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Conserved domains on  [gi|1958789102|ref|XP_038934926|]
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ADAMTS-like protein 5 isoform X9 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADAMTS_spacer1 super family cl20316
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 377-456 7.15e-22

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


The actual alignment was detected with superfamily member pfam05986:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 90.72  E-value: 7.15e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789102 377 GYWNVTLIPEGARHIRVTQR--SHNHLALVTRDGHYVLNGDGVLSL-PGTYEAAGTRVVYTRSAGPEETLQATGPTSQEL 453
Cdd:pfam05986  13 GYVTFVTIPAGATHIHIVNRkpSFTHLAVKNVQGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPALEELHAPGPTQEDL 92


                  ...
gi 1958789102 454 LLQ 456
Cdd:pfam05986  93 EIQ 95
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 263-362 2.55e-12

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 63.57  E-value: 2.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789102 263 IPFRDLQCSLYNGHPVL---GTQKTYQW---VPFHGAPNLCDLNCLAEGHAFYHSFG-RVLDGTPCTP------GTQGLC 329
Cdd:pfam19236   3 LEFMSQQCARTDGQPLRsspGGASFYHWgaaVPHSQGDALCRHMCRAIGESFIMKRGdSFLDGTRCMPsgpredGTLSLC 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1958789102 330 VAGRCLSAGCDGLLGSGTLEDRCGLCGGANDSC 362
Cdd:pfam19236  83 VLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 200-246 1.07e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 51.43  E-value: 1.07e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958789102  200 WTLWGSWSRCSSSCGRGVSVRRRHCVRLPE---EELCWGDSHEYRVCQLP 246
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPqngGGPCTGEDVETRACNEQ 50
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 377-456 7.15e-22

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 90.72  E-value: 7.15e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789102 377 GYWNVTLIPEGARHIRVTQR--SHNHLALVTRDGHYVLNGDGVLSL-PGTYEAAGTRVVYTRSAGPEETLQATGPTSQEL 453
Cdd:pfam05986  13 GYVTFVTIPAGATHIHIVNRkpSFTHLAVKNVQGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPALEELHAPGPTQEDL 92


                  ...
gi 1958789102 454 LLQ 456
Cdd:pfam05986  93 EIQ 95
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 263-362 2.55e-12

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 63.57  E-value: 2.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789102 263 IPFRDLQCSLYNGHPVL---GTQKTYQW---VPFHGAPNLCDLNCLAEGHAFYHSFG-RVLDGTPCTP------GTQGLC 329
Cdd:pfam19236   3 LEFMSQQCARTDGQPLRsspGGASFYHWgaaVPHSQGDALCRHMCRAIGESFIMKRGdSFLDGTRCMPsgpredGTLSLC 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1958789102 330 VAGRCLSAGCDGLLGSGTLEDRCGLCGGANDSC 362
Cdd:pfam19236  83 VLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 200-246 1.07e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 51.43  E-value: 1.07e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958789102  200 WTLWGSWSRCSSSCGRGVSVRRRHCVRLPE---EELCWGDSHEYRVCQLP 246
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPqngGGPCTGEDVETRACNEQ 50
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 203-246 4.02e-05

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 41.11  E-value: 4.02e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958789102 203 WGSWSRCSSSCGRGVSVRRRHCVRLPEE--ELCwGDSHEYRVCQLP 246
Cdd:pfam19028   6 WSEWSECSVTCGGGVQTRTRTVIVEPQNggRPC-PELLERRPCNLP 50
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 200-249 1.17e-04

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 44.55  E-value: 1.17e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958789102 200 WTLWGSWSRCSSSCGR--GVSVRRRHCVRlPEEELCWGDSHEYRVCQLPFYP 249
Cdd:PTZ00087  233 YTEWGEWSNCSMECDHpdNVQIRERKCAH-PSGDCFKGDLKETRPCQVPLPP 283
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 377-456 7.15e-22

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 90.72  E-value: 7.15e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789102 377 GYWNVTLIPEGARHIRVTQR--SHNHLALVTRDGHYVLNGDGVLSL-PGTYEAAGTRVVYTRSAGPEETLQATGPTSQEL 453
Cdd:pfam05986  13 GYVTFVTIPAGATHIHIVNRkpSFTHLAVKNVQGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPALEELHAPGPTQEDL 92


                  ...
gi 1958789102 454 LLQ 456
Cdd:pfam05986  93 EIQ 95
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 263-362 2.55e-12

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 63.57  E-value: 2.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958789102 263 IPFRDLQCSLYNGHPVL---GTQKTYQW---VPFHGAPNLCDLNCLAEGHAFYHSFG-RVLDGTPCTP------GTQGLC 329
Cdd:pfam19236   3 LEFMSQQCARTDGQPLRsspGGASFYHWgaaVPHSQGDALCRHMCRAIGESFIMKRGdSFLDGTRCMPsgpredGTLSLC 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1958789102 330 VAGRCLSAGCDGLLGSGTLEDRCGLCGGANDSC 362
Cdd:pfam19236  83 VLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 200-246 1.07e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 51.43  E-value: 1.07e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958789102  200 WTLWGSWSRCSSSCGRGVSVRRRHCVRLPE---EELCWGDSHEYRVCQLP 246
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPqngGGPCTGEDVETRACNEQ 50
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 203-246 4.02e-05

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 41.11  E-value: 4.02e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958789102 203 WGSWSRCSSSCGRGVSVRRRHCVRLPEE--ELCwGDSHEYRVCQLP 246
Cdd:pfam19028   6 WSEWSECSVTCGGGVQTRTRTVIVEPQNggRPC-PELLERRPCNLP 50
TSP_1 pfam00090
Thrombospondin type 1 domain;
201-246 6.13e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 40.48  E-value: 6.13e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958789102 201 TLWGSWSRCSSSCGRGVSVRRRHCV-RLPEEELCWGDSHEYRVCQLP 246
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKsPFPGGEPCTGDDIETQACKMD 47
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 200-249 1.17e-04

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 44.55  E-value: 1.17e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958789102 200 WTLWGSWSRCSSSCGR--GVSVRRRHCVRlPEEELCWGDSHEYRVCQLPFYP 249
Cdd:PTZ00087  233 YTEWGEWSNCSMECDHpdNVQIRERKCAH-PSGDCFKGDLKETRPCQVPLPP 283
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 204-246 3.19e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 35.89  E-value: 3.19e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958789102 204 GSWSRCSSSCGRGVSVRRRHCVR-----LPEEELCWGDS--HEYRVCQLP 246
Cdd:pfam19030   4 GPWGECSVTCGGGVQTRLVQCVQkgggsIVPDSECSAQKkpPETQSCNLK 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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