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Conserved domains on  [gi|1907185245|ref|XP_036009503|]
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acyl carrier protein, mitochondrial-like [Mus musculus]

Protein Classification

acyl carrier protein( domain architecture ID 10000104)

acyl carrier protein may function as a carrier of the growing fatty acid chain in fatty acid biosynthesis or as the carrier of activated (amino) acid groups in polyketide synthases and non-ribosomal peptide synthases

CATH:  1.10.1200.10
Gene Ontology:  GO:0006633|GO:0000036
SCOP:  4000857

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
acpP CHL00124
acyl carrier protein; Validated
 107-168 5.63e-23

acyl carrier protein; Validated


:

Pssm-ID: 177047 [Multi-domain]  Cd Length: 82  Bit Score: 86.61  E-value: 5.63e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907185245 107 IDPEKLSVNSYFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKKDV 168
Cdd:CHL00124   20 IEKSEVTLDANFTRDLGADSLDVVELVMAIEEKFDIEIPDEDAEKISTLQEAVDFISQKINK 81
 
Name Accession Description Interval E-value
acpP CHL00124
acyl carrier protein; Validated
 107-168 5.63e-23

acyl carrier protein; Validated


Pssm-ID: 177047 [Multi-domain]  Cd Length: 82  Bit Score: 86.61  E-value: 5.63e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907185245 107 IDPEKLSVNSYFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKKDV 168
Cdd:CHL00124   20 IEKSEVTLDANFTRDLGADSLDVVELVMAIEEKFDIEIPDEDAEKISTLQEAVDFISQKINK 81
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 91-166 4.04e-22

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 84.37  E-value: 4.04e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907185245  91 DGIKDRVLYVLKLYDKIDPEKLSVNSYFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKK 166
Cdd:TIGR00517   2 QEIFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEENQ 77
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 106-166 1.82e-17

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 72.58  E-value: 1.82e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907185245 106 KIDPEKLSVNSYFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKK 166
Cdd:COG0236    19 GVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEKL 79
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 106-148 1.30e-06

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 43.71  E-value: 1.30e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1907185245 106 KIDPEKLSVNSYFMkDLGLDSLDQVEIIMAMEDEFGFEIPDID 148
Cdd:pfam00550  12 GVPAEEIDPDTDLF-DLGLDSLLAVELIARLEEEFGVEIPPSD 53
 
Name Accession Description Interval E-value
acpP CHL00124
acyl carrier protein; Validated
 107-168 5.63e-23

acyl carrier protein; Validated


Pssm-ID: 177047 [Multi-domain]  Cd Length: 82  Bit Score: 86.61  E-value: 5.63e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907185245 107 IDPEKLSVNSYFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKKDV 168
Cdd:CHL00124   20 IEKSEVTLDANFTRDLGADSLDVVELVMAIEEKFDIEIPDEDAEKISTLQEAVDFISQKINK 81
PTZ00171 PTZ00171
acyl carrier protein; Provisional
 80-166 1.83e-22

acyl carrier protein; Provisional


Pssm-ID: 240304  Cd Length: 148  Bit Score: 87.45  E-value: 1.83e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907185245  80 RQYSdappLTLDGIKDRVLYVLKLYDKIDPEKLSVNSYFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIV 159
Cdd:PTZ00171   62 KQYL----LSKEDVLTRVKKVVKNFEKVDASKITPESNFVKDLGADSLDVVELLIAIEQEFNLTIPDHDAEKIKTVQDAI 137


                  ....*..
gi 1907185245 160 DYIADKK 166
Cdd:PTZ00171  138 DYIEQNN 144
acpP PRK00982
acyl carrier protein; Provisional
 107-166 3.58e-22

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 84.45  E-value: 3.58e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907185245 107 IDPEKLSVNSYFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKK 166
Cdd:PRK00982   18 VDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKHQ 77
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 91-166 4.04e-22

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 84.37  E-value: 4.04e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907185245  91 DGIKDRVLYVLKLYDKIDPEKLSVNSYFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKK 166
Cdd:TIGR00517   2 QEIFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEENQ 77
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 106-166 1.82e-17

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 72.58  E-value: 1.82e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907185245 106 KIDPEKLSVNSYFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKK 166
Cdd:COG0236    19 GVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEKL 79
PRK12449 PRK12449
acyl carrier protein; Provisional
 88-166 6.98e-12

acyl carrier protein; Provisional


Pssm-ID: 183533 [Multi-domain]  Cd Length: 80  Bit Score: 58.18  E-value: 6.98e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907185245  88 LTLDGIKDRVLYVLKLYDKIDPEKLSVNSYFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKK 166
Cdd:PRK12449    1 MTREEIFERLINLIQKQRSYLSLAITEQTHLKDDLAVDSIELVEFIINVEDEFHIAIPDEDVEDMVSMGDLLDYLVQRL 79
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 106-148 1.30e-06

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 43.71  E-value: 1.30e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1907185245 106 KIDPEKLSVNSYFMkDLGLDSLDQVEIIMAMEDEFGFEIPDID 148
Cdd:pfam00550  12 GVPAEEIDPDTDLF-DLGLDSLLAVELIARLEEEFGVEIPPSD 53
PRK06508 PRK06508
acyl carrier protein; Provisional
 95-145 1.52e-06

acyl carrier protein; Provisional


Pssm-ID: 180597  Cd Length: 93  Bit Score: 44.42  E-value: 1.52e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907185245  95 DRVLYVLKLYDKIDPEKLSVNSYFMKDLGLDSLDQVEIIMAMEDEFGFEIP 145
Cdd:PRK06508    6 DKVADIIAETSDIPRDTITPESHTIDDLGIDSLDFLDIVFAIDKAFGIKLP 56
PRK05828 PRK05828
acyl carrier protein; Validated
 119-168 6.37e-06

acyl carrier protein; Validated


Pssm-ID: 180278  Cd Length: 84  Bit Score: 42.55  E-value: 6.37e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907185245 119 MKDLGLDSLDQVEIIMAMEDEFGFEIPDidaEKLMCPQEIVDYIADKKDV 168
Cdd:PRK05828   32 YRELKIDSLDMFSIIVSLESEFNIEFSD---EKLMKLKNLADLILEVKEL 78
PRK07081 PRK07081
acyl carrier protein; Provisional
 121-146 1.67e-04

acyl carrier protein; Provisional


Pssm-ID: 180828  Cd Length: 83  Bit Score: 38.40  E-value: 1.67e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907185245 121 DLGLDSLDQVEIIMAMEDEFGFEIPD 146
Cdd:PRK07081   30 EAGLSSLATVQLMLAIEDAFDIEIPD 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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