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Conserved domains on  [gi|1720383973|ref|XP_030104350|]
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leucine-rich repeat-containing protein 14 isoform X2 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1001123)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Oryctolagus cuniculus monocyte differentiation antigen CD14, a coreceptor for bacterial lipopolysaccharide

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
116-232 6.50e-04

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 6.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383973 116 LESLELAFCAL--LPEDLRFLAQsshaahLKKLDLSGN------------------DLSGNQLTPFQGLLQAvaTTLLHL 175
Cdd:COG4886   184 LKELDLSNNQItdLPEPLGNLTN------LEELDLSGNqltdlpeplanltnletlDLSNNQLTDLPELGNL--TNLEEL 255

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720383973 176 ELTECQLADaqllatLPTLTRCASLRYLGLYGNPLSMAGLKELLRDSVVQAELRTVV 232
Cdd:COG4886   256 DLSNNQLTD------LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
116-232 6.50e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 6.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383973 116 LESLELAFCAL--LPEDLRFLAQsshaahLKKLDLSGN------------------DLSGNQLTPFQGLLQAvaTTLLHL 175
Cdd:COG4886   184 LKELDLSNNQItdLPEPLGNLTN------LEELDLSGNqltdlpeplanltnletlDLSNNQLTDLPELGNL--TNLEEL 255

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720383973 176 ELTECQLADaqllatLPTLTRCASLRYLGLYGNPLSMAGLKELLRDSVVQAELRTVV 232
Cdd:COG4886   256 DLSNNQLTD------LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 113-211 8.14e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.07  E-value: 8.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383973 113 QRPLESLELAFcallpeDLRFLAqsSHAAHLKKLDLSGNDLSgnQLTPFQGLlqavaTTLLHLELTECQLADAQllATLP 192
Cdd:cd21340   100 QRLPPGEKLTF------DPRSLA--ALSNSLRVLNISGNNID--SLEPLAPL-----RNLEQLDASNNQISDLE--ELLD 162

                          90
                  ....*....|....*....
gi 1720383973 193 TLTRCASLRYLGLYGNPLS 211
Cdd:cd21340   163 LLSSWPSLRELDLTGNPVC 181
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
116-232 6.50e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 6.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383973 116 LESLELAFCAL--LPEDLRFLAQsshaahLKKLDLSGN------------------DLSGNQLTPFQGLLQAvaTTLLHL 175
Cdd:COG4886   184 LKELDLSNNQItdLPEPLGNLTN------LEELDLSGNqltdlpeplanltnletlDLSNNQLTDLPELGNL--TNLEEL 255

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720383973 176 ELTECQLADaqllatLPTLTRCASLRYLGLYGNPLSMAGLKELLRDSVVQAELRTVV 232
Cdd:COG4886   256 DLSNNQLTD------LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
116-211 1.70e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.53  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383973 116 LESLELAFCAL--LPEDLRFLAQsshaahLKKLDLSGN------------------DLSGNQLTPFQGLLQAVaTTLLHL 175
Cdd:COG4886   161 LKSLDLSNNQLtdLPEELGNLTN------LKELDLSNNqitdlpeplgnltnleelDLSGNQLTDLPEPLANL-TNLETL 233

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1720383973 176 ELTECQLADaqllatLPTLTRCASLRYLGLYGNPLS 211
Cdd:COG4886   234 DLSNNQLTD------LPELGNLTNLEELDLSNNQLT 263
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 113-211 8.14e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.07  E-value: 8.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383973 113 QRPLESLELAFcallpeDLRFLAqsSHAAHLKKLDLSGNDLSgnQLTPFQGLlqavaTTLLHLELTECQLADAQllATLP 192
Cdd:cd21340   100 QRLPPGEKLTF------DPRSLA--ALSNSLRVLNISGNNID--SLEPLAPL-----RNLEQLDASNNQISDLE--ELLD 162

                          90
                  ....*....|....*....
gi 1720383973 193 TLTRCASLRYLGLYGNPLS 211
Cdd:cd21340   163 LLSSWPSLRELDLTGNPVC 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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