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Conserved domains on  [gi|1720376061|ref|XP_030103324|]
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zinc finger protein 782 isoform X3 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 12142358)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
146-439 3.61e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 3.61e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061 146 THISIRTGEKPFKCNLCDKSFSKHNHLQSHRRTHTGEKPYKC--DQCDKAFSEKCNLQTHIRIHSGEKPYKC-DQCDKTF 222
Cdd:COG5048    23 TLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSN 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061 223 SEKCHLQKHIRIHTGEKPYKCNQCDKAFSQYNTLKTHRRTHTGEKPYKCNQC----------------------DKAFSQ 280
Cdd:COG5048   103 SKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061 281 YGHLQTHRRTHTGEKPYKCNQCDKAFSQYNTLKTHRRTHTGEKPYKCNQCdkAFSEKCSLQRHIRIHTGEKPYKCNQCDK 360
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061 361 AFSQYSTLQTHRRTHTG---------EKPYKCNQCDKAFSQYSNLQTHRRT--HTGE--KPYKC--NQCDKAFSMKCNLQ 425
Cdd:COG5048   261 PRSSLPTASSQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALK 340

                         330
                  ....*....|....
gi 1720376061 426 NHVRIHTGQKPFKC 439
Cdd:COG5048   341 RHILLHTSISPAKE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
115-139 6.48e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.48e-03
                          10        20
                  ....*....|....*....|....*
gi 1720376061 115 HLKRHERYHTGEQPFTCNECDKVFS 139
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
146-439 3.61e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 3.61e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061 146 THISIRTGEKPFKCNLCDKSFSKHNHLQSHRRTHTGEKPYKC--DQCDKAFSEKCNLQTHIRIHSGEKPYKC-DQCDKTF 222
Cdd:COG5048    23 TLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSN 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061 223 SEKCHLQKHIRIHTGEKPYKCNQCDKAFSQYNTLKTHRRTHTGEKPYKCNQC----------------------DKAFSQ 280
Cdd:COG5048   103 SKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061 281 YGHLQTHRRTHTGEKPYKCNQCDKAFSQYNTLKTHRRTHTGEKPYKCNQCdkAFSEKCSLQRHIRIHTGEKPYKCNQCDK 360
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061 361 AFSQYSTLQTHRRTHTG---------EKPYKCNQCDKAFSQYSNLQTHRRT--HTGE--KPYKC--NQCDKAFSMKCNLQ 425
Cdd:COG5048   261 PRSSLPTASSQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALK 340

                         330
                  ....*....|....
gi 1720376061 426 NHVRIHTGQKPFKC 439
Cdd:COG5048   341 RHILLHTSISPAKE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
339-364 1.82e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.82e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720376061 339 SLQRHIRIHTGEKPYKCNQCDKAFSQ 364
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
115-139 6.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.48e-03
                          10        20
                  ....*....|....*....|....*
gi 1720376061 115 HLKRHERYHTGEQPFTCNECDKVFS 139
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
146-439 3.61e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 3.61e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061 146 THISIRTGEKPFKCNLCDKSFSKHNHLQSHRRTHTGEKPYKC--DQCDKAFSEKCNLQTHIRIHSGEKPYKC-DQCDKTF 222
Cdd:COG5048    23 TLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSN 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061 223 SEKCHLQKHIRIHTGEKPYKCNQCDKAFSQYNTLKTHRRTHTGEKPYKCNQC----------------------DKAFSQ 280
Cdd:COG5048   103 SKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061 281 YGHLQTHRRTHTGEKPYKCNQCDKAFSQYNTLKTHRRTHTGEKPYKCNQCdkAFSEKCSLQRHIRIHTGEKPYKCNQCDK 360
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061 361 AFSQYSTLQTHRRTHTG---------EKPYKCNQCDKAFSQYSNLQTHRRT--HTGE--KPYKC--NQCDKAFSMKCNLQ 425
Cdd:COG5048   261 PRSSLPTASSQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALK 340

                         330
                  ....*....|....
gi 1720376061 426 NHVRIHTGQKPFKC 439
Cdd:COG5048   341 RHILLHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
91-441 5.98e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 5.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061  91 HKRTQTGQKPYEC--KQCGKGFAKPSHLKRHERYHTGEQPFTCN-ECDKVFSFKHHLQTHISIRTGEKPFKCNLCDKSFS 167
Cdd:COG5048    52 HIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPS 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061 168 KHNHLQSHRRTHTGEKPYKCDQC----------------------DKAFSEKCNLQTHIRIHSGEKPYKCDQCDKTFSEK 225
Cdd:COG5048   132 SRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSI 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061 226 CHLQKHIRIHTGEKPYKCNQCDKAF-------SQYNTLKTHRRTHTGEKPYKCNQcDKAFSQYGHLQTHRRTHTG-EKPY 297
Cdd:COG5048   212 PSSSSDQNLENSSSSLPLTTNSQLSpksllsqSPSSLSSSDSSSSASESPRSSLP-TASSQSSSPNESDSSSEKGfSLPI 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061 298 KCNQCDKAFSQYNTLKTHRRT--HTGE--KPYKC--NQCDKAFSEKCSLQRHIRIHTGEKPYKC--NQCDKAFSQYST-- 367
Cdd:COG5048   291 KSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNne 370

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061 368 ---LQTHRRTHTGEKPYKC--NQCDKAFSQYSNLQTHRRTHTGEKP--YKCNQCDKAFSMKCNLQNHVRIHTGQKPFKCN 440
Cdd:COG5048   371 ppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450


                  .
gi 1720376061 441 Q 441
Cdd:COG5048   451 I 451
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
160-420 6.86e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 6.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061 160 NLCDKSFSKHNHLQSHRRTHTGEKPYKCDQCDKAFSEKCNLQTHIRIHSGEKPYKCDQCdkTFSEKCHLQKHIRIHTGEK 239
Cdd:COG5048   174 NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSS 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061 240 PYKCNQCDKAFSQYNTLKTHRRTHTG---------EKPYKCNQCDKAFSQYGHLQTHRRT--HTGE--KPYKC--NQCDK 304
Cdd:COG5048   252 DSSSSASESPRSSLPTASSQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGK 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061 305 AFSQYNTLKTHRRTHTGEKPYKC--NQCDKAFS-----EKCSLQRHIRIHTGEKPYKC--NQCDKAFSQYSTLQTHRRTH 375
Cdd:COG5048   332 LFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITH 411

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1720376061 376 TGEKP--YKCNQCDKAFSQYSNLQTHRRTHTGEKPYKCNQCDKAFSM 420
Cdd:COG5048   412 LSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 237-316 2.69e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 2.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061 237 GEKPYKCN--QCDKAFSQYNTLKTHRrthtgekpyKCNQCDKAFSQYGHLQTHRRTHTGEKPYKCNQCDKAFSQYNTLKT 314
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1720376061 315 HR 316
Cdd:COG5189   417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 181-260 1.13e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061 181 GEKPYKCD--QCDKAFSEKCNLQTHiRIHSgekpykcdQCDKTFSEKCHLQKHIRIHTGEKPYKCNQCDKAFSQYNTLKT 258
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1720376061 259 HR 260
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
339-364 1.82e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.82e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720376061 339 SLQRHIRIHTGEKPYKCNQCDKAFSQ 364
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
227-252 2.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.85e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720376061 227 HLQKHIRIHTGEKPYKCNQCDKAFSQ 252
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
171-195 6.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.44e-04
                          10        20
                  ....*....|....*....|....*
gi 1720376061 171 HLQSHRRTHTGEKPYKCDQCDKAFS 195
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
283-308 7.18e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 7.18e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720376061 283 HLQTHRRTHTGEKPYKCNQCDKAFSQ 308
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
395-419 1.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.04e-03
                          10        20
                  ....*....|....*....|....*
gi 1720376061 395 NLQTHRRTHTGEKPYKCNQCDKAFS 419
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
199-223 1.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.15e-03
                          10        20
                  ....*....|....*....|....*
gi 1720376061 199 NLQTHIRIHSGEKPYKCDQCDKTFS 223
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-280 1.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.28e-03
                          10        20
                  ....*....|....*....|....*
gi 1720376061 256 LKTHRRTHTGEKPYKCNQCDKAFSQ 280
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
368-392 1.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.43e-03
                          10        20
                  ....*....|....*....|....*
gi 1720376061 368 LQTHRRTHTGEKPYKCNQCDKAFSQ 392
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
312-335 2.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.42e-03
                          10        20
                  ....*....|....*....|....
gi 1720376061 312 LKTHRRTHTGEKPYKCNQCDKAFS 335
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
115-139 6.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.48e-03
                          10        20
                  ....*....|....*....|....*
gi 1720376061 115 HLKRHERYHTGEQPFTCNECDKVFS 139
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 321-400 9.28e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.16  E-value: 9.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720376061 321 GEKPYKCN--QCDKAFSEKCSLQRHiRIHtgekpykcNQCDKAFSQYSTLQTHRRTHTGEKPYKCNQCDKAFSQYSNLQT 398
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1720376061 399 HR 400
Cdd:COG5189   417 HR 418
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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