|
Name |
Accession |
Description |
Interval |
E-value |
| Tub super family |
cl08308 |
Tub family; |
1459-1529 |
1.79e-23 |
|
Tub family;
The actual alignment was detected with superfamily member pfam01167:
Pssm-ID: 460094 Cd Length: 251 Bit Score: 101.50 E-value: 1.79e-23
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907125969 1459 VMANKQPLWNEATQVYQLDFGGRVTQESAKNFQI---ELEGRQVMQFGRIDGNAYILDFQYPFSAVQAFAVALA 1529
Cdd:pfam01167 174 VLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLvapEDQDKVILQFGKVGKDMFTMDYRYPLSAFQAFAICLS 247
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
995-1326 |
3.18e-07 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 55.71 E-value: 3.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 995 ADSSRAPLQPLAKPKGGAAGAVAQLPARPPpalytcSQCSGAGPSSQSGAALAHAISTSPlasqssynllsPPDTSRDRT 1074
Cdd:PHA03247 2564 PDRSVPPPRPAPRPSEPAVTSRARRPDAPP------QSARPRAPVDDRGDPRGPAPPSPL-----------PPDTHAPDP 2626
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1075 DYVNSAFTEDEALSQHcQLEKPLRHPPLPEAAVTMKRPPPYQWDPMLGEDVWVPQERTAQPTVPNPLklsplmlgqGQHL 1154
Cdd:PHA03247 2627 PPPSPSPAANEPDPHP-PPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTV---------GSLT 2696
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1155 DVARVPFVPPKSPSSPTATFPTGYGMGMPYPGSYNNPSLPGVQAPCSPK-----DALSQAQFAQQESAVVLQPAyPPSLS 1229
Cdd:PHA03247 2697 SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPagpatPGGPARPARPPTTAGPPAPA-PPAAP 2775
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1230 YCTLPPTYPGSSTCSSVQLPPIALHPWN----------SYSTCPPMQNTQGTLPPKPHLVVEKPLVSPPPAELQSHMGTE 1299
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLPSPWDpadppaavlaPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS 2855
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1907125969 1300 VM----------------VETADNFQEVLSLTESPVPQRTEKF 1326
Cdd:PHA03247 2856 VApggdvrrrppsrspaaKPAAPARPPVRRLARPAVSRSTESF 2898
|
|
| SOCS super family |
cl02533 |
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ... |
319-354 |
4.15e-04 |
|
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.
The actual alignment was detected with superfamily member cd03717:
Pssm-ID: 470605 Cd Length: 39 Bit Score: 39.12 E-value: 4.15e-04
10 20 30
....*....|....*....|....*....|....*.
gi 1907125969 319 RVSSLQLLCQQAIASTLREDKdVNKLTLPPRLCSYL 354
Cdd:cd03717 2 SVRSLQHLCRFVIRQCTRRDL-IDQLPLPRRLKDYL 36
|
|
| WD40 super family |
cl43672 |
WD40 repeat [General function prediction only]; |
45-163 |
9.03e-04 |
|
WD40 repeat [General function prediction only];
The actual alignment was detected with superfamily member COG2319:
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 43.36 E-value: 9.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 45 WLATGNGRGVVGVTftsshcrrDRSTPQRInFNLRGHNSEVVLVRWNEPYQKLATCDADGGIFVW------------IQY 112
Cdd:COG2319 218 LLASGSADGTVRLW--------DLATGKLL-RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWdlatgellrtltGHS 288
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1907125969 113 EGRWSVELVNDrGAQVLFGTADGQVIVMDCHGRMLAHVLLHESDGILSMSW 163
Cdd:COG2319 289 GGVNSVAFSPD-GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 338
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Tub |
pfam01167 |
Tub family; |
1459-1529 |
1.79e-23 |
|
Tub family;
Pssm-ID: 460094 Cd Length: 251 Bit Score: 101.50 E-value: 1.79e-23
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907125969 1459 VMANKQPLWNEATQVYQLDFGGRVTQESAKNFQI---ELEGRQVMQFGRIDGNAYILDFQYPFSAVQAFAVALA 1529
Cdd:pfam01167 174 VLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLvapEDQDKVILQFGKVGKDMFTMDYRYPLSAFQAFAICLS 247
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
995-1326 |
3.18e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 55.71 E-value: 3.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 995 ADSSRAPLQPLAKPKGGAAGAVAQLPARPPpalytcSQCSGAGPSSQSGAALAHAISTSPlasqssynllsPPDTSRDRT 1074
Cdd:PHA03247 2564 PDRSVPPPRPAPRPSEPAVTSRARRPDAPP------QSARPRAPVDDRGDPRGPAPPSPL-----------PPDTHAPDP 2626
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1075 DYVNSAFTEDEALSQHcQLEKPLRHPPLPEAAVTMKRPPPYQWDPMLGEDVWVPQERTAQPTVPNPLklsplmlgqGQHL 1154
Cdd:PHA03247 2627 PPPSPSPAANEPDPHP-PPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTV---------GSLT 2696
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1155 DVARVPFVPPKSPSSPTATFPTGYGMGMPYPGSYNNPSLPGVQAPCSPK-----DALSQAQFAQQESAVVLQPAyPPSLS 1229
Cdd:PHA03247 2697 SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPagpatPGGPARPARPPTTAGPPAPA-PPAAP 2775
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1230 YCTLPPTYPGSSTCSSVQLPPIALHPWN----------SYSTCPPMQNTQGTLPPKPHLVVEKPLVSPPPAELQSHMGTE 1299
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLPSPWDpadppaavlaPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS 2855
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1907125969 1300 VM----------------VETADNFQEVLSLTESPVPQRTEKF 1326
Cdd:PHA03247 2856 VApggdvrrrppsrspaaKPAAPARPPVRRLARPAVSRSTESF 2898
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1039-1295 |
1.36e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 46.68 E-value: 1.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1039 SSQSGAALAHAISTSPLASQSSYNLLSPPDTSRDRTDYVNSAFTEDEALSQHCQLEKPLRHPP-----------LPEAAV 1107
Cdd:pfam03154 156 SDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPnqtqstaaphtLIQQTP 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1108 TMKRP------PPYQWDPMLGEDVWVPQERTAQPTVPNPLKLSPLMLGQGQHLDVARVPFVP-PKSPSSPTATFPTGYGM 1180
Cdd:pfam03154 236 TLHPQrlpsphPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPfPLTPQSSQSQVPPGPSP 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1181 GMPYPgSYNNPSLPGVQapcspkdalSQAQFAQQESAVVLQPAyPPSLSYCTLPPTYPGSstcssvQLPPIALHPWNSYS 1260
Cdd:pfam03154 316 AAPGQ-SQQRIHTPPSQ---------SQLQSQQPPREQPLPPA-PLSMPHIKPPPTTPIP------QLPNPQSHKHPPHL 378
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1907125969 1261 TCPPMQNTQGTLPPKPHLvveKPLVS----------PPPAELQSH 1295
Cdd:pfam03154 379 SGPSPFQMNSNLPPPPAL---KPLSSlsthhppsahPPPLQLMPQ 420
|
|
| SOCS_SOCS_like |
cd03717 |
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ... |
319-354 |
4.15e-04 |
|
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.
Pssm-ID: 239687 Cd Length: 39 Bit Score: 39.12 E-value: 4.15e-04
10 20 30
....*....|....*....|....*....|....*.
gi 1907125969 319 RVSSLQLLCQQAIASTLREDKdVNKLTLPPRLCSYL 354
Cdd:cd03717 2 SVRSLQHLCRFVIRQCTRRDL-IDQLPLPRRLKDYL 36
|
|
| SOCS_box |
smart00969 |
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ... |
321-355 |
6.94e-04 |
|
The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;
Pssm-ID: 198037 Cd Length: 34 Bit Score: 38.54 E-value: 6.94e-04
10 20 30
....*....|....*....|....*....|....*
gi 1907125969 321 SSLQLLCQQAIASTLredKDVNKLTLPPRLCSYLS 355
Cdd:smart00969 1 RSLQHLCRLAIRRSL---GGIDKLPLPPRLKDYLL 32
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
45-163 |
9.03e-04 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 43.36 E-value: 9.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 45 WLATGNGRGVVGVTftsshcrrDRSTPQRInFNLRGHNSEVVLVRWNEPYQKLATCDADGGIFVW------------IQY 112
Cdd:COG2319 218 LLASGSADGTVRLW--------DLATGKLL-RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWdlatgellrtltGHS 288
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1907125969 113 EGRWSVELVNDrGAQVLFGTADGQVIVMDCHGRMLAHVLLHESDGILSMSW 163
Cdd:COG2319 289 GGVNSVAFSPD-GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 338
|
|
| SOCS_box |
pfam07525 |
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ... |
320-354 |
2.24e-03 |
|
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.
Pssm-ID: 462192 Cd Length: 39 Bit Score: 37.14 E-value: 2.24e-03
10 20 30
....*....|....*....|....*....|....*..
gi 1907125969 320 VSSLQLLCQQAIASTL--REDKDVNKLTLPPRLCSYL 354
Cdd:pfam07525 2 PRSLQHLCRLAIRRALgkRRLGAIDKLPLPPLLKDYL 38
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
78-164 |
3.25e-03 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 41.17 E-value: 3.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 78 LRGHNSEVVLVRWNEPYQKLATCDADGGIFVW--------IQYEGR----WSVELVNDrGAQVLFGTADGQVIVMDCHGR 145
Cdd:cd00200 5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWdletgellRTLKGHtgpvRDVAASAD-GTYLASGSSDKTIRLWDLETG 83
|
90
....*....|....*....
gi 1907125969 146 MLAHVLLHESDGILSMSWN 164
Cdd:cd00200 84 ECVRTLTGHTSYVSSVAFS 102
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
78-109 |
8.37e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 35.75 E-value: 8.37e-03
10 20 30
....*....|....*....|....*....|..
gi 1907125969 78 LRGHNSEVVLVRWNEPYQKLATCDADGGIFVW 109
Cdd:smart00320 8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Tub |
pfam01167 |
Tub family; |
1459-1529 |
1.79e-23 |
|
Tub family;
Pssm-ID: 460094 Cd Length: 251 Bit Score: 101.50 E-value: 1.79e-23
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907125969 1459 VMANKQPLWNEATQVYQLDFGGRVTQESAKNFQI---ELEGRQVMQFGRIDGNAYILDFQYPFSAVQAFAVALA 1529
Cdd:pfam01167 174 VLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLvapEDQDKVILQFGKVGKDMFTMDYRYPLSAFQAFAICLS 247
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
995-1326 |
3.18e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 55.71 E-value: 3.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 995 ADSSRAPLQPLAKPKGGAAGAVAQLPARPPpalytcSQCSGAGPSSQSGAALAHAISTSPlasqssynllsPPDTSRDRT 1074
Cdd:PHA03247 2564 PDRSVPPPRPAPRPSEPAVTSRARRPDAPP------QSARPRAPVDDRGDPRGPAPPSPL-----------PPDTHAPDP 2626
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1075 DYVNSAFTEDEALSQHcQLEKPLRHPPLPEAAVTMKRPPPYQWDPMLGEDVWVPQERTAQPTVPNPLklsplmlgqGQHL 1154
Cdd:PHA03247 2627 PPPSPSPAANEPDPHP-PPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTV---------GSLT 2696
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1155 DVARVPFVPPKSPSSPTATFPTGYGMGMPYPGSYNNPSLPGVQAPCSPK-----DALSQAQFAQQESAVVLQPAyPPSLS 1229
Cdd:PHA03247 2697 SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPagpatPGGPARPARPPTTAGPPAPA-PPAAP 2775
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1230 YCTLPPTYPGSSTCSSVQLPPIALHPWN----------SYSTCPPMQNTQGTLPPKPHLVVEKPLVSPPPAELQSHMGTE 1299
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLPSPWDpadppaavlaPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS 2855
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1907125969 1300 VM----------------VETADNFQEVLSLTESPVPQRTEKF 1326
Cdd:PHA03247 2856 VApggdvrrrppsrspaaKPAAPARPPVRRLARPAVSRSTESF 2898
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
938-1290 |
3.58e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 52.25 E-value: 3.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 938 RLTVPRYSIPTGDPPPYP------EIASQLAQGRSAA----QRLDNSLIHATLRRNNREVALKMAQLADSS-RAPLQPLA 1006
Cdd:PHA03247 2609 RGPAPPSPLPPDTHAPDPpppspsPAANEPDPHPPPTvpppERPRDDPAPGRVSRPRRARRLGRAAQASSPpQRPRRRAA 2688
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1007 KPKGGAAGAVAQLPARPP---PALYTCSQCSGAGPSSQSGAALAHAISTSPLASQSSYNLLSPPDTSRDRTDYVNSAfte 1083
Cdd:PHA03247 2689 RPTVGSLTSLADPPPPPPtpePAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG--- 2765
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1084 dealsqhcqlekplrhPPLPEAAVTMKRPPPYQWDPMLGEDVWVpqERTAQPTVPNPLKLSPLMLGQGQHLDVARVPFVP 1163
Cdd:PHA03247 2766 ----------------PPAPAPPAAPAAGPPRRLTRPAVASLSE--SRESLPSPWDPADPPAAVLAPAAALPPAASPAGP 2827
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1164 PKSPSSPTATFPtgygmgmPYPGSYNNPSLP--GVQAPCSPkdaLSQAQFAQQESAVVLQPAYPPSLSyctLPPTYPGSS 1241
Cdd:PHA03247 2828 LPPPTSAQPTAP-------PPPPGPPPPSLPlgGSVAPGGD---VRRRPPSRSPAAKPAAPARPPVRR---LARPAVSRS 2894
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1907125969 1242 TCSSVQLPPIALHPWNSYSTCPPMQNTQGTLPPKPHLVVEKPLVSPPPA 1290
Cdd:PHA03247 2895 TESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPL 2943
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
890-1292 |
3.54e-05 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 48.52 E-value: 3.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 890 VEEVCRPRTRMLCSQNTYTLPGPGSSATLRLTATEKkVPQPCTSatlnrLTVPrYSIPTGDPPPYPEIASQLAQGRSAAQ 969
Cdd:PHA03378 426 IEEEHRKKKAARTEQPRATPHSQAPTVVLHRPPTQP-LEGPTGP-----LSVQ-APLEPWQPLPHPQVTPVILHQPPAQG 498
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 970 RLDNSLIHATLRRNNREVALK-MAQLADssRAPLQPLAKPKG-----GAAGAVAQLPARPPPALYTCSQCSGAGP---SS 1040
Cdd:PHA03378 499 VQAHGSMLDLLEKDDEDMEQRvMATLLP--PSPPQPRAGRRApcvytEDLDIESDEPASTEPVHDQLLPAPGLGPlqiQP 576
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1041 QSGAALAHAISTSPLASQSSYNLLSPPDTSRDRTdyVNSAFTEDEALSQHCQLEKPLRHPPLPEAAVTMK---RPPPY-- 1115
Cdd:PHA03378 577 LTSPTTSQLASSAPSYAQTPWPVPHPSQTPEPPT--TQSHIPETSAPRQWPMPLRPIPMRPLRMQPITFNvlvFPTPHqp 654
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1116 -QWDPMLGEDVWV-PQERTAQPTVPNPLKLSPLMLGQGQHLDVARVP--FVPPKSPSSPtATFPTGYGMGMPYPGSYNNP 1191
Cdd:PHA03378 655 pQVEITPYKPTWTqIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPtpMRPPAAPPGR-AQRPAAATGRARPPAAAPGR 733
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1192 SLPGVQAPcSPKDALSQAQFAQQESAVVLQPAYPPSLSYCTLPPTYPGsstcssvQLPPIalhpwnsystcpPMQNTQGT 1271
Cdd:PHA03378 734 ARPPAAAP-GRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPP-------QAPPA------------PQQRPRGA 793
|
410 420
....*....|....*....|.
gi 1907125969 1272 LPPKPhlvveKPLVSPPPAEL 1292
Cdd:PHA03378 794 PTPQP-----PPQAGPTSMQL 809
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1039-1295 |
1.36e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 46.68 E-value: 1.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1039 SSQSGAALAHAISTSPLASQSSYNLLSPPDTSRDRTDYVNSAFTEDEALSQHCQLEKPLRHPP-----------LPEAAV 1107
Cdd:pfam03154 156 SDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPnqtqstaaphtLIQQTP 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1108 TMKRP------PPYQWDPMLGEDVWVPQERTAQPTVPNPLKLSPLMLGQGQHLDVARVPFVP-PKSPSSPTATFPTGYGM 1180
Cdd:pfam03154 236 TLHPQrlpsphPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPfPLTPQSSQSQVPPGPSP 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1181 GMPYPgSYNNPSLPGVQapcspkdalSQAQFAQQESAVVLQPAyPPSLSYCTLPPTYPGSstcssvQLPPIALHPWNSYS 1260
Cdd:pfam03154 316 AAPGQ-SQQRIHTPPSQ---------SQLQSQQPPREQPLPPA-PLSMPHIKPPPTTPIP------QLPNPQSHKHPPHL 378
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1907125969 1261 TCPPMQNTQGTLPPKPHLvveKPLVS----------PPPAELQSH 1295
Cdd:pfam03154 379 SGPSPFQMNSNLPPPPAL---KPLSSlsthhppsahPPPLQLMPQ 420
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
935-1183 |
3.65e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 45.25 E-value: 3.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 935 TLNRLTVPRYSIPTGDPPPYPEIASQLAQGRSAAqrldnslihatlrrnnreVALKMAQLADSSRAPLQPLAKPKGGAAG 1014
Cdd:PRK12323 356 TLLRMLAFRPGQSGGGAGPATAAAAPVAQPAPAA------------------AAPAAAAPAPAAPPAAPAAAPAAAAAAR 417
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1015 AVAQLPARPPP---ALYTCSQCSGAGPSSQSGAALAHAISTSPLASQSSYNLLSPPDTSrdrtdyVNSAFTEDEALSQHC 1091
Cdd:PRK12323 418 AVAAAPARRSPapeALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAA------AAAPARAAPAAAPAP 491
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 1092 QLEKPlrhPPLPEAAVTMKRPPPYQWDPMLGEDVW--VPQERTAQPTVPNPLKLSPLMLGQGQHLDVARVPFVPPKSPSS 1169
Cdd:PRK12323 492 ADDDP---PPWEELPPEFASPAPAQPDAAPAGWVAesIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRA 568
|
250
....*....|....
gi 1907125969 1170 PTATFPTGYGMGMP 1183
Cdd:PRK12323 569 SASGLPDMFDGDWP 582
|
|
| SOCS_SOCS_like |
cd03717 |
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ... |
319-354 |
4.15e-04 |
|
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.
Pssm-ID: 239687 Cd Length: 39 Bit Score: 39.12 E-value: 4.15e-04
10 20 30
....*....|....*....|....*....|....*.
gi 1907125969 319 RVSSLQLLCQQAIASTLREDKdVNKLTLPPRLCSYL 354
Cdd:cd03717 2 SVRSLQHLCRFVIRQCTRRDL-IDQLPLPRRLKDYL 36
|
|
| SOCS_box |
smart00969 |
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ... |
321-355 |
6.94e-04 |
|
The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;
Pssm-ID: 198037 Cd Length: 34 Bit Score: 38.54 E-value: 6.94e-04
10 20 30
....*....|....*....|....*....|....*
gi 1907125969 321 SSLQLLCQQAIASTLredKDVNKLTLPPRLCSYLS 355
Cdd:smart00969 1 RSLQHLCRLAIRRSL---GGIDKLPLPPRLKDYLL 32
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
45-163 |
9.03e-04 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 43.36 E-value: 9.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 45 WLATGNGRGVVGVTftsshcrrDRSTPQRInFNLRGHNSEVVLVRWNEPYQKLATCDADGGIFVW------------IQY 112
Cdd:COG2319 218 LLASGSADGTVRLW--------DLATGKLL-RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWdlatgellrtltGHS 288
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1907125969 113 EGRWSVELVNDrGAQVLFGTADGQVIVMDCHGRMLAHVLLHESDGILSMSW 163
Cdd:COG2319 289 GGVNSVAFSPD-GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 338
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
45-163 |
1.61e-03 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 42.59 E-value: 1.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 45 WLATGNGRGVVGVtftsshcrRDRSTPQRInFNLRGHNSEVVLVRWNEPYQKLATCDADGGIFVW--------IQYEGR- 115
Cdd:COG2319 176 LLASGSDDGTVRL--------WDLATGKLL-RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWdlatgkllRTLTGHs 246
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1907125969 116 ---WSVELVNDrGAQVLFGTADGQVIVMDCHGRMLAHVLLHESDGILSMSW 163
Cdd:COG2319 247 gsvRSVAFSPD-GRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296
|
|
| SOCS_box |
pfam07525 |
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ... |
320-354 |
2.24e-03 |
|
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.
Pssm-ID: 462192 Cd Length: 39 Bit Score: 37.14 E-value: 2.24e-03
10 20 30
....*....|....*....|....*....|....*..
gi 1907125969 320 VSSLQLLCQQAIASTL--REDKDVNKLTLPPRLCSYL 354
Cdd:pfam07525 2 PRSLQHLCRLAIRRALgkRRLGAIDKLPLPPLLKDYL 38
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
78-164 |
3.25e-03 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 41.17 E-value: 3.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125969 78 LRGHNSEVVLVRWNEPYQKLATCDADGGIFVW--------IQYEGR----WSVELVNDrGAQVLFGTADGQVIVMDCHGR 145
Cdd:cd00200 5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWdletgellRTLKGHtgpvRDVAASAD-GTYLASGSSDKTIRLWDLETG 83
|
90
....*....|....*....
gi 1907125969 146 MLAHVLLHESDGILSMSWN 164
Cdd:cd00200 84 ECVRTLTGHTSYVSSVAFS 102
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
78-109 |
8.37e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 35.75 E-value: 8.37e-03
10 20 30
....*....|....*....|....*....|..
gi 1907125969 78 LRGHNSEVVLVRWNEPYQKLATCDADGGIFVW 109
Cdd:smart00320 8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| |
