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Conserved domains on  [gi|1952992814|ref|XP_038417648|]
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WD repeat-containing protein 54 [Canis lupus familiaris]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 116-280 7.78e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 55.80  E-value: 7.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952992814 116 SPVQAVFargIASSGHFICVGTWSGRILVFDIPakgpNIVLSEELAGHQTSVTDIATEPAQGQdcvadMVTADDSGLLCV 195
Cdd:cd00200   136 DWVNSVA---FSPDGTFVASSSQDGTIKLWDLR----TGKCVATLTGHTGEVNSVAFSPDGEK-----LLSSSSDGTIKL 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952992814 196 WQSgPEFKLMTRIPGFGVPCPSVQL--WHGIVAAGYGDGQVRLYEASTGTLHVQISAHARAICALDLAPEVGKLLSAAED 273
Cdd:cd00200   204 WDL-STGKCLGTLRGHENGVNSVAFspDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                  ....*..
gi 1952992814 274 TFIHIWK 280
Cdd:cd00200   283 GTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 116-280 7.78e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.80  E-value: 7.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952992814 116 SPVQAVFargIASSGHFICVGTWSGRILVFDIPakgpNIVLSEELAGHQTSVTDIATEPAQGQdcvadMVTADDSGLLCV 195
Cdd:cd00200   136 DWVNSVA---FSPDGTFVASSSQDGTIKLWDLR----TGKCVATLTGHTGEVNSVAFSPDGEK-----LLSSSSDGTIKL 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952992814 196 WQSgPEFKLMTRIPGFGVPCPSVQL--WHGIVAAGYGDGQVRLYEASTGTLHVQISAHARAICALDLAPEVGKLLSAAED 273
Cdd:cd00200   204 WDL-STGKCLGTLRGHENGVNSVAFspDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                  ....*..
gi 1952992814 274 TFIHIWK 280
Cdd:cd00200   283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
112-282 7.82e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.46  E-value: 7.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952992814 112 SGDVSPVQAVfarGIASSGHFICVGTWSGRILVFDIPAKgpniVLSEELAGHQTSVTDIATEPaQGQDcvadMVTADDSG 191
Cdd:COG2319   243 TGHSGSVRSV---AFSPDGRLLASGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAFSP-DGKL----LASGSDDG 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952992814 192 LLCVWqSGPEFKLMTRIPGFGVPCPSVQlWH---GIVAAGYGDGQVRLYEASTGTLHVQISAHARAICALDLAPEVGKLL 268
Cdd:COG2319   311 TVRLW-DLATGKLLRTLTGHTGAVRSVA-FSpdgKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA 388

                         170
                  ....*....|....
gi 1952992814 269 SAAEDTFIHIWKLS 282
Cdd:COG2319   389 SGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 116-280 7.78e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.80  E-value: 7.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952992814 116 SPVQAVFargIASSGHFICVGTWSGRILVFDIPakgpNIVLSEELAGHQTSVTDIATEPAQGQdcvadMVTADDSGLLCV 195
Cdd:cd00200   136 DWVNSVA---FSPDGTFVASSSQDGTIKLWDLR----TGKCVATLTGHTGEVNSVAFSPDGEK-----LLSSSSDGTIKL 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952992814 196 WQSgPEFKLMTRIPGFGVPCPSVQL--WHGIVAAGYGDGQVRLYEASTGTLHVQISAHARAICALDLAPEVGKLLSAAED 273
Cdd:cd00200   204 WDL-STGKCLGTLRGHENGVNSVAFspDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                  ....*..
gi 1952992814 274 TFIHIWK 280
Cdd:cd00200   283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
112-282 7.82e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.46  E-value: 7.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952992814 112 SGDVSPVQAVfarGIASSGHFICVGTWSGRILVFDIPAKgpniVLSEELAGHQTSVTDIATEPaQGQDcvadMVTADDSG 191
Cdd:COG2319   243 TGHSGSVRSV---AFSPDGRLLASGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAFSP-DGKL----LASGSDDG 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952992814 192 LLCVWqSGPEFKLMTRIPGFGVPCPSVQlWH---GIVAAGYGDGQVRLYEASTGTLHVQISAHARAICALDLAPEVGKLL 268
Cdd:COG2319   311 TVRLW-DLATGKLLRTLTGHTGAVRSVA-FSpdgKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA 388

                         170
                  ....*....|....
gi 1952992814 269 SAAEDTFIHIWKLS 282
Cdd:COG2319   389 SGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 128-282 9.20e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.64  E-value: 9.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952992814 128 SSGHFICVGTWSGRILVFDIPAKgpniVLSEELAGHQTSVTDIatepaqgqDCVADM---VTADDSGLLCVWqSGPEFKL 204
Cdd:cd00200    61 ADGTYLASGSSDKTIRLWDLETG----ECVRTLTGHTSYVSSV--------AFSPDGrilSSSSRDKTIKVW-DVETGKC 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952992814 205 MTRIPGF--GVPCPSVQLWHGIVAAGYGDGQVRLYEASTGTLHVQISAHARAICALDLAPEVGKLLSAAEDTFIHIWKLS 282
Cdd:cd00200   128 LTTLRGHtdWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207
WD40 COG2319
WD40 repeat [General function prediction only];
99-324 3.34e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.37  E-value: 3.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952992814  99 SDGSVMVyWHALDSGDVSPVQ----AVFARGIASSGHFICVGTWSGRILVFDIpAKGPNIvlsEELAGHQTSVTDIATEP 174
Cdd:COG2319    98 ADGTVRL-WDLATGLLLRTLTghtgAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLL---RTLTGHSGAVTSVAFSP 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952992814 175 aQGQDcvadMVTADDSGLLCVWQSgPEFKLMTRIPGFGVPCPSVQLWHG--IVAAGYGDGQVRLYEASTGTLHVQISAHA 252
Cdd:COG2319   173 -DGKL----LASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDgkLLASGSADGTVRLWDLATGKLLRTLTGHS 246

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1952992814 253 RAICALDLAPEvGKLL-SAAEDTFIHIWKLSrSPESGHTEVEHCHGecvpdtqVCGARFcDPSGSSFAVTGYD 324
Cdd:COG2319   247 GSVRSVAFSPD-GRLLaSGSADGTVRLWDLA-TGELLRTLTGHSGG-------VNSVAF-SPDGKLLASGSDD 309
WD40 COG2319
WD40 repeat [General function prediction only];
155-324 5.92e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.52  E-value: 5.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952992814 155 VLSEELAGHQTSVTDIATEPAQGQDCVADMVTADDSGLLCVWQSGPEFKLMTRIPGFGVPCPSVQLWHGIVAAGYGDGQV 234
Cdd:COG2319    23 AALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952992814 235 RLYEASTGTLHVQISAHARAICALDLAPEVGKLLSAAEDTFIHIWKLSRSPE----SGHTEvehchgecvpdtQVCGARF 310
Cdd:COG2319   103 RLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLlrtlTGHSG------------AVTSVAF 170

                         170
                  ....*....|....
gi 1952992814 311 cDPSGSSFAVTGYD 324
Cdd:COG2319   171 -SPDGKLLASGSDD 183
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 156-281 6.20e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 6.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952992814 156 LSEELAGHQTSVTDIATEPAQGQdcvadMVTADDSGLLCVWQSGPEFKLMT-RIPGFGVPCPSVQLWHGIVAAGYGDGQV 234
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKL-----LATGSGDGTIKVWDLETGELLRTlKGHTGPVRDVAASADGTYLASGSSDKTI 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1952992814 235 RLYEASTGTLHVQISAHARAICALDLAPEVGKLLSAAEDTFIHIWKL 281
Cdd:cd00200    76 RLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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