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Conserved domains on  [gi|1907081185|ref|XP_036012469|]
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ATP-dependent RNA helicase DHX33 isoform X1 [Mus musculus]

Protein Classification

ATP-dependent RNA helicase( domain architecture ID 13388279)

DEAD/DEAH box containing ATP-dependent RNA helicase catalyzes the unwinding of RNA, similar to DEAH box protein 34 (DHX34) that is required for nonsense-mediated decay (NMD) degradation of mRNA transcripts containing premature stop codons

CATH:  3.40.50.300
EC:  3.6.4.13
Gene Ontology:  GO:0005524|GO:0003724|GO:0003676|GO:0016887|GO:0003723
PubMed:  34680866|19747077|22922795|20206133|21779027|20225155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HrpA super family cl34328
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
1-430 1.24e-119

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG1643:

Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 371.72  E-value: 1.24e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKElgklPLKVIVMSATMDVDLFSQYFNRAPVLYLEG 80
Cdd:COG1643   110 ILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPALRP----DLKLLVMSATLDAERFARLLGDAPVIESSG 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  81 RQHPIQIFYT--KQPQQDYLHAALVSVFQIHQEAPAsqDILVFLTGQEEIEamsKTCRDIARHLPDGCpsmLVLPLYASL 158
Cdd:COG1643   186 RTYPVEVRYRplPADERDLEDAVADAVREALAEEPG--DILVFLPGEREIR---RTAEALRGRLPPDT---EILPLYGRL 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185 159 PYSQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGREDS 238
Cdd:COG1643   258 SAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAP 337

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185 239 GICYRLYTEDEFEKFEKMTVPEIQRCNLASVILQLLAMKVPNVLTFDFMSKPSPDHIEAAIAQLDLLGALehkDDQLTLT 318
Cdd:COG1643   338 GICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARALLQELGAL---DADGRLT 414

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185 319 PIGRKMAAFPLEPRFAKTILLSSKFHCTEEILTIVSLLSVDsvlynPPARRDevqsvrkkfisSEGDHITLLNIYRTFKN 398
Cdd:COG1643   415 PLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSER-----DPRRGA-----------AGSDLLARLNLWRRLRE 478

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1907081185 399 iggnkdwCKENFVNSknmLLVAEVR---AQLREIC 430
Cdd:COG1643   479 -------QQREFLSY---LRLREWRdlaRQLRRLL 503
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 447-524 4.08e-16

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


:

Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 73.44  E-value: 4.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185 447 VRRCMAHSLFMNTAELQTDG-TYATTDTHQPVAIHPSSVLFHC---KPACVVYTSLLYTNKCYMRDLCVVDAEWLYEAAP 522
Cdd:pfam07717   1 LRAALAAGLYPNVARRDPKGkGYTTLSDNQRVFIHPSSVLFNEktfPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80


                  ..
gi 1907081185 523 DY 524
Cdd:pfam07717  81 HI 82
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
1-430 1.24e-119

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 371.72  E-value: 1.24e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKElgklPLKVIVMSATMDVDLFSQYFNRAPVLYLEG 80
Cdd:COG1643   110 ILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPALRP----DLKLLVMSATLDAERFARLLGDAPVIESSG 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  81 RQHPIQIFYT--KQPQQDYLHAALVSVFQIHQEAPAsqDILVFLTGQEEIEamsKTCRDIARHLPDGCpsmLVLPLYASL 158
Cdd:COG1643   186 RTYPVEVRYRplPADERDLEDAVADAVREALAEEPG--DILVFLPGEREIR---RTAEALRGRLPPDT---EILPLYGRL 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185 159 PYSQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGREDS 238
Cdd:COG1643   258 SAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAP 337

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185 239 GICYRLYTEDEFEKFEKMTVPEIQRCNLASVILQLLAMKVPNVLTFDFMSKPSPDHIEAAIAQLDLLGALehkDDQLTLT 318
Cdd:COG1643   338 GICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARALLQELGAL---DADGRLT 414

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185 319 PIGRKMAAFPLEPRFAKTILLSSKFHCTEEILTIVSLLSVDsvlynPPARRDevqsvrkkfisSEGDHITLLNIYRTFKN 398
Cdd:COG1643   415 PLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSER-----DPRRGA-----------AGSDLLARLNLWRRLRE 478

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1907081185 399 iggnkdwCKENFVNSknmLLVAEVR---AQLREIC 430
Cdd:COG1643   479 -------QQREFLSY---LRLREWRdlaRQLRRLL 503
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
 1-522 1.04e-104

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 340.98  E-value: 1.04e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185    1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKELgklplKVIVMSATMDVDLFSQYFNRAPVLYLEG 80
Cdd:TIGR01967  166 ILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDL-----KIIITSATIDPERFSRHFNNAPIIEVSG 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185   81 RQHPIQIFY------TKQPQQDYLHAALVSVFQIHQEAPAsqDILVFLTGQEEI-EAMSKTCRDIARHLPdgcpsmlVLP 153
Cdd:TIGR01967  241 RTYPVEVRYrplveeQEDDDLDQLEAILDAVDELFAEGPG--DILIFLPGEREIrDAAEILRKRNLRHTE-------ILP 311

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  154 LYASLPYSQQLRVFQgaPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRA 233
Cdd:TIGR01967  312 LYARLSNKEQQRVFQ--PHSGRRIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRC 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  234 GREDSGICYRLYTEDEFEKFEKMTVPEIQRCNLASVILQLLAMKVPNVLTFDFMSKPSPDHIEAAIAQLDLLGALEHKDD 313
Cdd:TIGR01967  390 GRVAPGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGALDDDEA 469

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  314 QLTLTPIGRKMAAFPLEPRFAKTILLSSKFHCTEEILTIVSLLSVDSVLYNPPARRDEVQSVRKKFISSEGDHITLLNIY 393
Cdd:TIGR01967  470 EPQLTPIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPRERPMEKQQAADQAHARFKDPRSDFLSRVNLW 549

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  394 RTF----KNIGGN--KDWCKENFVNSKNMLLVAEVRAQLREICLKMSMPIMSSRGDMESVRRCMAHSLF----MNTAELQ 463
Cdd:TIGR01967  550 RHIeeqrQALSANqfRNACRKQYLNYLRVREWQDIYRQLTQVVKELGLKLNEEPADYDAIHKALLSGLLsqigMKDEKHE 629

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907081185  464 TDGTYATTdthqpVAIHPSSVLFHCKPACVVYTSLLYTNKCYMRDLCVVDAEWLYEAAP 522
Cdd:TIGR01967  630 YDGARGRK-----FHIFPGSPLFKKPPKWVMAAELVETSKLYARLVAKIEPEWVEPVAG 683
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 1-517 5.33e-96

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 317.39  E-value: 5.33e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185    1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKELgklplKVIVMSATMDVDLFSQYFNRAPVLYLEG 80
Cdd:PRK11131   173 ILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDL-----KVIITSATIDPERFSRHFNNAPIIEVSG 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185   81 RQHPIQIFY------TKQPQQDYLHAALVSVFQIHQEAPAsqDILVFLTGQEEI----EAMSKtcrdiaRHLPDgcpsML 150
Cdd:PRK11131   248 RTYPVEVRYrpiveeADDTERDQLQAIFDAVDELGREGPG--DILIFMSGEREIrdtaDALNK------LNLRH----TE 315

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  151 VLPLYASLPYSQQLRVFQgaPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRT 230
Cdd:PRK11131   316 ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRK 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  231 GRAGREDSGICYRLYTEDEFEKFEKMTVPEIQRCNLASVILQLLAMKVPNVLTFDFMSKPSPDHIEAAIAQLDLLGAL-- 308
Cdd:PRK11131   394 GRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAItt 473

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  309 EHKDDQLTLTPIGRKMAAFPLEPRFAKTILLSSKFHCTEEILTIVSLLSVDSVLYNPPARRDEVQSVRKKFISSEGDHIT 388
Cdd:PRK11131   474 DEQASAYKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDKQQASDEKHRRFADKESDFLA 553

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  389 LLNIYRTF----KNIGGN--KDWCKENFVnskNMLLVAE---VRAQLREICLKMSMPIMSSRGDMESVRRCMAHSLFMNT 459
Cdd:PRK11131   554 FVNLWNYLqeqqKALSSNqfRRLCRTDYL---NYLRVREwqdIYTQLRQVVKELGIPVNSEPAEYREIHTALLTGLLSHI 630

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907081185  460 AELQTDGTYATTDTHQPVAIHPSSVLFHCKPACVVYTSLLYTNKCYMRDLCVVDAEWL 517
Cdd:PRK11131   631 GMKDAEKQEYTGARNARFSIFPGSGLFKKPPKWVMVAELVETSRLWGRIAARIEPEWI 688
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 83-245 1.30e-74

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 233.58  E-value: 1.30e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  83 HPIQIFYTKQP-----------QQDYLHAALVSVFQIHQEAPaSQDILVFLTGQEEIEAMSKTCRDIARHlpDGCPSMLV 151
Cdd:cd18791     1 FPVEVYYLEDIlellgissekeDPDYVDAAVRLILQIHRTEE-PGDILVFLPGQEEIERLCELLREELLS--PDLGKLLV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185 152 LPLYASLPYSQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTG 231
Cdd:cd18791    78 LPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAG 157

                         170
                  ....*....|....
gi 1907081185 232 RAGREDSGICYRLY 245
Cdd:cd18791   158 RAGRTRPGKCYRLY 171
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 305-390 2.71e-25

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 99.26  E-value: 2.71e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  305 LGALehkDDQLTLTPIGRKMAAFPLEPRFAKTILLSSKFHCTEEILTIVSLLSVDSvlYNPPARRDEVQSVRKKFISSEG 384
Cdd:smart00847   2 LGAL---DDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGD--PRPKEKREDADAARRRFADPES 76


                   ....*.
gi 1907081185  385 DHITLL 390
Cdd:smart00847  77 DHLTLL 82
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 298-389 7.20e-25

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 98.85  E-value: 7.20e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185 298 AIAQLDLLGALehkDDQLTLTPIGRKMAAFPLEPRFAKTILLSSKFHCTEEILTIVSLLSVDSVLYNPP----------- 366
Cdd:pfam04408   1 ALELLYYLGAL---DEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNfldprsaakaa 77

                          90       100
                  ....*....|....*....|....*..
gi 1907081185 367 --ARRDEVQSVRKKFISS--EGDHITL 389
Cdd:pfam04408  78 rrRRRAADEKARAKFARLdlEGDHLTL 104
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 447-524 4.08e-16

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 73.44  E-value: 4.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185 447 VRRCMAHSLFMNTAELQTDG-TYATTDTHQPVAIHPSSVLFHC---KPACVVYTSLLYTNKCYMRDLCVVDAEWLYEAAP 522
Cdd:pfam07717   1 LRAALAAGLYPNVARRDPKGkGYTTLSDNQRVFIHPSSVLFNEktfPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80


                  ..
gi 1907081185 523 DY 524
Cdd:pfam07717  81 HI 82
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
1-430 1.24e-119

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 371.72  E-value: 1.24e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKElgklPLKVIVMSATMDVDLFSQYFNRAPVLYLEG 80
Cdd:COG1643   110 ILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPALRP----DLKLLVMSATLDAERFARLLGDAPVIESSG 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  81 RQHPIQIFYT--KQPQQDYLHAALVSVFQIHQEAPAsqDILVFLTGQEEIEamsKTCRDIARHLPDGCpsmLVLPLYASL 158
Cdd:COG1643   186 RTYPVEVRYRplPADERDLEDAVADAVREALAEEPG--DILVFLPGEREIR---RTAEALRGRLPPDT---EILPLYGRL 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185 159 PYSQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGREDS 238
Cdd:COG1643   258 SAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAP 337

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185 239 GICYRLYTEDEFEKFEKMTVPEIQRCNLASVILQLLAMKVPNVLTFDFMSKPSPDHIEAAIAQLDLLGALehkDDQLTLT 318
Cdd:COG1643   338 GICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARALLQELGAL---DADGRLT 414

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185 319 PIGRKMAAFPLEPRFAKTILLSSKFHCTEEILTIVSLLSVDsvlynPPARRDevqsvrkkfisSEGDHITLLNIYRTFKN 398
Cdd:COG1643   415 PLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSER-----DPRRGA-----------AGSDLLARLNLWRRLRE 478

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1907081185 399 iggnkdwCKENFVNSknmLLVAEVR---AQLREIC 430
Cdd:COG1643   479 -------QQREFLSY---LRLREWRdlaRQLRRLL 503
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
 1-522 1.04e-104

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 340.98  E-value: 1.04e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185    1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKELgklplKVIVMSATMDVDLFSQYFNRAPVLYLEG 80
Cdd:TIGR01967  166 ILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDL-----KIIITSATIDPERFSRHFNNAPIIEVSG 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185   81 RQHPIQIFY------TKQPQQDYLHAALVSVFQIHQEAPAsqDILVFLTGQEEI-EAMSKTCRDIARHLPdgcpsmlVLP 153
Cdd:TIGR01967  241 RTYPVEVRYrplveeQEDDDLDQLEAILDAVDELFAEGPG--DILIFLPGEREIrDAAEILRKRNLRHTE-------ILP 311

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  154 LYASLPYSQQLRVFQgaPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRA 233
Cdd:TIGR01967  312 LYARLSNKEQQRVFQ--PHSGRRIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRC 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  234 GREDSGICYRLYTEDEFEKFEKMTVPEIQRCNLASVILQLLAMKVPNVLTFDFMSKPSPDHIEAAIAQLDLLGALEHKDD 313
Cdd:TIGR01967  390 GRVAPGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGALDDDEA 469

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  314 QLTLTPIGRKMAAFPLEPRFAKTILLSSKFHCTEEILTIVSLLSVDSVLYNPPARRDEVQSVRKKFISSEGDHITLLNIY 393
Cdd:TIGR01967  470 EPQLTPIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPRERPMEKQQAADQAHARFKDPRSDFLSRVNLW 549

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  394 RTF----KNIGGN--KDWCKENFVNSKNMLLVAEVRAQLREICLKMSMPIMSSRGDMESVRRCMAHSLF----MNTAELQ 463
Cdd:TIGR01967  550 RHIeeqrQALSANqfRNACRKQYLNYLRVREWQDIYRQLTQVVKELGLKLNEEPADYDAIHKALLSGLLsqigMKDEKHE 629

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907081185  464 TDGTYATTdthqpVAIHPSSVLFHCKPACVVYTSLLYTNKCYMRDLCVVDAEWLYEAAP 522
Cdd:TIGR01967  630 YDGARGRK-----FHIFPGSPLFKKPPKWVMAAELVETSKLYARLVAKIEPEWVEPVAG 683
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 1-517 5.33e-96

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 317.39  E-value: 5.33e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185    1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKELgklplKVIVMSATMDVDLFSQYFNRAPVLYLEG 80
Cdd:PRK11131   173 ILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDL-----KVIITSATIDPERFSRHFNNAPIIEVSG 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185   81 RQHPIQIFY------TKQPQQDYLHAALVSVFQIHQEAPAsqDILVFLTGQEEI----EAMSKtcrdiaRHLPDgcpsML 150
Cdd:PRK11131   248 RTYPVEVRYrpiveeADDTERDQLQAIFDAVDELGREGPG--DILIFMSGEREIrdtaDALNK------LNLRH----TE 315

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  151 VLPLYASLPYSQQLRVFQgaPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRT 230
Cdd:PRK11131   316 ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRK 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  231 GRAGREDSGICYRLYTEDEFEKFEKMTVPEIQRCNLASVILQLLAMKVPNVLTFDFMSKPSPDHIEAAIAQLDLLGAL-- 308
Cdd:PRK11131   394 GRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAItt 473

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  309 EHKDDQLTLTPIGRKMAAFPLEPRFAKTILLSSKFHCTEEILTIVSLLSVDSVLYNPPARRDEVQSVRKKFISSEGDHIT 388
Cdd:PRK11131   474 DEQASAYKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDKQQASDEKHRRFADKESDFLA 553

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  389 LLNIYRTF----KNIGGN--KDWCKENFVnskNMLLVAE---VRAQLREICLKMSMPIMSSRGDMESVRRCMAHSLFMNT 459
Cdd:PRK11131   554 FVNLWNYLqeqqKALSSNqfRRLCRTDYL---NYLRVREwqdIYTQLRQVVKELGIPVNSEPAEYREIHTALLTGLLSHI 630

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907081185  460 AELQTDGTYATTDTHQPVAIHPSSVLFHCKPACVVYTSLLYTNKCYMRDLCVVDAEWL 517
Cdd:PRK11131   631 GMKDAEKQEYTGARNARFSIFPGSGLFKKPPKWVMVAELVETSRLWGRIAARIEPEWI 688
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 83-245 1.30e-74

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 233.58  E-value: 1.30e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  83 HPIQIFYTKQP-----------QQDYLHAALVSVFQIHQEAPaSQDILVFLTGQEEIEAMSKTCRDIARHlpDGCPSMLV 151
Cdd:cd18791     1 FPVEVYYLEDIlellgissekeDPDYVDAAVRLILQIHRTEE-PGDILVFLPGQEEIERLCELLREELLS--PDLGKLLV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185 152 LPLYASLPYSQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTG 231
Cdd:cd18791    78 LPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAG 157

                         170
                  ....*....|....
gi 1907081185 232 RAGREDSGICYRLY 245
Cdd:cd18791   158 RAGRTRPGKCYRLY 171
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 8-342 7.35e-64

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 222.88  E-value: 7.35e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185   8 SDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKElgklPLKVIVMSATMDVDLFSQYFNRAPVLYLEGRQHPIQI 87
Cdd:PRK11664  110 RDPELSGVGLVILDEFHERSLQADLALALLLDVQQGLRD----DLKLLIMSATLDNDRLQQLLPDAPVIVSEGRSFPVER 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  88 FYTKQPQQDYLHAAL-VSVFQIHQEAPASqdILVFLTGQEEIeamsktcRDIARHLPDGCPS-MLVLPLYASLPYSQQLR 165
Cdd:PRK11664  186 RYQPLPAHQRFDEAVaRATAELLRQESGS--LLLFLPGVGEI-------QRVQEQLASRVASdVLLCPLYGALSLAEQQK 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185 166 VFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGREDSGICYRLY 245
Cdd:PRK11664  257 AILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLY 336

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185 246 TEDEFEKFEKMTVPEIQRCNLASVILQLLAMKVPNVLTFDFMSKPSPDHIEAAIAQLDLLGALehkDDQLTLTPIGRKMA 325
Cdd:PRK11664  337 SKEQAERAAAQSEPEILHSDLSGLLLELLQWGCHDPAQLSWLDQPPAAALAAAKRLLQQLGAL---DGQGRLTARGRKMA 413

                         330
                  ....*....|....*..
gi 1907081185 326 AFPLEPRFAkTILLSSK 342
Cdd:PRK11664  414 ALGNDPRLA-AMLVAAK 429
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 1-78 4.81e-46

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 159.06  E-value: 4.81e-46
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907081185   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKELGKLPLKVIVMSATMDVDLFSQYFNRAPVLYL 78
Cdd:cd17978   101 MLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRKEQKLSPLKVIIMSATLDADLFSEYFNGAPVLYI 178
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 1-77 1.01e-32

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 122.57  E-value: 1.01e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907081185   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKElgklpLKVIVMSATMDVDLFSQYFNRAPVLY 77
Cdd:cd17917    87 ILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPD-----LKVILMSATLDAEKFSSYFGGAPVIH 158
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 1-76 3.83e-27

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 107.89  E-value: 3.83e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907081185   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKElgklpLKVIVMSATMDVDLFSQYFNRAPVL 76
Cdd:cd17973   115 MLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPD-----LKLIVMSATLDAGKFQKYFDNAPLL 185
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 305-390 2.71e-25

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 99.26  E-value: 2.71e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  305 LGALehkDDQLTLTPIGRKMAAFPLEPRFAKTILLSSKFHCTEEILTIVSLLSVDSvlYNPPARRDEVQSVRKKFISSEG 384
Cdd:smart00847   2 LGAL---DDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGD--PRPKEKREDADAARRRFADPES 76


                   ....*.
gi 1907081185  385 DHITLL 390
Cdd:smart00847  77 DHLTLL 82
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 298-389 7.20e-25

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 98.85  E-value: 7.20e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185 298 AIAQLDLLGALehkDDQLTLTPIGRKMAAFPLEPRFAKTILLSSKFHCTEEILTIVSLLSVDSVLYNPP----------- 366
Cdd:pfam04408   1 ALELLYYLGAL---DEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNfldprsaakaa 77

                          90       100
                  ....*....|....*....|....*..
gi 1907081185 367 --ARRDEVQSVRKKFISS--EGDHITL 389
Cdd:pfam04408  78 rrRRRAADEKARAKFARLdlEGDHLTL 104
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 1-75 1.85e-24

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 100.25  E-value: 1.85e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907081185   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKElgklpLKVIVMSATMDVDLFSQYFNRAPV 75
Cdd:cd17971   106 MLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPD-----LKLIVTSATLDAVKFSQYFYEAPI 175
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 1-71 7.36e-21

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 90.22  E-value: 7.36e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907081185   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKElgklpLKVIVMSATMDVDLFSQYFN 71
Cdd:cd17980   103 MLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGD-----LRLIVASATLDAEKFRDFFN 168
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 1-78 8.26e-21

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 89.87  E-value: 8.26e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907081185   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKElgklpLKVIVMSATMDVDLFSQYFNRAPVLYL 78
Cdd:cd17974   102 MLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPD-----LKLLISSATMDAEKFSAFFDDAPIFRI 174
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 2-78 4.96e-20

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 87.60  E-value: 4.96e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907081185   2 LLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKELGKLPLKVIVMSATMDVDLFSQYFNRAPVLYL 78
Cdd:cd17984   102 LLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATLELAKLSAFFGNCPVFDI 178
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 1-75 1.16e-19

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 86.36  E-value: 1.16e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907081185   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKElgklpLKVIVMSATMDVDLFSQYFNRAPV 75
Cdd:cd17983   101 ILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRD-----LKLIVTSATMDADKFADFFGNVPI 170
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 2-74 1.53e-18

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 83.56  E-value: 1.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185   2 LLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKELGK-----LPLKVIVMSATMDVDLFSQ---YFNRA 73
Cdd:cd17982   106 LLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKLYLqdqtvKPLKLVIMSATLRVEDFTEnklLFPRP 185


                  .
gi 1907081185  74 P 74
Cdd:cd17982   186 P 186
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 1-76 1.59e-17

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 80.19  E-value: 1.59e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907081185   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKElgklpLKVIVMSATMDVDLFSQYFNRAPVL 76
Cdd:cd17989   101 ILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPD-----LKVIITSATIDAERFSRHFNNAPII 171
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 1-76 6.35e-17

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 78.25  E-value: 6.35e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907081185   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKElgklpLKVIVMSATMDVDLFSQYFNRAPVL 76
Cdd:cd17979    98 LLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPD-----LKLILMSATINIELFSGYFEGAPVV 168
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 447-524 4.08e-16

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 73.44  E-value: 4.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185 447 VRRCMAHSLFMNTAELQTDG-TYATTDTHQPVAIHPSSVLFHC---KPACVVYTSLLYTNKCYMRDLCVVDAEWLYEAAP 522
Cdd:pfam07717   1 LRAALAAGLYPNVARRDPKGkGYTTLSDNQRVFIHPSSVLFNEktfPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80


                  ..
gi 1907081185 523 DY 524
Cdd:pfam07717  81 HI 82
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 1-76 7.48e-15

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 72.75  E-value: 7.48e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907081185   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKElgklPLKVIVMSATMDVDLFSQYFNRAPVL 76
Cdd:cd17990   101 VLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQLLRD----DLRLLAMSATLDGDGLAALLPEAPVV 172
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 1-78 2.09e-14

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 71.41  E-value: 2.09e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907081185   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKElgklpLKVIVMSATMDVDLFSQYFNRAPVLYL 78
Cdd:cd17981   108 IVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSD-----LKVILMSATLNAEKFSDYFNNCPMIHI 180
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 1-78 1.02e-13

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 69.48  E-value: 1.02e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907081185   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKELgklplKVIVMSATMDVDLFSQYFNRAPVLYL 78
Cdd:cd17985   105 VLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDL-----KVILMSATLNAELFSDYFNSCPVIHI 177
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
 1-76 2.25e-13

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 68.40  E-value: 2.25e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907081185   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKElgklpLKVIVMSATMDVDLFSQYFNRAPVL 76
Cdd:cd17975   111 VLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSD-----LHLILMSATVDCEKFSSYFTHCPIL 181
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 1-76 6.51e-12

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 64.08  E-value: 6.51e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907081185   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKElgklpLKVIVMSATMDVDLFSQYFNRAPVL 76
Cdd:cd17977   104 MLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPE-----LKLVIITCPHLSSKLLSYYGNVPLI 174
HELICc smart00490
helicase superfamily c-terminal domain;
151-235 6.60e-12

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 61.46  E-value: 6.60e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  151 VLPLYASLPYSQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMvkakkynpdsglevlavqRVSKTQAWQRT 230
Cdd:smart00490  14 VARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDL------------------PWSPASYIQRI 75


                   ....*
gi 1907081185  231 GRAGR 235
Cdd:smart00490  76 GRAGR 80
PHA02653 PHA02653
RNA helicase NPH-II; Provisional
 7-249 1.71e-11

RNA helicase NPH-II; Provisional


Pssm-ID: 177443 [Multi-domain]  Cd Length: 675  Bit Score: 66.92  E-value: 1.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185   7 ISDSLLRKYSCVILDEAHERTIHTDVLFGVVktaqkrRKELGKLPlKVIVMSATM--DVDLFSQYFNRAPVLYLEGRQ-H 83
Cdd:PHA02653  284 LTLNKLFDYGTVIIDEVHEHDQIGDIIIAVA------RKHIDKIR-SLFLMTATLedDRDRIKEFFPNPAFVHIPGGTlF 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185  84 PIQIFYTKQPQQ-----DYLHAALVSVFQIHQE--APASQDILVFLtgqeeiEAMSKtCRDIARHLPDGCPSMLVLPLYA 156
Cdd:PHA02653  357 PISEVYVKNKYNpknkrAYIEEEKKNIVTALKKytPPKGSSGIVFV------ASVSQ-CEEYKKYLEKRLPIYDFYIIHG 429

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185 157 SLP-YSQQLRVFQGAPKgyRKVIISTNIAETSITITGIKYVVDTGMVKAKKynPDSGLEVLavqrVSKTQAWQRTGRAGR 235
Cdd:PHA02653  430 KVPnIDEILEKVYSSKN--PSIIISTPYLESSVTIRNATHVYDTGRVYVPE--PFGGKEMF----ISKSMRTQRKGRVGR 501

                         250
                  ....*....|....
gi 1907081185 236 EDSGICYRLYTEDE 249
Cdd:PHA02653  502 VSPGTYVYFYDLDL 515
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 151-235 3.37e-11

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 60.30  E-value: 3.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185 151 VLPLYASLPYSQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDtgmvkakkYNPDSGLEVLavqrvsktqaWQRT 230
Cdd:pfam00271  41 VARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVDLVIN--------YDLPWNPASY----------IQRI 102


                  ....*
gi 1907081185 231 GRAGR 235
Cdd:pfam00271 103 GRAGR 107
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 1-76 2.79e-10

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 59.42  E-value: 2.79e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907081185   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKElgklpLKVIVMSATMDVDLFSQYFNRAPVL 76
Cdd:cd17976   106 VLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPE-----LRVVLMSATGDNQRLSRYFGGCPVV 176
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 1-78 3.05e-10

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 59.46  E-value: 3.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185   1 MLLREAIS-DSLLRKYSCVILDEAHERTIHTDVLFgvvktaQKRRKELGKLP-LKVIVMSATMDVDLFSQYFNRAPVLYL 78
Cdd:cd17987   103 VLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLL------TKLRDILQKHPnLKLILSSAALDVNLFIRYFGSCPVIYI 176
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 1-76 1.91e-09

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 58.31  E-value: 1.91e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907081185   1 MLLREAisDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKELgklplKVIVMSATMDVDLFSQYFNRAPVL 76
Cdd:cd17972   164 VLLRKL--EAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPDL-----RVILMSATIDTSMFCEYFFNCPVI 232
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 1-75 6.37e-09

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 55.67  E-value: 6.37e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907081185   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKELgKLplkVIVMSATMDVDLFSqYFNRAPV 75
Cdd:cd17986   105 LLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPEL-RV---VVVTSPALEPKLRA-FWGNPPV 174
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 1-70 2.70e-07

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 50.96  E-value: 2.70e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVktaqKRRKELGKLPLKVIVMSATMDVDLFSQYF 70
Cdd:cd17988   103 VLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVV----RRLLRTNSRHVKIILMSATISCKEFADYF 168
DEXDc smart00487
DEAD-like helicases superfamily;
1-88 3.91e-06

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 47.87  E-value: 3.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081185    1 MLLREAISDSL-LRKYSCVILDEAHERT--IHTDVLFGVVKTAQKRRkelgklplKVIVMSATM--DVDLFSQYFNRAPV 75
Cdd:smart00487 115 RLLDLLENDKLsLSNVDLVILDEAHRLLdgGFGDQLEKLLKLLPKNV--------QLLLLSATPpeEIENLLELFLNDPV 186

                           90
                   ....*....|....*
gi 1907081185   76 LYLEGR--QHPIQIF 88
Cdd:smart00487 187 FIDVGFtpLEPIEQF 201
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 176-245 1.23e-04

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 40.38  E-value: 1.23e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907081185 176 KVIISTNIAETSITITGIKYVVDTGMVKakkynpdsglevlavqrvSKTQAWQRTGRAGR--EDSGICYRLY 245
Cdd:cd18785    24 EILVATNVLGEGIDVPSLDTVIFFDPPS------------------SAASYIQRVGRAGRggKDEGEVILFV 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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