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Conserved domains on  [gi|1931211592|ref|XP_037295071|]
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protein VAC14 homolog [Manduca sexta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Vac14_Fig4_bd pfam11916
Vacuolar protein 14 C-terminal Fig4p binding; Vac14 is a scaffold for the Fab1 kinase complex, ...
 465-643 2.32e-93

Vacuolar protein 14 C-terminal Fig4p binding; Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. The C-terminal region of Vac14 binds to Fig4p. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.


:

Pssm-ID: 463395  Cd Length: 179  Bit Score: 287.07  E-value: 2.32e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931211592 465 ENLLEDRGAFIIRQLCVLLNAEDIYRAVSRILQQERNLRFVATMVDVLNTILLTSAELYDLRLQLRNFNKPATHSLFLSL 544
Cdd:pfam11916   1 RRLLERRGSLIIRQLCLLLNAERIYRTLAEILEKEEDLEFASTMVQTLNTILLTSPELAELRNKLRNLDSEEDRELFSTL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931211592 545 YGCWCHSPVSLLALCLLTHNYEHCNTLISLFGDLEITVDFLTEVDKLVQLIESPIFAYLRLELLWGADSEALRGALFGLL 624
Cdd:pfam11916  81 YKSWCHNPVATLSLCLLAQAYEHAYNLLQSFGELEITVEFLVQIDKLVQLLESPVFTYLRLQLLEPEKYPYLYKCLYGLL 160

                         170
                  ....*....|....*....
gi 1931211592 625 MLLPQSDAFRTLRDRLHCV 643
Cdd:pfam11916 161 MLLPQSSAFNTLRNRLQSV 179
HEAT super family cl46509
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 66-162 3.51e-36

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


The actual alignment was detected with superfamily member pfam12755:

Pssm-ID: 480849  Cd Length: 97  Bit Score: 131.18  E-value: 3.51e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931211592  66 NVKNGALMGLSSVAVGLGKSCIDYLPELTHPIVACFSESESRVRYQAAEALFNVLKIAREASLSQFPAVFDALARLSADP 145
Cdd:pfam12755   1 NARKGGLIGLAATAIALGKDIAPYLDDIIPPVLACFSDQDSRVRYYACESLYNIAKVARGEVLPYFNDIFDGLCKLFADS 80

                          90
                  ....*....|....*..
gi 1931211592 146 EPQVKHAAELLDRLLKD 162
Cdd:pfam12755  81 DPSVKNGAELLDRLLKD 97
 
Name Accession Description Interval E-value
Vac14_Fig4_bd pfam11916
Vacuolar protein 14 C-terminal Fig4p binding; Vac14 is a scaffold for the Fab1 kinase complex, ...
 465-643 2.32e-93

Vacuolar protein 14 C-terminal Fig4p binding; Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. The C-terminal region of Vac14 binds to Fig4p. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.


Pssm-ID: 463395  Cd Length: 179  Bit Score: 287.07  E-value: 2.32e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931211592 465 ENLLEDRGAFIIRQLCVLLNAEDIYRAVSRILQQERNLRFVATMVDVLNTILLTSAELYDLRLQLRNFNKPATHSLFLSL 544
Cdd:pfam11916   1 RRLLERRGSLIIRQLCLLLNAERIYRTLAEILEKEEDLEFASTMVQTLNTILLTSPELAELRNKLRNLDSEEDRELFSTL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931211592 545 YGCWCHSPVSLLALCLLTHNYEHCNTLISLFGDLEITVDFLTEVDKLVQLIESPIFAYLRLELLWGADSEALRGALFGLL 624
Cdd:pfam11916  81 YKSWCHNPVATLSLCLLAQAYEHAYNLLQSFGELEITVEFLVQIDKLVQLLESPVFTYLRLQLLEPEKYPYLYKCLYGLL 160

                         170
                  ....*....|....*....
gi 1931211592 625 MLLPQSDAFRTLRDRLHCV 643
Cdd:pfam11916 161 MLLPQSSAFNTLRNRLQSV 179
Vac14_Fab1_bd pfam12755
Vacuolar 14 Fab1-binding region; Vac14 is a scaffold for the Fab1 kinase complex, a complex ...
 66-162 3.51e-36

Vacuolar 14 Fab1-binding region; Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. This domain appears to be the one responsible for binding to Fab1. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.


Pssm-ID: 403838  Cd Length: 97  Bit Score: 131.18  E-value: 3.51e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931211592  66 NVKNGALMGLSSVAVGLGKSCIDYLPELTHPIVACFSESESRVRYQAAEALFNVLKIAREASLSQFPAVFDALARLSADP 145
Cdd:pfam12755   1 NARKGGLIGLAATAIALGKDIAPYLDDIIPPVLACFSDQDSRVRYYACESLYNIAKVARGEVLPYFNDIFDGLCKLFADS 80

                          90
                  ....*....|....*..
gi 1931211592 146 EPQVKHAAELLDRLLKD 162
Cdd:pfam12755  81 DPSVKNGAELLDRLLKD 97
 
Name Accession Description Interval E-value
Vac14_Fig4_bd pfam11916
Vacuolar protein 14 C-terminal Fig4p binding; Vac14 is a scaffold for the Fab1 kinase complex, ...
 465-643 2.32e-93

Vacuolar protein 14 C-terminal Fig4p binding; Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. The C-terminal region of Vac14 binds to Fig4p. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.


Pssm-ID: 463395  Cd Length: 179  Bit Score: 287.07  E-value: 2.32e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931211592 465 ENLLEDRGAFIIRQLCVLLNAEDIYRAVSRILQQERNLRFVATMVDVLNTILLTSAELYDLRLQLRNFNKPATHSLFLSL 544
Cdd:pfam11916   1 RRLLERRGSLIIRQLCLLLNAERIYRTLAEILEKEEDLEFASTMVQTLNTILLTSPELAELRNKLRNLDSEEDRELFSTL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931211592 545 YGCWCHSPVSLLALCLLTHNYEHCNTLISLFGDLEITVDFLTEVDKLVQLIESPIFAYLRLELLWGADSEALRGALFGLL 624
Cdd:pfam11916  81 YKSWCHNPVATLSLCLLAQAYEHAYNLLQSFGELEITVEFLVQIDKLVQLLESPVFTYLRLQLLEPEKYPYLYKCLYGLL 160

                         170
                  ....*....|....*....
gi 1931211592 625 MLLPQSDAFRTLRDRLHCV 643
Cdd:pfam11916 161 MLLPQSSAFNTLRNRLQSV 179
Vac14_Fab1_bd pfam12755
Vacuolar 14 Fab1-binding region; Vac14 is a scaffold for the Fab1 kinase complex, a complex ...
 66-162 3.51e-36

Vacuolar 14 Fab1-binding region; Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. This domain appears to be the one responsible for binding to Fab1. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.


Pssm-ID: 403838  Cd Length: 97  Bit Score: 131.18  E-value: 3.51e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931211592  66 NVKNGALMGLSSVAVGLGKSCIDYLPELTHPIVACFSESESRVRYQAAEALFNVLKIAREASLSQFPAVFDALARLSADP 145
Cdd:pfam12755   1 NARKGGLIGLAATAIALGKDIAPYLDDIIPPVLACFSDQDSRVRYYACESLYNIAKVARGEVLPYFNDIFDGLCKLFADS 80

                          90
                  ....*....|....*..
gi 1931211592 146 EPQVKHAAELLDRLLKD 162
Cdd:pfam12755  81 DPSVKNGAELLDRLLKD 97
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 65-116 5.68e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.50  E-value: 5.68e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1931211592  65 PNVKNGALMGLSSVAVGLGKSCIDYLPELTHPIVACFSESESRVRYQAAEAL 116
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWAL 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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