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Conserved domains on  [gi|1916946818|ref|XP_036388439|]
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protein bassoon isoform X2 [Megalops cyprinoides]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FYVE2_BSN_PCLO cd15772
FYVE-related domain 2 found in protein bassoon and piccolo; This family includes protein ...
 372-434 7.08e-42

FYVE-related domain 2 found in protein bassoon and piccolo; This family includes protein bassoon and piccolo. Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Both bassoon and piccolo contain two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. Their FYVE domain resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. This model corresponds to the second FYVE-related domain.


:

Pssm-ID: 277311 [Multi-domain]  Cd Length: 64  Bit Score: 148.64  E-value: 7.08e-42
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1916946818  372 VNCPLCKTELNIGSTEPPNYNSCTQCHTQVCNLCGFNPTPHLVEKKEWLCLNCQTQRLMSGGL 434
Cdd:cd15772      1 VTCPLCKTELNVGSKEPPNYNTCTQCHTQVCNLCGFNPTPHLVEKKEWLCLNCQTQRLMSGGL 63
FYVE1_BSN_PCLO cd15771
FYVE-related domain 1 found in protein bassoon and piccolo; This family includes protein ...
 5-64 8.77e-40

FYVE-related domain 1 found in protein bassoon and piccolo; This family includes protein bassoon and piccolo. Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Both bassoon and piccolo contain two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. Their FYVE domain resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. This model corresponds to the first FYVE-related domain.


:

Pssm-ID: 277310 [Multi-domain]  Cd Length: 61  Bit Score: 142.45  E-value: 8.77e-40
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1916946818    5 KLCPVCNTTELTSHD-QPNFNTCTECHATVCNQCGFNPNPHLTEVQEWLCLNCQMQRALGM 64
Cdd:cd15771      1 TLCPLCNTTELTLHVpKPNFNTCTQCHTTVCNQCGFNPNPHLTEVKEWLCLNCQMQRALGM 61
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 149-557 7.47e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 7.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  149 GPTPASQLGPQGGPAAHHMRSDPQAQRGP-----TSQAQTLGR--------QDPMGRGSQSGMGPVQGMAKAPSQPDLSR 215
Cdd:PHA03247  2630 SPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrPRRARRLGRaaqassppQRPRRRAARPTVGSLTSLADPPPPPPTPE 2709

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  216 SSPM----HQPSRQDQIRSAGSSPARQPAPPQEQPQDGLTgkLFGFGASLLNQASTLMSVDPLQGAQPQHSPARVAPKVV 291
Cdd:PHA03247  2710 PAPHalvsATPLPPGPAAARQASPALPAAPAPPAVPAGPA--TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPA 2787

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  292 FSDAS---SAASKPRGPAAAPGAVPGKPGGAPFPLGPhAPPQQTPTHHQQATPqqesPLKQQHQQKQARQEPAPQPKQPE 368
Cdd:PHA03247  2788 VASLSesrESLPSPWDPADPPAAVLAPAAALPPAASP-AGPLPPPTSAQPTAP----PPPPGPPPPSLPLGGSVAPGGDV 2862

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  369 RPKvncplcktelniGSTEPPNYNSCTQCHTQVCNLcgfnPTPHLVEKKEwlclncqTQRLMSGGLEDPPLPIPQMSPKH 448
Cdd:PHA03247  2863 RRR------------PPSRSPAAKPAAPARPPVRRL----ARPAVSRSTE-------SFALPPDQPERPPQPQAPPPPQP 2919

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  449 QPMGSPrhhppasqqqvqqPPHPKTPSQQHTGPKPAQQPQPKPASVQGSGPFAPVKQSVETRQDKTPIQ----PASTLTS 524
Cdd:PHA03247  2920 QPQPPP-------------PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPrfrvPQPAPSR 2986

                          410       420       430
                   ....*....|....*....|....*....|...
gi 1916946818  525 EAPRQQKTTEKDKIAPKIEKEDETPALPTEIKP 557
Cdd:PHA03247  2987 EAPASSTPPLTGHSLSRVSSWASSLALHEETDP 3019
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
4007-4103 8.01e-04

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14951:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 618  Bit Score: 45.48  E-value: 8.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818 4007 PGPVQARQPQAGTQPAPAAkTDTALTPGLAAKPAVAQPAKTPQPPLTGIGSK--AAPRPGGIGSAAAPQPSSEGESVLSK 4084
Cdd:PRK14951   387 AAPAAAPVAQAAAAPAPAA-APAAAASAPAAPPAAAPPAPVAAPAAAAPAAApaAAPAAVALAPAPPAQAAPETVAIPVR 465

                           90
                   ....*....|....*....
gi 1916946818 4085 ILPGGAAEQAGKLGEAVSA 4103
Cdd:PRK14951   466 VAPEPAVASAAPAPAAAPA 484
 
Name Accession Description Interval E-value
FYVE2_BSN_PCLO cd15772
FYVE-related domain 2 found in protein bassoon and piccolo; This family includes protein ...
 372-434 7.08e-42

FYVE-related domain 2 found in protein bassoon and piccolo; This family includes protein bassoon and piccolo. Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Both bassoon and piccolo contain two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. Their FYVE domain resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. This model corresponds to the second FYVE-related domain.


Pssm-ID: 277311 [Multi-domain]  Cd Length: 64  Bit Score: 148.64  E-value: 7.08e-42
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1916946818  372 VNCPLCKTELNIGSTEPPNYNSCTQCHTQVCNLCGFNPTPHLVEKKEWLCLNCQTQRLMSGGL 434
Cdd:cd15772      1 VTCPLCKTELNVGSKEPPNYNTCTQCHTQVCNLCGFNPTPHLVEKKEWLCLNCQTQRLMSGGL 63
FYVE1_BSN_PCLO cd15771
FYVE-related domain 1 found in protein bassoon and piccolo; This family includes protein ...
 5-64 8.77e-40

FYVE-related domain 1 found in protein bassoon and piccolo; This family includes protein bassoon and piccolo. Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Both bassoon and piccolo contain two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. Their FYVE domain resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. This model corresponds to the first FYVE-related domain.


Pssm-ID: 277310 [Multi-domain]  Cd Length: 61  Bit Score: 142.45  E-value: 8.77e-40
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1916946818    5 KLCPVCNTTELTSHD-QPNFNTCTECHATVCNQCGFNPNPHLTEVQEWLCLNCQMQRALGM 64
Cdd:cd15771      1 TLCPLCNTTELTLHVpKPNFNTCTQCHTTVCNQCGFNPNPHLTEVKEWLCLNCQMQRALGM 61
zf-piccolo pfam05715
Piccolo Zn-finger; This (predicted) Zinc finger is found in the bassoon and piccolo proteins. ...
 374-430 5.18e-38

Piccolo Zn-finger; This (predicted) Zinc finger is found in the bassoon and piccolo proteins. There are eight conserved cysteines, suggesting that it coordinates two zinc ligands.


Pssm-ID: 461722 [Multi-domain]  Cd Length: 60  Bit Score: 137.55  E-value: 5.18e-38
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1916946818  374 CPLCK-TELNIGSTEPPNYNSCTQCHTQVCNLCGFNPTPHLVEKKEWLCLNCQTQRLM 430
Cdd:pfam05715    3 CPLCKtTELNVGSKEPPNYNTCTECKSQVCNLCGFNPTPHLTEKKEWLCLNCQTQRAL 60
zf-piccolo pfam05715
Piccolo Zn-finger; This (predicted) Zinc finger is found in the bassoon and piccolo proteins. ...
 5-62 1.09e-36

Piccolo Zn-finger; This (predicted) Zinc finger is found in the bassoon and piccolo proteins. There are eight conserved cysteines, suggesting that it coordinates two zinc ligands.


Pssm-ID: 461722 [Multi-domain]  Cd Length: 60  Bit Score: 133.70  E-value: 1.09e-36
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818    5 KLCPVCNTTELTSH--DQPNFNTCTECHATVCNQCGFNPNPHLTEVQEWLCLNCQMQRAL 62
Cdd:pfam05715    1 TLCPLCKTTELNVGskEPPNYNTCTECKSQVCNLCGFNPTPHLTEKKEWLCLNCQTQRAL 60
PHA03247 PHA03247
large tegument protein UL36; Provisional
 149-557 7.47e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 7.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  149 GPTPASQLGPQGGPAAHHMRSDPQAQRGP-----TSQAQTLGR--------QDPMGRGSQSGMGPVQGMAKAPSQPDLSR 215
Cdd:PHA03247  2630 SPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrPRRARRLGRaaqassppQRPRRRAARPTVGSLTSLADPPPPPPTPE 2709

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  216 SSPM----HQPSRQDQIRSAGSSPARQPAPPQEQPQDGLTgkLFGFGASLLNQASTLMSVDPLQGAQPQHSPARVAPKVV 291
Cdd:PHA03247  2710 PAPHalvsATPLPPGPAAARQASPALPAAPAPPAVPAGPA--TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPA 2787

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  292 FSDAS---SAASKPRGPAAAPGAVPGKPGGAPFPLGPhAPPQQTPTHHQQATPqqesPLKQQHQQKQARQEPAPQPKQPE 368
Cdd:PHA03247  2788 VASLSesrESLPSPWDPADPPAAVLAPAAALPPAASP-AGPLPPPTSAQPTAP----PPPPGPPPPSLPLGGSVAPGGDV 2862

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  369 RPKvncplcktelniGSTEPPNYNSCTQCHTQVCNLcgfnPTPHLVEKKEwlclncqTQRLMSGGLEDPPLPIPQMSPKH 448
Cdd:PHA03247  2863 RRR------------PPSRSPAAKPAAPARPPVRRL----ARPAVSRSTE-------SFALPPDQPERPPQPQAPPPPQP 2919

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  449 QPMGSPrhhppasqqqvqqPPHPKTPSQQHTGPKPAQQPQPKPASVQGSGPFAPVKQSVETRQDKTPIQ----PASTLTS 524
Cdd:PHA03247  2920 QPQPPP-------------PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPrfrvPQPAPSR 2986

                          410       420       430
                   ....*....|....*....|....*....|...
gi 1916946818  525 EAPRQQKTTEKDKIAPKIEKEDETPALPTEIKP 557
Cdd:PHA03247  2987 EAPASSTPPLTGHSLSRVSSWASSLALHEETDP 3019
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 4007-4103 8.01e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 45.48  E-value: 8.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818 4007 PGPVQARQPQAGTQPAPAAkTDTALTPGLAAKPAVAQPAKTPQPPLTGIGSK--AAPRPGGIGSAAAPQPSSEGESVLSK 4084
Cdd:PRK14951   387 AAPAAAPVAQAAAAPAPAA-APAAAASAPAAPPAAAPPAPVAAPAAAAPAAApaAAPAAVALAPAPPAQAAPETVAIPVR 465

                           90
                   ....*....|....*....
gi 1916946818 4085 ILPGGAAEQAGKLGEAVSA 4103
Cdd:PRK14951   466 VAPEPAVASAAPAPAAAPA 484
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 141-346 2.88e-03

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 43.84  E-value: 2.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  141 SPGLHRQTGPTPASQLGPQGGPAAHHMRSDPQAQRGPTSQAQ--TLGRQDPMG-----------RGSQSGMGPvQGMAKA 207
Cdd:pfam09606  159 MQPSSGQPGSGTPNQMGPNGGPGQGQAGGMNGGQQGPMGGQMppQMGVPGMPGpadagaqmgqqAQANGGMNP-QQMGGA 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  208 PSQPDLSRSSPMHQPSrQDQIRSAGSSPARQPAPPQEQPQDGLTGKLFG------------FGASLLNQASTLMSVDPLQ 275
Cdd:pfam09606  238 PNQVAMQQQQPQQQGQ-QSQLGMGINQMQQMPQGVGGGAGQGGPGQPMGppgqqpgampnvMSIGDQNNYQQQQTRQQQQ 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  276 GAQPQHSPA-------------RVAPKVVFSDASSAASKPRGPAAAPGAVPGKPG--GAPFPLGPHAPPQQTPTHHQQAT 340
Cdd:pfam09606  317 QQGGNHPAAhqqqmnqsvgqggQVVALGGLNHLETWNPGNFGGLGANPMQRGQPGmmSSPSPVPGQQVRQVTPNQFMRQS 396


                   ....*.
gi 1916946818  341 PQQESP 346
Cdd:pfam09606  397 PQPSVP 402
 
Name Accession Description Interval E-value
FYVE2_BSN_PCLO cd15772
FYVE-related domain 2 found in protein bassoon and piccolo; This family includes protein ...
 372-434 7.08e-42

FYVE-related domain 2 found in protein bassoon and piccolo; This family includes protein bassoon and piccolo. Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Both bassoon and piccolo contain two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. Their FYVE domain resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. This model corresponds to the second FYVE-related domain.


Pssm-ID: 277311 [Multi-domain]  Cd Length: 64  Bit Score: 148.64  E-value: 7.08e-42
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1916946818  372 VNCPLCKTELNIGSTEPPNYNSCTQCHTQVCNLCGFNPTPHLVEKKEWLCLNCQTQRLMSGGL 434
Cdd:cd15772      1 VTCPLCKTELNVGSKEPPNYNTCTQCHTQVCNLCGFNPTPHLVEKKEWLCLNCQTQRLMSGGL 63
FYVE2_BSN cd15775
FYVE-related domain 2 found in protein bassoon; Protein bassoon, also termed zinc finger ...
 371-434 1.70e-41

FYVE-related domain 2 found in protein bassoon; Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Bassoon contains two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. This family corresponds to the second FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277314 [Multi-domain]  Cd Length: 65  Bit Score: 147.76  E-value: 1.70e-41
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1916946818  371 KVNCPLCKTELNIGSTEPPNYNSCTQCHTQVCNLCGFNPTPHLVEKKEWLCLNCQTQRLMSGGL 434
Cdd:cd15775      1 RVTCPLCKTELNVGSTEPPNYNTCTSCRTQVCNLCGFNPTPHLVEKNEWLCLNCQTQRLLEGSL 64
FYVE1_BSN_PCLO cd15771
FYVE-related domain 1 found in protein bassoon and piccolo; This family includes protein ...
 5-64 8.77e-40

FYVE-related domain 1 found in protein bassoon and piccolo; This family includes protein bassoon and piccolo. Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Both bassoon and piccolo contain two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. Their FYVE domain resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. This model corresponds to the first FYVE-related domain.


Pssm-ID: 277310 [Multi-domain]  Cd Length: 61  Bit Score: 142.45  E-value: 8.77e-40
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1916946818    5 KLCPVCNTTELTSHD-QPNFNTCTECHATVCNQCGFNPNPHLTEVQEWLCLNCQMQRALGM 64
Cdd:cd15771      1 TLCPLCNTTELTLHVpKPNFNTCTQCHTTVCNQCGFNPNPHLTEVKEWLCLNCQMQRALGM 61
FYVE1_BSN cd15773
FYVE-related domain 1 found in protein bassoon; Protein bassoon, also termed zinc finger ...
 2-64 1.73e-39

FYVE-related domain 1 found in protein bassoon; Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Bassoon contains two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. This family corresponds to the first FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277312 [Multi-domain]  Cd Length: 64  Bit Score: 141.76  E-value: 1.73e-39
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1916946818    2 PSSKLCPVCNTTELTSHD-QPNFNTCTECHATVCNQCGFNPNPHLTEVQEWLCLNCQMQRALGM 64
Cdd:cd15773      1 PSSTLCPICNTTELTSFPsQPNFNTCTQCHNKVCNQCGFNPNPHLTEVKEWLCLNCQMQRALGM 64
zf-piccolo pfam05715
Piccolo Zn-finger; This (predicted) Zinc finger is found in the bassoon and piccolo proteins. ...
 374-430 5.18e-38

Piccolo Zn-finger; This (predicted) Zinc finger is found in the bassoon and piccolo proteins. There are eight conserved cysteines, suggesting that it coordinates two zinc ligands.


Pssm-ID: 461722 [Multi-domain]  Cd Length: 60  Bit Score: 137.55  E-value: 5.18e-38
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1916946818  374 CPLCK-TELNIGSTEPPNYNSCTQCHTQVCNLCGFNPTPHLVEKKEWLCLNCQTQRLM 430
Cdd:pfam05715    3 CPLCKtTELNVGSKEPPNYNTCTECKSQVCNLCGFNPTPHLTEKKEWLCLNCQTQRAL 60
zf-piccolo pfam05715
Piccolo Zn-finger; This (predicted) Zinc finger is found in the bassoon and piccolo proteins. ...
 5-62 1.09e-36

Piccolo Zn-finger; This (predicted) Zinc finger is found in the bassoon and piccolo proteins. There are eight conserved cysteines, suggesting that it coordinates two zinc ligands.


Pssm-ID: 461722 [Multi-domain]  Cd Length: 60  Bit Score: 133.70  E-value: 1.09e-36
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818    5 KLCPVCNTTELTSH--DQPNFNTCTECHATVCNQCGFNPNPHLTEVQEWLCLNCQMQRAL 62
Cdd:pfam05715    1 TLCPLCKTTELNVGskEPPNYNTCTECKSQVCNLCGFNPTPHLTEKKEWLCLNCQTQRAL 60
FYVE2_PCLO cd15776
FYVE-related domain 2 found in protein piccolo; Protein piccolo, also termed aczonin, is a ...
 372-434 5.76e-34

FYVE-related domain 2 found in protein piccolo; Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Piccolo is a multi-domain protein containing two N-terminal FYVE zinc fingers, a polyproline tract, and a PDZ domain and two C-terminal C2 domains. This family corresponds to the second FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277315 [Multi-domain]  Cd Length: 64  Bit Score: 126.34  E-value: 5.76e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1916946818  372 VNCPLCKTELNIGSTEPPNYNSCTQCHTQVCNLCGFNPTPHLVEKKEWLCLNCQTQRLMSGGL 434
Cdd:cd15776      1 LLCPLCKTELNIGSKDPPNFNTCTECKKTVCNLCGFNPTPHLTEVKEWLCLNCQTQRAMSGQL 63
FYVE1_PCLO cd15774
FYVE-related domain 1 found in protein piccolo; Protein piccolo, also termed aczonin, is a ...
 6-64 1.81e-31

FYVE-related domain 1 found in protein piccolo; Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Piccolo is a multi-domain protein containing two N-terminal FYVE zinc fingers, a polyproline tract, and a PDZ domain and two C-terminal C2 domains. This family corresponds to the first FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277313 [Multi-domain]  Cd Length: 62  Bit Score: 118.98  E-value: 1.81e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1916946818    6 LCPVCNTTELTSH--DQPNFNTCTECHATVCNQCGFNPNPHLTEVQEWLCLNCQMQRALGM 64
Cdd:cd15774      2 ICPLCKTTELLLHtpEKANYNTCTQCQTTVCSLCGFNPNPHITEKKEWLCLNCQMQRALGG 62
FYVE_BSN_PCLO cd15751
FYVE-related domain found in protein bassoon and piccolo; This family includes protein bassoon ...
 5-64 3.09e-28

FYVE-related domain found in protein bassoon and piccolo; This family includes protein bassoon and piccolo. Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Both bassoon and piccolo contain two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. Their FYVE domain resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277290 [Multi-domain]  Cd Length: 62  Bit Score: 109.85  E-value: 3.09e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1916946818    5 KLCPVCNTTEL--TSHDQPNFNTCTECHATVCNQCGFNPNPHLTEVQEWLCLNCQMQRALGM 64
Cdd:cd15751      1 SACPLCGTSELplGSKSPPNYNTCTDCKNRVCNQCGFNSTPPVTKVKEWLCLNCQKKRALGA 62
FYVE1_PCLO cd15774
FYVE-related domain 1 found in protein piccolo; Protein piccolo, also termed aczonin, is a ...
 374-432 5.57e-28

FYVE-related domain 1 found in protein piccolo; Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Piccolo is a multi-domain protein containing two N-terminal FYVE zinc fingers, a polyproline tract, and a PDZ domain and two C-terminal C2 domains. This family corresponds to the first FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277313 [Multi-domain]  Cd Length: 62  Bit Score: 108.97  E-value: 5.57e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  374 CPLCK-TELNIGSTEPPNYNSCTQCHTQVCNLCGFNPTPHLVEKKEWLCLNCQTQRLMSG 432
Cdd:cd15774      3 CPLCKtTELLLHTPEKANYNTCTQCQTTVCSLCGFNPNPHITEKKEWLCLNCQMQRALGG 62
FYVE1_BSN_PCLO cd15771
FYVE-related domain 1 found in protein bassoon and piccolo; This family includes protein ...
 374-432 4.62e-26

FYVE-related domain 1 found in protein bassoon and piccolo; This family includes protein bassoon and piccolo. Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Both bassoon and piccolo contain two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. Their FYVE domain resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. This model corresponds to the first FYVE-related domain.


Pssm-ID: 277310 [Multi-domain]  Cd Length: 61  Bit Score: 103.54  E-value: 4.62e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1916946818  374 CPLCKTELNIGSTEPPNYNSCTQCHTQVCNLCGFNPTPHLVEKKEWLCLNCQTQRLMSG 432
Cdd:cd15771      3 CPLCNTTELTLHVPKPNFNTCTQCHTTVCNQCGFNPNPHLTEVKEWLCLNCQMQRALGM 61
FYVE2_PCLO cd15776
FYVE-related domain 2 found in protein piccolo; Protein piccolo, also termed aczonin, is a ...
 6-62 3.39e-25

FYVE-related domain 2 found in protein piccolo; Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Piccolo is a multi-domain protein containing two N-terminal FYVE zinc fingers, a polyproline tract, and a PDZ domain and two C-terminal C2 domains. This family corresponds to the second FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277315 [Multi-domain]  Cd Length: 64  Bit Score: 101.30  E-value: 3.39e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1916946818    6 LCPVCNTT-ELTSHDQPNFNTCTECHATVCNQCGFNPNPHLTEVQEWLCLNCQMQRAL 62
Cdd:cd15776      2 LCPLCKTElNIGSKDPPNFNTCTECKKTVCNLCGFNPTPHLTEVKEWLCLNCQTQRAM 59
FYVE1_BSN cd15773
FYVE-related domain 1 found in protein bassoon; Protein bassoon, also termed zinc finger ...
 374-430 1.55e-24

FYVE-related domain 1 found in protein bassoon; Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Bassoon contains two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. This family corresponds to the first FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277312 [Multi-domain]  Cd Length: 64  Bit Score: 99.39  E-value: 1.55e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1916946818  374 CPLCKTELNIGSTEPPNYNSCTQCHTQVCNLCGFNPTPHLVEKKEWLCLNCQTQRLM 430
Cdd:cd15773      6 CPICNTTELTSFPSQPNFNTCTQCHNKVCNQCGFNPNPHLTEVKEWLCLNCQMQRAL 62
FYVE_BSN_PCLO cd15751
FYVE-related domain found in protein bassoon and piccolo; This family includes protein bassoon ...
 374-430 5.23e-24

FYVE-related domain found in protein bassoon and piccolo; This family includes protein bassoon and piccolo. Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Both bassoon and piccolo contain two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. Their FYVE domain resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277290 [Multi-domain]  Cd Length: 62  Bit Score: 97.52  E-value: 5.23e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1916946818  374 CPLCK-TELNIGSTEPPNYNSCTQCHTQVCNLCGFNPTPHLVEKKEWLCLNCQTQRLM 430
Cdd:cd15751      3 CPLCGtSELPLGSKSPPNYNTCTDCKNRVCNQCGFNSTPPVTKVKEWLCLNCQKKRAL 60
FYVE2_BSN_PCLO cd15772
FYVE-related domain 2 found in protein bassoon and piccolo; This family includes protein ...
 7-62 5.46e-24

FYVE-related domain 2 found in protein bassoon and piccolo; This family includes protein bassoon and piccolo. Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Both bassoon and piccolo contain two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. Their FYVE domain resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. This model corresponds to the second FYVE-related domain.


Pssm-ID: 277311 [Multi-domain]  Cd Length: 64  Bit Score: 97.79  E-value: 5.46e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1916946818    7 CPVCNTT-ELTSHDQPNFNTCTECHATVCNQCGFNPNPHLTEVQEWLCLNCQMQRAL 62
Cdd:cd15772      3 CPLCKTElNVGSKEPPNYNTCTQCHTQVCNLCGFNPTPHLVEKKEWLCLNCQTQRLM 59
FYVE2_BSN cd15775
FYVE-related domain 2 found in protein bassoon; Protein bassoon, also termed zinc finger ...
 6-62 4.80e-22

FYVE-related domain 2 found in protein bassoon; Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Bassoon contains two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. This family corresponds to the second FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277314 [Multi-domain]  Cd Length: 65  Bit Score: 92.29  E-value: 4.80e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1916946818    6 LCPVCNTT-ELTSHDQPNFNTCTECHATVCNQCGFNPNPHLTEVQEWLCLNCQMQRAL 62
Cdd:cd15775      3 TCPLCKTElNVGSTEPPNYNTCTSCRTQVCNLCGFNPTPHLVEKNEWLCLNCQTQRLL 60
PHA03247 PHA03247
large tegument protein UL36; Provisional
 149-557 7.47e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 7.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  149 GPTPASQLGPQGGPAAHHMRSDPQAQRGP-----TSQAQTLGR--------QDPMGRGSQSGMGPVQGMAKAPSQPDLSR 215
Cdd:PHA03247  2630 SPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrPRRARRLGRaaqassppQRPRRRAARPTVGSLTSLADPPPPPPTPE 2709

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  216 SSPM----HQPSRQDQIRSAGSSPARQPAPPQEQPQDGLTgkLFGFGASLLNQASTLMSVDPLQGAQPQHSPARVAPKVV 291
Cdd:PHA03247  2710 PAPHalvsATPLPPGPAAARQASPALPAAPAPPAVPAGPA--TPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPA 2787

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  292 FSDAS---SAASKPRGPAAAPGAVPGKPGGAPFPLGPhAPPQQTPTHHQQATPqqesPLKQQHQQKQARQEPAPQPKQPE 368
Cdd:PHA03247  2788 VASLSesrESLPSPWDPADPPAAVLAPAAALPPAASP-AGPLPPPTSAQPTAP----PPPPGPPPPSLPLGGSVAPGGDV 2862

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  369 RPKvncplcktelniGSTEPPNYNSCTQCHTQVCNLcgfnPTPHLVEKKEwlclncqTQRLMSGGLEDPPLPIPQMSPKH 448
Cdd:PHA03247  2863 RRR------------PPSRSPAAKPAAPARPPVRRL----ARPAVSRSTE-------SFALPPDQPERPPQPQAPPPPQP 2919

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  449 QPMGSPrhhppasqqqvqqPPHPKTPSQQHTGPKPAQQPQPKPASVQGSGPFAPVKQSVETRQDKTPIQ----PASTLTS 524
Cdd:PHA03247  2920 QPQPPP-------------PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPrfrvPQPAPSR 2986

                          410       420       430
                   ....*....|....*....|....*....|...
gi 1916946818  525 EAPRQQKTTEKDKIAPKIEKEDETPALPTEIKP 557
Cdd:PHA03247  2987 EAPASSTPPLTGHSLSRVSSWASSLALHEETDP 3019
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 4007-4103 8.01e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 45.48  E-value: 8.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818 4007 PGPVQARQPQAGTQPAPAAkTDTALTPGLAAKPAVAQPAKTPQPPLTGIGSK--AAPRPGGIGSAAAPQPSSEGESVLSK 4084
Cdd:PRK14951   387 AAPAAAPVAQAAAAPAPAA-APAAAASAPAAPPAAAPPAPVAAPAAAAPAAApaAAPAAVALAPAPPAQAAPETVAIPVR 465

                           90
                   ....*....|....*....
gi 1916946818 4085 ILPGGAAEQAGKLGEAVSA 4103
Cdd:PRK14951   466 VAPEPAVASAAPAPAAAPA 484
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 294-370 1.81e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.59  E-value: 1.81e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1916946818  294 DASSAASKPRGPAAAPGAVPGKPGGAPFPLGPHAPPQQTPTHHQ-QATPQQESPLKQQHQQKQARQEPAPQPKQPERP 370
Cdd:PRK07764   391 AGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPApAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAP 468
PHA03247 PHA03247
large tegument protein UL36; Provisional
 265-586 2.36e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 2.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  265 ASTLMSVDPLQGAqPQHSPARVAPKVVFSDASSAASKPRGPAAAPGAVPGKPGGAPFPLGPHAPPQQTPTHHQQATPQQE 344
Cdd:PHA03247  2562 AAPDRSVPPPRPA-PRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDP 2640

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  345 SPLKQQHQQKQARQEPApqPKQPERPKVNCPLCKTELNIGSTEPPNYNSCTQCHTQVCNLCGFNPTPHLVEKK--EWLCL 422
Cdd:PHA03247  2641 HPPPTVPPPERPRDDPA--PGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAphALVSA 2718

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  423 NCQTQRLMSGGLEDPPLPI-PQMSPKHQPMGSPRHHPPASQQQVQQPPHPKTPSQQHTGPKPAQQPQPKPASVQGSGPFA 501
Cdd:PHA03247  2719 TPLPPGPAAARQASPALPAaPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESL 2798

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  502 PVKQSVETRQDKTPIQPASTLTSEAPR--QQKTTEKDKIAPKIEKEDETPALPTEIK-----PVAKKGaPEQVAVTTPVK 574
Cdd:PHA03247  2799 PSPWDPADPPAAVLAPAAALPPAASPAgpLPPPTSAQPTAPPPPPGPPPPSLPLGGSvapggDVRRRP-PSRSPAAKPAA 2877

                          330
                   ....*....|....*.
gi 1916946818  575 D----VKKTGEPQKSR 586
Cdd:PHA03247  2878 ParppVRRLARPAVSR 2893
PHA03247 PHA03247
large tegument protein UL36; Provisional
 140-388 2.50e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 2.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  140 ASPGLHRQTGPTPASQLGPqGGPAAHHMRSDPQAQRGPTSQAQTLGRQDPMGRGSQSG-MGPVQGMAKAPSQPDLSRSSP 218
Cdd:PHA03247  2715 LVSATPLPPGPAAARQASP-ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPpAAPAAGPPRRLTRPAVASLSE 2793

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  219 MHQ--PSRQDQIRSAGSSPARQPAPPQEQPQdgltgklfgfgASLLNQASTLMSVDPLQGAQPQHSP----ARVAPKVVF 292
Cdd:PHA03247  2794 SREslPSPWDPADPPAAVLAPAAALPPAASP-----------AGPLPPPTSAQPTAPPPPPGPPPPSlplgGSVAPGGDV 2862

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  293 SDASSAASKPRGPAAAP-------GAVPGKPGGAPFPLGPHAP-PQQTPTHHQQATPQQESPlkqqhqqkqARQEPAPQP 364
Cdd:PHA03247  2863 RRRPPSRSPAAKPAAPArppvrrlARPAVSRSTESFALPPDQPeRPPQPQAPPPPQPQPQPP---------PPPQPQPPP 2933

                          250       260
                   ....*....|....*....|....
gi 1916946818  365 KQPERPKVncPLCKTELNIGSTEP 388
Cdd:PHA03247  2934 PPPPRPQP--PLAPTTDPAGAGEP 2955
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 141-346 2.88e-03

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 43.84  E-value: 2.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  141 SPGLHRQTGPTPASQLGPQGGPAAHHMRSDPQAQRGPTSQAQ--TLGRQDPMG-----------RGSQSGMGPvQGMAKA 207
Cdd:pfam09606  159 MQPSSGQPGSGTPNQMGPNGGPGQGQAGGMNGGQQGPMGGQMppQMGVPGMPGpadagaqmgqqAQANGGMNP-QQMGGA 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  208 PSQPDLSRSSPMHQPSrQDQIRSAGSSPARQPAPPQEQPQDGLTGKLFG------------FGASLLNQASTLMSVDPLQ 275
Cdd:pfam09606  238 PNQVAMQQQQPQQQGQ-QSQLGMGINQMQQMPQGVGGGAGQGGPGQPMGppgqqpgampnvMSIGDQNNYQQQQTRQQQQ 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  276 GAQPQHSPA-------------RVAPKVVFSDASSAASKPRGPAAAPGAVPGKPG--GAPFPLGPHAPPQQTPTHHQQAT 340
Cdd:pfam09606  317 QQGGNHPAAhqqqmnqsvgqggQVVALGGLNHLETWNPGNFGGLGANPMQRGQPGmmSSPSPVPGQQVRQVTPNQFMRQS 396


                   ....*.
gi 1916946818  341 PQQESP 346
Cdd:pfam09606  397 PQPSVP 402
PHA03247 PHA03247
large tegument protein UL36; Provisional
 124-556 3.81e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 3.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  124 PKPQPKPQTQAQPqpqasPGLHRQTGPTPASQLGPQGGPAAHHMRSDPQAQR-GPTSQAQTLGR--------QDPMGRGS 194
Cdd:PHA03247  2614 PSPLPPDTHAPDP-----PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRvSRPRRARRLGRaaqassppQRPRRRAA 2688

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  195 QSGMGPVQGMAKAPSQPDLSRSSPM----HQPSRQDQIRSAGSSPARQPAPPQEQPQDGLTgkLFGFGASLLNQASTLMS 270
Cdd:PHA03247  2689 RPTVGSLTSLADPPPPPPTPEPAPHalvsATPLPPGPAAARQASPALPAAPAPPAVPAGPA--TPGGPARPARPPTTAGP 2766

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  271 VDPLQGAQPQHSPARVAPKVVFSDAS---SAASKPRGPAAAPGAVPGKPGGAPFPLGPhAPPQQTPTHHQQATPQQESPL 347
Cdd:PHA03247  2767 PAPAPPAAPAAGPPRRLTRPAVASLSesrESLPSPWDPADPPAAVLAPAAALPPAASP-AGPLPPPTSAQPTAPPPPPGP 2845

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  348 KQQHQQKQARQEPAP--QPKQPERPKVNCPLCKTELNIGSTEPPNYNSCTQCHTQvcnlcgfnPTPhlvekkewlclncQ 425
Cdd:PHA03247  2846 PPPSLPLGGSVAPGGdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAL--------PPD-------------Q 2904

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916946818  426 TQRLMSGGLEDPPLPIPQMSPKHQPMGSPRhhppasqqqvqQPPHPKTPSQQHTGPKPAQQPQPKPASVQgSGPFAPVKQ 505
Cdd:PHA03247  2905 PERPPQPQAPPPPQPQPQPPPPPQPQPPPP-----------PPPRPQPPLAPTTDPAGAGEPSGAVPQPW-LGALVPGRV 2972

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1916946818  506 SVETRQ--DKTPIQPASTLTSEAPRQQKTTEKDKIAPKIEKEDETPALPTEIK 556
Cdd:PHA03247  2973 AVPRFRvpQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLK 3025
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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