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Conserved domains on  [gi|1720353987|ref|XP_030107739|]
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protein crumbs homolog 1 isoform X8 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 181-316 1.56e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.02  E-value: 1.56e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  181 FHTVQPNALLLIRGN-KDVSMKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLALvggsckEKC 258
Cdd:pfam02210    1 FRTRQPNGLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERnGNTLTLSV------DGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720353987  259 TTKSSVPVENHQSICALQDSFLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 316
Cdd:pfam02210   75 TVVSSLPPGESLLLNLNGPLYLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 410-527 1.58e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 82.47  E-value: 1.58e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  410 VRTRQPLGLLLALENSTYQYVSVWLEHGSLALQTPGSPKFMVNFF----LSDGNVHLISLRIKPNEIELYQSSQNLGFIS 485
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSsgknLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1720353987  486 VPTW--TIRRGDVIFIGGLP--DREKTEVYGGFFKGCVQDVRLNSQ 527
Cdd:pfam02210   81 PPGEslLLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 647-772 1.09e-15

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 74.38  E-value: 1.09e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  647 FRTHDTNVMILHAE-KEPEFLNISIQDARLFFQLRSGNSFYTLHLMGSQLvNDGTWHQVTFSMidpvaQTSRWQMEVNDQ 725
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNL-NDGQWHSVRVER-----NGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720353987  726 TpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGGI 772
Cdd:pfam02210   75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
EGF_CA smart00179
Calcium-binding EGF-like domain;
64-105 3.47e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.63  E-value: 3.47e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1720353987    64 DVDECLL-HPCLNGGTCENLPGNYACHCPfddtsRTFYGGENC 105
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECP-----PGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 964-1000 9.28e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 9.28e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720353987  964 DINECAS-DPCINGGLCRDLVNRFLCICDVAFAGERCE 1000
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 343-374 8.44e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 8.44e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1720353987  343 CESQ-PCQNRGRCINLWQGYQCECDRPYTGSNC 374
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 844-879 1.32e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.32e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720353987  844 NIDECFS-SPC-IHGNCSDGVAAYHCRCEPGYTGVNCE 879
Cdd:cd00054      1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 808-842 1.64e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.64e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720353987  808 NACHS-SPCLHGGNCEDSYSSYRCACLSGWSGTHCE 842
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 881-916 1.88e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.88e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720353987  881 DVDNCKS-HQCANGATCVPEAHGYSCLCFGNFTGRFC 916
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 556-590 2.68e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 2.68e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720353987  556 NTCKS-NPCHNGGVCHSLWDDFSCSCPTNTAGRACE 590
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 113-148 2.65e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 2.65e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720353987  113 THHQCLNNGKCIphfqNGQHGFTCQCLSGYAGPLCE 148
Cdd:cd00054      7 SGNPCQNGGTCV----NTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 181-316 1.56e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.02  E-value: 1.56e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  181 FHTVQPNALLLIRGN-KDVSMKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLALvggsckEKC 258
Cdd:pfam02210    1 FRTRQPNGLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERnGNTLTLSV------DGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720353987  259 TTKSSVPVENHQSICALQDSFLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 316
Cdd:pfam02210   75 TVVSSLPPGESLLLNLNGPLYLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 410-527 1.58e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 82.47  E-value: 1.58e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  410 VRTRQPLGLLLALENSTYQYVSVWLEHGSLALQTPGSPKFMVNFF----LSDGNVHLISLRIKPNEIELYQSSQNLGFIS 485
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSsgknLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1720353987  486 VPTW--TIRRGDVIFIGGLP--DREKTEVYGGFFKGCVQDVRLNSQ 527
Cdd:pfam02210   81 PPGEslLLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 152-316 1.61e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 77.84  E-value: 1.61e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  152 TLSFGSNGFLWVTSGSHTGigPECNISLRFHTVQPNALLLIRGNKDVS--MKLELLNGCVHLSIEVwNQLKVLLSISHNT 229
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPR--TRLSISFSFRTTSPNGLLLYAGSQNGGdfLALELEDGRLVLRYDL-GSGSLVLSSKTPL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  230 SDGEWHFVEVTI-AETLTLALVGGSCKEKCTTKSSVPVENHQSIcalqdsFLGGLPMGTANNSVsvlniynvPSTPSFVG 308
Cdd:cd00110     78 NDGQWHSVSVERnGRSVTLSVDGERVVESGSPGGSALLNLDGPL------YLGGLPEDLKSPGL--------PVSPGFVG 143


                   ....*...
gi 1720353987  309 CLQDIRFD 316
Cdd:cd00110    144 CIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 647-772 1.09e-15

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 74.38  E-value: 1.09e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  647 FRTHDTNVMILHAE-KEPEFLNISIQDARLFFQLRSGNSFYTLHLMGSQLvNDGTWHQVTFSMidpvaQTSRWQMEVNDQ 725
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNL-NDGQWHSVRVER-----NGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720353987  726 TpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGGI 772
Cdd:pfam02210   75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 387-525 3.52e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.91  E-value: 3.52e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  387 DSTGYAAFSVNDNYGQNFSLSMFVRTRQPLGLLLALENSTY-QYVSVWLEHGSLALQ---TPGSPKFMVNFFLSDGNVHL 462
Cdd:cd00110      5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALELEDGRLVLRydlGSGSLVLSSKTPLNDGQWHS 84

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720353987  463 ISLRIKPNEIEL-------YQSSQNLGFISVPTwtirrGDVIFIGGLPDREKT--EVYGGFFKGCVQDVRLN 525
Cdd:cd00110     85 VSVERNGRSVTLsvdgervVESGSPGGSALLNL-----DGPLYLGGLPEDLKSpgLPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 619-769 4.98e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.52  E-value: 4.98e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  619 AVFSGLSReILFRSNGNITRElTNITFAFRTHDTNVMILHAEKEP--EFLNISIQDARLFFQLRSGNSfyTLHLMGSQLV 696
Cdd:cd00110      2 VSFSGSSY-VRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNggDFLALELEDGRLVLRYDLGSG--SLVLSSKTPL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  697 NDGTWHQVTFSMIDPVAqtsrwQMEVNDQTpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEI 769
Cdd:cd00110     78 NDGQWHSVSVERNGRSV-----TLSVDGER--VVESGSPGGSALLNLDGPLYLGglpedlkSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
642-771 1.13e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 66.21  E-value: 1.13e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987   642 NITFAFRTHDTNVMILHA--EKEPEFLNISIQDARLFFQLRSGNSFYTLHLmGSQLVNDGTWHQVTFSMIDPVAqtsrwQ 719
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgsKGGGDYLALELRDGRLVLRYDLGSGPARLTS-DPTPLNDGQWHRVAVERNGRSV-----T 74

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720353987   720 MEVNDQTPfvISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGG 771
Cdd:smart00282   75 LSVDGGNR--VSGESPGGLTILNLDGPLYLGglpedlkLPPLPVTPGFRGCIRNLKVNG 131
LamG smart00282
Laminin G domain;
176-316 4.07e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 64.28  E-value: 4.07e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987   176 NISLRFHTVQPNALLLIRGNKDVS--MKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLalvgg 252
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGdyLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERnGRSVTL----- 75

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720353987   253 sckekcttksSVPVENHQSICALQDS---------FLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 316
Cdd:smart00282   76 ----------SVDGGNRVSGESPGGLtilnldgplYLGGLP--------EDLKLPPLPVTPGFRGCIRNLKVN 130
LamG smart00282
Laminin G domain;
405-527 3.63e-10

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 58.89  E-value: 3.63e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987   405 SLSMFVRTRQPLGLLLALENSTY-QYVSVWLEHGSLALQ--TPGSPKFMVNFF--LSDGNVHLISLRIKPNEIELY--QS 477
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRydLGSGPARLTSDPtpLNDGQWHRVAVERNGRSVTLSvdGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1720353987   478 SQNLGFISVPTWTIRRGDVIFIGGLPD--REKTEVYGGFFKGCVQDVRLNSQ 527
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEdlKLPPLPVTPGFRGCIRNLKVNGK 132
EGF_CA smart00179
Calcium-binding EGF-like domain;
64-105 3.47e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.63  E-value: 3.47e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1720353987    64 DVDECLL-HPCLNGGTCENLPGNYACHCPfddtsRTFYGGENC 105
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECP-----PGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 964-1000 9.28e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 9.28e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720353987  964 DINECAS-DPCINGGLCRDLVNRFLCICDVAFAGERCE 1000
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 64-91 3.45e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 3.45e-06
                           10        20
                   ....*....|....*....|....*....
gi 1720353987   64 DVDECLL-HPCLNGGTCENLPGNYACHCP 91
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCP 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 343-374 8.44e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 8.44e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1720353987  343 CESQ-PCQNRGRCINLWQGYQCECDRPYTGSNC 374
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 844-879 1.32e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.32e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720353987  844 NIDECFS-SPC-IHGNCSDGVAAYHCRCEPGYTGVNCE 879
Cdd:cd00054      1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 808-842 1.64e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.64e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720353987  808 NACHS-SPCLHGGNCEDSYSSYRCACLSGWSGTHCE 842
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 343-373 1.69e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.37  E-value: 1.69e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1720353987  343 CESQPCQNRGRCINLWQGYQCECDRPYTGSN 373
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
964-1000 2.60e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 2.60e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720353987   964 DINECAS-DPCINGGLCRDLVNRFLCICDVAF-AGERCE 1000
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 881-916 1.88e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.88e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720353987  881 DVDNCKS-HQCANGATCVPEAHGYSCLCFGNFTGRFC 916
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 556-590 2.68e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 2.68e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720353987  556 NTCKS-NPCHNGGVCHSLWDDFSCSCPTNTAGRACE 590
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 558-587 3.24e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 3.24e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1720353987  558 CKSNPCHNGGVCHSLWDDFSCSCPTNTAGR 587
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 968-998 4.40e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 4.40e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1720353987  968 CASDPCINGGLCRDLVNRFLCICDVAFAGER 998
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
844-879 6.27e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 6.27e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720353987   844 NIDECFS-SPCIHG-NCSDGVAAYHCRCEPGYT-GVNCE 879
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 68-91 6.58e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 6.58e-04
                           10        20
                   ....*....|....*....|....
gi 1720353987   68 CLLHPCLNGGTCENLPGNYACHCP 91
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP 24
EGF_CA smart00179
Calcium-binding EGF-like domain;
808-842 7.95e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 7.95e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1720353987   808 NACHS-SPCLHGGNCEDSYSSYRCACLSGWS-GTHCE 842
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 810-838 1.22e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 1.22e-03
                           10        20
                   ....*....|....*....|....*....
gi 1720353987  810 CHSSPCLHGGNCEDSYSSYRCACLSGWSG 838
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
343-374 1.55e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.55e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1720353987   343 CES-QPCQNRGRCINLWQGYQCECDRPYT-GSNC 374
Cdd:smart00179    5 CASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 113-148 2.65e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 2.65e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720353987  113 THHQCLNNGKCIphfqNGQHGFTCQCLSGYAGPLCE 148
Cdd:cd00054      7 SGNPCQNGGTCV----NTVGSYRCSCPPGYTGRNCE 38
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
 848-922 3.01e-03

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 39.24  E-value: 3.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  848 CFSSPCIHGNCSDGVaayHCRCEPGYTGVNCE--VDVDNCKSHQCANGATCVPEAH------GYSCLCFGNFTGRFCRHS 919
Cdd:PHA03099    53 CLHGDCIHARDIDGM---YCRCSHGYTGIRCQhvVLVDYQRSEKPNTTTSYIPSPGivlvlvGIIITCCLLSVYRFTRRT 129


                   ...
gi 1720353987  920 RLP 922
Cdd:PHA03099   130 KLP 132
EGF_CA smart00179
Calcium-binding EGF-like domain;
558-590 8.12e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 8.12e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1720353987   558 CKS-NPCHNGGVCHSLWDDFSCSCPTN-TAGRACE 590
Cdd:smart00179    5 CASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 112-145 9.01e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 34.67  E-value: 9.01e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720353987  112 CTHHQCLNNGKCIphfqNGQHGFTCQCLSGYAGP 145
Cdd:pfam00008    1 CAPNPCSNGGTCV----DTPGGYTCICPEGYTGK 30
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 181-316 1.56e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.02  E-value: 1.56e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  181 FHTVQPNALLLIRGN-KDVSMKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLALvggsckEKC 258
Cdd:pfam02210    1 FRTRQPNGLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERnGNTLTLSV------DGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720353987  259 TTKSSVPVENHQSICALQDSFLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 316
Cdd:pfam02210   75 TVVSSLPPGESLLLNLNGPLYLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 410-527 1.58e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 82.47  E-value: 1.58e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  410 VRTRQPLGLLLALENSTYQYVSVWLEHGSLALQTPGSPKFMVNFF----LSDGNVHLISLRIKPNEIELYQSSQNLGFIS 485
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSsgknLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1720353987  486 VPTW--TIRRGDVIFIGGLP--DREKTEVYGGFFKGCVQDVRLNSQ 527
Cdd:pfam02210   81 PPGEslLLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 152-316 1.61e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 77.84  E-value: 1.61e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  152 TLSFGSNGFLWVTSGSHTGigPECNISLRFHTVQPNALLLIRGNKDVS--MKLELLNGCVHLSIEVwNQLKVLLSISHNT 229
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPR--TRLSISFSFRTTSPNGLLLYAGSQNGGdfLALELEDGRLVLRYDL-GSGSLVLSSKTPL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  230 SDGEWHFVEVTI-AETLTLALVGGSCKEKCTTKSSVPVENHQSIcalqdsFLGGLPMGTANNSVsvlniynvPSTPSFVG 308
Cdd:cd00110     78 NDGQWHSVSVERnGRSVTLSVDGERVVESGSPGGSALLNLDGPL------YLGGLPEDLKSPGL--------PVSPGFVG 143


                   ....*...
gi 1720353987  309 CLQDIRFD 316
Cdd:cd00110    144 CIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 647-772 1.09e-15

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 74.38  E-value: 1.09e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  647 FRTHDTNVMILHAE-KEPEFLNISIQDARLFFQLRSGNSFYTLHLMGSQLvNDGTWHQVTFSMidpvaQTSRWQMEVNDQ 725
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNL-NDGQWHSVRVER-----NGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720353987  726 TpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGGI 772
Cdd:pfam02210   75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 387-525 3.52e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.91  E-value: 3.52e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  387 DSTGYAAFSVNDNYGQNFSLSMFVRTRQPLGLLLALENSTY-QYVSVWLEHGSLALQ---TPGSPKFMVNFFLSDGNVHL 462
Cdd:cd00110      5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALELEDGRLVLRydlGSGSLVLSSKTPLNDGQWHS 84

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720353987  463 ISLRIKPNEIEL-------YQSSQNLGFISVPTwtirrGDVIFIGGLPDREKT--EVYGGFFKGCVQDVRLN 525
Cdd:cd00110     85 VSVERNGRSVTLsvdgervVESGSPGGSALLNL-----DGPLYLGGLPEDLKSpgLPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 619-769 4.98e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.52  E-value: 4.98e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  619 AVFSGLSReILFRSNGNITRElTNITFAFRTHDTNVMILHAEKEP--EFLNISIQDARLFFQLRSGNSfyTLHLMGSQLV 696
Cdd:cd00110      2 VSFSGSSY-VRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNggDFLALELEDGRLVLRYDLGSG--SLVLSSKTPL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  697 NDGTWHQVTFSMIDPVAqtsrwQMEVNDQTpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEI 769
Cdd:cd00110     78 NDGQWHSVSVERNGRSV-----TLSVDGER--VVESGSPGGSALLNLDGPLYLGglpedlkSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
642-771 1.13e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 66.21  E-value: 1.13e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987   642 NITFAFRTHDTNVMILHA--EKEPEFLNISIQDARLFFQLRSGNSFYTLHLmGSQLVNDGTWHQVTFSMIDPVAqtsrwQ 719
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgsKGGGDYLALELRDGRLVLRYDLGSGPARLTS-DPTPLNDGQWHRVAVERNGRSV-----T 74

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720353987   720 MEVNDQTPfvISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGG 771
Cdd:smart00282   75 LSVDGGNR--VSGESPGGLTILNLDGPLYLGglpedlkLPPLPVTPGFRGCIRNLKVNG 131
LamG smart00282
Laminin G domain;
176-316 4.07e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 64.28  E-value: 4.07e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987   176 NISLRFHTVQPNALLLIRGNKDVS--MKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLalvgg 252
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGdyLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERnGRSVTL----- 75

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720353987   253 sckekcttksSVPVENHQSICALQDS---------FLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 316
Cdd:smart00282   76 ----------SVDGGNRVSGESPGGLtilnldgplYLGGLP--------EDLKLPPLPVTPGFRGCIRNLKVN 130
LamG smart00282
Laminin G domain;
405-527 3.63e-10

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 58.89  E-value: 3.63e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987   405 SLSMFVRTRQPLGLLLALENSTY-QYVSVWLEHGSLALQ--TPGSPKFMVNFF--LSDGNVHLISLRIKPNEIELY--QS 477
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRydLGSGPARLTSDPtpLNDGQWHRVAVERNGRSVTLSvdGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1720353987   478 SQNLGFISVPTWTIRRGDVIFIGGLPD--REKTEVYGGFFKGCVQDVRLNSQ 527
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEdlKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
647-771 1.77e-09

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 56.94  E-value: 1.77e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  647 FRTHDTNVMILHAEK--EPEFLNISIQDARLFFQLRSGNSfyTLHLMGSQLVNDGTWHQVTFSMIdpvaqTSRWQMEVND 724
Cdd:pfam00054    1 FRTTEPSGLLLYNGTqtERDFLALELRDGRLEVSYDLGSG--AAVVRSGDKLNDGKWHSVELERN-----GRSGTLSVDG 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1720353987  725 QTPFVISEVaTGSLNFLKDNTDIYVG---DQSVDNP-----KGLQGCLSTIEIGG 771
Cdd:pfam00054   74 EARPTGESP-LGATTDLDVDGPLYVGglpSLGVKKRrlaisPSFDGCIRDVIVNG 127
EGF_CA smart00179
Calcium-binding EGF-like domain;
64-105 3.47e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.63  E-value: 3.47e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1720353987    64 DVDECLL-HPCLNGGTCENLPGNYACHCPfddtsRTFYGGENC 105
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECP-----PGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 964-1000 9.28e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 9.28e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720353987  964 DINECAS-DPCINGGLCRDLVNRFLCICDVAFAGERCE 1000
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Laminin_G_1 pfam00054
Laminin G domain;
181-316 3.38e-06

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 47.31  E-value: 3.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  181 FHTVQPNALLLIRG--NKDVSMKLELLNGCVHLSIEVWNQlKVLLSISHNTSDGEWHFVEVTIAET-LTLALVGGSckek 257
Cdd:pfam00054    1 FRTTEPSGLLLYNGtqTERDFLALELRDGRLEVSYDLGSG-AAVVRSGDKLNDGKWHSVELERNGRsGTLSVDGEA---- 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720353987  258 cTTKSSVPVENHQSICALQDSFLGGLPmgtannSVSVLNiYNVPSTPSFVGCLQDIRFD 316
Cdd:pfam00054   76 -RPTGESPLGATTDLDVDGPLYVGGLP------SLGVKK-RRLAISPSFDGCIRDVIVN 126
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 64-91 3.45e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 3.45e-06
                           10        20
                   ....*....|....*....|....*....
gi 1720353987   64 DVDECLL-HPCLNGGTCENLPGNYACHCP 91
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCP 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 343-374 8.44e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 8.44e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1720353987  343 CESQ-PCQNRGRCINLWQGYQCECDRPYTGSNC 374
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 844-879 1.32e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.32e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720353987  844 NIDECFS-SPC-IHGNCSDGVAAYHCRCEPGYTGVNCE 879
Cdd:cd00054      1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 808-842 1.64e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.64e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720353987  808 NACHS-SPCLHGGNCEDSYSSYRCACLSGWSGTHCE 842
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 343-373 1.69e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.37  E-value: 1.69e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1720353987  343 CESQPCQNRGRCINLWQGYQCECDRPYTGSN 373
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
964-1000 2.60e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 2.60e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720353987   964 DINECAS-DPCINGGLCRDLVNRFLCICDVAF-AGERCE 1000
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 881-916 1.88e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.88e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720353987  881 DVDNCKS-HQCANGATCVPEAHGYSCLCFGNFTGRFC 916
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 556-590 2.68e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 2.68e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720353987  556 NTCKS-NPCHNGGVCHSLWDDFSCSCPTNTAGRACE 590
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 558-587 3.24e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 3.24e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1720353987  558 CKSNPCHNGGVCHSLWDDFSCSCPTNTAGR 587
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 968-998 4.40e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 4.40e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1720353987  968 CASDPCINGGLCRDLVNRFLCICDVAFAGER 998
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
844-879 6.27e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 6.27e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1720353987   844 NIDECFS-SPCIHG-NCSDGVAAYHCRCEPGYT-GVNCE 879
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 68-91 6.58e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 6.58e-04
                           10        20
                   ....*....|....*....|....
gi 1720353987   68 CLLHPCLNGGTCENLPGNYACHCP 91
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP 24
EGF_CA smart00179
Calcium-binding EGF-like domain;
808-842 7.95e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 7.95e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1720353987   808 NACHS-SPCLHGGNCEDSYSSYRCACLSGWS-GTHCE 842
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 810-838 1.22e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 1.22e-03
                           10        20
                   ....*....|....*....|....*....
gi 1720353987  810 CHSSPCLHGGNCEDSYSSYRCACLSGWSG 838
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
343-374 1.55e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.55e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1720353987   343 CES-QPCQNRGRCINLWQGYQCECDRPYT-GSNC 374
Cdd:smart00179    5 CASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 812-842 2.01e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 2.01e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1720353987  812 SSPCLHGGNCEDSYSSYRCACLSGWSG-THCE 842
Cdd:cd00053      5 SNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
Laminin_G_1 pfam00054
Laminin G domain;
410-530 2.34e-03

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 39.22  E-value: 2.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  410 VRTRQPLGLLLALENSTY-QYVSVWLEHGSL----------ALQTPGSPkfmvnffLSDGNVHLI---------SLRIKP 469
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTErDFLALELRDGRLevsydlgsgaAVVRSGDK-------LNDGKWHSVelerngrsgTLSVDG 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720353987  470 NEIELYQS-SQNLGFISVPTwtirrgdVIFIGGLPDREKTE---VYGGFFKGCVQDVRLNSQTLE 530
Cdd:pfam00054   74 EARPTGESpLGATTDLDVDG-------PLYVGGLPSLGVKKrrlAISPSFDGCIRDVIVNGKPLD 131
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 113-148 2.65e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 2.65e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1720353987  113 THHQCLNNGKCIphfqNGQHGFTCQCLSGYAGPLCE 148
Cdd:cd00054      7 SGNPCQNGGTCV----NTVGSYRCSCPPGYTGRNCE 38
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
 848-922 3.01e-03

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 39.24  E-value: 3.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720353987  848 CFSSPCIHGNCSDGVaayHCRCEPGYTGVNCE--VDVDNCKSHQCANGATCVPEAH------GYSCLCFGNFTGRFCRHS 919
Cdd:PHA03099    53 CLHGDCIHARDIDGM---YCRCSHGYTGIRCQhvVLVDYQRSEKPNTTTSYIPSPGivlvlvGIIITCCLLSVYRFTRRT 129


                   ...
gi 1720353987  920 RLP 922
Cdd:PHA03099   130 KLP 132
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 344-373 4.37e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 4.37e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1720353987  344 ESQPCQNRGRCINLWQGYQCECDRPYTGSN 373
Cdd:cd00053      4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
558-590 8.12e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 8.12e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1720353987   558 CKS-NPCHNGGVCHSLWDDFSCSCPTN-TAGRACE 590
Cdd:smart00179    5 CASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 67-91 8.13e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.15  E-value: 8.13e-03
                           10        20
                   ....*....|....*....|....*.
gi 1720353987   67 ECLL-HPCLNGGTCENLPGNYACHCP 91
Cdd:cd00053      1 ECAAsNPCSNGGTCVNTPGSYRCVCP 26
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 112-145 9.01e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 34.67  E-value: 9.01e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1720353987  112 CTHHQCLNNGKCIphfqNGQHGFTCQCLSGYAGP 145
Cdd:pfam00008    1 CAPNPCSNGGTCV----DTPGGYTCICPEGYTGK 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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