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Conserved domains on  [gi|1720380234|ref|XP_030103758|]
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actin-related protein 8 isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_NBD_Arp8-like cd10206
nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The ...
 1-327 1.17e-102

nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The Arp8-like family includes Arp8, also called actin-like protein 8, from vertebrates and fungi. Human Arp8 is encoded by the ACTR8 gene and is also known as INO80 complex subunit N. It plays an important role in the functional organization of mitotic chromosomes. Arp8 exhibits low basal ATPase activity, and is unable to polymerize. It is probably a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication, and probably DNA repair. it is required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Arp8 strongly prefers nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. This subfamily also contains Arabidopsis thaliana Arp9.


:

Pssm-ID: 466812 [Multi-domain]  Cd Length: 447  Bit Score: 312.64  E-value: 1.17e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234   1 MILMKMGFAGIVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYR 80
Cdd:cd10206   207 LLLRRLGFSSVFVHQESVCATFGAGLSSACVVDIGAQKTSVACVEDGLSIPNSRIRLPYGGDDITRCFLWLLRRSGFPYR 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234  81 ECQLTNKMDCLLLQHLKETFCHLDQDISGLQDHEFQIRHPDSPALLYQFRLgdeklqapmalfypatfgivgqkmttlqh 160
Cdd:cd10206   287 ECNLNSPLDFLLLERLKETYCTLDQDDIGVQLHEFYVREPGQPTLKYQFKL----------------------------- 337

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234 161 rsqgdpedphdehyllatqskqeqsakatadrksaskpigfegdlrgqssdlperlhsqevdlassqgdclmagneseea 240
Cdd:cd10206       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234 241 ltalmsrktaislfegkaLGLDKAILHSVDCCSSDDTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFrRIIENV 320
Cdd:cd10206   338 ------------------LPLDEAIVQSILSCASDELKRKMYSSILLVGGGAKIPGLAEALEDRLLIKIPSLF-EAVETV 398


                  ....*..
gi 1720380234 321 DVITRPK 327
Cdd:cd10206   399 EVLPPPK 405
 
Name Accession Description Interval E-value
ASKHA_NBD_Arp8-like cd10206
nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The ...
 1-327 1.17e-102

nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The Arp8-like family includes Arp8, also called actin-like protein 8, from vertebrates and fungi. Human Arp8 is encoded by the ACTR8 gene and is also known as INO80 complex subunit N. It plays an important role in the functional organization of mitotic chromosomes. Arp8 exhibits low basal ATPase activity, and is unable to polymerize. It is probably a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication, and probably DNA repair. it is required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Arp8 strongly prefers nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. This subfamily also contains Arabidopsis thaliana Arp9.


Pssm-ID: 466812 [Multi-domain]  Cd Length: 447  Bit Score: 312.64  E-value: 1.17e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234   1 MILMKMGFAGIVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYR 80
Cdd:cd10206   207 LLLRRLGFSSVFVHQESVCATFGAGLSSACVVDIGAQKTSVACVEDGLSIPNSRIRLPYGGDDITRCFLWLLRRSGFPYR 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234  81 ECQLTNKMDCLLLQHLKETFCHLDQDISGLQDHEFQIRHPDSPALLYQFRLgdeklqapmalfypatfgivgqkmttlqh 160
Cdd:cd10206   287 ECNLNSPLDFLLLERLKETYCTLDQDDIGVQLHEFYVREPGQPTLKYQFKL----------------------------- 337

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234 161 rsqgdpedphdehyllatqskqeqsakatadrksaskpigfegdlrgqssdlperlhsqevdlassqgdclmagneseea 240
Cdd:cd10206       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234 241 ltalmsrktaislfegkaLGLDKAILHSVDCCSSDDTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFrRIIENV 320
Cdd:cd10206   338 ------------------LPLDEAIVQSILSCASDELKRKMYSSILLVGGGAKIPGLAEALEDRLLIKIPSLF-EAVETV 398


                  ....*..
gi 1720380234 321 DVITRPK 327
Cdd:cd10206   399 EVLPPPK 405
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
 5-150 4.33e-10

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 61.12  E-value: 4.33e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234    5 KMGFAGIVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRcfywLMQRAgFPYRECQL 84
Cdd:smart00268 121 TFNFPALYIAIQAVLSLYASGRTTGLVIDSGDGVTHVVPVVDGYVLPHAIKRIDIAGRDITD----YLKEL-LSERGYQF 195

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720380234   85 TNKMDCLLLQHLKETFCHLDQDIsglqDHEFQIRHPDSPALL----YQF------RLGDEKLQAPMALFYPATFGI 150
Cdd:smart00268 196 NSSAEFEIVREIKEKLCYVAEDF----EKEMKLARESSESSKlektYELpdgntiKVGNERFRIPEILFSPELIGL 267
Actin pfam00022
Actin;
18-89 2.98e-04

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 42.68  E-value: 2.98e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720380234  18 VCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYRECQLTNKMD 89
Cdd:pfam00022 132 VLSAFASGRTTGLVVDSGAGVTSVVPVHDGYVLQKAIRRSDLGGDFLTDYLRELLRSRNIEITPRYLIKSKK 203
PTZ00466 PTZ00466
actin-like protein; Provisional
 11-150 5.36e-04

actin-like protein; Provisional


Pssm-ID: 240426 [Multi-domain]  Cd Length: 380  Bit Score: 41.85  E-value: 5.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234  11 IVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYrecQLTNKMDc 90
Cdd:PTZ00466  138 LFISIQAILSLYSCGKTNGTVLDCGDGVCHCVSIYEGYSITNTITRTDVAGRDITTYLGYLLRKNGHLF---NTSAEME- 213

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720380234  91 lLLQHLKETFCHL--------DQDISGLQDHEFQIrhPDSPallyQFRLGDEKLQAPMALFYPATFGI 150
Cdd:PTZ00466  214 -VVKNMKENCCYVsfnmnkekNSSEKALTTLPYIL--PDGS----QILIGSERYRAPEVLFNPSILGL 274
 
Name Accession Description Interval E-value
ASKHA_NBD_Arp8-like cd10206
nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The ...
 1-327 1.17e-102

nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The Arp8-like family includes Arp8, also called actin-like protein 8, from vertebrates and fungi. Human Arp8 is encoded by the ACTR8 gene and is also known as INO80 complex subunit N. It plays an important role in the functional organization of mitotic chromosomes. Arp8 exhibits low basal ATPase activity, and is unable to polymerize. It is probably a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication, and probably DNA repair. it is required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Arp8 strongly prefers nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. This subfamily also contains Arabidopsis thaliana Arp9.


Pssm-ID: 466812 [Multi-domain]  Cd Length: 447  Bit Score: 312.64  E-value: 1.17e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234   1 MILMKMGFAGIVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYR 80
Cdd:cd10206   207 LLLRRLGFSSVFVHQESVCATFGAGLSSACVVDIGAQKTSVACVEDGLSIPNSRIRLPYGGDDITRCFLWLLRRSGFPYR 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234  81 ECQLTNKMDCLLLQHLKETFCHLDQDISGLQDHEFQIRHPDSPALLYQFRLgdeklqapmalfypatfgivgqkmttlqh 160
Cdd:cd10206   287 ECNLNSPLDFLLLERLKETYCTLDQDDIGVQLHEFYVREPGQPTLKYQFKL----------------------------- 337

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234 161 rsqgdpedphdehyllatqskqeqsakatadrksaskpigfegdlrgqssdlperlhsqevdlassqgdclmagneseea 240
Cdd:cd10206       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234 241 ltalmsrktaislfegkaLGLDKAILHSVDCCSSDDTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFrRIIENV 320
Cdd:cd10206   338 ------------------LPLDEAIVQSILSCASDELKRKMYSSILLVGGGAKIPGLAEALEDRLLIKIPSLF-EAVETV 398


                  ....*..
gi 1720380234 321 DVITRPK 327
Cdd:cd10206   399 EVLPPPK 405
ASKHA_NBD_actin-like cd10169
nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ...
 1-105 7.71e-18

nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ubiquitous in eukaryotes, and the major component of the actin cytoskeleton; monomeric globular protein (G-actin) reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. F-actin filaments form with the consequent hydrolysis of ATP. Some actin-related proteins (Arps) have roles in cytoskeletal functions, such as actin polymerization (Arp2/3) and dynein motor activity (Arp1). Both conventional actin and specific Arps have been implicated in chromatin remodeling and/or transcription regulation. The actin/ARP family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466810 [Multi-domain]  Cd Length: 258  Bit Score: 82.92  E-value: 7.71e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234   1 MILMKMGFAGIVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYr 80
Cdd:cd10169    69 ILFETFNVPSLYIANQAVLSLYASGRTTGLVVDSGEGVTHIVPVYEGYVLPHAVRRLDIGGRDLTDYLAKLLREKGYSF- 147

                          90       100
                  ....*....|....*....|....*
gi 1720380234  81 ecqlTNKMDCLLLQHLKETFCHLDQ 105
Cdd:cd10169   148 ----STSAEREIVRDIKEKLCGLHE 168
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
 5-150 4.33e-10

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 61.12  E-value: 4.33e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234    5 KMGFAGIVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRcfywLMQRAgFPYRECQL 84
Cdd:smart00268 121 TFNFPALYIAIQAVLSLYASGRTTGLVIDSGDGVTHVVPVVDGYVLPHAIKRIDIAGRDITD----YLKEL-LSERGYQF 195

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720380234   85 TNKMDCLLLQHLKETFCHLDQDIsglqDHEFQIRHPDSPALL----YQF------RLGDEKLQAPMALFYPATFGI 150
Cdd:smart00268 196 NSSAEFEIVREIKEKLCYVAEDF----EKEMKLARESSESSKlektYELpdgntiKVGNERFRIPEILFSPELIGL 267
ASKHA_NBD_Arp2 cd10220
nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, ...
 5-152 5.19e-07

nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, also called actin-like protein 2, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp2 is encoded by the ACTR2 gene.


Pssm-ID: 466821  Cd Length: 381  Bit Score: 51.41  E-value: 5.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234   5 KMGFAGIVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVS--HRNTRLCLAygGSDVSRCFYWLMQRAGFPYrec 82
Cdd:cd10220   123 KYGFAGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHIVPVYEGFSlpHLTRRLDVA--GRDITRYLIKLLLLRGYAF--- 197

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720380234  83 qltNK-MDCLLLQHLKETFCHLDQDIsglqDHEFQIRHpDSPALLYQF--------RLGDEKLQAPMALFYPATFGIVG 152
Cdd:cd10220   198 ---NRtADFETVREIKEKLCYVAYDI----ELEQKLAL-ETTVLVESYtlpdgrviKVGGERFEAPEALFQPHLIDVEG 268
ASKHA_NBD_AtARP7-like cd10209
nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 7 and similar ...
 9-150 1.21e-05

nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 7 and similar proteins; Arabidopsis thaliana ARP7 is an essential nuclear protein, ubiquitously expressed in all cell types. It is needed for normal embryogenesis, plant architecture, and floral organ abscission. It may play a role in regulating various phases of plant development through chromatin-mediated gene regulation.


Pssm-ID: 466815 [Multi-domain]  Cd Length: 354  Bit Score: 47.00  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234   9 AGIVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGfPYRecqltnKM 88
Cdd:cd10209   111 SGLYASEQAVLSLYAVGRISGCVVDVGHGKIDIAPVWEGAIQHNAVRRFEIGGRDLTELLAAELGKSN-PKV------KL 183

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720380234  89 DCLLLQHLKETFCHLDQD-------ISGLQDHEFQIrhPDSPallyQFRLGDEKLQAPMALFYPATFGI 150
Cdd:cd10209   184 DRSIVERLKEAVAWSADDeeayekkVLTCSPETYTL--PDGR----VISVGKERYCVGEALFRPSILGI 246
ASKHA_NBD_ScArp9-like cd10208
nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein 9 (Arp9) and ...
 9-66 2.72e-04

nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein 9 (Arp9) and similar proteins; Saccharomyces cerevisiae Arp9, also called actin-like protein 9, chromatin structure-remodeling complex protein ARP9, or SWI/SNF complex component ARP9, is a component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. It is also part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of many genes. Arp9 forms a stable heterodimer with Arp7 protein in both the RSC and SWI/SNF chromatin-remodeling complexes. It has been suggested that this dimer functions as a module with DNA bending proteins, to achieve correct architecture and facilitate complex-complex interactions. Fission yeast SWI/SNF and RSC complexes do not contain Arp7 and Arp8, but instead contain Arp9 and Arp42.


Pssm-ID: 466814  Cd Length: 356  Bit Score: 42.68  E-value: 2.72e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720380234   9 AGIVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSR 66
Cdd:cd10208   100 PAFAILEAPLAALYAAGATSGIVVDIGHEKTDITPIVDSQVVPHALVSIPIGGQDCTA 157
Actin pfam00022
Actin;
18-89 2.98e-04

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 42.68  E-value: 2.98e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720380234  18 VCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYRECQLTNKMD 89
Cdd:pfam00022 132 VLSAFASGRTTGLVVDSGAGVTSVVPVHDGYVLQKAIRRSDLGGDFLTDYLRELLRSRNIEITPRYLIKSKK 203
PTZ00466 PTZ00466
actin-like protein; Provisional
 11-150 5.36e-04

actin-like protein; Provisional


Pssm-ID: 240426 [Multi-domain]  Cd Length: 380  Bit Score: 41.85  E-value: 5.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234  11 IVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYrecQLTNKMDc 90
Cdd:PTZ00466  138 LFISIQAILSLYSCGKTNGTVLDCGDGVCHCVSIYEGYSITNTITRTDVAGRDITTYLGYLLRKNGHLF---NTSAEME- 213

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720380234  91 lLLQHLKETFCHL--------DQDISGLQDHEFQIrhPDSPallyQFRLGDEKLQAPMALFYPATFGI 150
Cdd:PTZ00466  214 -VVKNMKENCCYVsfnmnkekNSSEKALTTLPYIL--PDGS----QILIGSERYRAPEVLFNPSILGL 274
PTZ00004 PTZ00004
actin-2; Provisional
 2-149 6.87e-04

actin-2; Provisional


Pssm-ID: 240225 [Multi-domain]  Cd Length: 378  Bit Score: 41.68  E-value: 6.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234   2 ILM-KMGFAGIVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYr 80
Cdd:PTZ00004  123 IMFeTHNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYSLPHAIHRLDVAGRDLTEYMMKILHERGTTF- 201

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720380234  81 ecqlTNKMDCLLLQHLKETFCH--LDQDISGLQDHE----FQIRH--PDSPALlyqfRLGDEKLQAPMALFYPATFG 149
Cdd:PTZ00004  202 ----TTTAEKEIVRDIKEKLCYiaLDFDEEMGNSAGssdkYEESYelPDGTII----TVGSERFRCPEALFQPSLIG 270
ASKHA_NBD_ACTL7 cd10214
nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ...
 252-350 7.71e-04

nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ACTL7-like family includes ACTL7A, ACTL7B and ACTL9 (also known as ACTL7C). In mammalian, ACTL7A is expressed in a wide variety of adult tissues, while the ACTL7B is expressed in spermatids through the elongation phase of spermatid development. ACTL7A, also called actin-like-7-alpha, or T-ACTIN-2 in mouse, may play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis. ACTL7B, also called actin-like-7-beta, acts as a key regulator of spermiogenesis that is required for male fertility. ACTL9 is a testis-specific protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation.


Pssm-ID: 466819 [Multi-domain]  Cd Length: 368  Bit Score: 41.64  E-value: 7.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234 252 SLFEGKALGLDKAILHSVDCCSSDdTKKKMYSSILVVGGGLMFHKAQEFLQhRILNKMPPSFRRIIEnvdvitrpkvsrl 331
Cdd:cd10214   260 SLIGSKQPGLHTLTMNSLNKCDAN-LKKDLAKNILLCGGSTMFDGFPDRFQ-KELSKLCPNDNPIVA------------- 324

                          90
                  ....*....|....*....
gi 1720380234 332 VIPVRRYSlrpVWLHRTVM 350
Cdd:cd10214   325 ASPERKYS---VWTGGSIL 340
ASKHA_NBD_actin_Arp-T1-3 cd13397
nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar ...
 16-150 8.32e-04

nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar proteins; The family includes actin and human actin-related proteins T1, T2, and T3. Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Arp-T1, encoded by ACTRT1/ARPT1 gene expressed in testis, negatively regulates the Hedgehog (SHH) signaling, binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression. Arp-T2 (also called actin-related protein M2; encoded by ACTRT2/ARPM2 gene expressed in testis and various other cell types) and Arp-T3 (also called actin-related protein M1; encoded by ACTRT3/ARPM1 gene expressed in all tested human tissues) play general roles in the organization of the cytoskeleton like other cytoplasmic actin-related proteins.


Pssm-ID: 466848 [Multi-domain]  Cd Length: 359  Bit Score: 41.40  E-value: 8.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234  16 ESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVS--HRNTRLCLAygGSDVSRCFYWLMQRAGFPYR---ECQLTNKMdc 90
Cdd:cd13397   132 QAVLSLYSSGRTTGLVLDSGDGVTHTVPIYEGYAlpHAVQRLDLA--GRDLTEYLMKLLKERGHSFTttaEREIVRDI-- 207

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720380234  91 lllqhlKETFCHLDQDIsglqDHEFQIRHPDSPALlYQ------FRLGDEKLQAPMALFYPATFGI 150
Cdd:cd13397   208 ------KEKLCYVALDY----EEELKKKSEELEKE-YTlpdgqvIKIGSERFRCPEALFRPSLIGR 262
ASKHA_NBD_ACTL7 cd10214
nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ...
 16-149 1.12e-03

nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ACTL7-like family includes ACTL7A, ACTL7B and ACTL9 (also known as ACTL7C). In mammalian, ACTL7A is expressed in a wide variety of adult tissues, while the ACTL7B is expressed in spermatids through the elongation phase of spermatid development. ACTL7A, also called actin-like-7-alpha, or T-ACTIN-2 in mouse, may play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis. ACTL7B, also called actin-like-7-beta, acts as a key regulator of spermiogenesis that is required for male fertility. ACTL9 is a testis-specific protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation.


Pssm-ID: 466819 [Multi-domain]  Cd Length: 368  Bit Score: 40.87  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234  16 ESVCATFGSGLSSTCVVDVGDQKTSVCCVEDG--VSHRNTRLclAYGGSDVSRCFYWLMQRAGFPYRECQLTnkmdclLL 93
Cdd:cd10214   135 QSRLSLYSYGRTSGLVVESGHGVSYVVPIHEGynLPHITGRA--DYAGSDLTAYLMKLLNEAGNKFTDDQLH------IV 206

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720380234  94 QHLKETFCHLDQDIS---GLQDHEFQIRH--PDSPALlyqfRLGDEKLQAPMALFYPATFG 149
Cdd:cd10214   207 EDIKKKCCYVALDFEeemGLPPQEYTVDYelPDGHLI----TIGKERFRCPEMLFNPSLIG 263
ASKHA_NBD_Arp4_ACTL6-like cd13395
nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The ...
 17-160 1.19e-03

nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The Arp4-like subfamily includes Arp4, also called actin-like protein 4, from fungi and plants. Saccharomyces cerevisiae Arp4 acts synergistically with Arp8 to depolymerize F-actin; it binds ATP, but unlike conventional actin, does not form filaments. It is a component of the NuA4 histone acetyltransferase complex, the chromatin-remodeling INO80 complex and the SWR1 chromatin remodeling complex. Arabidopsis thaliana Arp4 is involved in several developmental processes including organization of plant organs, flowering time, anther development, flower senescence and fertility, probably by regulating the chromatin structure. This family also includes human homologs of yeast and plant, which are actin-like protein 6A (encoded by the ACTL6A gene; also known as ArpNbeta, 53 kDa BRG1-associated factor A/BRG1-associated factor 53A/BAF35A, and INO80 complex subunit K/INO80K) and actin-like protein 6B (encoded by the ACTL6B gene; also known as ArpNalpha, 53 kDa BRG1-associated factor B/BRG1-associated factor 53B/BAF35B). ACTL6A and ACTL6B are involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). They are components of numerous complexes with chromatin remodeling and histone acetyltransferase activity. ACTL6A is also a putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Schizosaccharomyces pombe actin-related protein 42 (Arp42) is also included in this family. It is also a component of SWI/SNF and RSC complexes.


Pssm-ID: 466846 [Multi-domain]  Cd Length: 413  Bit Score: 41.01  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234  17 SVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGF----PYR---------ECQ 83
Cdd:cd13395   144 AVLSAFANGRSTALVVDSGATSTSVVPVHDGYVLQKAIVRSPLGGDFLTDQLLKLLESKNIeiipRYMikskepvegGAP 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234  84 LTNKMDCL--------------LLQHLKETFCHLdqdisgLQDHEFQIRHPDSPALLYQF------RLGDEKLQAPMALF 143
Cdd:cd13395   224 AKYTKKDLpnttssyhrymvrrVLQDFKESVCQV------SDSPFDESEAASIPTVSYELpdgyniEFGAERFKIPELLF 297

                         170       180
                  ....*....|....*....|...
gi 1720380234 144 YPATF------GIVGQKMTTLQH 160
Cdd:cd13395   298 DPSLVkgipapPSEGNELLGLPQ 320
ASKHA_NBD_actin_Arp-T1-3 cd13397
nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar ...
 252-345 2.78e-03

nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar proteins; The family includes actin and human actin-related proteins T1, T2, and T3. Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Arp-T1, encoded by ACTRT1/ARPT1 gene expressed in testis, negatively regulates the Hedgehog (SHH) signaling, binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression. Arp-T2 (also called actin-related protein M2; encoded by ACTRT2/ARPM2 gene expressed in testis and various other cell types) and Arp-T3 (also called actin-related protein M1; encoded by ACTRT3/ARPM1 gene expressed in all tested human tissues) play general roles in the organization of the cytoskeleton like other cytoplasmic actin-related proteins.


Pssm-ID: 466848 [Multi-domain]  Cd Length: 359  Bit Score: 39.86  E-value: 2.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720380234 252 SLFEGKALGLDKAILHSVDCCSSDdTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSfrriiENVDVITRPKvsrl 331
Cdd:cd13397   258 SLIGREAPGIHKLVYNSIMKCDID-IRKDLYSNIVLSGGSTMFPGLPERLQKELEALAPSS-----TKVKVIAPPE---- 327

                          90
                  ....*....|....
gi 1720380234 332 vipvRRYSlrpVWL 345
Cdd:cd13397   328 ----RKYS---VWI 334
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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