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Conserved domains on  [gi|1958787569|ref|XP_038934272|]
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cytokine receptor common subunit beta isoform X1 [Rattus norvegicus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10637190)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; similar to Homo sapiens interleukin-27 subunit beta that associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 344-438 2.41e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.64  E-value: 2.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958787569 344 NPPTLNLTK-NRDSYSLHWETQKMSYPFIQHaFQVQYKKKLDS-WEDSKTENLNhAHSMDLPQLEPGTSYCARVRVKTip 421
Cdd:cd00063     3 PPTNLRVTDvTSTSVTLSWTPPEDDGGPITG-YVVEYREKGSGdWKEVEVTPGS-ETSYTLTGLKPGTEYEFRVRAVN-- 78

                          90
                  ....*....|....*..
gi 1958787569 422 eyKGLWSEWSNECTWTT 438
Cdd:cd00063    79 --GGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 136-224 2.82e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.29  E-value: 2.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958787569  136 PPPPKDISISP-SGDHFLLKWSVPHGDAQVSllsqKDIQFEVAYKRLQDSWEDASSLHTSNlWVTLEPklFLPNSIYVAR 214
Cdd:smart00060   1 PSPPSNLRVTDvTSTSVTLSWEPPPDDGITG----YIVGYRVEYREEGSEWKEVNVTPSST-SYTLTG--LKPGTEYEFR 73

                           90
                   ....*....|
gi 1958787569  215 VRTQLAPGSS 224
Cdd:smart00060  74 VRAVNGAGEG 83
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 344-438 2.41e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.64  E-value: 2.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958787569 344 NPPTLNLTK-NRDSYSLHWETQKMSYPFIQHaFQVQYKKKLDS-WEDSKTENLNhAHSMDLPQLEPGTSYCARVRVKTip 421
Cdd:cd00063     3 PPTNLRVTDvTSTSVTLSWTPPEDDGGPITG-YVVEYREKGSGdWKEVEVTPGS-ETSYTLTGLKPGTEYEFRVRAVN-- 78

                          90
                  ....*....|....*..
gi 1958787569 422 eyKGLWSEWSNECTWTT 438
Cdd:cd00063    79 --GGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 136-224 2.82e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.29  E-value: 2.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958787569  136 PPPPKDISISP-SGDHFLLKWSVPHGDAQVSllsqKDIQFEVAYKRLQDSWEDASSLHTSNlWVTLEPklFLPNSIYVAR 214
Cdd:smart00060   1 PSPPSNLRVTDvTSTSVTLSWEPPPDDGITG----YIVGYRVEYREEGSEWKEVNVTPSST-SYTLTG--LKPGTEYEFR 73

                           90
                   ....*....|
gi 1958787569  215 VRTQLAPGSS 224
Cdd:smart00060  74 VRAVNGAGEG 83
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 335-438 3.35e-03

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 38.09  E-value: 3.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958787569 335 IESFN---HIQMNPPTLNLTKNRdsySLHWETQKMSYpfiqhafQVQYKKKLDSWEDSKTENLNHAHSmdLPQLEPGTSY 411
Cdd:pfam09294  10 LEVEGgslNVTVKDPETREGKNL---SLRDLYGSLQY-------RVSYWKNSSNGEKKNTTSTNSFVV--LSDLEPGTTY 77

                          90       100
                  ....*....|....*....|....*...
gi 1958787569 412 CARVRVKTIPEYK-GLWSEWsnECTWTT 438
Cdd:pfam09294  78 CVSVQAFSPLDNKsSQRSPP--QCIRTT 103
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 344-438 2.41e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.64  E-value: 2.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958787569 344 NPPTLNLTK-NRDSYSLHWETQKMSYPFIQHaFQVQYKKKLDS-WEDSKTENLNhAHSMDLPQLEPGTSYCARVRVKTip 421
Cdd:cd00063     3 PPTNLRVTDvTSTSVTLSWTPPEDDGGPITG-YVVEYREKGSGdWKEVEVTPGS-ETSYTLTGLKPGTEYEFRVRAVN-- 78

                          90
                  ....*....|....*..
gi 1958787569 422 eyKGLWSEWSNECTWTT 438
Cdd:cd00063    79 --GGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 136-224 2.82e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.29  E-value: 2.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958787569  136 PPPPKDISISP-SGDHFLLKWSVPHGDAQVSllsqKDIQFEVAYKRLQDSWEDASSLHTSNlWVTLEPklFLPNSIYVAR 214
Cdd:smart00060   1 PSPPSNLRVTDvTSTSVTLSWEPPPDDGITG----YIVGYRVEYREEGSEWKEVNVTPSST-SYTLTG--LKPGTEYEFR 73

                           90
                   ....*....|
gi 1958787569  215 VRTQLAPGSS 224
Cdd:smart00060  74 VRAVNGAGEG 83
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 335-438 3.35e-03

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 38.09  E-value: 3.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958787569 335 IESFN---HIQMNPPTLNLTKNRdsySLHWETQKMSYpfiqhafQVQYKKKLDSWEDSKTENLNHAHSmdLPQLEPGTSY 411
Cdd:pfam09294  10 LEVEGgslNVTVKDPETREGKNL---SLRDLYGSLQY-------RVSYWKNSSNGEKKNTTSTNSFVV--LSDLEPGTTY 77

                          90       100
                  ....*....|....*....|....*...
gi 1958787569 412 CARVRVKTIPEYK-GLWSEWsnECTWTT 438
Cdd:pfam09294  78 CVSVQAFSPLDNKsSQRSPP--QCIRTT 103
fn3 pfam00041
Fibronectin type III domain;
345-431 8.61e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 36.24  E-value: 8.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958787569 345 PPTLNLTKNRDSY-SLHWETQKMSYPFIQHaFQVQYKKKLDSWEDSKTENLNHAHSMDLPQLEPGTSYcaRVRVKTIpeY 423
Cdd:pfam00041   3 PSNLTVTDVTSTSlTVSWTPPPDGNGPITG-YEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEY--EVRVQAV--N 77


                  ....*...
gi 1958787569 424 KGLWSEWS 431
Cdd:pfam00041  78 GGGEGPPS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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