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Conserved domains on  [gi|1907070575|ref|XP_036010039|]
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testis-expressed protein 30 isoform X1 [Mus musculus]

Protein Classification

COG3571 superfamily protein( domain architecture ID 1903980)

COG3571 superfamily protein

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG3571 super family cl43903
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
31-220 6.62e-33

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


The actual alignment was detected with superfamily member COG3571:

Pssm-ID: 442792 [Multi-domain]  Cd Length: 202  Bit Score: 117.67  E-value: 6.62e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575  31 GIILTHGASGDMNLPHLMSLASHLASHGFFCLRFtckglNIVHRIK-------------AYKAVLNYLKTsgeyKLAG-- 95
Cdd:COG3571    11 TLLLAHGAGAGMDSPFMVALAEALAAAGIAVARF-----EFPYMVAgrrppdrapvldaAWRAVIAALRA----RLAGlp 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575  96 VFLGGRSMGSRAAasvmCHTEpdDADDFVRGLICISYPLHHPKQQHKLRDEDLFRIKDPVLFVSGSADEMCEKNLLEKVA 175
Cdd:COG3571    82 LVIGGKSMGGRVA----SMLA--AEGGGAAGLVCLGYPFHPPGKPEKLRTEHLADLTVPTLIVQGERDPFGTPEEVAGYP 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1907070575 176 qkMQAPSKIHWIEKANHSMAVK---GRSTNDVFKEINTQILFWIQEIT 220
Cdd:COG3571   156 --LPPAIELVWLPGGDHDLKPRkrsGRTQEDHLAAAADAVAAWLARLL 201
 
Name Accession Description Interval E-value
COG3571 COG3571
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
31-220 6.62e-33

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 442792 [Multi-domain]  Cd Length: 202  Bit Score: 117.67  E-value: 6.62e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575  31 GIILTHGASGDMNLPHLMSLASHLASHGFFCLRFtckglNIVHRIK-------------AYKAVLNYLKTsgeyKLAG-- 95
Cdd:COG3571    11 TLLLAHGAGAGMDSPFMVALAEALAAAGIAVARF-----EFPYMVAgrrppdrapvldaAWRAVIAALRA----RLAGlp 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575  96 VFLGGRSMGSRAAasvmCHTEpdDADDFVRGLICISYPLHHPKQQHKLRDEDLFRIKDPVLFVSGSADEMCEKNLLEKVA 175
Cdd:COG3571    82 LVIGGKSMGGRVA----SMLA--AEGGGAAGLVCLGYPFHPPGKPEKLRTEHLADLTVPTLIVQGERDPFGTPEEVAGYP 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1907070575 176 qkMQAPSKIHWIEKANHSMAVK---GRSTNDVFKEINTQILFWIQEIT 220
Cdd:COG3571   156 --LPPAIELVWLPGGDHDLKPRkrsGRTQEDHLAAAADAVAAWLARLL 201
Abhydrolase_11 pfam20408
Alpha/beta hydrolase domain; This entry represents a protein that belongs to the alpha/beta ...
 32-217 2.21e-26

Alpha/beta hydrolase domain; This entry represents a protein that belongs to the alpha/beta hydrolase superfamily. Although proteins in this family are uncharacterized they are likely to have an enzymatic activity.


Pssm-ID: 466557 [Multi-domain]  Cd Length: 193  Bit Score: 100.74  E-value: 2.21e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575  32 IILTHGASGDMNLPHLMSLASHLASHGFFCLRFT--------CKG-------LNIVhrIKAYKAVLNYLKTSGeyklAGV 96
Cdd:pfam20408   5 LLLAHGAGAGMDSPFMQAMAAALAARGIAVVRFNfpymqrrrRTGkrrppdrAPKL--LEAFRAVIAALRGPD----LPL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575  97 FLGGRSMGSRAAAsvMCHTEPDdaddfVRGLICISYPLHHPKQQHKLRDEDLFRIKDPVLFVSGSADEMCEKNLLEkvAQ 176
Cdd:pfam20408  79 FIGGKSMGGRVAS--LLADDSG-----VKGVIALGYPFHPPGKPEKLRLEHLPDLTCPTLILQGERDPFGNREEVA--AY 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1907070575 177 KMQAPSKIHWIEKANHSMAVK---GRSTNDVFKEINTQILFWIQ 217
Cdd:pfam20408 150 PLPDNVSLHWLEDGDHDFKPRkrsGLTHEQNLQEAADAIAAFIA 193
 
Name Accession Description Interval E-value
COG3571 COG3571
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
31-220 6.62e-33

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 442792 [Multi-domain]  Cd Length: 202  Bit Score: 117.67  E-value: 6.62e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575  31 GIILTHGASGDMNLPHLMSLASHLASHGFFCLRFtckglNIVHRIK-------------AYKAVLNYLKTsgeyKLAG-- 95
Cdd:COG3571    11 TLLLAHGAGAGMDSPFMVALAEALAAAGIAVARF-----EFPYMVAgrrppdrapvldaAWRAVIAALRA----RLAGlp 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575  96 VFLGGRSMGSRAAasvmCHTEpdDADDFVRGLICISYPLHHPKQQHKLRDEDLFRIKDPVLFVSGSADEMCEKNLLEKVA 175
Cdd:COG3571    82 LVIGGKSMGGRVA----SMLA--AEGGGAAGLVCLGYPFHPPGKPEKLRTEHLADLTVPTLIVQGERDPFGTPEEVAGYP 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1907070575 176 qkMQAPSKIHWIEKANHSMAVK---GRSTNDVFKEINTQILFWIQEIT 220
Cdd:COG3571   156 --LPPAIELVWLPGGDHDLKPRkrsGRTQEDHLAAAADAVAAWLARLL 201
Abhydrolase_11 pfam20408
Alpha/beta hydrolase domain; This entry represents a protein that belongs to the alpha/beta ...
 32-217 2.21e-26

Alpha/beta hydrolase domain; This entry represents a protein that belongs to the alpha/beta hydrolase superfamily. Although proteins in this family are uncharacterized they are likely to have an enzymatic activity.


Pssm-ID: 466557 [Multi-domain]  Cd Length: 193  Bit Score: 100.74  E-value: 2.21e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575  32 IILTHGASGDMNLPHLMSLASHLASHGFFCLRFT--------CKG-------LNIVhrIKAYKAVLNYLKTSGeyklAGV 96
Cdd:pfam20408   5 LLLAHGAGAGMDSPFMQAMAAALAARGIAVVRFNfpymqrrrRTGkrrppdrAPKL--LEAFRAVIAALRGPD----LPL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575  97 FLGGRSMGSRAAAsvMCHTEPDdaddfVRGLICISYPLHHPKQQHKLRDEDLFRIKDPVLFVSGSADEMCEKNLLEkvAQ 176
Cdd:pfam20408  79 FIGGKSMGGRVAS--LLADDSG-----VKGVIALGYPFHPPGKPEKLRLEHLPDLTCPTLILQGERDPFGNREEVA--AY 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1907070575 177 KMQAPSKIHWIEKANHSMAVK---GRSTNDVFKEINTQILFWIQ 217
Cdd:pfam20408 150 PLPDNVSLHWLEDGDHDFKPRkrsGLTHEQNLQEAADAIAAFIA 193
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
1-194 8.61e-12

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 62.33  E-value: 8.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575   1 MSHTEVKLKIPFGNKLlDAVCLVPNKNIAYGIILTHGASGDMNlpHLMSLASHLASHGFFCLRF-------TCKGLNIVH 73
Cdd:COG2267     1 MTRRLVTLPTRDGLRL-RGRRWRPAGSPRGTVVLVHGLGEHSG--RYAELAEALAAAGYAVLAFdlrghgrSDGPRGHVD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575  74 RIKAY----KAVLNYLKTSGEYKlagVFLGGRSMGSRAAASVMchtepDDADDFVRGLICIS-----YPLHHPKQQHkLR 144
Cdd:COG2267    78 SFDDYvddlRAALDALRARPGLP---VVLLGHSMGGLIALLYA-----ARYPDRVAGLVLLApayraDPLLGPSARW-LR 148

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907070575 145 D----EDLFRIKDPVLFVSGSADEMCEKNLLEKVAQKMQAPSKIHWIEKANHSM 194
Cdd:COG2267   149 AlrlaEALARIDVPVLVLHGGADRVVPPEAARRLAARLSPDVELVLLPGARHEL 202
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
17-192 2.54e-09

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 55.17  E-value: 2.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575  17 LDAVCLVPNKNIAYGIILTH---GASGDMNLPHLMSLASHLASHGFFCLRF----TCK--GlnivhrikAY--------- 78
Cdd:COG2945    11 LEGRLDLPEGPPRGVALILHphpLFGGTMDNKVVYTLARALVAAGFAVLRFnfrgVGRseG--------EFdegrgeldd 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575  79 -KAVLNYLKTSGeykLAGVFLGGRSMGSRAAASVMCHTEPddaddfVRGLICISYPLHHpkqqhkLRDEDLFRIKDPVLF 157
Cdd:COG2945    83 aAAALDWLRAQN---PLPLWLAGFSFGAYVALQLAMRLPE------VEGLILVAPPVNR------YDFSFLAPCPAPTLV 147

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1907070575 158 VSGSADEMCEKNLLEKVAQKMQAPSKIHWIEKANH 192
Cdd:COG2945   148 IHGEQDEVVPPAEVLDWARPLSPPLPVVVVPGADH 182
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
32-208 1.17e-08

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 53.48  E-value: 1.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575  32 IILTHGASGDMNlPHLMSLASHLASHGFFCLRF------TCKGLNIVHRIKAYKAVLNYLKTSGEYKLAGVFLGGRSMGS 105
Cdd:COG1506    26 VVYVHGGPGSRD-DSFLPLAQALASRGYAVLAPdyrgygESAGDWGGDEVDDVLAAIDYLAARPYVDPDRIGIYGHSYGG 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575 106 RAAASVMCHTepddaDDFVRGLICIS------------YPLHHPKQQHKLRDEDLF----------RIKDPVLFVSGSAD 163
Cdd:COG1506   105 YMALLAAARH-----PDRFKAAVALAgvsdlrsyygttREYTERLMGGPWEDPEAYaarsplayadKLKTPLLLIHGEAD 179

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1907070575 164 EMCEKNLLEKVAQKMQA---PSKIHWIEKANHSMAvkGRSTNDVFKEI 208
Cdd:COG1506   180 DRVPPEQAERLYEALKKagkPVELLVYPGEGHGFS--GAGAPDYLERI 225
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
31-203 1.21e-08

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 53.43  E-value: 1.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575  31 GIILTHGASGdMNlPHLMSLASHLASHGFFCL---RFTCKG--------------LNIVHRIKAYKAVLNYLKTSGEYKL 93
Cdd:COG0412    31 GVVVLHEIFG-LN-PHIRDVARRLAAAGYVVLapdLYGRGGpgddpdearalmgaLDPELLAADLRAALDWLKAQPEVDA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575  94 AGVFLGGRSMGSRAAASVMCHTEPDDAddfvrgliCISYplhHPKQQHKLRDEDLFRIKDPVLFVSGSADEMCEKNLLEK 173
Cdd:COG0412   109 GRVGVVGFCFGGGLALLAAARGPDLAA--------AVSF---YGGLPADDLLDLAARIKAPVLLLYGEKDPLVPPEQVAA 177

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1907070575 174 VAQKMQA---PSKIHWIEKANHSMAVKGRSTND 203
Cdd:COG0412   178 LEAALAAagvDVELHVYPGAGHGFTNPGRPRYD 210
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
30-221 4.83e-07

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 48.78  E-value: 4.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575  30 YGIILTHGASGDMNlpHLMSLASHLASHGFFCLRFTCKG--------LNIVHR--IKAYKAVLNYLKTSGEYklagVFLG 99
Cdd:COG1647    16 KGVLLLHGFTGSPA--EMRPLAEALAKAGYTVYAPRLPGhgtspedlLKTTWEdwLEDVEEAYEILKAGYDK----VIVI 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575 100 GRSMGSrAAASVMCHTEPDdaddfVRGLICIS------------------------------------------YPLHHP 137
Cdd:COG1647    90 GLSMGG-LLALLLAARYPD-----VAGLVLLSpalkiddpsapllpllkylarslrgigsdiedpevaeyaydrTPLRAL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575 138 KQQHKLRDE---DLFRIKDPVLFVSGSADEMCEKNLLEKVAQKMQAPSK-IHWIEKANHSMAVkGRSTNDVFKEINTqil 213
Cdd:COG1647   164 AELQRLIREvrrDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKeLVWLEDSGHVITL-DKDREEVAEEILD--- 239


                  ....*...
gi 1907070575 214 fWIQEITE 221
Cdd:COG1647   240 -FLERLAA 246
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
32-215 2.07e-05

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 44.33  E-value: 2.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575  32 IILTHGASGDMNLphLMSLASHLASHGFFC-------------------LRFTCKGLNIVHRIKAYKAVLNYLKTSGEYK 92
Cdd:COG4188    65 VVLSHGLGGSREG--YAYLAEHLASHGYVVaapdhpgsnaadlsaaldgLADALDPEELWERPLDLSFVLDQLLALNKSD 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575  93 --LAG------VFLGGRSMGSRAAASVMcHTEPDDAD-----DFVRGLICISYPLHHPKQQhkLRD-------------- 145
Cdd:COG4188   143 ppLAGrldldrIGVIGHSLGGYTALALA-GARLDFAAlrqycGKNPDLQCRALDLPRLAYD--LRDprikavvalapggs 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575 146 -----EDLFRIKDPVLFVSGSADEMcEKNLLE--KVAQKMQAPSK-IHWIEKANHSM---------------AVKGRSTN 202
Cdd:COG4188   220 glfgeEGLAAITIPVLLVAGSADDV-TPAPDEqiRPFDLLPGADKyLLTLEGATHFSfldpctpgaailpepDPPGPDRA 298

                         250
                  ....*....|....
gi 1907070575 203 DVFKEINTQIL-FW 215
Cdd:COG4188   299 AIHEYLNALSLaFF 312
DLH pfam01738
Dienelactone hydrolase family;
79-200 3.14e-04

Dienelactone hydrolase family;


Pssm-ID: 396343 [Multi-domain]  Cd Length: 213  Bit Score: 40.41  E-value: 3.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907070575  79 KAVLNYLKTSGEYKLAGVFLGGRSMGSRAAASVMCHTEPDDAddfvrgliCISYPLHHPKQQHKLRDedlfRIKDPVLFV 158
Cdd:pfam01738  81 EAAVNYLKSQPEVSPKKVGVVGYCMGGALAVLLAAKGPLVDA--------AVGFYGVGPEPPLIEAP----DIKAPILFH 148

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1907070575 159 SGSADEMCEKNLLEKVAQKM---QAPSKIHWIEKANHSMAVKGRS 200
Cdd:pfam01738 149 FGEEDHFVPADSRELIEEALkaaNVDHQIHSYPGAGHAFANDSRP 193
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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