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Conserved domains on  [gi|1907152426|ref|XP_036019278|]
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GON-4-like protein isoform X2 [Mus musculus]

Protein Classification

PAH and CASP8AP2 domain-containing protein( domain architecture ID 10496266)

PAH and CASP8AP2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CASP8AP2 cd12202
Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of ...
 2162-2227 2.29e-35

Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of Caspase 8-associated protein 2 (CASP8AP2) / GON-4 like proteins. CASP8AP2 (aka Flice-Associated Huge Protein (FLASH)) is implicated in numerous gene regulatory roles including roles in embryogenesis, oncogenesis, down-regulation of replication-dependent histone genes, regulation of Caspase 8 activity at the death-inducing signaling complex (DISC), and as a useful marker in leukemia prognosis. Gon-4 is critical in Caenorhabditis elegans gonadogenesis. Danio rerio GON4 is a regulator of gene expression in hematopoietic development, possibly by repressing expression. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


:

Pssm-ID: 213401  Cd Length: 66  Bit Score: 129.41  E-value: 2.29e-35
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907152426 2162 NSKVSSTGEKVVLWTREADRVILTMCQEQGAQPHTFSVISQQLGNKTPVEVSHRFRELMQLFHTAC 2227
Cdd:cd12202      1 NNVIKSKGEKVVLWTRDADRVILTACQEKGASPKTFAALASKLGKKTPQEVSERFRQLMKLFHKSC 66
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 1672-1717 5.99e-07

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


:

Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 47.80  E-value: 5.99e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1907152426 1672 KYEDFLQIIYEFesSTQMHSAVDLFKSLQTLLQDWPQLLKDFAAFL 1717
Cdd:pfam02671    2 VYDEFLKILNDY--KQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 992-1258 2.38e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 2.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152426  992 PGSKRFSRKAWRQKRPL-----VQKPLLIQPSPSVQPVFNPGKMATWPTQSEVPPSNTVVQIPHLIQPAAVLQTLPGFPS 1066
Cdd:PHA03247  2658 PGRVSRPRRARRLGRAAqasspPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPA 2737

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152426 1067 VGV--------------------RGEDGFESPTAlPAMPCGSEARTTFPLSETQSAPPSCSAPKLMLPSLAPSKFRKPYV 1126
Cdd:PHA03247  2738 APAppavpagpatpggparparpPTTAGPPAPAP-PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAA 2816

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152426 1127 RRKPTRRKGAKVSPCVKPAPIIHPTPVIFTVPATTVKVVSIGGGCNMIQPVSAAVAPSPQTipittllvnPTTFPCS-LN 1205
Cdd:PHA03247  2817 ALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAA---------PARPPVRrLA 2887

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907152426 1206 QPLVASSISPLIVSSNPLT------LPVTSIPEDKAQVKLDVAEGKNAPQNPESKLKPQ 1258
Cdd:PHA03247  2888 RPAVSRSTESFALPPDQPErppqpqAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPT 2946
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 1772-1798 6.65e-04

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


:

Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 39.33  E-value: 6.65e-04
                           10        20
                   ....*....|....*....|....*..
gi 1907152426 1772 DIAELKTQMWQLLRGHDHLQDEFSIFF 1798
Cdd:pfam02671   19 DIAEVIARVSELLKGHPDLLEGFNTFL 45
 
Name Accession Description Interval E-value
CASP8AP2 cd12202
Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of ...
 2162-2227 2.29e-35

Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of Caspase 8-associated protein 2 (CASP8AP2) / GON-4 like proteins. CASP8AP2 (aka Flice-Associated Huge Protein (FLASH)) is implicated in numerous gene regulatory roles including roles in embryogenesis, oncogenesis, down-regulation of replication-dependent histone genes, regulation of Caspase 8 activity at the death-inducing signaling complex (DISC), and as a useful marker in leukemia prognosis. Gon-4 is critical in Caenorhabditis elegans gonadogenesis. Danio rerio GON4 is a regulator of gene expression in hematopoietic development, possibly by repressing expression. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 213401  Cd Length: 66  Bit Score: 129.41  E-value: 2.29e-35
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907152426 2162 NSKVSSTGEKVVLWTREADRVILTMCQEQGAQPHTFSVISQQLGNKTPVEVSHRFRELMQLFHTAC 2227
Cdd:cd12202      1 NNVIKSKGEKVVLWTRDADRVILTACQEKGASPKTFAALASKLGKKTPQEVSERFRQLMKLFHKSC 66
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 1672-1717 5.99e-07

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 47.80  E-value: 5.99e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1907152426 1672 KYEDFLQIIYEFesSTQMHSAVDLFKSLQTLLQDWPQLLKDFAAFL 1717
Cdd:pfam02671    2 VYDEFLKILNDY--KQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
PHA03247 PHA03247
large tegument protein UL36; Provisional
 992-1258 2.38e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 2.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152426  992 PGSKRFSRKAWRQKRPL-----VQKPLLIQPSPSVQPVFNPGKMATWPTQSEVPPSNTVVQIPHLIQPAAVLQTLPGFPS 1066
Cdd:PHA03247  2658 PGRVSRPRRARRLGRAAqasspPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPA 2737

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152426 1067 VGV--------------------RGEDGFESPTAlPAMPCGSEARTTFPLSETQSAPPSCSAPKLMLPSLAPSKFRKPYV 1126
Cdd:PHA03247  2738 APAppavpagpatpggparparpPTTAGPPAPAP-PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAA 2816

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152426 1127 RRKPTRRKGAKVSPCVKPAPIIHPTPVIFTVPATTVKVVSIGGGCNMIQPVSAAVAPSPQTipittllvnPTTFPCS-LN 1205
Cdd:PHA03247  2817 ALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAA---------PARPPVRrLA 2887

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907152426 1206 QPLVASSISPLIVSSNPLT------LPVTSIPEDKAQVKLDVAEGKNAPQNPESKLKPQ 1258
Cdd:PHA03247  2888 RPAVSRSTESFALPPDQPErppqpqAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPT 2946
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 1772-1798 6.65e-04

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 39.33  E-value: 6.65e-04
                           10        20
                   ....*....|....*....|....*..
gi 1907152426 1772 DIAELKTQMWQLLRGHDHLQDEFSIFF 1798
Cdd:pfam02671   19 DIAEVIARVSELLKGHPDLLEGFNTFL 45
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1004-1303 9.45e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.37  E-value: 9.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152426 1004 QKRPLVQKPLLIQPSPSVQPVFNPGKMATWPTQSEVPPS--NTVVQIPHLIQ--PAAVLQTLP--GFPSVGVRGEdGFES 1077
Cdd:pfam03154  232 QQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhGQMPPMPHSLQtgPSHMQHPVPpqPFPLTPQSSQ-SQVP 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152426 1078 PTALPAMPCGSEARTTFPLSetQSAPPSCSAPKLMlpSLAPSKFRKPYVRRKPTrrkgAKVSPCVKPAPIIHPTPVIFTV 1157
Cdd:pfam03154  311 PGPSPAAPGQSQQRIHTPPS--QSQLQSQQPPREQ--PLPPAPLSMPHIKPPPT----TPIPQLPNPQSHKHPPHLSGPS 382

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152426 1158 PATtvkvvsigggcnmiqpVSAAVAPSPQTIPITTLLVN--PTTFPCSL-----NQPLVASSISPLIVSSNPlTLPVTSI 1230
Cdd:pfam03154  383 PFQ----------------MNSNLPPPPALKPLSSLSTHhpPSAHPPPLqlmpqSQQLPPPPAQPPVLTQSQ-SLPPPAA 445

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907152426 1231 PEDKAQVKLDVAEGKNAPQNPESKLKPQELTPLCTtvfskeePKSWHSSADTGSQEAFSESSACSWAVVKTES 1303
Cdd:pfam03154  446 SHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSG-------PPTSTSSAMPGIQPPSSASVSSSGPVPAAVS 511
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
2175-2219 8.18e-03

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 36.43  E-value: 8.18e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1907152426  2175 WTREADRVILTMCQEQGaqPHTFSVISQQLGNKTPVEVSHRFREL 2219
Cdd:smart00717    4 WTEEEDELLIELVKKYG--KNNWEKIAKELPGRTAEQCRERWRNL 46
 
Name Accession Description Interval E-value
CASP8AP2 cd12202
Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of ...
 2162-2227 2.29e-35

Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of Caspase 8-associated protein 2 (CASP8AP2) / GON-4 like proteins. CASP8AP2 (aka Flice-Associated Huge Protein (FLASH)) is implicated in numerous gene regulatory roles including roles in embryogenesis, oncogenesis, down-regulation of replication-dependent histone genes, regulation of Caspase 8 activity at the death-inducing signaling complex (DISC), and as a useful marker in leukemia prognosis. Gon-4 is critical in Caenorhabditis elegans gonadogenesis. Danio rerio GON4 is a regulator of gene expression in hematopoietic development, possibly by repressing expression. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 213401  Cd Length: 66  Bit Score: 129.41  E-value: 2.29e-35
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907152426 2162 NSKVSSTGEKVVLWTREADRVILTMCQEQGAQPHTFSVISQQLGNKTPVEVSHRFRELMQLFHTAC 2227
Cdd:cd12202      1 NNVIKSKGEKVVLWTRDADRVILTACQEKGASPKTFAALASKLGKKTPQEVSERFRQLMKLFHKSC 66
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 1672-1717 5.99e-07

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 47.80  E-value: 5.99e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1907152426 1672 KYEDFLQIIYEFesSTQMHSAVDLFKSLQTLLQDWPQLLKDFAAFL 1717
Cdd:pfam02671    2 VYDEFLKILNDY--KQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
PHA03247 PHA03247
large tegument protein UL36; Provisional
 992-1258 2.38e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 2.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152426  992 PGSKRFSRKAWRQKRPL-----VQKPLLIQPSPSVQPVFNPGKMATWPTQSEVPPSNTVVQIPHLIQPAAVLQTLPGFPS 1066
Cdd:PHA03247  2658 PGRVSRPRRARRLGRAAqasspPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPA 2737

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152426 1067 VGV--------------------RGEDGFESPTAlPAMPCGSEARTTFPLSETQSAPPSCSAPKLMLPSLAPSKFRKPYV 1126
Cdd:PHA03247  2738 APAppavpagpatpggparparpPTTAGPPAPAP-PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAA 2816

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152426 1127 RRKPTRRKGAKVSPCVKPAPIIHPTPVIFTVPATTVKVVSIGGGCNMIQPVSAAVAPSPQTipittllvnPTTFPCS-LN 1205
Cdd:PHA03247  2817 ALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAA---------PARPPVRrLA 2887

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907152426 1206 QPLVASSISPLIVSSNPLT------LPVTSIPEDKAQVKLDVAEGKNAPQNPESKLKPQ 1258
Cdd:PHA03247  2888 RPAVSRSTESFALPPDQPErppqpqAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPT 2946
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 1772-1798 6.65e-04

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 39.33  E-value: 6.65e-04
                           10        20
                   ....*....|....*....|....*..
gi 1907152426 1772 DIAELKTQMWQLLRGHDHLQDEFSIFF 1798
Cdd:pfam02671   19 DIAEVIARVSELLKGHPDLLEGFNTFL 45
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1004-1303 9.45e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.37  E-value: 9.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152426 1004 QKRPLVQKPLLIQPSPSVQPVFNPGKMATWPTQSEVPPS--NTVVQIPHLIQ--PAAVLQTLP--GFPSVGVRGEdGFES 1077
Cdd:pfam03154  232 QQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhGQMPPMPHSLQtgPSHMQHPVPpqPFPLTPQSSQ-SQVP 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152426 1078 PTALPAMPCGSEARTTFPLSetQSAPPSCSAPKLMlpSLAPSKFRKPYVRRKPTrrkgAKVSPCVKPAPIIHPTPVIFTV 1157
Cdd:pfam03154  311 PGPSPAAPGQSQQRIHTPPS--QSQLQSQQPPREQ--PLPPAPLSMPHIKPPPT----TPIPQLPNPQSHKHPPHLSGPS 382

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152426 1158 PATtvkvvsigggcnmiqpVSAAVAPSPQTIPITTLLVN--PTTFPCSL-----NQPLVASSISPLIVSSNPlTLPVTSI 1230
Cdd:pfam03154  383 PFQ----------------MNSNLPPPPALKPLSSLSTHhpPSAHPPPLqlmpqSQQLPPPPAQPPVLTQSQ-SLPPPAA 445

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907152426 1231 PEDKAQVKLDVAEGKNAPQNPESKLKPQELTPLCTtvfskeePKSWHSSADTGSQEAFSESSACSWAVVKTES 1303
Cdd:pfam03154  446 SHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSG-------PPTSTSSAMPGIQPPSSASVSSSGPVPAAVS 511
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 2175-2220 7.96e-03

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 36.40  E-value: 7.96e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1907152426 2175 WTREADRVILTMCQEQGaqPHTFSVISQQLGNKTPVEVSHRFRELM 2220
Cdd:cd00167      2 WTEEEDELLLEAVKKYG--KNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
2175-2219 8.18e-03

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 36.43  E-value: 8.18e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1907152426  2175 WTREADRVILTMCQEQGaqPHTFSVISQQLGNKTPVEVSHRFREL 2219
Cdd:smart00717    4 WTEEEDELLIELVKKYG--KNNWEKIAKELPGRTAEQCRERWRNL 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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