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Conserved domains on  [gi|1953305611|ref|XP_038547586|]
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tetratricopeptide repeat protein 31 isoform X2 [Canis lupus familiaris]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
292-406 5.24e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 74.66  E-value: 5.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 292 QSPKAEACpglLAAALQQSQELAK----LGTSFAQNGFYHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADA 367
Cdd:COG0457    23 RYEEAIED---YEKALELDPDDAEalynLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDY 99

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1953305611 368 QVALTLRPGWPRGLFRLGKALMGLQRFEEAAAVFQETLR 406
Cdd:COG0457   100 DKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALE 138
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
292-406 5.24e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 74.66  E-value: 5.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 292 QSPKAEACpglLAAALQQSQELAK----LGTSFAQNGFYHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADA 367
Cdd:COG0457    23 RYEEAIED---YEKALELDPDDAEalynLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDY 99

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1953305611 368 QVALTLRPGWPRGLFRLGKALMGLQRFEEAAAVFQETLR 406
Cdd:COG0457   100 DKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALE 138
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 326-464 2.06e-08

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 56.33  E-value: 2.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 326 YHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADAQVALTLRPGWPRGLFRLGKALMGLQRFEEAAAVFQE-- 403
Cdd:PLN03088   18 FALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMKLEEYQTAKAALEKga 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1953305611 404 TLRGGcQPDAARELHSCLLHLAldpqrggiREPPGFPQPFCHAGPSVSSLLPVS---RPPSAAP 464
Cdd:PLN03088   98 SLAPG-DSRFTKLIKECDEKIA--------EEEKDLVQPVPSDLPSSVTAPPVEeadATPVVPP 152
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 259-397 2.07e-07

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 53.83  E-value: 2.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 259 EKGLNPEPRGKTRgPHQKMRQEEGSSRIEESPRQSPKAEACPGLLA---------AALQQSQE------LAKLGTSFAQN 323
Cdd:TIGR00990  62 QRESKPKISKKER-RKRKQAEKETEGKTEEKKSTAPKNAPVEPADElpeidessvANLSEEERkkyaakLKEKGNKAYRN 140

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1953305611 324 GFYHKAVVLFTQALKLNPrDHRLFGNRSFCHERLGQPTWALADAQVALTLRPGWPRGLFRLGKALMGLQRFEEA 397
Cdd:TIGR00990 141 KDFNKAIKLYSKAIECKP-DPVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKALNRRANAYDGLGKYADA 213
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 378-406 4.71e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 34.81  E-value: 4.71e-03
                          10        20
                  ....*....|....*....|....*....
gi 1953305611 378 PRGLFRLGKALMGLQRFEEAAAVFQETLR 406
Cdd:pfam07719   1 AEALYNLGLAYYKLGDYEEALEAYEKALE 29
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
292-406 5.24e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 74.66  E-value: 5.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 292 QSPKAEACpglLAAALQQSQELAK----LGTSFAQNGFYHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADA 367
Cdd:COG0457    23 RYEEAIED---YEKALELDPDDAEalynLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDY 99

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1953305611 368 QVALTLRPGWPRGLFRLGKALMGLQRFEEAAAVFQETLR 406
Cdd:COG0457   100 DKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALE 138
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
313-406 1.65e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 73.12  E-value: 1.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 313 LAKLGTSFAQNGFYHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADAQVALTLRPGWPRGLFRLGKALMGLQ 392
Cdd:COG0457    11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALG 90

                          90
                  ....*....|....
gi 1953305611 393 RFEEAAAVFQETLR 406
Cdd:COG0457    91 RYEEALEDYDKALE 104
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
313-427 2.05e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 73.12  E-value: 2.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 313 LAKLGTSFAQNGFYHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADAQVALTLRPGWPRGLFRLGKALMGLQ 392
Cdd:COG0457    79 LNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLG 158

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1953305611 393 RFEEAAAVFQETLRGGCQPDAARELHSCLLHLALD 427
Cdd:COG0457   159 RYEEALELLEKLEAAALAALLAAALGEAALALAAA 193
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
304-429 2.13e-14

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 72.64  E-value: 2.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 304 AAALQQSQELAKLGTSFAQNGFYHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADAQVALTLRPGWPRGLFR 383
Cdd:COG4785    67 LALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLN 146

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1953305611 384 LGKALMGLQRFEEAAAVFQETLRGGCQpDAARELHSCLLHLALDPQ 429
Cdd:COG4785   147 RGIALYYLGRYELAIADLEKALELDPN-DPERALWLYLAERKLDPE 191
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 290-406 3.07e-14

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 70.37  E-value: 3.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 290 PRQSPKAEACPGLLAAALQQSQELAKLGTSFAQNGFYHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADAQV 369
Cdd:COG5010    34 ANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEK 113

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1953305611 370 ALTLRPGWPRGLFRLGKALMGLQRFEEAAAVFQETLR 406
Cdd:COG5010   114 ALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALG 150
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 295-406 1.35e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 67.91  E-value: 1.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 295 KAEAcpgLLAAALQQSQE----LAKLGTSFAQNGFYHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADAQVA 370
Cdd:COG4783    22 EAEA---LLEKALELDPDnpeaFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKA 98

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1953305611 371 LTLRPGWPRGLFRLGKALMGLQRFEEAAAVFQETLR 406
Cdd:COG4783    99 LKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALE 134
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 313-426 2.89e-13

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 72.33  E-value: 2.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 313 LAKLGTSFAQNGFYHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADAQVALTLRPGWPRGLFRLGKALMGLQ 392
Cdd:COG3914   115 LFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLG 194

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1953305611 393 RFEEAAAVFQETLRggCQPDAArELHSCLLHLAL 426
Cdd:COG3914   195 RLEEAIAAYRRALE--LDPDNA-DAHSNLLFALR 225
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 301-426 2.11e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 66.56  E-value: 2.11e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 301 GLLAAALQQSQELAKLGTSFAQ----NGFYHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADAQVALTLRPG 376
Cdd:COG3914    65 GEAAAAAAALLLLAALLELAALllqaLGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPD 144

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1953305611 377 WPRGLFRLGKALMGLQRFEEAAAVFQETLRggCQPDAArELHsclLHLAL 426
Cdd:COG3914   145 FAEAYLNLGEALRRLGRLEEAIAALRRALE--LDPDNA-EAL---NNLGN 188
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 308-406 3.54e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 60.98  E-value: 3.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 308 QQSQELAKLGTSFAQNGFYHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADAQVALTLRPGWPRGLFRLGKA 387
Cdd:COG4783     2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLA 81

                          90
                  ....*....|....*....
gi 1953305611 388 LMGLQRFEEAAAVFQETLR 406
Cdd:COG4783    82 LLKAGDYDEALALLEKALK 100
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
320-415 1.03e-10

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 58.26  E-value: 1.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 320 FAQNGFYHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALAdAQVALTLRPGWPRGLFRLGKALMGLQRFEEAAA 399
Cdd:COG3063     2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALA 80

                          90
                  ....*....|....*.
gi 1953305611 400 VFQETLRGgcQPDAAR 415
Cdd:COG3063    81 YLERALEL--DPSALR 94
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 303-406 1.20e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 59.25  E-value: 1.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 303 LAAALQQSQE----LAKLGTSFAQNGFYHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADAQVALTLRPGWP 378
Cdd:COG4235     6 LRQALAANPNdaegWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNP 85

                          90       100
                  ....*....|....*....|....*...
gi 1953305611 379 RGLFRLGKALMGLQRFEEAAAVFQETLR 406
Cdd:COG4235    86 EALYLLGLAAFQQGDYAEAIAAWQKLLA 113
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
337-406 4.88e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.02  E-value: 4.88e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 337 LKLNPRDHRLFGNRSFCHERLGQPTWALADAQVALTLRPGWPRGLFRLGKALMGLQRFEEAAAVFQETLR 406
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALE 70
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 326-464 2.06e-08

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 56.33  E-value: 2.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 326 YHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADAQVALTLRPGWPRGLFRLGKALMGLQRFEEAAAVFQE-- 403
Cdd:PLN03088   18 FALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMKLEEYQTAKAALEKga 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1953305611 404 TLRGGcQPDAARELHSCLLHLAldpqrggiREPPGFPQPFCHAGPSVSSLLPVS---RPPSAAP 464
Cdd:PLN03088   98 SLAPG-DSRFTKLIKECDEKIA--------EEEKDLVQPVPSDLPSSVTAPPVEeadATPVVPP 152
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 302-417 3.51e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 54.74  E-value: 3.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 302 LLAAALQQSQELAKLGTSFAQNGFYHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADAQVALTLRPGWPRGL 381
Cdd:COG2956   136 LLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPAL 215

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1953305611 382 FRLGKALMGLQRFEEAAAVFQETLRGGCQPDAAREL 417
Cdd:COG2956   216 PRLAELYEKLGDPEEALELLRKALELDPSDDLLLAL 251
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 302-415 1.60e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.81  E-value: 1.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 302 LLAAALQQSQELAKLGTSFAQNGFYHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADAQVALTLRPGWPRGL 381
Cdd:COG2956    68 LLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAY 147

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1953305611 382 FRLGKALMGLQRFEEAAAVFQETLRggCQPDAAR 415
Cdd:COG2956   148 CELAELYLEQGDYDEAIEALEKALK--LDPDCAR 179
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 259-397 2.07e-07

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 53.83  E-value: 2.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 259 EKGLNPEPRGKTRgPHQKMRQEEGSSRIEESPRQSPKAEACPGLLA---------AALQQSQE------LAKLGTSFAQN 323
Cdd:TIGR00990  62 QRESKPKISKKER-RKRKQAEKETEGKTEEKKSTAPKNAPVEPADElpeidessvANLSEEERkkyaakLKEKGNKAYRN 140

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1953305611 324 GFYHKAVVLFTQALKLNPrDHRLFGNRSFCHERLGQPTWALADAQVALTLRPGWPRGLFRLGKALMGLQRFEEA 397
Cdd:TIGR00990 141 KDFNKAIKLYSKAIECKP-DPVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKALNRRANAYDGLGKYADA 213
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 295-406 2.72e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.04  E-value: 2.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 295 KAEAcpgLLAAALQQSQE----LAKLGTSFAQNGFYHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADAQVA 370
Cdd:COG2956    94 RAEE---LLEKLLELDPDdaeaLRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKA 170

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1953305611 371 LTLRPGWPRGLFRLGKALMGLQRFEEAAAVFQETLR 406
Cdd:COG2956   171 LKLDPDCARALLLLAELYLEQGDYEEAIAALERALE 206
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 328-406 3.55e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 49.23  E-value: 3.55e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1953305611 328 KAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADAQVALTLRPGWPRGLFRLGKALMGLQRFEEAAAVFQETLR 406
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALA 79
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 295-448 1.23e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.15  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 295 KAEACpglLAAALQQSQELA----KLGTSFAQNGFYHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADAQVA 370
Cdd:COG3914   130 EALAA---LRRALALNPDFAeaylNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRA 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 371 LTLRPGWPRGLFRLGKALMGLQRFEEAAAVFQETLRGGCQPDAARELHscLLHLALDP---------QRGGIREPPGFPQ 441
Cdd:COG3914   207 LELDPDNADAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFA--LLYLPDDDpaellalarAWAQLVAAAAAPE 284


                  ....*..
gi 1953305611 442 PFCHAGP 448
Cdd:COG3914   285 LPPPPNP 291
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 305-375 5.19e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 46.49  E-value: 5.19e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1953305611 305 AALQQSQELAK--------LGTSFAQNGFYHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADAQVALTLRP 375
Cdd:COG5010    75 ALLEQALQLDPnnpelyynLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 302-403 5.43e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.19  E-value: 5.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 302 LLAAALQQSQELAKlGTSFAQNGFYHKAVVLFTQALKLNPRD---HRLFGNrsfCHERLGQPTWALADAQVALTLRPGWP 378
Cdd:COG2956     1 LLLPVAAALGWYFK-GLNYLLNGQPDKAIDLLEEALELDPETveaHLALGN---LYRRRGEYDRAIRIHQKLLERDPDRA 76

                          90       100
                  ....*....|....*....|....*
gi 1953305611 379 RGLFRLGKALMGLQRFEEAAAVFQE 403
Cdd:COG2956    77 EALLELAQDYLKAGLLDRAEELLEK 101
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
353-406 4.06e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 42.46  E-value: 4.06e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1953305611 353 CHERLGQPTWALADAQVALTLRPGWPRGLFRLGKALMGLQRFEEAAAvFQETLR 406
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALK 53
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 319-403 2.01e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 41.13  E-value: 2.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 319 SFAQNGFYHKAVVLFTQALKLNPrDHRLFGNRSF----CHERLGQPTWALADAQVALTLRPGW---PRGLFRLGKALMGL 391
Cdd:COG1729     2 ALLKAGDYDEAIAAFKAFLKRYP-NSPLAPDALYwlgeAYYALGDYDEAAEAFEKLLKRYPDSpkaPDALLKLGLSYLEL 80

                          90
                  ....*....|..
gi 1953305611 392 QRFEEAAAVFQE 403
Cdd:COG1729    81 GDYDKARATLEE 92
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 313-375 2.09e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 41.72  E-value: 2.09e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1953305611 313 LAKLGTSFAQNGFYHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADAQVALTLRP 375
Cdd:COG4783    75 RLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDP 137
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
295-399 2.25e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.07  E-value: 2.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 295 KAEACpglLAAALQQSQELAK----LGTSFAQNGFYHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADAQVA 370
Cdd:COG0457    94 EALED---YDKALELDPDDAEalynLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKL 170

                          90       100
                  ....*....|....*....|....*....
gi 1953305611 371 LTLRPGWPRGLFRLGKALMGLQRFEEAAA 399
Cdd:COG0457   171 EAAALAALLAAALGEAALALAAAEVLLAL 199
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 302-406 4.27e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.10  E-value: 4.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 302 LLAAALQQSQELAKLGTSFAQNGFYHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADAQVALTLRPGWPRGL 381
Cdd:COG5010    12 LYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELY 91

                          90       100
                  ....*....|....*....|....*
gi 1953305611 382 FRLGKALMGLQRFEEAAAVFQETLR 406
Cdd:COG5010    92 YNLALLYSRSGDKDEAKEYYEKALA 116
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 304-375 5.77e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 39.99  E-value: 5.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 304 AAALQQSQEL--------AKLGTSFAQNGFYHKAVVLFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADAQVALTLRP 375
Cdd:COG4235    37 LAAYEKALRLdpdnadalLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLP 116
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
295-375 7.66e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 39.00  E-value: 7.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 295 KAEACpglLAAALQQSQELAK----LGTSFAQNGFYHKAVVlFTQALKLNPRDHRLFGNRSFCHERLGQPTWALADAQVA 370
Cdd:COG3063    10 EAEEY---YEKALELDPDNADalnnLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERA 85


                  ....*
gi 1953305611 371 LTLRP 375
Cdd:COG3063    86 LELDP 90
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 248-424 1.77e-03

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 40.66  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 248 RKEDWP------PGARREKGLNPEPRgktrgphQKMRQEEGSSRIEESPRQSPKAEACPGLLAAALQQSQEL-AKLGTSF 320
Cdd:COG3071   131 QLGDWEellellPALRKHKALSAEEA-------QALERRAYLGLLRQAARDAEALKALWKALPRAERRDPELaAAYARAL 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 321 AQNGFYHKAVVLFTQALKLNPRDH--RLFGNRsfcheRLGQPTWALADAQVALTLRPGWPRGLFRLGKALMGLQRFEEAA 398
Cdd:COG3071   204 IALGDHDEAERLLREALKRQWDPRlvRLYGRL-----QGGDPAKQLKRAEKWLKKHPNDPDLLLALGRLCLRNQLWGKAR 278

                         170       180
                  ....*....|....*....|....*.
gi 1953305611 399 AVFQETLRGGCQPDAARELHSCLLHL 424
Cdd:COG3071   279 EYLEAALALRPSAEAYAELARLLEQL 304
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 302-399 4.50e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.68  E-value: 4.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953305611 302 LLAAALQQSQELAKLGTSF--AQNGFYHKAVVLFTQALKLNPRD---HRLFGNRSFCherLGQPTWALADAQVALTLRPG 376
Cdd:TIGR02917 149 EQALAIDPRSLYAKLGLAQlaLAENRFDEARALIDEVLTADPGNvdaLLLKGDLLLS---LGNIELALAAYRKAIALRPN 225

                          90       100
                  ....*....|....*....|...
gi 1953305611 377 WPRGLFRLGKALMGLQRFEEAAA 399
Cdd:TIGR02917 226 NIAVLLALATILIEAGEFEEAEK 248
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 378-406 4.71e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 34.81  E-value: 4.71e-03
                          10        20
                  ....*....|....*....|....*....
gi 1953305611 378 PRGLFRLGKALMGLQRFEEAAAVFQETLR 406
Cdd:pfam07719   1 AEALYNLGLAYYKLGDYEEALEAYEKALE 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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