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Conserved domains on  [gi|1907077582|ref|XP_036011859|]
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cilia- and flagella-associated protein 410 isoform X2 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 2-92 3.33e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 55.18  E-value: 3.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907077582   2 PSLEVITLSVNSVSTLEPVRSCRRLSELYLRRNRIPSLNELF-YLKDLPHLRVLWLAENPCCgtSPHLYRMTVLRNLPHL 80
Cdd:cd21340   120 NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC--KKPKYRDKIILASKSL 197

                          90
                  ....*....|..
gi 1907077582  81 QKLDNQAVTEEE 92
Cdd:cd21340   198 EVLDGKEITDTE 209
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 2-92 3.33e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.18  E-value: 3.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907077582   2 PSLEVITLSVNSVSTLEPVRSCRRLSELYLRRNRIPSLNELF-YLKDLPHLRVLWLAENPCCgtSPHLYRMTVLRNLPHL 80
Cdd:cd21340   120 NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC--KKPKYRDKIILASKSL 197

                          90
                  ....*....|..
gi 1907077582  81 QKLDNQAVTEEE 92
Cdd:cd21340   198 EVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-84 1.07e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.69  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907077582   1 MPSLEVITLSVNSVSTL-EPVRSCRRLSELYLRRNRIpslNELFYLKDLPHLRVLWLAENpccgtspHLYRMTVLRNLPH 79
Cdd:COG4886   204 LTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQL---TDLPELGNLTNLEELDLSNN-------QLTDLPPLANLTN 273


                  ....*
gi 1907077582  80 LQKLD 84
Cdd:COG4886   274 LKTLD 278
LRR_9 pfam14580
Leucine-rich repeat;
26-96 1.68e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.21  E-value: 1.68e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907077582  26 LSELYLRRNRIPSLNELFYLKDLPHLRVLWLAENPCCgTSPHlYRMTVLRNLPHLQKLDNQAVTEEELTRA 96
Cdd:pfam14580  90 LTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVT-NKPH-YRLYVIYKVPQLRLLDFRKVKQKERQAA 158
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 2-92 3.33e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.18  E-value: 3.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907077582   2 PSLEVITLSVNSVSTLEPVRSCRRLSELYLRRNRIPSLNELF-YLKDLPHLRVLWLAENPCCgtSPHLYRMTVLRNLPHL 80
Cdd:cd21340   120 NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC--KKPKYRDKIILASKSL 197

                          90
                  ....*....|..
gi 1907077582  81 QKLDNQAVTEEE 92
Cdd:cd21340   198 EVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-84 1.07e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.69  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907077582   1 MPSLEVITLSVNSVSTL-EPVRSCRRLSELYLRRNRIpslNELFYLKDLPHLRVLWLAENpccgtspHLYRMTVLRNLPH 79
Cdd:COG4886   204 LTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQL---TDLPELGNLTNLEELDLSNN-------QLTDLPPLANLTN 273


                  ....*
gi 1907077582  80 LQKLD 84
Cdd:COG4886   274 LKTLD 278
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-84 6.16e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 6.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907077582   1 MPSLEVITLSVNSVSTL-EPVRSCRRLSELYLRRNRIPSLNElfYLKDLPHLRVLWLAENPccgtsphLYRMTVLRNLPH 79
Cdd:COG4886   181 LTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLPE--PLANLTNLETLDLSNNQ-------LTDLPELGNLTN 251


                  ....*
gi 1907077582  80 LQKLD 84
Cdd:COG4886   252 LEELD 256
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 2-92 1.95e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 1.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907077582   2 PSLEVITLSVNSVSTLEPVRSCRRLSELYLRRNRIPSLNelfYLKDLPHLRVLWLAENpccgtsphlyRMTV---LRNLP 78
Cdd:cd21340    24 KNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIE---NLENLVNLKKLYLGGN----------RISVvegLENLT 90

                          90
                  ....*....|....*.
gi 1907077582  79 HLQ--KLDNQAVTEEE 92
Cdd:cd21340    91 NLEelHIENQRLPPGE 106
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-77 6.22e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 6.22e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907077582   1 MPSLEVITLSVNSVSTL-EPVRSCRRLSELYLRRNRIPSLNElfYLKDLPHLRVLWLAENPCCGTSPHLYRMTVLRNL 77
Cdd:COG4886   112 LTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKEL 187
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-60 1.30e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.53  E-value: 1.30e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907077582   1 MPSLEVITLSVNSVSTLEPVRSCRRLSELYLRRNRIPSLNElfyLKDLPHLRVLWLAENP 60
Cdd:COG4886   227 LTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPP---LANLTNLKTLDLSNNQ 283
LRR_9 pfam14580
Leucine-rich repeat;
26-96 1.68e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.21  E-value: 1.68e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907077582  26 LSELYLRRNRIPSLNELFYLKDLPHLRVLWLAENPCCgTSPHlYRMTVLRNLPHLQKLDNQAVTEEELTRA 96
Cdd:pfam14580  90 LTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVT-NKPH-YRLYVIYKVPQLRLLDFRKVKQKERQAA 158
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 21-83 4.81e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.07  E-value: 4.81e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907077582  21 RSCRRLSELYLRRNRIPSLNELFYlkdLPHLRVLWLAENpccgtspHLYRMTVLRNLPHLQKL 83
Cdd:cd21340    21 SLCKNLKVLYLYDNKITKIENLEF---LTNLTHLYLQNN-------QIEKIENLENLVNLKKL 73
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 2-42 6.31e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 33.76  E-value: 6.31e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907077582   2 PSLEVITLSVNSVSTLEPVRSCRRLSELYLRRN-RIPSLNEL 42
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDL 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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