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Conserved domains on  [gi|1907069717|ref|XP_036008247|]
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tRNA endonuclease ANKZF1 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
bVLRF1 pfam18826
Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging ...
 1-141 1.15e-68

Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging to the VLRF1 clade observed primarily in the bacteroidetes bacterial lineage. Contains a conserved glutamine residue in the release factor catalytic loop, suggesting it functions as an active peptidyl-tRNA hydrolase at the ribosome.


:

Pssm-ID: 465880  Cd Length: 143  Bit Score: 218.53  E-value: 1.15e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069717   1 MAAAGHFAGAIFQGREVVAHKTFHRYTVRAKRGTAQGLQDAHGRASRSAGANLRRYNEAMLYKDVRNLLAGpiWSKALGE 80
Cdd:pfam18826   5 MIGGGHFAGAVFSGGEVLAHKTFHRYTTRRKQGGSQSSNDNAKGKAKSAGASLRRYNEQALQEDIRELLSE--WKEDIDK 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907069717  81 AETVLFRAPRSGRSLFFGGQGAPLQRDDPRLWDIPLTTRRPTFGELQRVLHKLTTLQVYDE 141
Cdd:pfam18826  83 CELIFIRAPGSNRKILFGYEGAPLDKDDPRLRSIPFPTRRPTFSELKRVFSELTTVKVSHK 143
VATC pfam18716
Vms1-associating treble clef domain; Treble clef fold domain found at C-terminus of many, but ...
 539-578 1.77e-18

Vms1-associating treble clef domain; Treble clef fold domain found at C-terminus of many, but not all, Vms1/ANKZF1-like proteins.


:

Pssm-ID: 465846  Cd Length: 43  Bit Score: 78.90  E-value: 1.77e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1907069717 539 FRRCWSCGVSLQGLIPFHYLDFSFCSTRCLRDHRSQAGRP 578
Cdd:pfam18716   3 YRRCWICGESLLGKVPFHKLDFSYCSTKCLRAHRRAGFAP 42
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
286-388 4.30e-11

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.20  E-value: 4.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069717 286 LLAACRAGEVEVLKLQLATGlVDPgvksllNAPlGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVQDSRARPPYTVAAD 365
Cdd:COG0666   157 LHLAAANGNLEIVKLLLEAG-ADV------NAR-DNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAE 228

                          90       100
                  ....*....|....*....|...
gi 1907069717 366 KSTRNEFRRFMEKNLDAYDYNKA 388
Cdd:COG0666   229 NGNLEIVKLLLEAGADLNAKDKD 251
 
Name Accession Description Interval E-value
bVLRF1 pfam18826
Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging ...
 1-141 1.15e-68

Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging to the VLRF1 clade observed primarily in the bacteroidetes bacterial lineage. Contains a conserved glutamine residue in the release factor catalytic loop, suggesting it functions as an active peptidyl-tRNA hydrolase at the ribosome.


Pssm-ID: 465880  Cd Length: 143  Bit Score: 218.53  E-value: 1.15e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069717   1 MAAAGHFAGAIFQGREVVAHKTFHRYTVRAKRGTAQGLQDAHGRASRSAGANLRRYNEAMLYKDVRNLLAGpiWSKALGE 80
Cdd:pfam18826   5 MIGGGHFAGAVFSGGEVLAHKTFHRYTTRRKQGGSQSSNDNAKGKAKSAGASLRRYNEQALQEDIRELLSE--WKEDIDK 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907069717  81 AETVLFRAPRSGRSLFFGGQGAPLQRDDPRLWDIPLTTRRPTFGELQRVLHKLTTLQVYDE 141
Cdd:pfam18826  83 CELIFIRAPGSNRKILFGYEGAPLDKDDPRLRSIPFPTRRPTFSELKRVFSELTTVKVSHK 143
VATC pfam18716
Vms1-associating treble clef domain; Treble clef fold domain found at C-terminus of many, but ...
 539-578 1.77e-18

Vms1-associating treble clef domain; Treble clef fold domain found at C-terminus of many, but not all, Vms1/ANKZF1-like proteins.


Pssm-ID: 465846  Cd Length: 43  Bit Score: 78.90  E-value: 1.77e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1907069717 539 FRRCWSCGVSLQGLIPFHYLDFSFCSTRCLRDHRSQAGRP 578
Cdd:pfam18716   3 YRRCWICGESLLGKVPFHKLDFSYCSTKCLRAHRRAGFAP 42
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
286-388 4.30e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.20  E-value: 4.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069717 286 LLAACRAGEVEVLKLQLATGlVDPgvksllNAPlGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVQDSRARPPYTVAAD 365
Cdd:COG0666   157 LHLAAANGNLEIVKLLLEAG-ADV------NAR-DNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAE 228

                          90       100
                  ....*....|....*....|...
gi 1907069717 366 KSTRNEFRRFMEKNLDAYDYNKA 388
Cdd:COG0666   229 NGNLEIVKLLLEAGADLNAKDKD 251
Ank_2 pfam12796
Ankyrin repeats (3 copies);
286-353 7.97e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 7.97e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907069717 286 LLAACRAGEVEVLKLQLATGLVDpgvksllnapLGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVQD 353
Cdd:pfam12796  34 LHLAAKNGHLEIVKLLLEHADVN----------LKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 323-395 5.13e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.51  E-value: 5.13e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907069717 323 GFTLLHAAAAAGRGLVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNLDAYDYNKARVPGPLT 395
Cdd:PTZ00322  115 GRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELGANAKPDSFT 187
 
Name Accession Description Interval E-value
bVLRF1 pfam18826
Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging ...
 1-141 1.15e-68

Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging to the VLRF1 clade observed primarily in the bacteroidetes bacterial lineage. Contains a conserved glutamine residue in the release factor catalytic loop, suggesting it functions as an active peptidyl-tRNA hydrolase at the ribosome.


Pssm-ID: 465880  Cd Length: 143  Bit Score: 218.53  E-value: 1.15e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069717   1 MAAAGHFAGAIFQGREVVAHKTFHRYTVRAKRGTAQGLQDAHGRASRSAGANLRRYNEAMLYKDVRNLLAGpiWSKALGE 80
Cdd:pfam18826   5 MIGGGHFAGAVFSGGEVLAHKTFHRYTTRRKQGGSQSSNDNAKGKAKSAGASLRRYNEQALQEDIRELLSE--WKEDIDK 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907069717  81 AETVLFRAPRSGRSLFFGGQGAPLQRDDPRLWDIPLTTRRPTFGELQRVLHKLTTLQVYDE 141
Cdd:pfam18826  83 CELIFIRAPGSNRKILFGYEGAPLDKDDPRLRSIPFPTRRPTFSELKRVFSELTTVKVSHK 143
VATC pfam18716
Vms1-associating treble clef domain; Treble clef fold domain found at C-terminus of many, but ...
 539-578 1.77e-18

Vms1-associating treble clef domain; Treble clef fold domain found at C-terminus of many, but not all, Vms1/ANKZF1-like proteins.


Pssm-ID: 465846  Cd Length: 43  Bit Score: 78.90  E-value: 1.77e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1907069717 539 FRRCWSCGVSLQGLIPFHYLDFSFCSTRCLRDHRSQAGRP 578
Cdd:pfam18716   3 YRRCWICGESLLGKVPFHKLDFSYCSTKCLRAHRRAGFAP 42
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
286-388 4.30e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.20  E-value: 4.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069717 286 LLAACRAGEVEVLKLQLATGlVDPgvksllNAPlGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVQDSRARPPYTVAAD 365
Cdd:COG0666   157 LHLAAANGNLEIVKLLLEAG-ADV------NAR-DNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAE 228

                          90       100
                  ....*....|....*....|...
gi 1907069717 366 KSTRNEFRRFMEKNLDAYDYNKA 388
Cdd:COG0666   229 NGNLEIVKLLLEAGADLNAKDKD 251
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
283-366 3.49e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.12  E-value: 3.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069717 283 WDTLLAACRAGEVEVLKLqlatgLVDPGVKslLNAPlGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVQDSRARPPYTV 362
Cdd:COG0666   121 ETPLHLAAYNGNLEIVKL-----LLEAGAD--VNAQ-DNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHL 192


                  ....
gi 1907069717 363 AADK 366
Cdd:COG0666   193 AAEN 196
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
281-366 1.14e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.58  E-value: 1.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069717 281 ELWDTLLAACRAGEVEVLKLQLATGlVDPgvksllNAPlGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVQDSRARPPY 360
Cdd:COG0666    86 GGNTLLHAAARNGDLEIVKLLLEAG-ADV------NAR-DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPL 157


                  ....*.
gi 1907069717 361 TVAADK 366
Cdd:COG0666   158 HLAAAN 163
Ank_2 pfam12796
Ankyrin repeats (3 copies);
286-353 7.97e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 7.97e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907069717 286 LLAACRAGEVEVLKLQLATGLVDpgvksllnapLGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVQD 353
Cdd:pfam12796  34 LHLAAKNGHLEIVKLLLEHADVN----------LKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
282-366 2.86e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 49.18  E-value: 2.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069717 282 LWDTLLAACRAGEVEVLKLQLAtglvdpgvKSLLNAPLGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVQDSRARPPYT 361
Cdd:COG0666    54 GALLLLAAALAGDLLVALLLLA--------AGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125


                  ....*
gi 1907069717 362 VAADK 366
Cdd:COG0666   126 LAAYN 130
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 323-395 5.13e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.51  E-value: 5.13e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907069717 323 GFTLLHAAAAAGRGLVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNLDAYDYNKARVPGPLT 395
Cdd:PTZ00322  115 GRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELGANAKPDSFT 187
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 323-353 2.85e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.12  E-value: 2.85e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907069717 323 GFTLLHAAAA-AGRGLVVRLLLEAGADPTVQD 353
Cdd:pfam00023   2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
286-389 1.42e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 44.17  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069717 286 LLAACRAGEVEVLKLQLATGlVDPGVKSllnaplgSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVQDSRARPPYTVAAD 365
Cdd:COG0666   190 LHLAAENGHLEIVKLLLEAG-ADVNAKD-------NDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAA 261

                          90       100
                  ....*....|....*....|....
gi 1907069717 366 KSTRNEFRRFMEKNLDAYDYNKAR 389
Cdd:COG0666   262 AGAALIVKLLLLALLLLAAALLDL 285
Ank_5 pfam13857
Ankyrin repeats (many copies);
322-363 2.66e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.17  E-value: 2.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907069717 322 GGFTLLHAAAAAGRGLVVRLLLEAGADPTVQDSRARPPYTVA 363
Cdd:pfam13857  15 EGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_2 pfam12796
Ankyrin repeats (3 copies);
327-387 4.66e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 36.63  E-value: 4.66e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907069717 327 LHAAAAAGRGLVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEK-NLDAYDYNK 387
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHaDVNLKDNGR 62
Ank_2 pfam12796
Ankyrin repeats (3 copies);
286-344 5.19e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 36.63  E-value: 5.19e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907069717 286 LLAACRAGEVEVLKLQLATGlVDPGVKSLLnaplgsgGFTLLHAAAAAGRGLVVRLLLE 344
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENG-ADANLQDKN-------GRTALHLAAKNGHLEIVKLLLE 51
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 323-349 6.26e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.54  E-value: 6.26e-03
                          10        20
                  ....*....|....*....|....*..
gi 1907069717 323 GFTLLHAAAAAGRGLVVRLLLEAGADP 349
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADI 28
Ank_4 pfam13637
Ankyrin repeats (many copies);
325-364 8.50e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.94  E-value: 8.50e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1907069717 325 TLLHAAAAAGRGLVVRLLLEAGADPTVQDSRARPPYTVAA 364
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAA 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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