NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907156750|ref|XP_036020177|]
View 

WD repeat-containing protein WRAP73 isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
17-249 1.57e-16

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.80  E-value: 1.57e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750  17 VLLYSLD-GRLLSAYCAYEWSlgIKSVAWSPSSQFLAIGSYDGKVRLLNHVTWKMITEF-GHPATINnpkTVVYkeaekS 94
Cdd:COG2319   186 VRLWDLAtGKLLRTLTGHTGA--VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLtGHSGSVR---SVAF-----S 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750  95 PLlglGHLsfpppramagALSTSESK----YEIASGPVsLQTLKPVADRANPrmgvgmLAFSSDSYFLASRNDNvpNAVW 170
Cdd:COG2319   256 PD---GRL----------LASGSADGtvrlWDLATGEL-LRTLTGHSGGVNS------VAFSPDGKLLASGSDD--GTVR 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750 171 IWDIQKLKLFVVLE-HMSPVRSFQWDPQQPRLAICTGGSKVYLWSPAGCVSVQVPGEGDFPVLGLCWHLSGDSLALLSKD 249
Cdd:COG2319   314 LWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
17-249 1.57e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.80  E-value: 1.57e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750  17 VLLYSLD-GRLLSAYCAYEWSlgIKSVAWSPSSQFLAIGSYDGKVRLLNHVTWKMITEF-GHPATINnpkTVVYkeaekS 94
Cdd:COG2319   186 VRLWDLAtGKLLRTLTGHTGA--VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLtGHSGSVR---SVAF-----S 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750  95 PLlglGHLsfpppramagALSTSESK----YEIASGPVsLQTLKPVADRANPrmgvgmLAFSSDSYFLASRNDNvpNAVW 170
Cdd:COG2319   256 PD---GRL----------LASGSADGtvrlWDLATGEL-LRTLTGHSGGVNS------VAFSPDGKLLASGSDD--GTVR 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750 171 IWDIQKLKLFVVLE-HMSPVRSFQWDPQQPRLAICTGGSKVYLWSPAGCVSVQVPGEGDFPVLGLCWHLSGDSLALLSKD 249
Cdd:COG2319   314 LWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 36-249 6.41e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.58  E-value: 6.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750  36 SLGIKSVAWSPSSQFLAIGSYDGKVRLLNHVTWKMITEF-GHPATINnpktvvykeaekspllglgHLSFPPPRAMAgaL 114
Cdd:cd00200    51 TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLtGHTSYVS-------------------SVAFSPDGRIL--S 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750 115 STSESK----YEIASGpVSLQTLKPVADRANprmgvgMLAFSSDSYFLA-SRNDNvpnAVWIWDIQKLKLFVVLE-HMSP 188
Cdd:cd00200   110 SSSRDKtikvWDVETG-KCLTTLRGHTDWVN------SVAFSPDGTFVAsSSQDG---TIKLWDLRTGKCVATLTgHTGE 179

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907156750 189 VRSFQWDPQQPRLAICTGGSKVYLWSPAGCVSVQVPGEGDFPVLGLCWHLSGDSLALLSKD 249
Cdd:cd00200   180 VNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 38-62 3.88e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 3.88e-04
                           10        20
                   ....*....|....*....|....*
gi 1907156750   38 GIKSVAWSPSSQFLAIGSYDGKVRL 62
Cdd:smart00320  14 PVTSVAFSPDGKYLASGSDDGTIKL 38
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 16-71 7.96e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.64  E-value: 7.96e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907156750  16 KVLLYSLDGRLLSAYCAYEWSLGIKSVAWSPSSQFLAIGSYDGKVRLLNHVTWKMI 71
Cdd:pfam12894  18 ELLLHRLNWQRVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV 73
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
17-249 1.57e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.80  E-value: 1.57e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750  17 VLLYSLD-GRLLSAYCAYEWSlgIKSVAWSPSSQFLAIGSYDGKVRLLNHVTWKMITEF-GHPATINnpkTVVYkeaekS 94
Cdd:COG2319   186 VRLWDLAtGKLLRTLTGHTGA--VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLtGHSGSVR---SVAF-----S 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750  95 PLlglGHLsfpppramagALSTSESK----YEIASGPVsLQTLKPVADRANPrmgvgmLAFSSDSYFLASRNDNvpNAVW 170
Cdd:COG2319   256 PD---GRL----------LASGSADGtvrlWDLATGEL-LRTLTGHSGGVNS------VAFSPDGKLLASGSDD--GTVR 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750 171 IWDIQKLKLFVVLE-HMSPVRSFQWDPQQPRLAICTGGSKVYLWSPAGCVSVQVPGEGDFPVLGLCWHLSGDSLALLSKD 249
Cdd:COG2319   314 LWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393
WD40 COG2319
WD40 repeat [General function prediction only];
38-250 5.42e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 5.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750  38 GIKSVAWSPSSQFLAIGSYDGKVRLLNHVTWKMITEF-GHPATINnpktvvykeaekspllglgHLSFPPPRAMAgaLST 116
Cdd:COG2319   122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLtGHSGAVT-------------------SVAFSPDGKLL--ASG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750 117 SESK----YEIASGPVsLQTLKPVADRanprmgVGMLAFSSDSYFLASRNDNvpNAVWIWDIQKLKLFVVLE-HMSPVRS 191
Cdd:COG2319   181 SDDGtvrlWDLATGKL-LRTLTGHTGA------VRSVAFSPDGKLLASGSAD--GTVRLWDLATGKLLRTLTgHSGSVRS 251

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907156750 192 FQWDPQQPRLAICTGGSKVYLWSPAGCVSVQVPGEGDFPVLGLCWHLSGDSLALLSKDH 250
Cdd:COG2319   252 VAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310
WD40 COG2319
WD40 repeat [General function prediction only];
36-250 1.93e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 1.93e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750  36 SLGIKSVAWSPSSQFLAIGSYDGKVRLLNHVTWKMITEF-GHPATINnpktvvykeaekspllglgHLSFPPpramagal 114
Cdd:COG2319   162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtGHTGAVR-------------------SVAFSP-------- 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750 115 stsESKYeIASGPV-------SLQTLKPVADRANPRMGVGMLAFSSDSYFLASRNDNvpNAVWIWDIQKLKLFVVLE-HM 186
Cdd:COG2319   215 ---DGKL-LASGSAdgtvrlwDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD--GTVRLWDLATGELLRTLTgHS 288

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907156750 187 SPVRSFQWDPQQPRLAICTGGSKVYLWSPAGCVSVQVPGEGDFPVLGLCWHLSGDSLALLSKDH 250
Cdd:COG2319   289 GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDG 352
WD40 COG2319
WD40 repeat [General function prediction only];
38-217 1.22e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.16  E-value: 1.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750  38 GIKSVAWSPSSQFLAIGSYDGKVRLLNHVTWKMITEF-GHPATINnpktvvykeaekspllglgHLSFPPpramagalst 116
Cdd:COG2319   248 SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLtGHSGGVN-------------------SVAFSP---------- 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750 117 sESKYeIASG-------PVSLQTLKPVADRANPRMGVGMLAFSSDSYFLASRNDNvpNAVWIWDIQKLKLFVVLE-HMSP 188
Cdd:COG2319   299 -DGKL-LASGsddgtvrLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDD--GTVRLWDLATGELLRTLTgHTGA 374

                         170       180
                  ....*....|....*....|....*....
gi 1907156750 189 VRSFQWDPQQPRLAICTGGSKVYLWSPAG 217
Cdd:COG2319   375 VTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 36-249 6.41e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.58  E-value: 6.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750  36 SLGIKSVAWSPSSQFLAIGSYDGKVRLLNHVTWKMITEF-GHPATINnpktvvykeaekspllglgHLSFPPPRAMAgaL 114
Cdd:cd00200    51 TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLtGHTSYVS-------------------SVAFSPDGRIL--S 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750 115 STSESK----YEIASGpVSLQTLKPVADRANprmgvgMLAFSSDSYFLA-SRNDNvpnAVWIWDIQKLKLFVVLE-HMSP 188
Cdd:cd00200   110 SSSRDKtikvWDVETG-KCLTTLRGHTDWVN------SVAFSPDGTFVAsSSQDG---TIKLWDLRTGKCVATLTgHTGE 179

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907156750 189 VRSFQWDPQQPRLAICTGGSKVYLWSPAGCVSVQVPGEGDFPVLGLCWHLSGDSLALLSKD 249
Cdd:cd00200   180 VNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-214 3.26e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 3.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750  39 IKSVAWSPSSQFLAIGSYDGKVRLLNHVTWKMITEF-GHPATINnpktvvykeaekspllglgHLSFPPPRA--MAGALS 115
Cdd:cd00200   138 VNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLtGHTGEVN-------------------SVAFSPDGEklLSSSSD 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750 116 TSESKYEIASGpVSLQTLKPvadranPRMGVGMLAFSSDSYFLASRNDNvpNAVWIWDIQKLK-LFVVLEHMSPVRSFQW 194
Cdd:cd00200   199 GTIKLWDLSTG-KCLGTLRG------HENGVNSVAFSPDGYLLASGSED--GTIRVWDLRTGEcVQTLSGHTNSVTSLAW 269

                         170       180
                  ....*....|....*....|
gi 1907156750 195 DPQQPRLAICTGGSKVYLWS 214
Cdd:cd00200   270 SPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 38-249 1.19e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.73  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750  38 GIKSVAWSPSSQFLAIGSYDGKVRLlnhvtWKMITEfghpatinnpktvvykeaekSPLLGL-GHLSFpppraMAGALST 116
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGTIKV-----WDLETG--------------------ELLRTLkGHTGP-----VRDVAAS 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750 117 SESKYEIASGP------VSLQTLKPVADRANPRMGVGMLAFSSD-SYFLASRNDNVpnaVWIWDIQKLKLFVVLE-HMSP 188
Cdd:cd00200    61 ADGTYLASGSSdktirlWDLETGECVRTLTGHTSYVSSVAFSPDgRILSSSSRDKT---IKVWDVETGKCLTTLRgHTDW 137

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907156750 189 VRSFQWDPQQPRLAICTGGSKVYLWSPAGCVSVQV-PGEGDfPVLGLCWHLSGDSLALLSKD 249
Cdd:cd00200   138 VNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATlTGHTG-EVNSVAFSPDGEKLLSSSSD 198
WD40 COG2319
WD40 repeat [General function prediction only];
102-250 1.63e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750 102 LSFPPPRAMAGALSTSESKYEIASGPVSLQTLKPVADRANPrmgvgmLAFSSDSYFLASRNDnvPNAVWIWDIQKLKLFV 181
Cdd:COG2319    43 AASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS------VAFSPDGRLLASASA--DGTVRLWDLATGLLLR 114

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750 182 VLE-HMSPVRSFQWDPQQPRLAICTGGSKVYLWSPAGCVSVQVPGEGDFPVLGLCWHLSGDSLALLSKDH 250
Cdd:COG2319   115 TLTgHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDG 184
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 38-62 3.88e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 3.88e-04
                           10        20
                   ....*....|....*....|....*
gi 1907156750   38 GIKSVAWSPSSQFLAIGSYDGKVRL 62
Cdd:smart00320  14 PVTSVAFSPDGKYLASGSDDGTIKL 38
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 16-71 7.96e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.64  E-value: 7.96e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907156750  16 KVLLYSLDGRLLSAYCAYEWSLGIKSVAWSPSSQFLAIGSYDGKVRLLNHVTWKMI 71
Cdd:pfam12894  18 ELLLHRLNWQRVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV 73
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 179-264 1.37e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.24  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907156750 179 LFVVLEHMSPVRSFQWDPQQPRLAICTGGSKVYLWSPAGCVSVQVPGEGDFPVLGLCWHLSGDSLALLSKDHFCLCF-LE 257
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWdLE 81


                  ....*..
gi 1907156750 258 TKERVGT 264
Cdd:cd00200    82 TGECVRT 88
WD40 pfam00400
WD domain, G-beta repeat;
38-62 1.43e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 1.43e-03
                          10        20
                  ....*....|....*....|....*
gi 1907156750  38 GIKSVAWSPSSQFLAIGSYDGKVRL 62
Cdd:pfam00400  13 SVTSLAFSPDGKLLASGSDDGTVKV 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH