNSRPRPRAGHCAVAIGTRLYFWSGRDGY 336
Cdd:COG3055   191 ---------APLPTARAGHAAAVLGGKILVFGGESGF 218
PLN02193 PLN02193
nitrile-specifier protein
 2-262 4.09e-12

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 69.21  E-value: 4.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070   2 AAPSLL-NWRRV-SSFTGPVPRARHGHRAVAIRelMIIFGGG---NEGIADELHVYNTVTNQWFLPAVRGDIPP-GCAAH 75
Cdd:PLN02193  145 STPKLLgKWIKVeQKGEGPGLRCSHGIAQVGNK--IYSFGGEftpNQPIDKHLYVFDLETRTWSISPATGDVPHlSCLGV 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070  76 GFVCDGTRILVFGGMvEYGRYSNELYELQASRWLWKKVkpqpPPSGFPPCPRLGHSFSLYGNKCYLFGGLANESE----D 151
Cdd:PLN02193  223 RMVSIGSTLYVFGGR-DASRQYNGFYSFDTTTNEWKLL----TPVEEGPTPRSFHSMAADEENVYVFGGVSATARlktlD 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 152 SNNNVPRylndfyelelqhgsgvvGWSIPATkgvvpsPRESHTAIIYCKKDSASPKMYVFGGMCGARLDDLWQLDLETMS 231
Cdd:PLN02193  298 SYNIVDK-----------------KWFHCST------PGDSFSIRGGAGLEVVQGKVWVVYGFNGCEVDDVHYYDPVQDK 354

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1720362070 232 WSKPETKGTVPLPRSLHTASVIGNKMYIFGG 262
Cdd:PLN02193  355 WTQVETFGVRPSERSVFASAAVGKHIVIFGG 385
PLN02153 PLN02153
epithiospecifier protein
 16-264 3.92e-10

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 61.93  E-value: 3.92e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070  16 TGPVPRARHGHRAVAirELMIIFGGG---NEGIADELHVYNTVTNQWFLPAVRGDIPP-GCAAHGFVCDGTRILVFGGMV 91
Cdd:PLN02153   18 KGPGPRCSHGIAVVG--DKLYSFGGElkpNEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGGRD 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070  92 EYGRYSN-ELYELQASRWLWkkvkPQPPPSGFPPCPRLGHSFSLYGNKCYLFGGLaneSEDSNNNVPRYLNDFYELELQH 170
Cdd:PLN02153   96 EKREFSDfYSYDTVKNEWTF----LTKLDEEGGPEARTFHSMASDENHVYVFGGV---SKGGLMKTPERFRTIEAYNIAD 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 171 GsgvvGWSipatkgVVPSPRESHTA--------------IIYCKKDSASPkmyvfGGMCGARLDDLWQLDLETMSWSKPE 236
Cdd:PLN02153  169 G----KWV------QLPDPGENFEKrggagfavvqgkiwVVYGFATSILP-----GGKSDYESNAVQFFDPASGKWTEVE 233

                         250       260
                  ....*....|....*....|....*...
gi 1720362070 237 TKGTVPLPRSLHTASVIGNKMYIFGGWV 264
Cdd:PLN02153  234 TTGAKPSARSVFAHAVVGKYIIIFGGEV 261
PLN02153 PLN02153
epithiospecifier protein
 17-268 8.57e-08

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 54.99  E-value: 8.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070  17 GPVPR-ARHGHRAVAIRELMIIFGGGNEGIA-DELHVYNTVTNQW-FLPAVrgDIPPGCAA---HGFVCDGTRILVFGGM 90
Cdd:PLN02153   69 GDVPRiSCLGVRMVAVGTKLYIFGGRDEKREfSDFYSYDTVKNEWtFLTKL--DEEGGPEArtfHSMASDENHVYVFGGV 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070  91 VEYG------RYSN-ELYELQASRWLwkkvkpQPPPSGFPPCPRLGHSFSLYGNKCYLFGGLANESedsnnnVPRYLNDF 163
Cdd:PLN02153  147 SKGGlmktpeRFRTiEAYNIADGKWV------QLPDPGENFEKRGGAGFAVVQGKIWVVYGFATSI------LPGGKSDY 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 164 YELELQHGSGVVG-WSIPATKGVVPSPRE--SHTA-----IIYCKKDSASPKMYVFGGMCGarlDDLWQLDLETMSWSKP 235
Cdd:PLN02153  215 ESNAVQFFDPASGkWTEVETTGAKPSARSvfAHAVvgkyiIIFGGEVWPDLKGHLGPGTLS---NEGYALDTETLVWEKL 291

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1720362070 236 ETKGTVPLPR---SLHTASVIG-NKMYIFGGWVPHKG 268
Cdd:PLN02153  292 GECGEPAMPRgwtAYTTATVYGkNGLLMHGGKLPTNE 328
PLN02193 PLN02193
nitrile-specifier protein
 77-262 1.65e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 54.58  E-value: 1.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070  77 FVCDGTRILVFggmveYGRYSNELYELQASRWL---------WKKVKPQPPPSGFppcpRLGHSFSLYGNKCYLFGGlan 147
Cdd:PLN02193  116 FVLQGGKIVGF-----HGRSTDVLHSLGAYISLpstpkllgkWIKVEQKGEGPGL----RCSHGIAQVGNKIYSFGG--- 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 148 eSEDSNNNVPRYLNDFyELELQhgsgvvGWSIPATKGVVPspresHTAIIYCKKDSASPKMYVFGGMCGAR-LDDLWQLD 226
Cdd:PLN02193  184 -EFTPNQPIDKHLYVF-DLETR------TWSISPATGDVP-----HLSCLGVRMVSIGSTLYVFGGRDASRqYNGFYSFD 250

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1720362070 227 LETMSWS--KPETKGtvPLPRSLHTASVIGNKMYIFGG 262
Cdd:PLN02193  251 TTTNEWKllTPVEEG--PTPRSFHSMAADEENVYVFGG 286
Kelch_3 pfam13415
Galactose oxidase, central domain;
207-253 1.63e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 45.36  E-value: 1.63e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720362070 207 KMYVFGGMC---GARLDDLWQLDLETMSWSKPetkGTVPLPRSLHTASVI 253
Cdd:pfam13415   3 KLYIFGGLGfdgQTRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
PRK14131 PRK14131
N-acetylneuraminate epimerase;
9-89 1.30e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 48.09  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070   9 WRRVSSFTGPvprARHGHRAVAIRELMIIFGG----GNEG---IADELHVYNTVTNQWFLPAVRGdiPPGCAAH-GFVCD 80
Cdd:PRK14131   64 WTKIAAFPGG---PREQAVAAFIDGKLYVFGGigktNSEGspqVFDDVYKYDPKTNSWQKLDTRS--PVGLAGHvAVSLH 138


                  ....*....
gi 1720362070  81 GTRILVFGG 89
Cdd:PRK14131  139 NGKAYITGG 147
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
8-104 1.36e-05

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 47.46  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070   8 NWRRVSSFtgPVPRARHGHRAVAIRelmIIFGGGNEGIADELHVYNTVTNQWFlpaVRGDIPPGCAAHGFVCDGTRILVF 87
Cdd:COG3055   186 TWTTLAPL--PTARAGHAAAVLGGK---ILVFGGESGFSDEVEAYDPATNTWT---ALGELPTPRHGHAAVLTDGKVYVI 257

                          90
                  ....*....|....*..
gi 1720362070  88 GGMVEYGRYSNELYELQ 104
Cdd:COG3055   258 GGETKPGVRTPLVTSAE 274
PLN02193 PLN02193
nitrile-specifier protein
 232-375 1.92e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 47.64  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 232 WSKPETKGTVPLPRSLHTASVIGNKMYIFGG-WVPHKGENPETSPHDCEWRcTSSFSYLNLDTAEWTTLvsdsqedkkns 310
Cdd:PLN02193  153 WIKVEQKGEGPGLRCSHGIAQVGNKIYSFGGeFTPNQPIDKHLYVFDLETR-TWSISPATGDVPHLSCL----------- 220

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720362070 311 rprpraGHCAVAIGTRLYFWSGRDGYKK--ALNSQVCCKDLWYLDT--EKPPAPSQVQLIKATTNSFHV 375
Cdd:PLN02193  221 ------GVRMVSIGSTLYVFGGRDASRQynGFYSFDTTTNEWKLLTpvEEGPTPRSFHSMAADEENVYV 283
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 547-601 2.20e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.64  E-value: 2.20e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720362070 547 PKGKQSMSKVGNADVPDYSLlKKQDLVPGTVYKFRVAAINGCGIGPLSKVSEFKT 601
Cdd:cd00063    40 EKGSGDWKEVEVTPGSETSY-TLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 607-707 4.36e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.87  E-value: 4.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 607 PGAPSTVRISK-NVDGIHLSWEPPTSPSGNILEYSaylaIRTAQMQDNPSQLVfmRIYCGLKTSCTVTagQLaNAHIDYT 685
Cdd:cd00063     1 PSPPTNLRVTDvTSTSVTLSWTPPEDDGGPITGYV----VEYREKGSGDWKEV--EVTPGSETSYTLT--GL-KPGTEYE 71

                          90       100
                  ....*....|....*....|..
gi 1720362070 686 srpaivFRISAKNEKGYGPATQ 707
Cdd:cd00063    72 ------FRVRAVNGGGESPPSE 87
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
571-632 5.38e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.53  E-value: 5.38e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720362070 571 DLVPGTVYKFRVAAINGCGI-GPLSKVSEFKTCTPGfPGAPSTVRISKNVD-GIHLSWEPPTSP 632
Cdd:COG3401   291 GLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTP-PAAPSGLTATAVGSsSITLSWTASSDA 353
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
385-633 2.31e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.61  E-value: 2.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 385 GYLLQLNTDLTYQATSSDSSAAPSVLGGRMDPHRQGSNSTLHNSVSDTVNSTKTEHTAVRGTSLRSKPDSRAVDSSAALH 464
Cdd:COG3401     4 SYLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 465 SPLAPNTSNNSSWVTdMLRKNEVDEICALPATKISRVEVHAAATPFSKETPSNPVAILK---AEQWCDVGIFKNNTALVS 541
Cdd:COG3401    84 VAAAPPTATGLTTLT-GSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYalgAGLYGVDGANASGTTASS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 542 QFYL------LPKGKQSMSKVGNADVPDYSLLKKQDLVPGTVYKFRVAAINGCGIGPLSKVSEFKTCTPgFPGAPSTVRI 615
Cdd:COG3401   163 VAGAgvvvspDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTT-PPSAPTGLTA 241

                         250
                  ....*....|....*....
gi 1720362070 616 SKNVDG-IHLSWEPPTSPS 633
Cdd:COG3401   242 TADTPGsVTLSWDPVTESD 260
Kelch_3 pfam13415
Galactose oxidase, central domain;
254-323 4.38e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 38.43  E-value: 4.38e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 254 GNKMYIFGGWVPHKGEnpetsphdcewrCTSSFSYLNLDTAEWTTLvsdsqedkkNSRPRPRAGHCAVAI 323
Cdd:pfam13415   1 GDKLYIFGGLGFDGQT------------RLNDLYVYDLDTNTWTQI---------GDLPPPRSGHSATYI 49
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 244-301 7.03e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.98  E-value: 7.03e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720362070 244 PRSLHTASVIGNKMYIFGGWvphkgenpetsphdCEWRCTSSFSYLNLDTAEWTTLVS 301
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGF--------------DGNQSLNSVEVYDPETNTWSKLPS 44
fn3 pfam00041
Fibronectin type III domain;
570-594 9.41e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.55  E-value: 9.41e-04
                          10        20
                  ....*....|....*....|....*
gi 1720362070 570 QDLVPGTVYKFRVAAINGCGIGPLS 594
Cdd:pfam00041  61 TGLKPGTEYEVRVQAVNGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
608-706 1.12e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.55  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 608 GAPSTVRIS-KNVDGIHLSWEPPTSPSGNILEYSaylaIRTAQMQDNPSQLVFMRiyCGLKTSCTVTagQLaNAHIDYTs 686
Cdd:pfam00041   1 SAPSNLTVTdVTSTSLTVSWTPPPDGNGPITGYE----VEYRPKNSGEPWNEITV--PGTTTSVTLT--GL-KPGTEYE- 70

                          90       100
                  ....*....|....*....|
gi 1720362070 687 rpaivFRISAKNEKGYGPAT 706
Cdd:pfam00041  71 -----VRVQAVNGGGEGPPS 85
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 312-355 1.31e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 36.77  E-value: 1.31e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1720362070 312 PRPRAGHCAVAIGTRLYFWSGRDGYkkalNSQVcCKDLWYLDTE 355
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGG----EGQP-SDDVYVLSLP 39
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
231-337 1.40e-03

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 41.29  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362070 231 SWSkpeTKGTVPLPRSLHTASVIGNKMYIFGGWVphkgenpetsphdcEWRCTSSFSYLNLDTAEWTTLVSDSQEdkkns 310
Cdd:COG3055     2 TWS---SLPDLPTPRSEAAAALLDGKVYVAGGLS--------------GGSASNSFEVYDPATNTWSELAPLPGP----- 59

                          90       100
                  ....*....|....*....|....*..
gi 1720362070 311 rprPRAGHCAVAIGTRLYFWSGRDGYK 337
Cdd:COG3055    60 ---PRHHAAAVAQDGKLYVFGGFTGAN 83
Kelch_4 pfam13418
Galactose oxidase, central domain;
189-234 2.42e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.44  E-value: 2.42e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1720362070 189 PRESHTAIiYCKKDSAspkmYVFGGMC--GARLDDLWQLDLETMSWSK 234
Cdd:pfam13418   1 PRAYHTST-SIPDDTI----YLFGGEGedGTLLSDLWVFDLSTNEWTR 43
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 187-229 2.89e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 36.00  E-value: 2.89e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1720362070 187 PSPRESHTAIIyckkdsASPKMYVFGGMCGAR---LDDLWQLDLET 229
Cdd:pfam13854   1 PVPRYGHCAVT------VGDYIYLYGGYTGGEgqpSDDVYVLSLPT 40
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 22-59 4.44e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 35.67  E-value: 4.44e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720362070  22 ARHGHRAVAIRELMIIFGGGNEGIA-DELHVYNTVTNQW 59
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSlNSVEVYDPETNTW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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